Annotation Detail

Information
Associated Genes
NOTCH3
Associated Variants
NOTCH3 p.Arg133Cys (p.R133C) ( ENST00000263388.7 )
NOTCH3 p.Arg133Ser (p.R133S) ( ENST00000263388.7 )
NOTCH3 p.Arg133Cys (p.R133C) ( ENST00000263388.7 )
NOTCH3 p.Arg133Ser (p.R133S) ( ENST00000263388.7 )
Associated Disease
CADASIL Syndrome
Source Database
DisGeNET
Description
Arg133Cys mutation of Notch3 in two unrelated Japanese families with CADASIL.
Pubmed
10969905
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.537478390901604
Year of publication
2000
Drugs