Annotation Detail

Information
Associated Genes
BARD1
Associated Variants
BARD1 p.Ser538Asn (p.S538N) ( ENST00000260947.9, ENST00000421162.2, ENST00000613374.5, ENST00000613706.5, ENST00000617164.5, ENST00000619009.5, ENST00000620057.4 )
BARD1 p.Ser538Asn (p.S538N) ( ENST00000260947.9, ENST00000421162.2, ENST00000613374.5, ENST00000613706.5, ENST00000617164.5, ENST00000619009.5, ENST00000620057.4 )
Associated Disease
Hereditary cancer-predisposing syndrome
Source Database
ClinVar
Description
NM_000465.4(BARD1):c.1613G>A (p.Ser538Asn) AND Hereditary cancer-predisposing syndrome
ClinVar Allele ID
181781
ClinVar RefSeq Alternation Syntax
NM_001282545.2:c.260G>A
ClinVar RefSeq Alternation Syntax
NM_001282543.2:c.1556G>A
ClinVar RefSeq Alternation Syntax
NR_104216.2:n.777G>A
ClinVar RefSeq Alternation Syntax
NM_001282549.2:c.365-22003G>A
ClinVar RefSeq Alternation Syntax
NM_000465.4:c.1613G>A
ClinVar RefSeq Alternation Syntax
NR_104212.2:n.1578G>A
ClinVar RefSeq Alternation Syntax
NR_104215.2:n.1521G>A
ClinVar RefSeq Alternation Syntax
NM_001282548.2:c.203G>A
Clinical Significance Description
Conflicting interpretations of pathogenicity
Clinical Significance Last Update
2021-05-03
Clinical Significance Review Status
criteria provided, conflicting interpretations
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000165715
ClinVar Disease
Hereditary cancer-predisposing syndrome
Observed Origin Sample
germline
Drugs