Annotation Detail
Information
- Associated Genes
- DRD2
- Associated Variants
-
DRD2 p.Ser311Cys (p.S311C)
(
ENST00000538967.5,
ENST00000346454.7,
ENST00000362072.8,
ENST00000542968.5,
ENST00000544518.5 )
DRD2 p.Ser311Cys (p.S311C) ( ENST00000346454.7, ENST00000362072.8, ENST00000538967.5, ENST00000542968.5, ENST00000544518.5 ) - Associated Disease
- Neurobehavioral Manifestations
- Source Database
- DisGeNET
- Description
- The dopamine D2 receptor (DRD2) Ser311Cys polymorphism may also play a role in determining risperidone efficacy for positive, negative and cognitive symptoms, the DRD2 Ins-A2/Del-A1 diplotype may predict better risperidone response, and the DRD3 Ser311Cys variant may affect general treatment response of several atypical agents.
- Pubmed
- 15882132
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
- Year of publication
- 2005
Drugs