Annotation Detail

Information
Associated Genes
CFH
Associated Variants
ENSG00000289697 p.Ser1191Leu (p.S1191L), CFH p.Ser1191Leu (p.S1191L) ( ENST00000696029.1, ENST00000695976.1, ENST00000696028.1, ENST00000696027.1, ENST00000695984.1, ENST00000695981.1, ENST00000695971.1, ENST00000695974.1, ENST00000695970.1, ENST00000367429.9 )
ENSG00000289697 p.Ser1191Leu (p.S1191L), CFH p.Ser1191Leu (p.S1191L) ( ENST00000367429.9, ENST00000695970.1, ENST00000695971.1, ENST00000695974.1, ENST00000695976.1, ENST00000695981.1, ENST00000695984.1, ENST00000696027.1, ENST00000696028.1, ENST00000696029.1 )
Associated Disease
Hemolytic uremic syndrome, atypical, susceptibility to, 1 Factor H deficiency basal laminar drusen age related macular degeneration 4
Source Database
ClinVar
Description
NM_000186.4(CFH):c.3572C>T (p.Ser1191Leu) AND multiple conditions
ClinVar Allele ID
31584
ClinVar RefSeq Alternation Syntax
NM_000186.4:c.3572C>T
Clinical Significance Description
Pathogenic
Clinical Significance Last Update
2022-04-19
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002496396
ClinVar Disease
Basal laminar drusen
ClinVar Disease
Factor H deficiency
ClinVar Disease
Hemolytic uremic syndrome, atypical, susceptibility to, 1
ClinVar Disease
Age related macular degeneration 4
Observed Origin Sample
unknown
Drugs