Annotation Detail

Information
Associated Genes
JAK1
Associated Variants
JAK1 p.Ser703Ile (p.S703I) ( ENST00000672751.2, ENST00000673046.1, ENST00000673246.2, ENST00000699312.1, ENST00000671929.2, ENST00000699259.1, ENST00000673254.1, ENST00000672574.2, ENST00000672179.2, ENST00000671954.2, ENST00000699310.1, ENST00000699262.1, ENST00000699260.1, ENST00000342505.5, ENST00000672247.2, ENST00000672434.2 )
JAK1 p.Ser703Ile (p.S703I) ( ENST00000342505.5, ENST00000672179.2, ENST00000672247.2, ENST00000672434.2, ENST00000672574.2, ENST00000672751.2, ENST00000673046.1, ENST00000673246.2, ENST00000671929.2, ENST00000671954.2, ENST00000673254.1, ENST00000699259.1, ENST00000699260.1, ENST00000699262.1, ENST00000699310.1, ENST00000699312.1 )
Associated Disease
Autoinflammation, immune dysregulation, and eosinophilia
Source Database
ClinVar
Description
NM_002227.4(JAK1):c.2108G>T (p.Ser703Ile) AND Autoinflammation, immune dysregulation, and eosinophilia
ClinVar Allele ID
965590
ClinVar RefSeq Alternation Syntax
NM_001321852.2:c.2108G>T
ClinVar RefSeq Alternation Syntax
NM_001321856.2:c.2108G>T
ClinVar RefSeq Alternation Syntax
NM_002227.4:c.2108G>T
ClinVar RefSeq Alternation Syntax
NM_001321854.2:c.2108G>T
ClinVar RefSeq Alternation Syntax
NM_001321853.2:c.2108G>T
ClinVar RefSeq Alternation Syntax
NM_001321855.2:c.2108G>T
ClinVar RefSeq Alternation Syntax
NM_001321857.2:c.2105G>T
ClinVar RefSeq Alternation Syntax
NM_001320923.2:c.2108G>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2020-09-01
Clinical Significance Review Status
no assertion criteria provided
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001255135
ClinVar Disease
Autoinflammation, immune dysregulation, and eosinophilia
Observed Origin Sample
unknown
Pubmed
32750333
Drugs