Annotation Detail
Information
- Associated Genes
- NQO1
- Associated Variants
- NQO1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Decreased expression of NQO1 is associated with resistance to 17-AAG
- MMMP State
- downregulated
- MMMP Molecule
- NQO1
- MMMP Molecule Alias
- NADPH quinone oxidoreductase
- MMMP Relationship
- resistance to
- MMMP Drug
- 17-AAG
- MMMP Drug Alias
- Tanespimycin (17-allylamino-17-demethoxygeldanamycin)
- MMMP Model
- 3
- MMMP Reference
- Gaspar N, Cancer Res 2009, 69:1966-75
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| 17-AAG | Resitance or Non-Reponse | true |