Annotation Detail

Information
Associated Genes
CFH
Associated Variants
ENSG00000289697 p.Thr956Met (p.T956M), CFH p.Thr956Met (p.T956M) ( ENST00000696029.1, ENST00000696027.1, ENST00000696028.1, ENST00000695976.1, ENST00000695970.1, ENST00000367429.9, ENST00000695971.1, ENST00000695974.1, ENST00000695981.1, ENST00000695984.1 )
ENSG00000289697 c.3580+10T>C, CFH p.Val1197Ala (p.V1197A) ( ENST00000695981.1, ENST00000695984.1, ENST00000695976.1, ENST00000367429.9, ENST00000695970.1, ENST00000695971.1, ENST00000695974.1, ENST00000696028.1, ENST00000696029.1, ENST00000696027.1 )
ENSG00000289697 p.Thr956Met (p.T956M), CFH p.Thr956Met (p.T956M) ( ENST00000367429.9, ENST00000695970.1, ENST00000695971.1, ENST00000695974.1, ENST00000695976.1, ENST00000695981.1, ENST00000695984.1, ENST00000696027.1, ENST00000696028.1, ENST00000696029.1 )
ENSG00000289697 c.3580+10T>C, CFH p.Val1197Ala (p.V1197A) ( ENST00000367429.9, ENST00000695970.1, ENST00000695971.1, ENST00000695974.1, ENST00000695976.1, ENST00000695981.1, ENST00000695984.1, ENST00000696027.1, ENST00000696028.1, ENST00000696029.1 )
Associated Disease
Hemolytic uremic syndrome, atypical, susceptibility to, 1
Source Database
DisGeNET
Description
Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome.
Pubmed
11170895
Original source reporting the Gene Disease association
UNIPROT
DisGENET score for the Gene Disease association
0.32
Year of publication
2001
Drugs