Annotation Detail

Information
Associated Genes
CLCN1
Associated Variants
CLCN1 p.Thr268Met (p.T268M) ( ENST00000343257.7, ENST00000650516.2 )
CLCN1 p.Thr268Met (p.T268M) ( ENST00000343257.7, ENST00000650516.2 )
Associated Disease
Congenital myotonia, autosomal dominant form Congenital myotonia, autosomal recessive form
Source Database
ClinVar
Description
NM_000083.3(CLCN1):c.803C>T (p.Thr268Met) AND multiple conditions
ClinVar Allele ID
33899
ClinVar RefSeq Alternation Syntax
NM_000083.3:c.803C>T
ClinVar RefSeq Alternation Syntax
NR_046453.2:n.908C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-11-08
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000763168
ClinVar Disease
Congenital myotonia, autosomal dominant form
ClinVar Disease
Congenital myotonia, autosomal recessive form
Observed Origin Sample
germline
Observed Origin Sample
unknown
Drugs