Annotation Detail

Information

Associated Genes: ATRX
Associated Variants: ATRX UNDEREXPRESSION ( ENST00000373344.11 )
ATRX UNDEREXPRESSION ( ENST00000373344.11 )
Associated Disease: malignant astrocytoma
Source Database: CIViC Evidence
Description: A retrospective tumor sample study found that the loss of ATRX expression (less than 10% of nuclei) in IDH-mutant astrocytomas treated with temozolomide or a combination of procarbazine, lomustine and vincristine was associated with a greater time to treatment failure (55.6 months vs. 31.8 months; P = .0168) and a greater progression-free survival (37.1 months vs. 18.1 months; P = .038).
Variant Origin: N/A
Variant Origin: N/A
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/1647
Gene URL: https://civic.genome.wustl.edu/links/genes/525
Variant URL: https://civic.genome.wustl.edu/links/variants/648
Rating: 3
Evidence Type: Predictive
Disease: Astrocytoma
Evidence Direction: Supports
Drug: Procarbazine,Lomustine,Vincristine,Temozolomide
Evidence Level: B
Pubmed: 23904111

Drugs