Annotation Detail
Information
- Associated Genes
- MITF
- Associated Variants
- MITF UNDEREXPRESSION
- Source Database
- MMMP
- Description
- MITF amplification is prevalent in metastatic disease and correlates with decreased overall patient survival. Ectopic MITF expression in conjunction with the BRAF(V600E) mutant transform primary human melanocytes, and thus MITF can function as a melanoma oncogene
- MMMP State
- downregulated by
- MMMP Molecule
- MITF
- MMMP Molecule Alias
- Microphthalmia-associated transcription factor
- MMMP Modifier
- MITF dominant negative
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Docetaxel
- MMMP Model
- 3
- MMMP Reference
- Garraway LA, Nature 2005, 436:117-22
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Docetaxel | Sensitivity | true |