Annotation Detail

Information
Associated Genes
CFH
Associated Variants
ENSG00000289697 c.3580+48C>T, CFH p.Arg1210Cys (p.R1210C) ( ENST00000696028.1, ENST00000696027.1, ENST00000696029.1, ENST00000695984.1, ENST00000695981.1, ENST00000695971.1, ENST00000695974.1, ENST00000367429.9, ENST00000695970.1, ENST00000695976.1 )
ENSG00000289697 c.3580+48C>T, CFH p.Arg1210Cys (p.R1210C) ( ENST00000367429.9, ENST00000695970.1, ENST00000695971.1, ENST00000695974.1, ENST00000695976.1, ENST00000695981.1, ENST00000695984.1, ENST00000696027.1, ENST00000696028.1, ENST00000696029.1 )
Associated Disease
age related macular degeneration 4
Source Database
ClinVar
Description
NM_000186.4(CFH):c.3628C>T (p.Arg1210Cys) AND Age related macular degeneration 4
ClinVar Allele ID
31597
ClinVar RefSeq Alternation Syntax
NM_000186.4:c.3628C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-08-09
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000022540
ClinVar Disease
Age related macular degeneration 4
Observed Origin Sample
germline
Pubmed
22019782
Pubmed
24036949
Pubmed
25880396
Pubmed
17018561
Pubmed
12697737
Drugs