Annotation Detail
Information
- Associated Genes
- IGF1
- Associated Variants
-
IGF1 MUTATION
IGF1 MUTATION - Associated Disease
- spinal muscular atrophy
- Source Database
- DisGeNET
- Description
- Recent evidence of IGF-1 axis alteration in spinal muscular atrophy (SMA), a very severe neurodegenerative disease affecting specifically the motor neurons, have triggered a renewed interest in insulin-like growth factor-1 (IGF-1) pathway activation as a potential therapeutic approach for motor neuron diseases.
- Pubmed
- 26311784
- Section of the abstract supporting the evidence
- SIGNIFICANCE STATEMENT
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00108576748832121
Drugs