Annotation Detail

Information
Associated Genes
HTRA2 LOXL3
Associated Variants
LOXL3 c.*908C>T, HTRA2 p.Gly399Ser (p.G399S) ( ENST00000258080.8, ENST00000352222.7, ENST00000437202.2, ENST00000696727.1, ENST00000264094.8, ENST00000409249.5 )
LOXL3 c.*908C>T, HTRA2 p.Gly399Ser (p.G399S) ( ENST00000258080.8, ENST00000352222.7, ENST00000437202.2, ENST00000696727.1, ENST00000264094.8, ENST00000409249.5 )
Associated Disease
Parkinson disease 13, autosomal dominant, susceptibility to
Source Database
ClinVar
Description
NM_013247.5(HTRA2):c.1195G>A (p.Gly399Ser) AND Parkinson disease 13, autosomal dominant, susceptibility to
ClinVar Allele ID
19380
ClinVar RefSeq Alternation Syntax
NM_145074.2:c.921-122G>A
ClinVar RefSeq Alternation Syntax
NM_032603.5:c.*908C>T
ClinVar RefSeq Alternation Syntax
NM_001321727.1:c.1146-122G>A
ClinVar RefSeq Alternation Syntax
NR_135772.1:n.1269G>A
ClinVar RefSeq Alternation Syntax
NR_135771.1:n.1249G>A
ClinVar RefSeq Alternation Syntax
NM_001321728.1:c.1116-122G>A
ClinVar RefSeq Alternation Syntax
NM_001289164.3:c.*908C>T
ClinVar RefSeq Alternation Syntax
NM_013247.5:c.1195G>A
ClinVar RefSeq Alternation Syntax
NR_135769.1:n.1837G>A
ClinVar RefSeq Alternation Syntax
NR_135770.1:n.1265G>A
ClinVar RefSeq Alternation Syntax
NM_001289165.2:c.*908C>T
Clinical Significance Description
Likely benign
Clinical Significance Last Update
2017-04-27
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000004589
ClinVar Disease
Parkinson disease 13, autosomal dominant, susceptibility to
Observed Origin Sample
germline
Pubmed
18364387
Pubmed
15961413
Drugs