Annotation Detail

Information
Associated Genes
PIK3CA
Associated Variants
PIK3CA WILD TYPE
PIK3CA WILD TYPE
Associated Disease
colorectal cancer
Source Database
CIViC Evidence
Description
This was a retrospective study of 964 colorectal cancer patients who participated in the Nurses' Health Study and the Health Professionals Follow-up Study. Of 964 patients, 803 patients had wildtype PIK3CA (aspirin use: 337/803, no aspirin use: 466/803) and 161 had mutated PIK3CA (aspirin use: 66/161, no aspirin use: 95/161). Among patients with wild-type PIK3CA, regular use of aspirin after diagnosis was not significantly associated with increased survival. The 5-year cumulative colorectal cancer specific mortality was the same (15%) for users and nonusers of aspirin after diagnosis (P = 0.92).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/2038
Gene URL
https://civic.genome.wustl.edu/links/genes/37
Variant URL
https://civic.genome.wustl.edu/links/variants/2590
Rating
3
Evidence Type
Predictive
Disease
Colorectal Cancer
Evidence Direction
Does Not Support
Drug
Aspirin
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
23094721
Drugs
Drug NameSensitivitySupported
AspirinSensitivityfalse