Annotation Detail
Information
- Associated Genes
- ITGA3
- Associated Variants
-
ITGA3 p.Phe332= (p.F332=)
(
ENST00000320031.13,
ENST00000007722.11 )
ITGAV c.*1208G>C ( ENST00000261023.8, ENST00000374907.7, ENST00000696906.1, ENST00000696907.1, ENST00000696909.1, ENST00000696910.1, ENST00000696911.1, ENST00000696912.1, ENST00000696913.1 )
ITGA3 p.Phe332= (p.F332=) ( ENST00000007722.11, ENST00000320031.13 )
ITGAV c.*1208G>C ( ENST00000261023.8, ENST00000374907.7, ENST00000696906.1, ENST00000696907.1, ENST00000696909.1, ENST00000696910.1, ENST00000696911.1, ENST00000696912.1, ENST00000696913.1 ) - Associated Disease
- Neoplasm Metastasis
- Source Database
- DisGeNET
- Description
- The following factors resulted independently associated with peritoneal carcinosis or hematogenous metastases: the A genotype of rs2269772 (ITGA3) [odds ratio (OR) for peritoneal carcinosis: 22.2, 95% confidence interval 1.2-40, P=0.03], the G genotype of rs2269772 (ITGA3) (OR for hematogenous metastases: 5.5, 95% confidence interval 2.2-14.15, P=0.0003), the C genotype of rs11902171 (ITGV) (OR for peritoneal carcinosis: 6.8, 95% confidence interval 1.3-33.4, P=0.01), the G genotype of rs11902171 (ITGV) (OR for hematogenous metastases: 2.5, 95% confidence interval 1.1-5.7, P = 0.02), diffuse histology (OR for peritoneal carcinosis: 4.7, 95% confidence interval 1.9-11.3, P=0.0005) and intestinal histology (OR for hematogenous metastases: 4.2, 95% confidence interval 1.9-9.9, P=0.0008).
- Pubmed
- 20926544
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00626302610117525
- Year of publication
- 2011
Drugs