Annotation Detail
Information
- Associated Genes
- FANCC
- Associated Variants
-
FANCC LOSS-OF-FUNCTION
FANCC LOSS-OF-FUNCTION - Associated Disease
- pancreatic cancer
- Source Database
- CIViC Evidence
- Description
- In the pancreatic cell lines PL11 (FANCC homozygous deletion) and Hs766T (FANCG-mutated), sensitivity to DNA cross-linking agents was observed. PL11 cells (empty vector transduced) were more sensitive to mitomycin C (MMC), cisplatin, chlorambucil, and melphalan than PL11 cells transduced with a vector wildtype FANCC. Similarly, mouse xenografts of PL11 cells (empty vector) were more sensitive to MMC or gemcitabine than PL11 cells expressing a wildtype FANCC.
- Variant Origin
- Unknown
- Variant Origin
- Unknown
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1307
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1811
- Variant URL
- https://civic.genome.wustl.edu/links/variants/534
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Pancreatic Cancer
- Evidence Direction
- Supports
- Drug
- Mitomycin,Cisplatin,Chlorambucil,Melphalan,Gemcitabine
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 16243825
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Chlorambucil | Sensitivity | true |
| Cisplatin | Sensitivity | true |
| Gemcitabine | Sensitivity | true |
| Melphalan | Sensitivity | true |
| Mitomycin | Sensitivity | true |