Annotation Detail
Information
- Associated Genes
- RET
- Associated Variants
-
RET EXPRESSION
RET EXPRESSION - Associated Disease
- lung adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- ASCL1 and RET mRNA levels were examined in lung cancer samples. High expression of RET (RET-high) correlated with shorter overall survival compared to the RET-low group in patients with ASCL1 expression in stage I (P=0.007) and all adenocarcinoma (P=0.037). However, expression of RET did not affect survival in the ASCL1- tumors.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/7056
- Gene URL
- https://civic.genome.wustl.edu/links/genes/42
- Variant URL
- https://civic.genome.wustl.edu/links/variants/295
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Lung Adenocarcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 24037524
Drugs