Annotation Detail

Information
Associated Genes
BRCA1
Associated Variants
BRCA1 p.Asp821IlefsTer25 (p.D821Ifs*25) ( ENST00000473961.6, ENST00000468300.5, ENST00000644555.2, ENST00000477152.6, ENST00000484087.6, ENST00000494123.6, ENST00000478531.6, ENST00000493795.5, ENST00000471181.7, ENST00000497488.2, ENST00000591534.5, ENST00000357654.9, ENST00000461574.2, ENST00000352993.7, ENST00000493919.6, ENST00000634433.2, ENST00000591849.5, ENST00000713676.1, ENST00000644379.2, ENST00000470026.6, ENST00000491747.6, ENST00000586385.5, ENST00000618469.2, ENST00000476777.6, ENST00000700182.1, ENST00000489037.2 )
BRCA1 p.Asp821IlefsTer25 (p.D821Ifs*25) ( ENST00000352993.7, ENST00000357654.9, ENST00000461574.2, ENST00000468300.5, ENST00000470026.6, ENST00000471181.7, ENST00000473961.6, ENST00000476777.6, ENST00000477152.6, ENST00000478531.6, ENST00000484087.6, ENST00000489037.2, ENST00000491747.6, ENST00000493795.5, ENST00000493919.6, ENST00000494123.6, ENST00000497488.2, ENST00000586385.5, ENST00000591534.5, ENST00000591849.5, ENST00000618469.2, ENST00000634433.2, ENST00000644379.2, ENST00000644555.2, ENST00000700182.1, ENST00000713676.1 )
BRCA1 p.Val1757Gly (p.V1757G) ( ENST00000468300.5, ENST00000644555.2, ENST00000473961.6, ENST00000477152.6, ENST00000478531.6, ENST00000484087.6, ENST00000494123.6, ENST00000493795.5, ENST00000497488.2, ENST00000471181.7, ENST00000591534.5, ENST00000461574.2, ENST00000357654.9, ENST00000352993.7, ENST00000493919.6, ENST00000634433.2, ENST00000591849.5, ENST00000644379.2, ENST00000713676.1, ENST00000491747.6, ENST00000470026.6, ENST00000618469.2, ENST00000586385.5, ENST00000476777.6, ENST00000489037.2 )
BRCA1 p.Val1757Ala (p.V1757A) ( ENST00000713676.1, ENST00000644379.2, ENST00000470026.6, ENST00000491747.6, ENST00000586385.5, ENST00000618469.2, ENST00000634433.2, ENST00000591849.5, ENST00000489037.2, ENST00000476777.6, ENST00000484087.6, ENST00000494123.6, ENST00000478531.6, ENST00000493795.5, ENST00000473961.6, ENST00000644555.2, ENST00000468300.5, ENST00000477152.6, ENST00000352993.7, ENST00000493919.6, ENST00000471181.7, ENST00000497488.2, ENST00000591534.5, ENST00000357654.9, ENST00000461574.2 )
BRCA1 p.Val1757Gly (p.V1757G) ( ENST00000352993.7, ENST00000357654.9, ENST00000461574.2, ENST00000468300.5, ENST00000470026.6, ENST00000471181.7, ENST00000473961.6, ENST00000476777.6, ENST00000477152.6, ENST00000478531.6, ENST00000484087.6, ENST00000489037.2, ENST00000491747.6, ENST00000493795.5, ENST00000493919.6, ENST00000494123.6, ENST00000497488.2, ENST00000586385.5, ENST00000591534.5, ENST00000591849.5, ENST00000618469.2, ENST00000634433.2, ENST00000644379.2, ENST00000644555.2, ENST00000713676.1 )
BRCA1 p.Val1757Ala (p.V1757A) ( ENST00000352993.7, ENST00000357654.9, ENST00000461574.2, ENST00000468300.5, ENST00000470026.6, ENST00000471181.7, ENST00000473961.6, ENST00000476777.6, ENST00000477152.6, ENST00000478531.6, ENST00000484087.6, ENST00000489037.2, ENST00000491747.6, ENST00000493795.5, ENST00000493919.6, ENST00000494123.6, ENST00000497488.2, ENST00000586385.5, ENST00000591534.5, ENST00000591849.5, ENST00000618469.2, ENST00000634433.2, ENST00000644379.2, ENST00000644555.2, ENST00000713676.1 )
Associated Disease
Epithelial ovarian cancer
Source Database
DisGeNET
Description
This study describes an individual who was diagnosed with ovarian carcinoma at age 28 and found to have one allele with a deleterious mutation in BRCA1, c.2457delC (p.Asp821Ilefs*25), and a second allele with a variant of unknown significance in BRCA1, c.5207T>C (p.Val1736Ala).
Pubmed
23269703
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.0319541960353551
Year of publication
2013
Drugs