Annotation Detail

Information
Associated Genes
MSH2
Associated Variants
MSH2 p.Ala636Pro (p.A636P) ( ENST00000233146.7, ENST00000406134.5, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713919.1 )
MSH2 p.Ala636Pro (p.A636P) ( ENST00000233146.7, ENST00000406134.5, ENST00000543555.6, ENST00000645506.1, ENST00000713854.1, ENST00000713919.1 )
Associated Disease
Mismatch repair cancer syndrome 1 Lynch syndrome 1 Muir-Torré syndrome
Source Database
ClinVar
Description
NM_000251.3(MSH2):c.1906G>C (p.Ala636Pro) AND multiple conditions
ClinVar Allele ID
16803
ClinVar RefSeq Alternation Syntax
NM_000251.3:c.1906G>C
ClinVar RefSeq Alternation Syntax
NM_001258281.1:c.1708G>C
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2018-10-31
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV000763493
ClinVar Disease
Lynch syndrome 1
ClinVar Disease
Mismatch repair cancer syndrome 1
ClinVar Disease
Muir-Torré syndrome
Observed Origin Sample
unknown
Drugs