Annotation Detail

Information
Associated Genes
CLCN1
Associated Variants
CLCN1 p.Arg317Gln (p.R317Q) ( ENST00000343257.7, ENST00000650516.2 )
CLCN1 p.Arg317Gln (p.R317Q) ( ENST00000343257.7, ENST00000650516.2 )
Associated Disease
Congenital myotonia, autosomal dominant form Congenital myotonia, autosomal recessive form
Source Database
ClinVar
Description
NM_000083.3(CLCN1):c.950G>A (p.Arg317Gln) AND multiple conditions
ClinVar Allele ID
32581
ClinVar RefSeq Alternation Syntax
NM_000083.3:c.950G>A
ClinVar RefSeq Alternation Syntax
NR_046453.2:n.1055G>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2023-09-03
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000763169
ClinVar Disease
Congenital myotonia, autosomal dominant form
ClinVar Disease
Congenital myotonia, autosomal recessive form
Observed Origin Sample
germline
Observed Origin Sample
unknown
Drugs