Annotation Detail

Information
Associated Genes
CAPN3
Associated Variants
CAPN3 p.Arg490Trp (p.R490W) ( ENST00000318023.11, ENST00000357568.8, ENST00000349748.8, ENST00000397163.8 )
CAPN3 p.Arg490Trp (p.R490W) ( ENST00000397163.8, ENST00000318023.11, ENST00000349748.8, ENST00000357568.8 )
Associated Disease
autosomal recessive limb-girdle muscular dystrophy type 2A
Source Database
ClinVar
Description
NM_000070.3(CAPN3):c.1468C>T (p.Arg490Trp) AND Autosomal recessive limb-girdle muscular dystrophy type 2A
ClinVar Allele ID
177281
ClinVar RefSeq Alternation Syntax
NM_173087.2:c.1324C>T
ClinVar RefSeq Alternation Syntax
NM_000070.3:c.1468C>T
ClinVar RefSeq Alternation Syntax
NM_024344.2:c.1468C>T
Clinical Significance Description
Pathogenic/Likely pathogenic
Clinical Significance Last Update
2024-01-29
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000173975
ClinVar Disease
Autosomal recessive limb-girdle muscular dystrophy type 2A
Observed Origin Sample
germline
Observed Origin Sample
unknown
Drugs