Annotation Detail

Information
Associated Genes
NLRP3
Associated Variants
NLRP3 p.Lys129Arg (p.K129R) ( ENST00000474792.2, ENST00000391828.8, ENST00000391827.3, ENST00000697408.2, ENST00000366496.7, ENST00000348069.7, ENST00000643234.2, ENST00000697350.1, ENST00000336119.8 )
NLRP3 p.Lys129Arg (p.K129R) ( ENST00000336119.8, ENST00000348069.7, ENST00000366496.7, ENST00000391827.3, ENST00000391828.8, ENST00000474792.2, ENST00000643234.2, ENST00000697350.1, ENST00000697408.2 )
Associated Disease
Hearing loss, autosomal dominant 34, with or without inflammation Keratitis fugax hereditaria familial cold autoinflammatory syndrome 1 Chronic infantile neurological, cutaneous and articular syndrome Familial amyloid nephropathy with urticaria AND deafness
Source Database
ClinVar
Description
NM_001243133.2(NLRP3):c.386A>G (p.Lys129Arg) AND multiple conditions
ClinVar Allele ID
231468
ClinVar RefSeq Alternation Syntax
NM_001127462.3:c.386A>G
ClinVar RefSeq Alternation Syntax
NM_001127461.3:c.386A>G
ClinVar RefSeq Alternation Syntax
NM_001079821.3:c.386A>G
ClinVar RefSeq Alternation Syntax
NM_001243133.2:c.386A>G
ClinVar RefSeq Alternation Syntax
NM_183395.3:c.386A>G
ClinVar RefSeq Alternation Syntax
NM_004895.5:c.392A>G
Clinical Significance Description
Uncertain significance
Clinical Significance Last Update
2022-01-06
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002485437
ClinVar Disease
Chronic infantile neurological, cutaneous and articular syndrome
ClinVar Disease
Familial amyloid nephropathy with urticaria AND deafness
ClinVar Disease
Familial cold autoinflammatory syndrome 1
ClinVar Disease
Keratitis fugax hereditaria
ClinVar Disease
Hearing loss, autosomal dominant 34, with or without inflammation
Observed Origin Sample
unknown
Drugs