Annotation Detail

Information
Associated Genes
FECH
Associated Variants
FECH p.Cys417Gly (p.C417G) ( ENST00000262093.11, ENST00000382873.8, ENST00000652755.1 )
FECH p.Pro415Ser (p.P415S) ( ENST00000262093.11, ENST00000382873.8, ENST00000652755.1 )
FECH p.Asn414Lys (p.N414K) ( ENST00000262093.11, ENST00000382873.8, ENST00000652755.1 )
FECH p.Cys417Gly (p.C417G) ( ENST00000262093.11, ENST00000382873.8, ENST00000652755.1 )
FECH p.Pro415Ser (p.P415S) ( ENST00000262093.11, ENST00000382873.8, ENST00000652755.1 )
FECH p.Asn414Lys (p.N414K) ( ENST00000262093.11, ENST00000382873.8, ENST00000652755.1 )
Associated Disease
Protoporphyria, erythropoietic, 1
Source Database
ClinVar
Description
NM_000140.3(FECH):c.[1224T>A;1225C>T;1231T>G] AND Protoporphyria, erythropoietic, 1
ClinVar Allele ID
38382
ClinVar Allele ID
15600
ClinVar Allele ID
38381
ClinVar RefSeq Alternation Syntax
NM_001012515.4:c.1249T>G
ClinVar RefSeq Alternation Syntax
NM_001374778.1:c.1171T>G
ClinVar RefSeq Alternation Syntax
NM_001371094.1:c.1125T>A
ClinVar RefSeq Alternation Syntax
NM_000140.5:c.1231T>G
ClinVar RefSeq Alternation Syntax
NM_001371094.1:c.1126C>T
ClinVar RefSeq Alternation Syntax
NM_000140.5:c.1224T>A
ClinVar RefSeq Alternation Syntax
NM_000140.5:c.1225C>T
ClinVar RefSeq Alternation Syntax
NM_001371094.1:c.1132T>G
ClinVar RefSeq Alternation Syntax
NM_001371095.1:c.1015T>G
ClinVar RefSeq Alternation Syntax
NM_001371095.1:c.1009C>T
ClinVar RefSeq Alternation Syntax
NM_001371095.1:c.1008T>A
ClinVar RefSeq Alternation Syntax
NM_001374778.1:c.1164T>A
ClinVar RefSeq Alternation Syntax
NM_001012515.4:c.1243C>T
ClinVar RefSeq Alternation Syntax
NM_001012515.4:c.1242T>A
ClinVar RefSeq Alternation Syntax
NM_001374778.1:c.1165C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2000-08-15
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000000591
ClinVar Disease
Protoporphyria, erythropoietic, 1
Observed Origin Sample
germline
Pubmed
10942404
Drugs