Annotation Detail

Information
Associated Genes
CLCN1
Associated Variants
CLCN1 p.Phe428Ser (p.F428S) ( ENST00000343257.7, ENST00000650516.2 )
CLCN1 p.Phe428Ser (p.F428S) ( ENST00000343257.7, ENST00000650516.2 )
Associated Disease
Congenital myotonia, autosomal recessive form Congenital myotonia, autosomal dominant form
Source Database
ClinVar
Description
NM_000083.3(CLCN1):c.1283T>C (p.Phe428Ser) AND multiple conditions
ClinVar Allele ID
204362
ClinVar RefSeq Alternation Syntax
NM_000083.3:c.1283T>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2024-01-20
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000701519
ClinVar Disease
Congenital myotonia, autosomal dominant form
ClinVar Disease
Congenital myotonia, autosomal recessive form
Observed Origin Sample
germline
Drugs