Annotation Detail

Information
Associated Genes
SDHC
Associated Variants
SDHC p.His127Arg (p.H127R) ( ENST00000515731.2, ENST00000367975.7, ENST00000714063.1, ENST00000714064.1, ENST00000513009.5, ENST00000714065.1, ENST00000392169.6, ENST00000714066.1, ENST00000342751.8, ENST00000432287.6 )
SDHC p.His127Arg (p.H127R) ( ENST00000342751.8, ENST00000367975.7, ENST00000392169.6, ENST00000432287.6, ENST00000513009.5, ENST00000515731.2, ENST00000714063.1, ENST00000714064.1, ENST00000714065.1, ENST00000714066.1 )
Associated Disease
Hereditary pheochromocytoma-paraganglioma
Source Database
ClinVar
Description
NM_003001.5(SDHC):c.380A>G (p.His127Arg) AND Hereditary pheochromocytoma-paraganglioma
ClinVar Allele ID
181599
ClinVar RefSeq Alternation Syntax
NM_001035513.3:c.221A>G
ClinVar RefSeq Alternation Syntax
NM_001407116.1:c.323A>G
ClinVar RefSeq Alternation Syntax
NM_001278172.3:c.140-5514A>G
ClinVar RefSeq Alternation Syntax
NM_001407115.1:c.500A>G
ClinVar RefSeq Alternation Syntax
NM_001407117.1:c.317A>G
ClinVar RefSeq Alternation Syntax
NM_003001.5:c.380A>G
ClinVar RefSeq Alternation Syntax
NM_001407119.1:c.269A>G
ClinVar RefSeq Alternation Syntax
NM_001407118.1:c.272A>G
ClinVar RefSeq Alternation Syntax
NM_001407121.1:c.185-5514A>G
ClinVar RefSeq Alternation Syntax
NM_001035511.3:c.242-5514A>G
ClinVar RefSeq Alternation Syntax
NM_001035512.3:c.278A>G
ClinVar RefSeq Alternation Syntax
NM_001407120.1:c.269A>G
ClinVar RefSeq Alternation Syntax
NR_103459.3:n.432A>G
Clinical Significance Description
Likely pathogenic
Clinical Significance Last Update
2023-10-02
Clinical Significance Review Status
criteria provided, multiple submitters, no conflicts
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV003995530
ClinVar Disease
Hereditary pheochromocytoma-paraganglioma
Observed Origin Sample
germline
Drugs