Annotation Detail
Information
- Associated Genes
- CASP8
- Associated Variants
-
CASP8 EXPRESSION
CASP8 EXPRESSION - Associated Disease
- Ewing sarcoma of bone
- Source Database
- CIViC Evidence
- Description
- In-vitro and in-vivo sensitivity to DR5 antibody conatumumab was correlated with expression of caspase-8.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/831
- Gene URL
- https://civic.genome.wustl.edu/links/genes/761
- Variant URL
- https://civic.genome.wustl.edu/links/variants/346
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ewing Sarcoma Of Bone
- Evidence Direction
- Supports
- Drug
- Conatumumab
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26291055
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Conatumumab | Sensitivity | true |