Annotation Detail
Information
- Associated Genes
- FGFR1
- Associated Variants
-
FGFR1 EXPRESSION
FGFR1 EXPRESSION - Associated Disease
- bladder carcinoma
- Source Database
- CIViC Evidence
- Description
- One urothelial cell line (JMSU1) with high expression of FGFR1 was sensitive to treatment with FGFR inhibitors (SU5402, TKI258 or PD173074). IC50 values for PD173074 and TKI-258 (Dovitinib) were in nanomolar range compared with micromolar concentration for SU5402.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/801
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1885
- Variant URL
- https://civic.genome.wustl.edu/links/variants/268
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Bladder Carcinoma
- Evidence Direction
- Supports
- Drug
- PD173074,Dovitinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21119661