Annotation Detail

Information
Associated Genes
SCN1A LOC102724058
Associated Variants
SCN1A p.Thr1174Ser (p.T1174S) ( ENST00000303395.9, ENST00000375405.7, ENST00000409050.2, ENST00000635750.1, ENST00000635776.1, ENST00000637988.1, ENST00000640036.1, ENST00000641575.1, ENST00000641603.1, ENST00000674923.1, ENST00000713692.1 )
SCN1A p.Thr1174Ser (p.T1174S) ( ENST00000303395.9, ENST00000375405.7, ENST00000409050.2, ENST00000635750.1, ENST00000635776.1, ENST00000637988.1, ENST00000640036.1, ENST00000641575.1, ENST00000641603.1, ENST00000674923.1, ENST00000713692.1 )
Associated Disease
Migraine, familial hemiplegic, 3
Source Database
ClinVar
Description
NM_001165963.4(SCN1A):c.3521C>G (p.Thr1174Ser) AND Migraine, familial hemiplegic, 3
Observed Origin Sample
unknown
ClinVar Allele ID
79508
ClinVar RefSeq Alternation Syntax
NM_001353954.2:c.3485C>G
ClinVar RefSeq Alternation Syntax
NM_001353955.2:c.3485C>G
ClinVar RefSeq Alternation Syntax
NM_001353951.2:c.3488C>G
ClinVar RefSeq Alternation Syntax
NM_001353957.2:c.3437C>G
ClinVar RefSeq Alternation Syntax
NM_001353950.2:c.3488C>G
ClinVar RefSeq Alternation Syntax
NM_001353958.2:c.3437C>G
ClinVar RefSeq Alternation Syntax
NR_148667.2:n.3874C>G
ClinVar RefSeq Alternation Syntax
NM_001202435.3:c.3521C>G
ClinVar RefSeq Alternation Syntax
NM_001353960.2:c.3434C>G
ClinVar RefSeq Alternation Syntax
NM_001353961.2:c.1079C>G
ClinVar RefSeq Alternation Syntax
NM_001165963.4:c.3521C>G
ClinVar RefSeq Alternation Syntax
NM_006920.6:c.3488C>G
ClinVar RefSeq Alternation Syntax
NM_001165964.3:c.3437C>G
ClinVar RefSeq Alternation Syntax
NM_001353948.2:c.3521C>G
ClinVar RefSeq Alternation Syntax
NR_110598.1:n.199G>C
ClinVar RefSeq Alternation Syntax
NM_001353949.2:c.3488C>G
ClinVar RefSeq Alternation Syntax
NM_001353952.2:c.3488C>G
Clinical Significance Description
Conflicting interpretations of pathogenicity
Clinical Significance Last Update
2017-04-27
Clinical Significance Review Status
criteria provided, conflicting interpretations
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000059493
ClinVar Disease
Migraine, familial hemiplegic, 3
Observed Origin Sample
germline
Observed Origin Sample
not provided
Drugs