Annotation Detail

Information
Associated Genes
CAPN3
Associated Variants
CAPN3 p.Ala798Glu (p.A798E) ( ENST00000673851.1, ENST00000397204.9, ENST00000673886.1, ENST00000673928.1, ENST00000397163.8, ENST00000674093.1, ENST00000673771.1, ENST00000673743.1, ENST00000569136.6, ENST00000318023.11, ENST00000674119.1, ENST00000673692.1, ENST00000357568.8, ENST00000397200.8, ENST00000674149.1, ENST00000673978.1, ENST00000561817.5, ENST00000337571.9, ENST00000673890.1, ENST00000674052.1, ENST00000673750.1, ENST00000674018.1, ENST00000673936.1, ENST00000674146.1, ENST00000674139.1, ENST00000349748.8 )
CAPN3 p.Ala798Glu (p.A798E) ( ENST00000318023.11, ENST00000337571.9, ENST00000349748.8, ENST00000357568.8, ENST00000397163.8, ENST00000397200.8, ENST00000397204.9, ENST00000561817.5, ENST00000569136.6, ENST00000673692.1, ENST00000673743.1, ENST00000673750.1, ENST00000673771.1, ENST00000673851.1, ENST00000673886.1, ENST00000673890.1, ENST00000673928.1, ENST00000673936.1, ENST00000673978.1, ENST00000674018.1, ENST00000674052.1, ENST00000674093.1, ENST00000674119.1, ENST00000674139.1, ENST00000674146.1, ENST00000674149.1 )
Associated Disease
autosomal recessive limb-girdle muscular dystrophy
Source Database
ClinVar
Description
NM_000070.3(CAPN3):c.2393C>A (p.Ala798Glu) AND Autosomal recessive limb-girdle muscular dystrophy
ClinVar Allele ID
98325
ClinVar RefSeq Alternation Syntax
NM_173087.2:c.2117C>A
ClinVar RefSeq Alternation Syntax
NM_000070.3:c.2393C>A
ClinVar RefSeq Alternation Syntax
NM_024344.2:c.2375C>A
ClinVar RefSeq Alternation Syntax
NM_173090.2:c.398C>A
ClinVar RefSeq Alternation Syntax
NM_173089.2:c.398C>A
ClinVar RefSeq Alternation Syntax
NM_173088.2:c.857C>A
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2021-12-28
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV001804832
ClinVar Disease
Autosomal recessive limb-girdle muscular dystrophy
Observed Origin Sample
germline
Drugs