Annotation Detail
Information
- Associated Genes
- GRN
- Associated Variants
-
rs1990622
rs1990622 - Associated Disease
- frontotemporal dementia
- Source Database
- DisGeNET
- Description
- Previous reports have shown that TMEM106B is a genetic modifier of FTLD-TDP caused by progranulin (GRN) mutations, with the major (risk) allele of rs1990622 associating with earlier age at onset of disease.
- Pubmed
- 24442578
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.282117097434165
- Year of publication
- 2013
Drugs