Annotation Detail

Information
Associated Genes
FECH
Associated Variants
FECH p.Met273Ile (p.M273I) ( ENST00000262093.11, ENST00000382873.8, ENST00000652755.1 )
FECH p.Met273Ile (p.M273I) ( ENST00000262093.11, ENST00000382873.8, ENST00000652755.1 )
Associated Disease
Protoporphyria, erythropoietic, 1
Source Database
ClinVar
Description
NM_000140.5(FECH):c.801G>A (p.Met267Ile) AND Protoporphyria, erythropoietic, 1
ClinVar Allele ID
15588
ClinVar RefSeq Alternation Syntax
NM_001374778.1:c.801G>A
ClinVar RefSeq Alternation Syntax
NM_000140.5:c.801G>A
ClinVar RefSeq Alternation Syntax
NM_001012515.4:c.819G>A
ClinVar RefSeq Alternation Syntax
NM_001371095.1:c.585G>A
ClinVar RefSeq Alternation Syntax
NM_001371094.1:c.705+3726G>A
Clinical Significance Description
Conflicting interpretations of pathogenicity
Clinical Significance Last Update
2024-03-26
Clinical Significance Review Status
criteria provided, conflicting interpretations
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000000579
ClinVar Disease
Protoporphyria, erythropoietic, 1
Observed Origin Sample
germline
Pubmed
1755842
Drugs