Sepsis

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Information
Disease name
Sepsis
Disease ID
Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04974775 Active, not recruiting Swecrit Biobank - Blood Samples From Critically Ill Patients and Healthy Controls June 2014 December 31, 2024
NCT05623098 Active, not recruiting Effects of Dietary Fiber on Bone Metabolism April 1, 2022 December 31, 2024
NCT04855786 Active, not recruiting N/A External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients January 13, 2022 January 2025
NCT04257136 Active, not recruiting Phase 2 VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock Patients February 17, 2020 December 31, 2023
NCT04796285 Active, not recruiting N/A A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor August 1, 2022 August 2024
NCT05296590 Active, not recruiting Monocyte Distribution Width (MDW) in the General Population of Emergency Department Patients With and Without Bacteremia July 1, 2021 June 2026
NCT04118179 Active, not recruiting New Strategy to Predict Early Sepsis August 1, 2018 July 31, 2023
NCT06253377 Active, not recruiting Continuous Renal Replacement Therapy With Oxiris in Acute Kidney Injury and Sepsis December 8, 2023 April 2025
NCT03865706 Active, not recruiting Phase 2 Inulin for Infections in the Intensive Care Unit October 14, 2019 September 30, 2024
NCT06197828 Active, not recruiting Novel Biomarkers for Early Renal Injury in Children With Sepsis May 1, 2021 December 1, 2024
NCT03807414 Active, not recruiting Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients June 28, 2019 December 31, 2024
NCT03797157 Active, not recruiting Phase 2/Phase 3 Human Milk Fortification in Extremely Preterm Infants February 1, 2019 December 31, 2027
NCT06373159 Active, not recruiting An Observational Study to Learn About the Occurrence of Disseminated Intravascular Coagulation Among Adults With Sepsis in Japan April 10, 2024 September 30, 2024
NCT05151094 Active, not recruiting Registry of Hospitalized Patients in University Hospital Dubrava Respiratory Center April 1, 2021 January 1, 2026
NCT04990232 Active, not recruiting Phase 2 Personalized Immunotherapy in Sepsis July 29, 2021 April 30, 2025
NCT04612413 Active, not recruiting Phase 2 A Phase 2 Study Evaluating Efficacy, Safety and Tolerability of Different Doses and Regimens of Allocetra-OTS for the Treatment of Organ Failure in Adult Sepsis Patients November 30, 2020 March 31, 2025
NCT03133208 Active, not recruiting Sepsis Associated Encephalopathy (SAE) Biomarkers June 1, 2017 July 6, 2025
NCT06181604 Active, not recruiting Multicenter Symphony IL-6 Monitoring Sepsis ICU Study January 12, 2024 June 30, 2024
NCT04552821 Active, not recruiting Study of Biomarkers in Patients of Sepsis Complicated With Acute Respiratory Distress Syndrome (ARDS) June 2, 2020 July 30, 2024
NCT03115840 Active, not recruiting Measuring Outcomes of Activity in Intensive Care March 27, 2017 December 31, 2024
NCT04542473 Active, not recruiting Phase 2/Phase 3 Pancreatic Enzymes and Bile Acids in Acutely Ill Severely Malnourished Children July 1, 2021 June 30, 2024
NCT04328818 Active, not recruiting Indwelling Device-associated Biofilms June 5, 2019 October 5, 2025
NCT06376318 Active, not recruiting Shock and Acute Conditions OutcOmes Platform January 1, 2024 January 1, 2026
NCT02711709 Active, not recruiting Persistent Inflammation, Immunosuppression and Catabolism Syndrome (PICS): A New Horizon for Surgical Critical Care and Induced Frailty April 2016 December 31, 2024
NCT02276417 Active, not recruiting PICS: Subtitle Cardiac Dysfunction in Older Sepsis Survivors January 2015 July 24, 2025
NCT00883597 Active, not recruiting Sidestream Dark-Field (SDF) Imaging of the Intestinal Microcirculation November 2011 December 2024
NCT04282785 Active, not recruiting Point-of-care Monitoring of Antibiotic Concentration in Blood With UV-VIS Absorption Spectroscopy April 26, 2019 December 31, 2024
NCT03245528 Approved for marketing Expanded Access for LJPC-501
NCT00250666 Completed Phase 4 Procalcitonin-Guided Antimicrobial Discontinuation January 2006 May 2007
NCT00252915 Completed Phase 2 Reconstruction of Monocytic Immunocompetence by Granulocyte-macrophage-colony Stimulating Factor (GM-CSF) in Patients With Severe Sepsis and Septic Shock November 2005 April 2007
NCT00271752 Completed N/A The Procalcitonin and Survival Study January 2006 September 2009
NCT00273728 Completed Phase 4 BaSES Trial: Basel Starch Evaluation in Sepsis May 2005 May 2011
NCT00279214 Completed Phase 4 Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock November 2005 November 2007
NCT00282594 Completed N/A The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit July 2003 October 2005
NCT00284570 Completed Pro-Calcitonin Levels Following Pediatric Cardiac Surgery January 2006 March 2007
NCT00297674 Completed Phase 4 Intravenous Clarithromycin in Septic Syndrome June 2004 December 2005
NCT00307333 Completed N/A Impact of Heart Rate Characteristics Monitoring in Neonates August 2005 May 2011
NCT00318552 Completed Phase 4 Pharmacoeconomic Analysis of First Line Meropenem Versus Standard Antibiotic Treatment in Seriously Infected Secondary Nosocomial Sepsis Syndrome Patients. January 2002 June 2006
NCT00321165 Completed Phase 3 The AOT (Acridine Orange and Taurolidine) Trial June 2006 March 2008
NCT00329680 Completed Phase 4 The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis June 2007 October 2009
NCT00333593 Completed Phase 1/Phase 2 Super High-Flux - High Volume Dialysis in Sepsis-Induced Acute Renal Failure June 2006 November 2006
NCT00346580 Completed Phase 1 The Effects of HIV Protease Inhibitors in Severe Sepsis June 2003 September 2005
NCT00347386 Completed Phase 2/Phase 3 Therapeutic Zinc in Infant Bacterial Illness July 2005 December 2008
NCT00360048 Completed Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers August 2006
NCT00371241 Completed Antibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO September 2006 November 2007
NCT00396344 Completed N/A Cortisol Control of Human Inflammatory Responses to Endotoxin October 2006 November 2007
NCT00397956 Completed Phase 3 To Evaluate the Treatment Effect of an Anti-Infective Agent for Complicated Infections (0826-053) September 2004 December 2005
NCT00406198 Completed Phase 4 Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis March 1997 December 1999
NCT00410111 Completed Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy January 2007 July 2007
NCT00427076 Completed Phase 3 Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections June 2007 June 2014
NCT00430859 Completed Phase 2 Bovine Intestinal Alkaline Phosphatase for the Treatment of Patients With Sepsis September 2004 March 2006
NCT00441792 Completed N/A The Effect of Etomidate on Patient Outcomes After Single Bolus Doses October 2007 December 2010
NCT00448968 Completed The Utility of Ischemia Modified Albumin (IMA) in Sepsis March 2007 September 2007
NCT00457873 Completed Phase 3 Isotonic Versus Hypotonic Fluid for Maintenance IV Therapy January 2007 April 2008
NCT00464204 Completed Phase 3 Effects of Voluven on Hemodynamics and Tolerability of Enteral Nutrition in Patients With Severe Sepsis July 2007 December 2010
NCT06461390 Completed Phase 2/Phase 3 The Effect of Fluid Loading With Early Norepinephrine Administration on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock March 25, 2024 May 31, 2024
NCT00001338 Completed Phase 3 A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer June 1993 January 2001
NCT00004494 Completed Phase 1 Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis September 1998
NCT00005775 Completed Phase 3 Glutamine Supplementation to Prevent Death or Infection in Extremely Premature Infants July 1999 August 2001
NCT00005888 Completed N/A Study of the Relationship Between Feeding and Late Onset Sepsis and/or Necrotizing Enterocolitis in Low Birth Weight Infants January 1997
NCT00027248 Completed Phase 3 Safety and Efficacy of MBI 226 for the Prevention of Central Venous Catheter-Related Bloodstream Infections September 2000 July 2003
NCT00034476 Completed Phase 1/Phase 2 A Phase IIb Study to Determine the Efficacy and Safety of the Study Drug in Patients With Severe Sepsis October 2001 October 2002
NCT00042588 Completed Phase 2 A Safety and Efficacy Study of Hospitalized Patients With Community-Acquired Pneumonia and Sepsis May 2002
NCT00045760 Completed Phase 4 The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients With Severe Sepsis September 2002
NCT00046072 Completed Phase 2 A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis October 2001 April 2005
NCT00049764 Completed Phase 3 Investigation of the Efficacy and Safety of Drotrecogin Alfa (Activated) in Pediatric Severe Sepsis November 2002 April 2005
NCT00049777 Completed Phase 4 A Trial of Heparin in Patients With Severe Sepsis Who Are Undergoing Treatment With Drotrecogin Alfa (Activated) December 2002 August 2005
NCT00067730 Completed Phase 4 A Safety Evaluation of Drotrecogin Alfa (Activated) in Patients With Blood Cancer, Severe Infection Related to Bone Marrow Transplantation March 2003 October 2003
NCT00089986 Completed Phase 2 GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults September 1, 2004 April 15, 2007
NCT00100308 Completed Phase 3 Unfractioned Heparin for Treatment of Sepsis July 2005 July 2007
NCT00113191 Completed N/A Safety and Efficacy of Veronate® Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants May 2004 June 2006
NCT00121394 Completed Phase 3 Chlorhexidine Vaginal and Infant Wash in Pakistan June 2005 June 2008
NCT00130221 Completed Phase 1 Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections June 2005 July 26, 2006
NCT00133978 Completed N/A Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients April 2005 May 2012
NCT00141973 Completed Time Course of Procalcitonin and C Reactive Protein in Septic Patients Under Treatment With Corticosteroids November 2004 December 2005
NCT00143611 Completed Phase 3 Efficacy & Safety of Resatorvid in Adults With Severe Sepsis September 2005 February 2007
NCT00158769 Completed Phase 1 A Study To Compare The Effects Of The Infusion Of A Sepsis Drug Between Healthy Adults And Adults With Damaged Livers March 31, 2005 October 26, 2005
NCT00176124 Completed Phase 4 Leukocyte Depletion of Autologous Whole Blood April 2001 September 2005
NCT00185783 Completed Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis March 2005 November 2006
NCT00190788 Completed Phase 3 Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion June 2004 May 2007
NCT00197691 Completed Botswana Pediatric Respiratory Disease and Bloodstream Infection Study March 2001 October 2005
NCT00222222 Completed N/A Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis March 2003 December 2011
NCT00229034 Completed Effect of APC and Epo on the Inflammatory Response During Sepsis September 2005 September 2011
NCT00487656 Completed Phase 2 Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation July 2007 August 2010
NCT00488917 Completed Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study) June 2007 August 2009
NCT00490477 Completed Phase 3 The Effects of Polymyxin-B Protects on Sepsis Induced Kidney Dysfunction: a Randomized Clinical Trial May 2006 December 2007
NCT00493415 Completed Phase 3 The Effect of Nitroglycerine on Microcirculatory Abnormalities During Sepsis June 2007 July 2008
NCT00495690 Completed Phase 3 Impact of Daily Zinc Supplementation to Infants Born With Low Birth Weight on Death and Severe Disease November 2004 May 2008
NCT00510835 Completed N/A Protocolized Care for Early Septic Shock March 2008 December 2013
NCT00518596 Completed Phase 2 Prevention of Infection in Indian Neonates - Phase II Probiotics Study July 2005 August 2006
NCT00518609 Completed Prevention of Infection in Indian Neonates - Phase I Observational Study July 2003 July 2006
NCT00519350 Completed Towards a High-fat Feeding Intervention Study: Identification of Markers for Inflammation and Organ Damage August 2007 June 2009
NCT00527384 Completed Biomarker Analysis of Stress October 2007 May 2011
NCT00537693 Completed N/A Cytokine Removal by CRRT in Pediatric Sepsis September 2007 May 2010
NCT00548002 Completed Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia January 1999 August 2002
NCT00559130 Completed N/A Efficacy Study of CytoSorb Hemoperfusion Device on IL-6 Removal in ARDS/ALI Patients With Sepsis November 2007 June 2011
NCT00561639 Completed Benefit of SeptiFast Multiplex PCR in the Etiologic Diagnosis and Therapeutic Approach for Onco-hematology Patients Presenting Sepsis December 2007 November 2008
NCT00568737 Completed Phase 3 The Study of Drotrecogin Alfa (Activated) in Adult Patients With Severe Sepsis at a Low Risk of Death November 2002 February 2005
NCT00591955 Completed Infected Elders in the Emergency Department: Outcomes and Processes of Care January 2006 September 2009
NCT00599794 Completed A Simple Clinical Tool to Help Assess Patient Volume (Fluid) Status January 2006 January 2008
NCT00604214 Completed Phase 3 Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock March 2008 February 2012
NCT00605696 Completed Phase 2 Early Insulin and Development of ARDS April 2008 September 2013
NCT00608322 Completed Phase 3 Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis August 2009 April 2013
NCT00609375 Completed Phase 4 Efficacy of Cefepime Continuous Infusion Versus an Intermittent Dosing Regimen September 2006 December 2007
NCT00615862 Completed Relationship Between Alcohol Use Disorders and Cortisol Levels in Patients With Sepsis March 2008 May 2009
NCT00616876 Completed Phase 2 Lactulose Supplementation in Premature Infants February 2005 January 2007
NCT00629382 Completed Phase 4 Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis December 2004 April 2008
NCT00698048 Completed Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock August 2008 December 2011
NCT00707785 Completed Phase 3 Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis December 2006 June 2012
NCT00716781 Completed Management of Infants Born to Group B Streptococcus Positive Mothers. July 2004 December 2006
NCT00732277 Completed Phase 2 Evaluation of Corticosteroid Therapy in Childhood Severe Sepsis - a Randomised Pilot Study April 2008 April 2012
NCT00735384 Completed Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies September 1, 2006 December 30, 2019
NCT00736723 Completed NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock August 2008 December 2012
NCT00736827 Completed BK Virus and Renal Dysfunction in Postoperative/Posttraumatic Critically Ill Patients August 2008 December 2012
NCT00772096 Completed Phase 4 Septic Encephalopathy and Late Cognitive Dysfunction October 2008 June 2011
NCT00780520 Completed N/A The Effect of Glutamine on Systemic Inflammation During Human Experimental Endotoxemia June 2007 October 2007
NCT00781040 Completed Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients December 2006 January 1, 2019
NCT00783068 Completed N/A Anti-inflammatory Effects of GTS-21 After LPS August 2008 August 2010
NCT00791505 Completed Phase 3 Antibiotic/COPD in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Requiring Mechanical Ventilation July 2002 June 2005
NCT00792883 Completed Clinical Protocol Validation to Identify Prognostic Markers for Critical Care Pediatric Patients October 2007 January 2012
NCT00793442 Completed Endothelium in Severe Sepsis March 2008 May 2013
NCT00799916 Completed Phase 3 Saline Solution Versus Voluven®: A Controlled Study of Fluid Resuscitation in Severe Sepsis January 2006 August 2009
NCT00803231 Completed Follow-up Data of Patients Treated With XIGRIS® in France November 2008 December 2009
NCT00806325 Completed Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia November 2007 May 2010
NCT00808691 Completed Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit September 2007 July 2011
NCT00811980 Completed The Effects of Linezolid and Vancomycin on Inflammation and Cellular Signaling Vents January 2009 June 2010
NCT00814151 Completed MicroPhage S. Aureus / MSSA / MRSA Blood Culture Beta Trial July 2008 December 2008
NCT00818220 Completed Phase 2 Protective Effects of Delayed Cord Clamping in Very Low Birth Weight (VLBW) Infants February 2008 March 2014
NCT00819416 Completed Phase 2 Fluid Resuscitation in Early Septic Shock February 2009 February 2010
NCT00825357 Completed Biological Markers to Identify Early Sepsis and Acute Lung Injury September 2006 August 2011
NCT00839358 Completed Phase 4 Effect of Midodrine and Albumine in the Prevention of Complications in Cirrhotic Patients Awaiting Liver Transplantation August 2008 February 2016
NCT00844337 Completed N/A Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh March 2009 September 2013
NCT00850122 Completed Phase 1 An Open Label Study to Describe the Pharmacokinetics of Cefazolin in Preterm Neonates July 2013 July 2018
NCT00851214 Completed Use of Non Invasive Hemodynamic Cardiovascular Monitoring to Evaluate Emergency Department Patients March 2009 June 2009
NCT00862290 Completed Circulating microRNAs as Biomarkers of Sepsis August 2008 June 2009
NCT00873327 Completed Phase 1 Pharmacokinetics and Safety of Piperacillin-tazobactam in Neonates October 2009 July 2010
NCT00874367 Completed Early-Onset Sepsis Surveillance Study February 2006 May 2011
NCT00879606 Completed Phase 2 Anti-TF Antibody (ALT-836) to Treat Septic Patients With Acute Lung Injury or Acute Respiratory Distress Syndrome April 2009 January 2013
NCT00880204 Completed N/A Evaluation of Essential Surgical Skills-Emergency Maternal and Child Health Training May 1, 2009 November 30, 2009
NCT00891423 Completed N/A A Study of Meropenem Standard 30 Minute Infusion Versus Prolonged 3 Hour Infusion in Intensive Care Unit (ICU) Patients April 2009 January 2010
NCT00916448 Completed N/A The Effects of Atazanavir-induced Hyperbilirubinemia During Human Endotoxemia May 2009 July 2015
NCT00922870 Completed N/A Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock April 2009 March 2013
NCT00926497 Completed N/A Procalcitonin-Guided Decision Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis June 2005 January 2007
NCT00930085 Completed N/A Evaluation of Predictive Proteic Profile on Mortality in the Acute Phase of Septic Shock in Cancer Patients August 2008 May 2011
NCT00942149 Completed Phase 1 An Open Label Study to Describe the Pharmacokinetics of Daptomycin in Infants January 2010 December 2011
NCT00995839 Completed Phase 2/Phase 3 Terlipressin in Septic Shock: Effects on Microcirculation November 2008 February 2010
NCT01012115 Completed Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis October 2009 September 2011
NCT01013662 Completed N/A Lipid Profile in Patients With Severe Sepsis or Septic Shock Under Strict or Liberal Glycemic Control January 2005 July 2007
NCT01014117 Completed Phase 1 Effect of SRT2104 on Endotoxin-induced Inflammation December 9, 2009 May 10, 2010
NCT01023087 Completed Renal Impairment Associated With Colistin Levels December 2009 January 2011
NCT01027429 Completed Phase 3 Simplified Antibiotic Therapy for Sepsis in Young Infants December 2009 December 2013
NCT01027897 Completed Phase 4 Pharmacokinetic and Pharmacodynamic Evaluation of Doripenem in Critically Ill Trauma Patients April 2010 December 2011
NCT01029080 Completed Cerebrovascular Autoregulation During Sepsis December 2009 March 2011
NCT01069146 Completed N/A Mild Therapeutic Hypothermia During Severe Sepsis January 2002 January 2005
NCT01089361 Completed Phase 1/Phase 2 Immunomodulatory Properties of Ketamine in Sepsis December 2009 June 2011
NCT01099566 Completed Phase 4 The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation November 2009 November 2010
NCT01099813 Completed Sepsis Pathophysiological & Organisational Timing November 2010 December 2012
NCT01114165 Completed Phase 4 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients May 2010 September 2012
NCT01128283 Completed Indicators of Inflammation and Coagulation in Sepsis January 2002 May 2014
NCT01135277 Completed Immune Suppression and Ventilator Associated Pneumonias February 2010 November 2012
NCT01139489 Completed N/A Safety and Efficacy of Procalcitonin Guided Antibiotic Therapy in Adult Intensive Care Units (ICU's) November 2009 August 2014
NCT01140269 Completed N/A Rapid Detection of Staphylococcus Aureus in Burn Patients May 30, 2010 September 29, 2019
NCT01151579 Completed Phase 4 Effect of Nebulized Bronchodilators on Heart Rate December 2008 November 2009
NCT01155830 Completed Inflammatory Cytokine Quantification in Infants June 2010 June 2013
NCT01161745 Completed PD-1/PD-L1 Pathway Study on Septic Patients December 2008 April 2010
NCT01167075 Completed N/A A Study in Critically Ill Patients Investigating Tolerability and Efficacy of Low-volume Pharmaconutrition (Intestamin) February 2006 February 2009
NCT01187004 Completed Extracardiac Complications After Cardiac Surgery April 2007 December 2009
NCT01187134 Completed N/A Medical Education for Sepsis Source Control and Antibiotics July 2011 July 2013
NCT01191905 Completed N/A Effects of HIgh Volume COntinuous REnal Replacement Therapy in Patients With Septic Acute Kidney Injury January 2011 July 2015
NCT01197326 Completed The Prevention of Failure to Rescue Using Early Warning Scoring August 2009 June 2010
NCT01201577 Completed Phase 1 Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals October 2009 May 2011
NCT01203345 Completed Phase 2/Phase 3 Intravenous Immune Globulin (IVIG) to Prevent Neonatal Infection January 1988 March 1991
NCT01203488 Completed Phase 1/Phase 2 Vitamin A Supplementation for Extremely-Low-Birth-Weight Infants January 1996 July 1999
NCT01223690 Completed Phase 3 Clarithromycin as Immunomodulator for the Management of Sepsis July 2007 April 2011
NCT01236703 Completed Hematological Infection Score Compared to the Hospital Standard for Diagnosis of SIRS or Sepsis on ICU March 2010 October 2010
NCT01241318 Completed Phase 2/Phase 3 Zambia Chlorhexidine Application Trial February 2011 September 2013
NCT01262911 Completed Phase 1 Effect of SRT2379 on Endotoxin-Induced Inflammation February 17, 2011 April 26, 2011
NCT01263041 Completed Phase 2/Phase 3 Effect of L-arginine and Glutamine on Preterm May 2011 March 2014
NCT01264536 Completed Phase 2 Pilot Study: Lactoferrin for Prevention of Neonatal Sepsis December 2010 December 2011
NCT01275638 Completed Phase 4 The Effect of Moderate-Dose Steroid Therapy in Sepsis April 2005 May 2009
NCT01286610 Completed N/A Applicability and Safety of Vibration Therapy in Intensive Care Unit (ICU) Patients February 2011 May 2012
NCT01309321 Completed N/A Perinatal Handwashing Intervention in Bangladesh October 2010 July 2013
NCT01328509 Completed Zinc and Inflammation in Sepsis January 2012 May 2013
NCT01333657 Completed The Application of Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Sepsis & Relevant Acute Kidney Injuries May 2010 April 2011
NCT01333982 Completed N/A Neonatal Sepsis, Evaluation, Bangladesh April 2010 December 2013
NCT01355042 Completed Studies of Blood DNA in Patients With Severe Infection DYNAMICS November 2010 September 2016
NCT01359891 Completed Clinical Evaluation of Novel Biomarkers in Patients With Septicemia November 2010 August 2021
NCT01362504 Completed Pro-adrenomedullin as a Prognostic Marker in Neonatal Sepsis May 2011 September 2011
NCT01362829 Completed Outcome Predictors in Patients With Severe Sepsis and Optimized Central Venous Oxygen Saturation August 2009 May 2011
NCT01362920 Completed Diagnostic and Prognostic Value of Serial Procalcitonin (PCT) Measurements in Critically Ill Patients April 2011 November 2012
NCT01374711 Completed N/A The Effects of Immunostimulation With GM-CSF or IFN-y on Immunoparalysis Following Human Endotoxemia May 2011 November 2011
NCT01378169 Completed SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU January 1, 2011 June 1, 2013
NCT01379404 Completed Bioimpedance Analysis in Septic Intensive Care Unit (ICU) Patients February 2011 April 2012
NCT01388114 Completed N/A Clinical Evaluation of e- Ab Sensor - Based Real-time Diagnosis of Serum Procalcitonin Level November 2010 July 2012
NCT01388725 Completed Comparison the Value of Several Biomarkers of Sepsis September 2009 July 2011
NCT01392508 Completed IMproved PREdiction of Severe Sepsis in the Emergency Department March 2011 September 2015
NCT01396798 Completed Validation of Vital Signs and Symptoms for the Diagnosis of Serious Infections in Children in the Paediatric A&E. February 2011 March 2012
NCT01406951 Completed Diagnostic Value of sTREM-1 and PCT Level as Well as CPIS Score for Ventilator-Associated Pneumonia Among ICU Sepsis Patients September 2009 March 2011
NCT01410578 Completed The Value of sTREM-1, PCT, and CRP as Markers for the Detection of Sepsis and Bacteremia Among Patients With a FUO September 2009 March 2011
NCT01411670 Completed Phase 2 Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. January 2011 April 2015
NCT01416376 Completed Phase 1 Effect of Multiple Dose Levels of SRT2379 on Endotoxin-Induced Inflammation August 30, 2011 December 12, 2011
NCT01423968 Completed N/A Effect of Lipopolysaccharide on Skeletal Muscle Functions July 2011 December 2012
NCT01426711 Completed Critical Care Excellence in Sepsis and Trauma September 2009 March 2012
NCT01431326 Completed Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care November 2011 November 2019
NCT01434121 Completed Phase 1/Phase 2 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis May 2010 September 2012
NCT01438853 Completed Phase 1 Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome December 2004 February 2008
NCT01447875 Completed Phase 1 The Effects of Sedative on the Fluid Responsiveness in Critically Ill Patients May 2011 December 2013
NCT01449721 Completed N/A Preemptive Resuscitation for Eradication of Septic Shock September 2011 January 2016
NCT01450358 Completed Phase 4 Evaluation in the Treatment of Nosocomial Sepsis Comparing Polymerase Chain Reaction With Conventional Blood Culture. January 2012 May 2016
NCT01453270 Completed N/A Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial November 2011 March 2014
NCT01465711 Completed The Value of PSP in Predicting Outcome in ICU Surgical Peritonitis Patients July 2007 December 2014
NCT01480544 Completed N/A Improving Maternal and Child Health in India: Evaluating Demand and Supply Side Strategies (IMATCHINE) August 2012 November 2015
NCT01484106 Completed N/A Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Severe Sepsis November 2011 August 2014
NCT01490424 Completed TREM-1 Gene Polymorphisms May 2010 October 2011
NCT01494675 Completed N/A Procalcitonin as a Tool to Shorten Antibiotic Therapy in the ICU March 2008 February 2010
NCT01511952 Completed N/A A Multi-Site Study of Music Therapy Interventions on Vitals, Feeding and Sleep in Premature Infants January 2007 December 2010
NCT01528358 Completed Tissue Near InfraRed Spectroscopy (NIRS) in Critically Ill Patients April 4, 2012 August 12, 2019
NCT01530854 Completed Plasma Free Fatty Acids in Risk Assessment of Sepsis in the Emergency Department: A Prospective Pilot Study February 2008 January 2012
NCT01530932 Completed Immune Activation, Hypoxia and Vasoreaction in Sepsis of Pulmonary Versus Abdominal Origin February 2012 April 2014
NCT01551394 Completed Phase 3 Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis September 2012 December 2014
NCT01578226 Completed Procalcitonin in Cirrhotic Patients at High Risk for Sepsis October 2009 September 2011
NCT01580826 Completed N/A Pasteurization of Mother's Own Milk for Preterm Infants March 2006 April 2012
NCT01603368 Completed Phase 2 Prophylactic Probiotics to Extremely Low Birth Weight Prematures June 2012 December 2015
NCT01618396 Completed N/A Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock March 2011 August 2011
NCT01632059 Completed Examination of ADMA Serum Level and DDAH II February 2012 April 2017
NCT01636232 Completed Vitamin D and Critically Ill Patients October 2011 December 2011
NCT01647997 Completed N/A Lactate Metabolism After an Endotoxin Challenge in Healthy Humans April 2002 December 2004
NCT01649440 Completed Sepsis Metabolomics July 2010 March 2012
NCT01649921 Completed Phase 3 The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis November 2012 December 2016
NCT01653665 Completed Phase 1/Phase 2 Does GM-CSF Restore Neutrophil Phagocytosis in Critical Illness? August 2012 February 2015
NCT01663701 Completed N/A Simplified Severe Sepsis Protocol-2 (SSSP-2) in Zambia October 2012 January 2014
NCT01708759 Completed IL8 Monitoring and Its Correlation With 251-gene Polymorphism November 2012 February 2013
NCT01708772 Completed Serum TNF-a in Comparison to Sequential Organ Failure Assessment (SOFA) Score Monitoring in Critically Ill Patients November 2012 January 2013
NCT01724424 Completed Phase 1 Melatonin in Healthy Volunteers June 2012 May 2013
NCT01725061 Completed Study of the Function of Cells Involved in Inflammation in the Lungs of Those With Acute Lung Injury and Sepsis December 2009 September 2012
NCT01739933 Completed Phase 3 The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure May 15, 2013 July 2019
NCT01751945 Completed N/A Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project November 2012 December 2013
NCT01753024 Completed Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients January 2012 December 31, 2015
NCT01756755 Completed N/A Endotoxin Adsorber Hemoperfusion and Microcirculation December 2012 June 2019
NCT01760044 Completed N/A Noninvasive Assessment of Tissue Perfusion Status in Critically Ill Pediatric Patients January 2013 November 2014
NCT01760967 Completed Phase 4 Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial January 2013 January 2016
NCT01766414 Completed Phase 3 In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II September 2013 January 2014
NCT01775020 Completed Early Phase 1 Dose-response Study of Arginine Supplementation in Severe Sepsis October 2003 May 2012
NCT01790620 Completed N/A Impact of CVVHD With Adsorption Capacity Membranes in Septic Acute Kidney Injury May 2013 October 2017
NCT01791712 Completed N/A Efficacy of Online Hemodiafiltrationlysis in Cytokine Removal January 2010 October 2011
NCT01793012 Completed Drug Monitoring of Antibiotics in Critical Care Patients March 2013 January 2015
NCT01801501 Completed Role of FGF-23 as a Prognosis Biomarker in Intensive Care Patients January 2012 December 2018
NCT01801839 Completed Detection Of Monocytes/Macrophages Function And Tim-3 Expression In Septic Patients August 2012
NCT01817881 Completed Investigation of the Accuracy of Temporal Artery Thermometers March 2013 June 2013
NCT01847248 Completed HSPA12B as a Potential Biomarker for Sepsis and Severe Sepsis May 2011 October 2013
NCT01862185 Completed Phase 3 The Effect of Semi-quantitative Procalcitonin Assay to The Adequacy of Empirical Antibiotics and Mortality in Septic Patients December 2012 April 2013
NCT01865656 Completed N/A A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka July 2013 January 2015
NCT01878968 Completed N/A Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes? April 2013 November 2014
NCT01889264 Completed Methionine Metabolism in Enterally Fed Pediatric Sepsis December 2011 October 2016
NCT01890928 Completed Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis March 2011 October 2013
NCT01891682 Completed Methionine Metabolism in Parenterally Fed Pediatric Sepsis October 2012 October 2016
NCT01900275 Completed Urinary Heparanase Activity as a Predictor of Acute Kidney Injury in Critically Ill Adults July 2013
NCT01928745 Completed Experimental Determination of Atot en Ka in the Critically Ill September 2013 May 2014
NCT01936766 Completed Optimal Fluid Management in Adult Severe Malaria May 2013 December 2017
NCT01947127 Completed Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department March 2013 January 2015
NCT01948063 Completed Phase 2 Ubiquinol (Reduced COQ10) for Patients With Sepsis October 2012 April 2014
NCT01964690 Completed Lactate Use as Triage Tool in Sepsis : Veinous, Capillary or Arterial? December 2013 April 2014
NCT01968746 Completed The AVERT Sepsis Investigation August 2012 April 2015
NCT01973829 Completed N/A The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN) November 2013 March 2018
NCT01976754 Completed N/A Safety Study of Dexmedetomidine in Septic Patients September 2013 July 2015
NCT01976884 Completed Expression and the Clinical Significance of Neutrophil PD-L1 During Sepsis June 2011 January 2013
NCT01988428 Completed N/A Prehospital Antibiotics Against Sepsis Trial June 2014 June 2017
NCT02024282 Completed N/A Optimising Diagnosis and Antibiotic Prescribing for Acutely Ill Children in Primary Care January 2013 December 2014
NCT02025699 Completed Prospective Study to Characterize Host-pathogen Related Factors in Hospitalized and ED Patients With LRTI and/or Sepsis February 2014 September 2016
NCT02039297 Completed N/A Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE) March 2013 June 2017
NCT02052895 Completed Utility of Presepsin in Distinguishing Between Sepsis and SIRS January 2014 July 2015
NCT02053935 Completed Phase 1 Impact of Dopamine Infusion on Insulin Secretion in Healthy Subjects December 2013 January 2016
NCT02054091 Completed N/A Feeding Bovine Colostrum to Preterm Infants February 2014 January 2017
NCT02068716 Completed Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery March 2014 September 29, 2018
NCT02073760 Completed Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2 June 2014 September 29, 2018
NCT02079402 Completed Phase 4 Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care September 2014 November 2015
NCT02085590 Completed Phase 2/Phase 3 Effects of BCG on Immune Response March 2014 November 2014
NCT02106975 Completed Phase 2 Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury April 2014 January 8, 2018
NCT02108405 Completed The Value of Memory B Cells Marker (CD27) and Howell Jelly Bodies Detrection in Critically Ill Patients May 2013 January 2014
NCT02120534 Completed Serum CD14 and CD88 Mointoring in ICU March 2013 October 2014
NCT02127502 Completed VENUS: Septic Gene Expression Using SeptiCyte April 2014 December 2016
NCT02128399 Completed Antimicrobial Stewardship Reduces MDRO Isolates in Critically Ill Patients June 2012 December 2013
NCT02157259 Completed An Observational Study of the Causes, Management, and Outcomes of Community-acquired Sepsis and Severe Sepsis in Southeast Asia December 2013 February 2016
NCT02159079 Completed N/A A Randomized Controlled Trial of a Conservative Fluid Balance Strategy for Patients With Sepsis and Cardiopulmonary Dysfunction (BALANCE Study) July 2014 April 2016
NCT02163473 Completed Hypoxia Inducible Factor 1 Alpha as a Novel Biomarker in Septic Shock January 2013 June 2015
NCT02170233 Completed SHOCK US STUDY: Fluid Responsiveness in Sepsis Measured by Ultrasonography August 2014 June 2016
NCT02180009 Completed Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis December 2013 December 2015
NCT02186522 Completed Immune Failure in Critical Therapy (INFECT) Study July 2014 January 2016
NCT02188992 Completed Early PREdiction of Severe Sepsis I (ExPRES-Sepsis I) Study January 2014 January 2016
NCT02189096 Completed Validation of Early Warning Score & Lactate in Prehospital Screening May 2014 July 2015
NCT02202941 Completed N/A Procalcitonin-guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients August 2014 March 2015
NCT02203019 Completed Phase 4 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure August 2014 September 22, 2016
NCT02207114 Completed N/A Using Biomarkers to Optimize Antibiotic Strategies in Sepsis January 2012 December 2023
NCT02210169 Completed N/A RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates September 2014 May 2018
NCT02217592 Completed Causes and Factors Associated With Outcomes in Community-acquired Sepsis and Severe Sepsis in Northeast Thailand May 20, 2012 February 28, 2017
NCT02238795 Completed Sepsis-Associated Purpura Fulminans International Registry - Europe April 2016 September 30, 2020
NCT02266589 Completed Phase 3 Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock November 2011 October 2013
NCT02266901 Completed Transluminal or Percutaneous Endoscopic Drainage and Debridement of Abcesses After Bariatric Surgery October 2007 September 2014
NCT02288715 Completed Relationship of Cerebral Perfusion Pressure Variability to Sepsis-associated Encephalopathy May 2014 March 2017
NCT02288975 Completed Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study October 2014 December 2017
NCT02295514 Completed N/A Correlation Between PTP1B Expression and Organ Failure During Sepsis January 2015 May 2016
NCT02308371 Completed N/A PPV to Guide Fluid Management in the PICU November 2014 June 2016
NCT02325258 Completed N/A Assessment of a Proposed Microbiological Alert and Its Impact on a Sepsis Campaign August 2012 January 2013
NCT02327130 Completed N/A Changes in Exhaled 13CO2/12CO2 Breath Delta Value as an Early Indicator of Infection in ICU Patients April 2015 December 2017
NCT02328612 Completed Phase 1 Randomized, Parallel Group, Placebo Control, Unicentric, Interventional Study to Assess the Effect of Expanded Human Allogeneic Adipose-derived Mesenchymal Adult Stem Cells on the Human Response to Lipopolysaccharyde in Human Volunteers October 2014 March 2015
NCT02330432 Completed Phase 2/Phase 3 Mycobacterium w in Patients With Severe Sepsis January 2016 October 31, 2018
NCT02336620 Completed Phase 3 Balanced Salt Solution VS. Normal Saline Solution in Septic Shock December 2014 January 30, 2017
NCT02338843 Completed Phase 3 A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension March 2015 February 18, 2017
NCT02340182 Completed N/A The Role of the Microbiota in the Systemic Immune Response March 2013 September 2013
NCT02344043 Completed Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness March 2014 September 2016
NCT02346331 Completed N/A Epidemiology, Acute Management, and Outcomes of Patients With Sepsis Presenting to a Referral Hospital in Western Kenya January 2015 September 2016
NCT02361970 Completed Study on the Role of Gamma Delta T Cells in Sepsis Immunosuppression and Its Molecular Mechanism May 2014 May 2015
NCT02365272 Completed Phase 4 Pharmacokinetic/Pharmacodynamic Evaluation Amikacin in Critically Ill Patients Admitted at the Emergency Department December 2012 December 2014
NCT02370186 Completed The Role of Dysfunctional HDL in Severe Sepsis February 2015 March 12, 2017
NCT02378545 Completed Phase 4 Trial of Hyperoxic O2 Therapy vs. Normoxic O2 Therapy in Sepsis October 2015 November 10, 2016
NCT02389036 Completed Phase 3 Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients May 1, 2017 April 26, 2023
NCT02398981 Completed N/A Implementation of a Web Based Real Time Clinical Decision Support Tool. February 2015 December 31, 2018
NCT02399397 Completed Phase 4 Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics February 2014 December 2015
NCT02400697 Completed Placental Transfusion Project for Preterm Infants September 2014 December 2016
NCT02430142 Completed Microcirculatory Oxygen Uptake in Sepsis April 2015 August 1, 2017
NCT02444871 Completed IgM-enriched Immunoglobulin Attenuates Systemic Endotoxin Activity in Early Severe Sepsis January 2013 July 2013
NCT02446392 Completed The Distribution of Plasma Drug Concentrations of Beta-lactam Antibiotics in Intensive Care Unit Patients October 2014 March 2016
NCT02447042 Completed N/A Minimal Volume for a Fluid Challenge in Septic Patients November 2014 February 2016
NCT02448472 Completed Epidemiology of Sepsis in China November 2015 January 2016
NCT02455180 Completed Phase 4 Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients March 2015 November 2016
NCT02467023 Completed N/A Project 4B: Lower Extremity Strength Training in ICU Patients September 2015 July 15, 2016
NCT02469571 Completed N/A Modulation of Gut Microbiota in Early Sepsis: A Pilot Study September 1, 2015 March 1, 2018
NCT02474797 Completed N/A Ultrasound Diaphragmatic Thickening to Monitor Its Dysfunction in Patients With Sepsis May 4, 2015 April 1, 2020
NCT02508272 Completed Transcriptomic Profiling in Severely Injured Patients December 2009 July 2015
NCT02533011 Completed Evaluation of the Heparin Binding Protein Levels in Sepsis July 2015 July 2017
NCT02536547 Completed Diagnostic Value of Pulmonary Ultrasound in the Diagnosis of Ventilator-associated Pneumoniae June 2013 June 2014
NCT02544230 Completed Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia January 2004 December 2011
NCT02544490 Completed Defining Circulating Micro-RNA Biomarkers for the Early Diagnosis and Prognosis of Sepsis September 2013 December 2018
NCT02560129 Completed MICU Recovery Clinic July 2015 November 30, 2023
NCT02560402 Completed The Relation Between the Renal Resistive Index and Glomerular Hyper Filtration August 2015 February 2016
NCT02569086 Completed Piperacillin PK Analysis in Severe Sepsis Patients November 1, 2015 June 30, 2016
NCT02605681 Completed Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis November 1, 2016 June 15, 2018
NCT02647554 Completed Phase 4 Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China December 2016 August 1, 2021
NCT02656459 Completed Longitudinal Gene Expression Profiling in Adults After Traumatic Injury January 2016 August 2017
NCT02661269 Completed Relation Between the Increase of Peripheral Edema by Fluid Therapy and the Decrease in Microcirculatory Vesseldensity November 1, 2015 February 15, 2018
NCT02679625 Completed Comparison of Non-Invasive Methods of Assessing Fluid Responsiveness in ED and ICU Patients November 1, 2014 December 1, 2019
NCT02682355 Completed Optimizing Clinical Use of Polymyxin B February 2016 August 3, 2022
NCT02694159 Completed Physician Judgment and Machine Predictions February 2016 December 30, 2021
NCT02706275 Completed N/A Pilot Trial of External Warming in Septic Patients March 2016 May 12, 2019
NCT02707718 Completed Biomarkers for the Early Identification of Sepsis in the Emergency Department March 1, 2016 March 3, 2018
NCT02714595 Completed Phase 3 Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens September 7, 2016 April 22, 2019
NCT02721134 Completed N/A Diagnostic Performance of a New Bio-marker During Bacterial Sepsis March 2016 November 17, 2020
NCT02728401 Completed Genotypes and Phenotypes in Pediatric SIRS and Sepsis May 1, 2013 December 31, 2017
NCT02730468 Completed SEP-SEQ Trial - Determining the Etiology of Sepsis Using an Infectious Disease Diagnostic Sequencing Assay April 2016 October 2017
NCT02738164 Completed SEPSIS 3 Critera for Risk Stratification in Emergency Patients May 2016 July 2016
NCT02739152 Completed TRIAGE: TRIage of Sepsis At emerGency dEpartment April 2015 March 2018
NCT02747121 Completed N/A Effects of External Inspection on Sepsis Detection and Treatment April 2016 December 2020
NCT02748382 Completed Phase 2/Phase 3 Fluids in Sepsis and Septic Shock August 18, 2016 August 19, 2017
NCT02755025 Completed Clinical Score Usefulness and EHR Integration July 1, 2016 August 31, 2016
NCT02782013 Completed Study of Progression of Community Acquired Pneumonia in the Hospital August 25, 2009 June 1, 2022
NCT02789995 Completed N/A Dysfunctions of Human Muscle Stem Cells in Sepsis June 23, 2016 June 28, 2018
NCT02820675 Completed N/A Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions August 2015 July 2019
NCT02837731 Completed N/A Fluid Responsiveness Evaluation in Sepsis-associated Hypotension October 2016 March 13, 2019
NCT02843685 Completed Regression Discontinuity Design to Evaluate of Drotrecogin Alpha Effectiveness December 2002
NCT02846948 Completed N/A The Impact of Focused Transthoracic Echocardiography in Urgent Abdominal Surgery for Septic Patients January 2016 February 1, 2018
NCT02852902 Completed Impact of Specific Antimicrobials and MIC Values on the Outcome of Bloodstream Infections Due to ESBL- or Carbapenemase-producing Enterobacterales in Solid Organ Transplantation: an Observational Multinational Study. January 1, 2016 January 1, 2018
NCT02855671 Completed Infrared Imaging in Septic Illness July 2016 February 1, 2019
NCT02860572 Completed N/A Non-interventional Follow-up Versus Fluid Bolus in RESPONSE to Oliguria in the Critically Ill January 10, 2017 December 10, 2020
NCT02867267 Completed Phase 3 The Efficacy and Safety of Ta1 for Sepsis September 6, 2016 March 23, 2021
NCT02871544 Completed N/A Predictive Value of Dynamic Combination of BNP and NGAL for the Prognosis of Patients With Sepsis June 2015 February 2016
NCT02883218 Completed Dynamic Alterations of Th2/Th1 With New Onset of Community-acquired Severe Sepsis Patients September 2014 August 1, 2018
NCT02883595 Completed Phase 4 Efficacy of Thymosin Alpha 1 on Improving Monocyte Function for Sepsis March 31, 2016 December 31, 2016
NCT02888470 Completed Administration of Amino-glycoside in ICU Patients : Clinical Practices in 2013 June 2013 November 2013
NCT02898961 Completed Phase 4 Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis October 2014 February 2015
NCT02907931 Completed N/A Carotid Doppler Ultrasound for the Measurement of Intravascular Volume Status September 2016 January 2020
NCT02914756 Completed HMGB1 in ICU-survivors May 2014 September 2018
NCT02926664 Completed Delta qSOFA for Risk Stratification in Emergency Infected Patients October 2016 May 1, 2017
NCT02927054 Completed N/A Effect of Education on Resident Physician Knowledge of Sepsis July 2014 September 2016
NCT02933307 Completed N/A Continuous Monitoring on the General Ward April 2015 September 2016
NCT02934997 Completed The Role of Dysfunctional HDL in Sepsis November 1, 2016 May 3, 2019
NCT02945241 Completed Phase 1 Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project April 2014 March 2016
NCT02953002 Completed The Correlation Between The New Sepsis Scores - SOFA, Quick SOFA and Calibrated Automated Thrombogram Values January 17, 2017 September 2021
NCT02960256 Completed The Impact of Infectious Disease on QT Segment December 2016 March 2017
NCT02963480 Completed Investigation of Inflammatory Parameters in a Perioperative Closed-meshed Standard Progress in CPB Patients October 30, 2016 February 5, 2018
NCT02971111 Completed Thromboelastometry in Assessment of Sepsis Coagulopathy January 2013 October 2016
NCT02971670 Completed Phase 1 Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial October 2015 May 2016
NCT02986542 Completed N/A Comparison of Success Rates of Femoral Artery Catheterization December 2016 April 2, 2018
NCT03005145 Completed N/A Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness February 24, 2017 August 3, 2023
NCT03013322 Completed N/A Anticholium® Per Se January 28, 2015 February 18, 2017
NCT03014232 Completed N/A Comparison Cytokine Clearance Between SLED-f Using High Cut-off Dialyzer and High-flux Dialyzer in Septic AKI Patients June 2012 June 2013
NCT03015454 Completed N/A An Algorithm Driven Sepsis Prediction Biomarker December 2016
NCT03015584 Completed Systems Biology Approach to Cognitive Impairment After SepsiS June 2015 July 2017
NCT03019965 Completed N/A Efficacy of Betalactam Antibiotics in Prolonged Infusion Compared to Intermittent in Pediatric Patients With Sepsis February 1, 2017 January 30, 2020
NCT03025802 Completed Fast Assay for Pathogen Identification and Characterization - Prospective Study January 2017 June 2017
NCT03031275 Completed N/A Long-term Follow Up of Adult Patients Treated With Extracorporeal Membrane Oxygenation for Respiratory Failure January 2014
NCT03037281 Completed Release of Nociceptin From Granulocytes in Sepsis April 7, 2016 June 30, 2019
NCT03066362 Completed N/A Respiratory Variations for Predicting Fluid Responsiveness November 2011 February 2014
NCT03066375 Completed N/A Respiratory Variations For Predicting Fluid Responsiveness 2 May 2012 June 2015
NCT03077672 Completed Mitochondrial DNA as a Biomarker of Sepsis Severity February 10, 2017 December 22, 2020
NCT03126032 Completed Early Detection of Glycocalyx Damage in Emergency Room Patients April 3, 2017 December 31, 2019
NCT03129542 Completed Phase 1 Midodrine Hydrochloride in Early Sepsis August 30, 2017 May 15, 2020
NCT03131063 Completed Pharmacokinetic Study of Antibiotics in Patients Assisted by Extracorporeal Membrane Oxygenation (PHARMECMO) May 2014 March 2017
NCT03145428 Completed Evaluation of Monocyte Volume Distribution Width (MDW) for Early Detection of Sepsis June 19, 2017 January 26, 2018
NCT03152474 Completed Phase 4 Adrenal Cortical Function and Vitamin A Deficiency in Sepsis February 1993 January 2000
NCT03158493 Completed Assessment of qSOFA in the Latin America Sepsis Institute Database May 2016 April 2017
NCT03179215 Completed Dynamic Arterial Elastance as a Predictor of Arterial Blood Pressure Response to Fluid Administration in Septic Patients July 1, 2017 June 30, 2018
NCT03201679 Completed The Association Between Preoperative Sepsis and the Mortality After Hip Fracture Surgery January 1, 2014 August 1, 2017
NCT03213990 Completed N/A Beta-Lactam InfusioN Group Study March 26, 2018 June 29, 2023
NCT03224052 Completed Empirical ANtibiotic THErapy in Adults Hospitalised With Malaria May 1, 2016 January 1, 2018
NCT03226366 Completed Effect of Emergency Department Care Reorganization on Door-to-antibiotic Times for Sepsis (LDS SWARM) May 16, 2015 April 11, 2020
NCT03235193 Completed N/A Predictive algoRithm for EValuation and Intervention in SEpsis July 1, 2017 August 30, 2017
NCT03237728 Completed Phase 1 Study of Multiple-dose Kukoamine B Mesilate in Sepsis Patients July 28, 2017 September 25, 2019
NCT03238742 Completed Phase 4 The Efficacy of Xuebijing Injection on Sepsis October 20, 2017 January 8, 2020
NCT03249246 Completed Epidemiology of Sepsis in Turkish ICUs. January 27, 2016 February 27, 2016
NCT03249597 Completed Predict Sepsis; the Predictive Value of Bedside Measures in the Ambulance April 3, 2017 August 30, 2018
NCT03258684 Completed N/A Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock September 25, 2017 February 2, 2019
NCT03270774 Completed Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units April 19, 2016 April 19, 2017
NCT03277677 Completed Phase 3 The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients July 1, 2017 March 1, 2021
NCT03280576 Completed Validation of Progranulin as a Biomarker for Sepsis April 2015 June 2019
NCT03295825 Completed N/A Heparin Binding Protein in Early Sepsis Diagnosis September 22, 2017 September 30, 2018
NCT03306186 Completed N/A Hemospec Device for the Diagnosis of Sepsis October 9, 2017 March 31, 2018
NCT03332225 Completed Phase 2 A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis December 15, 2017 December 31, 2019
NCT03333278 Completed Phase 2 The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial May 2, 2018 October 6, 2019
NCT03333304 Completed N/A A Clinical Trial of Procalcitonin-guided Antimicrobial Therapy in Sepsis October 24, 2017 July 20, 2019
NCT03338569 Completed Phase 2/Phase 3 Vitamin C and Septic Shock December 20, 2017 August 10, 2020
NCT03344627 Completed N/A Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients November 27, 2017 December 31, 2018
NCT03345992 Completed Phase 3 Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System December 15, 2017 December 19, 2020
NCT03348579 Completed Hospital-acquired Pneumonia in Intensive Care Unit September 15, 2017 December 15, 2018
NCT03350113 Completed N/A Hemospec Device for Sepsis Diagnosis October 2, 2017 April 30, 2018
NCT03355833 Completed Comparing Prognostic Performance of SEPSIS 2 and SEPSIS 3 Strategies at the Emergency Service January 2016 December 2016
NCT03356249 Completed Next-Generation Sequencing Diagnostics of Bacteremia in Sepsis March 1, 2019 September 30, 2021
NCT03378258 Completed Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA. November 9, 2017 June 30, 2019
NCT03385850 Completed N/A The Th17/Treg Cells and IL-23/IL-17 Axis and Early Enteral Nutrition in Sepsis October 1, 2017 December 31, 2018
NCT03388450 Completed N/A Omega-3 Fatty Acid for Critically Ill Patients. January 15, 2015 November 30, 2017
NCT03388944 Completed N/A PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis October 21, 2019 February 28, 2023
NCT03389555 Completed Phase 2/Phase 3 Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial February 9, 2018 February 28, 2020
NCT03392701 Completed N/A Possible Links Between Inflammation and Lipid Metabolism December 20, 2017 September 30, 2018
NCT03395951 Completed Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients October 1, 2014 January 31, 2015
NCT03431077 Completed Phase 2 A Study of LJPC-501 in Pediatric Patients With Hypotension February 11, 2018 April 14, 2018
NCT03433846 Completed Predictors of Sepsis in Ex-Preterm Infants April 18, 2019 May 1, 2022
NCT03440593 Completed N/A Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients September 10, 2018 October 3, 2019
NCT03440918 Completed N/A Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit February 12, 2018 May 11, 2019
NCT03441126 Completed Blood Culture Improvement Guidelines and Diagnostic Stewardship for Antibiotic Reduction in Critically Ill Children April 1, 2018 December 28, 2021
NCT03452865 Completed Phase 3 Esomeprazole to Reduce Organ Failure in Sepsis January 28, 2020 August 21, 2023
NCT03454087 Completed N/A Study of Early Enteral Dextrose in Sepsis June 4, 2018 April 1, 2020
NCT03474809 Completed Early Diagnostic of Sepsis and Potential Impact on Antibiotic Management Based on Serial.Pancreatic Stone Protein (PSP) Measured Using the AbioScope. June 14, 2018 March 15, 2019
NCT03475732 Completed N/A Pharmacokinetics of XueBiJing in Patients With Sepsis March 18, 2018 December 31, 2019
NCT03489447 Completed Mortality of Sepsis in Swedish Intensive Care Units 2008-2016 January 1, 2008 October 25, 2017
NCT03494790 Completed Markers of Inflammation and Metabolism in the ER December 15, 2017 August 1, 2019
NCT03497182 Completed N/A Sepsis, Severe Sepsis and Septic Shock Detection by Breath Analysis May 2, 2017 October 31, 2018
NCT03506152 Completed Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis January 1, 2014 December 3, 2015
NCT03509350 Completed Phase 3 Vitamin C, Thiamine, and Steroids in Sepsis August 22, 2018 January 29, 2020
NCT03509727 Completed Procalcitonin in Diagnosis of Bacterial Infections in Young Infants August 1, 2017 January 1, 2018
NCT03509753 Completed N/A Prebiotic Fiber to Prevent Pathogen Colonization in the ICU August 16, 2018 August 1, 2019
NCT03512392 Completed N/A Role of Active Deresuscitation After Resuscitation-2 April 10, 2018 July 17, 2021
NCT03523169 Completed Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis December 31, 2016 December 31, 2017
NCT03525067 Completed Colonization of Bile Ducts and Postoperative Infectious Complications of Pancreaticoduodenectomies February 1, 2017 April 2, 2018
NCT03550794 Completed Phase 2 Thiamine as a Renal Protective Agent in Septic Shock September 4, 2018 April 5, 2022
NCT03565159 Completed Phase 4 Pneumococcal Vaccination to Accelerate Immune Recovery in Sepsis Survivors August 2, 2018 August 31, 2023
NCT03584594 Completed Presepsin in the Diagnosis of Sepsis in Critically Ill Patients June 1, 2018 March 30, 2022
NCT03588325 Completed Evaluation of MDW for Early Detection of Sepsis, Clinical Validity August 8, 2018 August 30, 2019
NCT03592277 Completed Phase 2 Vitamin C & Thiamine to Treat Sepsis and Septic Shock September 14, 2018 February 22, 2021
NCT03597074 Completed Doppler Ultrasound for Prediction of Reversibility of Acute Kidney Injury in Septic ICU Patients March 2, 2017 September 2, 2017
NCT03604731 Completed Persistent Multiorgan Failure in Intensive Care Units January 1, 2017 September 1, 2020
NCT03620409 Completed Identification of Cardiovascular and Molecular Prognostic Factors for the Mid- and Long-term Outcome of Sepsis May 9, 2018 June 15, 2022
NCT03628300 Completed Neurotoxicity Evaluation of Beta-lactams in Intensive Care Unit and Identification of the Risk Factors January 1, 2017 July 1, 2017
NCT03644030 Completed Phase Angle, Lean Body Mass Index and Tissue Edema and Immediate Outcome of Cardiac Surgery Patients September 6, 2018 September 1, 2019
NCT03645668 Completed Phase 4 Efficacy and Pharmacokinetics of Meropenem in Severe Septic Patients January 30, 2018 December 14, 2019
NCT03655626 Completed N/A Implementation and Evaluations of Sepsis Watch November 5, 2018 July 5, 2019
NCT03661450 Completed Evaluation of CDSS in Detection of SIRS and Sepsis in Pediatric Patients August 1, 2018 March 31, 2019
NCT03680274 Completed Phase 3 Lessening Organ Dysfunction With VITamin C November 8, 2018 January 24, 2022
NCT03708796 Completed DIAGNOSis of Infection in Emergency Department April 9, 2018 September 1, 2018
NCT03715647 Completed Correlation of Survival in Puerperae by Electrical Impedance Tomography January 2017 June 2018
NCT03716310 Completed Platelet Reactivity in Septic Shock April 1, 2017 August 30, 2018
NCT03728998 Completed N/A Non-invasive Measurement of CO in Patients With Uncomplicated Sepsis May 1, 2018 March 23, 2019
NCT03730636 Completed N/A Procalcitonin and Duration of AntiBiotherapy In Late Onset Sepsis of Neonate February 15, 2019 March 7, 2023
NCT03744741 Completed HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot Study July 23, 2018 January 20, 2020
NCT03748537 Completed N/A Mitochondrial Function in Septic Patients January 1, 2017 December 31, 2019
NCT03752047 Completed Can Respiratory Rate Predict the Risk of Deterioration of Septic Patients March 23, 2017 November 21, 2017
NCT03756220 Completed Phase 2 Ascorbic Acid and Thiamine Effect in Septic Shock December 1, 2018 April 14, 2020
NCT03764085 Completed Phase 4 Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Sepsis. December 6, 2016 December 11, 2019
NCT03767517 Completed N/A A Culturally-Based Palliative Care Tele-consult Program for Rural Southern Elders August 24, 2020 December 30, 2023
NCT03768752 Completed Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients October 11, 2018 May 3, 2019
NCT03789838 Completed Effect of Sepsis Response Team in the Emergency Department May 15, 2017 May 15, 2018
NCT03796715 Completed Red Cell Distribution Width Versus Presepsin (Soluble CD14) as a Prognostic Marker in Critically-ill Sepsis Patients August 1, 2018 December 24, 2018
NCT03799159 Completed Renal Arterial Resistive Index Versus Novel Biomarkers for Early Prediction of Sepsis Associated-acute Kidney Injury May 15, 2019 February 28, 2021
NCT03803813 Completed Incidence of Sepsis After Craniocerebral Operation January 1, 2017 June 30, 2020
NCT03817996 Completed Fluid Responsiveness in HFNC Patients January 1, 2017 April 30, 2019
NCT03829683 Completed Phase 2 Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis April 16, 2019 June 23, 2022
NCT03841162 Completed Fast Assay for Pathogen Identification and Characterization February 12, 2019 April 17, 2020
NCT03842722 Completed Insufficient Oxygenation in Septic Patients February 13, 2019 September 28, 2023
NCT03859726 Completed Predictive Value of Sublingual Microcirculation and Peripheral Tissue Oxygen Monitoring March 20, 2019 March 31, 2020
NCT03876535 Completed Performance Evaluation of the Nanomix eLab® CRP, PCT, and LAC Assays With the Nanomix eLab System December 11, 2018 August 30, 2019
NCT03881566 Completed Presepsin as Detective Marker of Sepsis in Immunodeficiency ICU Patients March 1, 2019 December 31, 2020
NCT03884894 Completed Neonatal Sepsis Diagnosis: ; PCR Commercial Technique and Blood Culture January 2015 June 2017
NCT03891342 Completed N/A Effect of Fluid Challenge on Glycocalyx February 2016 August 2018
NCT03919851 Completed Physician Administered Antibiotics in a Prehospital Setting October 31, 2018 February 15, 2019
NCT03924518 Completed Phase 2 Adjunctive Granisetron Therapy in Patients With Sepsis or Septic Shock April 25, 2019 December 28, 2020
NCT03931967 Completed Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection November 8, 2018 June 4, 2019
NCT03937245 Completed Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care August 30, 2019 June 3, 2021
NCT03938220 Completed Electrical Cardiometry Compared to Transthoracic Echocardiography in Fluid Responsiveness in Sepsis June 1, 2019 September 10, 2021
NCT03952390 Completed Effect of Renin-Angiotensin System on Platelet in Patient With Sepsis January 1, 2018 December 15, 2019
NCT03960307 Completed Glycocalyx and Microcirculation in Sepsis July 1, 2017 September 30, 2017
NCT03992794 Completed Assessment of Disease Severity, Progression and Treatment in Infected Patients Presenting to the Emergency Department March 15, 2018 August 31, 2018
NCT03996720 Completed Early Identification and Effective Management of Pediatric Sepsis October 1, 2018 September 30, 2021
NCT04029675 Completed N/A High Dose of Vitamin C on Mechanically Ventilated Septic Patients in Intensive Care Unit July 15, 2019 February 15, 2020
NCT04033029 Completed Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®) January 1, 2021 June 30, 2023
NCT04033653 Completed Long-term Quality of Life Among Survivors of Sepsis in China Assessed by EQ-5D November 2015 August 2018
NCT04044703 Completed Phase 4 Improving Dosing of Vancomycin in Young Infants With Infections August 30, 2019 January 3, 2021
NCT04048525 Completed N/A Cytokine Removal With CVVHD Compared to CVVH March 13, 2013 March 1, 2016
NCT04049565 Completed CRP Versus PCT as Bio-markers for Sepsis and in Guiding Antibiotics in Critically Ill Patients October 1, 2018 March 15, 2019
NCT04067622 Completed N/A Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment September 1, 2019 December 28, 2021
NCT04078594 Completed N/A Electronic Early Notification of Sepsis in Hospitalized Ward Patients October 1, 2019 November 30, 2022
NCT04080479 Completed N/A Bolus Versus Continuous Enteral Tube Feeding October 1, 2019 December 31, 2021
NCT04103203 Completed N/A Fast Assay for Pathogen Identification - Quasi-Experimental Intervention Study July 1, 2019 April 30, 2020
NCT04105699 Completed Evaluation of Immunoassay Measurements of Pancreatic Stone Protein Performed on abioSCOPE® Device With the PSP Assay on ICU Patients at Risk of Sepsis as an Aid in Identifying Sepsis December 10, 2019 December 28, 2023
NCT04111822 Completed Phase 3 Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock October 31, 2018 October 31, 2020
NCT04114214 Completed Objective Sepsis Identification Tool to Study Sepsis Epidemiology September 10, 2019 October 15, 2019
NCT04137276 Completed N/A Effect of Intravenous Vitamin C on SOFA Score Among Septic Patients April 1, 2019 July 31, 2019
NCT04147221 Completed Phase 1 Imipenem-Relebactam Pharmacokinetics in Augmented Renal Clearance February 10, 2020 September 19, 2021
NCT04148989 Completed N/A Effects of Code Sepsis Implementation on Emergency Department (ED) Sepsis Care November 13, 2018 December 28, 2023
NCT04149132 Completed Pulse Photoplethysmography as an Early Tool for the Diagnosis of Sepsis October 30, 2019 June 30, 2020
NCT04155060 Completed The Prognostic Value of Lactate is Different Among Septic Patients April 1, 2017 April 1, 2019
NCT04157452 Completed Prediction of Sepsis After Flexible Ureteroscopy June 1, 2019 October 20, 2019
NCT04160676 Completed N/A Therapy With Hydrocortisone, Ascorbic Acid, Thamine in Patients With Sepsis December 1, 2019 July 26, 2021
NCT04169412 Completed Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient February 22, 2019 August 20, 2019
NCT04197115 Completed Phase 3 Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis September 1, 2019 September 30, 2020
NCT04203784 Completed Meropenem and Piperacillin Plasma Concentrations During CRRT November 1, 2012 December 31, 2016
NCT04214743 Completed Ocular Microvascular Changes in Patients With Sepsis January 2, 2018 August 31, 2019
NCT04216459 Completed N/A Effect of Anti-inflammatory and Anti-microbial Co-supplementations in Traumatic ICU Patients at High Risk of Sepsis February 18, 2020 October 4, 2021
NCT04217629 Completed Phase 1 Single-dose/Multiple-doses Incremental Intravenous Injection of SY-005 （Recombinant Human Annexin A5）in Healthy Subjects April 26, 2019 August 19, 2020
NCT04226430 Completed Effect of Cytosorb on Blood Levels of Inflammatory Biomarkers of Sepsis. June 1, 2016 June 30, 2017
NCT04227652 Completed N/A Control of Fever in Septic Patients September 3, 2013 March 31, 2019
NCT04255979 Completed Phase 1 A Study of HY209 in Healthy Male Volunteers for Sepsis December 5, 2019 June 12, 2020
NCT04261621 Completed Early Identification of SEPsis SIGNs in Emergency Department July 6, 2020 May 2, 2022
NCT04285021 Completed Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings March 5, 2020 November 30, 2022
NCT04291417 Completed Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Baylor S&W November 20, 2019 June 17, 2020
NCT04291508 Completed Phase 2 Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery October 13, 2021 July 27, 2023
NCT04292431 Completed Leukocyte MOrphology and CORticosteroids Response in SEPtic Patients (MOCORSEP) November 1, 2019 December 30, 2020
NCT04304235 Completed N/A Paediatric Rapid Sepsis Trigger (PRST) Tool April 27, 2020 July 1, 2023
NCT04313790 Completed Phase 2 Assessment of the Anti-inflammatory Effect of Heparin Infusion Versus Subcutaneous Injection in Septic Patients August 29, 2020 October 11, 2022
NCT04332861 Completed Evaluation of Infection in Obstructing Urolithiasis September 3, 2019 July 28, 2020
NCT04335539 Completed Phase 2 A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of Cefiderocol in Hospitalized Pediatric Participants August 21, 2020 February 6, 2023
NCT04335955 Completed Platelet Indices in Prediction of Mortality in Critically Ill Septic Patients May 1, 2020 November 30, 2020
NCT04353388 Completed Sepsis Post Market Observational Study and Potential Reduction of Time to Antibiotics - Washington University February 3, 2020 July 17, 2020
NCT04356950 Completed Analysis of the Coagulopathy Developed by COVID-19 Infected Patients April 28, 2020 June 2, 2022
NCT04393909 Completed N/A Improving Safety of Diagnosis and Therapy in the Inpatient Setting July 1, 2019 December 30, 2021
NCT04409561 Completed Reference Range for abioSCOPE® Device With the PSP Assay in a Generally Healthy Adult Population November 15, 2021 January 15, 2022
NCT04414189 Completed Clinical Validation of HostDx Sepsis™ on NanoString; a Prospective Observational Validation Trial June 7, 2020 October 19, 2021
NCT04426032 Completed Predictive Value of Doppler RSI for Prediction of AKI in Septic Patients in ICU July 1, 2020 January 31, 2021
NCT04438187 Completed N/A Trial of Antimicrobial Restraint in Presumed Pneumonia February 1, 2021 June 30, 2022
NCT04441944 Completed TELEmedicine as an Intervention for Sepsis in Emergency Departments August 1, 2016 October 30, 2022
NCT04448548 Completed Possible Roles of MDW in Infection Management in Emergency Care September 1, 2019 January 31, 2020
NCT04458571 Completed Effect of CRRT Duration on Solute Removal October 1, 2020 December 21, 2022
NCT04493151 Completed Phase 1 Imipenem/Cilastatin/Relebactam PK in ECMO January 1, 2021 June 30, 2023
NCT04495946 Completed N/A Implementation and Effectiveness of Engagement and Collaborative Management to Proactively Advance Sepsis Survivorship July 1, 2020 April 1, 2024
NCT04508946 Completed Phase 3 Triple Therapy in Septic Shock Patients August 1, 2019 November 9, 2020
NCT04530045 Completed Target Attainment of TDM-guided Infusion of Piperacillin/Tazobactam and Cefepim in Critically Ill Patients May 2, 2018 November 2, 2019
NCT04533256 Completed Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Sepsis July 10, 2016 July 30, 2021
NCT04542538 Completed The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome April 11, 2018 January 11, 2021
NCT04549740 Completed The Role of Salivary Alpha Amylase in Sepsis September 15, 2020 March 1, 2024
NCT04567199 Completed Influence of Cytosorb on Amount of Catecholamine and Mortality in Sepsis December 1, 2018 December 1, 2020
NCT04567433 Completed Days Alive and Out of Hospital for Patients With Sepsis September 14, 2020 February 23, 2024
NCT04570618 Completed N/A Early Prediction of Sepsis December 1, 2020 November 1, 2021
NCT04582240 Completed Bile Duct Injury Digestif January 1, 2008 December 31, 2018
NCT04611425 Completed Phase 2 REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study November 30, 2020 October 22, 2021
NCT04620486 Completed N/A Effect of BPA on Anchor Antibiotic Continuity in the ED: Randomized Controlled Trial October 20, 2020 December 20, 2022
NCT04643639 Completed Phase 3 Assessing the Effects of CytoSorb Hemoperfusion on the Development on Immunoparalysis September 16, 2020 October 19, 2022
NCT04644302 Completed Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis February 1, 2020 July 1, 2021
NCT04644926 Completed Phase 1/Phase 2 The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis February 1, 2018 September 1, 2020
NCT04662242 Completed Phase 4 The Prognostic Impact of Selenium On Critical Surgical Patients December 1, 2020 November 16, 2022
NCT04665089 Completed N/A Erythromycin in Septic Patients: Immunomodulatory Role and Clinical Impact January 1, 2022 April 30, 2023
NCT04683094 Completed Comparative Study for the Validity of Various Severity Scoring System April 1, 2020 December 30, 2021
NCT04711564 Completed The Effects of Different Lipid Emulsions on the Adipokines in Critically Ill Patients With Sepsis March 29, 2018 April 15, 2020
NCT04724044 Completed Phase 3 Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia January 25, 2021 April 11, 2023
NCT04740333 Completed Prognostic Impact of Admission Glucose Level in Septic Patients Admitted to the Intensive Care Unit December 1, 2023 February 1, 2024
NCT04747795 Completed Phase 3 Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments June 1, 2021 November 15, 2023
NCT04748757 Completed Phase 2 Annexin A5 in Patients With Severe COVID-19 Disease April 20, 2021 December 1, 2022
NCT04749238 Completed N/A Effect of Extracorporeal Adsorption of Plasma Neutrophil Extracellular Traps (NET) in Sepsis January 26, 2021 October 24, 2021
NCT04755777 Completed Provider Perspectives on Beta-lactam Therapeutic Drug Monitoring Programs in the Critically Ill October 22, 2020 December 31, 2022
NCT04767893 Completed Diagnostic and Prognostic Biomarkers of Sepsis June 14, 2019 December 28, 2020
NCT04773717 Completed N/A The Effect of High Dose Parenteral Ascorbic Acid On Microcirculation In Sepsis January 1, 2019 January 31, 2021
NCT04791566 Completed Phase 4 Preoperative High-dose Dexamethasone and Emergency Laparotomy March 1, 2021 December 9, 2022
NCT04797117 Completed N/A Analytical Validation of the abioSCOPE Device With a PSP Test: Point-of-Care Precision, Sample Type Comparison and Sample Stability April 29, 2021 November 26, 2021
NCT04804306 Completed Sepsis Post Market Clinical Utility Simple Endpoint Study - HUMC September 5, 2021 June 6, 2022
NCT04816630 Completed Feasibility Study of Hematology Parameters in COVID-19 Disease December 21, 2020 September 22, 2021
NCT04819035 Completed Sepsis Post Market Clinical Utility Simple Endpoint Study - Indiana University Hospital June 17, 2021 May 30, 2022
NCT04823026 Completed Host RNA Profiles to Detect Infections in Young Infants May 15, 2020 December 31, 2021
NCT04823039 Completed N/A Vaccine Response in Patient With Sepsis April 19, 2021 June 6, 2023
NCT04825509 Completed Ultrasound-Assessed Diaphragmatic Dysfunction as a Predictor of Weaning Outcome April 18, 2021 November 1, 2021
NCT04825639 Completed Identifying Risk Factors for Developing AKI in Sepsis March 15, 2021 March 31, 2022
NCT04913246 Completed Triage Score VS Quick-Sofa Score in Septic Patients in the Emergency Department March 1, 2014 March 31, 2019
NCT04916223 Completed N/A Study to Determine Therapeutic Massage Dosing to Improve Quality of Life in Hospitalized Patients Receiving Palliative Care November 1, 2017 March 26, 2019
NCT04945889 Completed Sepsis in Geriatric Patients With Suspected Infection. April 1, 2019 October 31, 2019
NCT04963569 Completed Mechanistic Inflammatory Sub-study Embedded Within the Albumin vs Balanced Crystalloid Trial December 13, 2021 June 8, 2022
NCT04963699 Completed The Study of NT-proBNP Combined With HS-cTnT in Evaluating the Prognosis of Sepsis May 26, 2021 June 9, 2021
NCT04968262 Completed Urinary Actin, as a Potential Marker of Sepsis-related Acute Kidney Injury January 1, 2016 December 31, 2019
NCT04969159 Completed The Degree, Duration and Frequency of Insulin Resistance in Non-operated Patients With Sepsis September 1, 2018 March 1, 2021
NCT04989569 Completed N/A Serial Body Composition Change for Risk Prediction and Nutritional Guide in Treating Patients With Sepsis August 1, 2020 April 28, 2023
NCT04991376 Completed Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment May 2, 2019 December 1, 2022
NCT05018546 Completed N/A Safety and Efficacy of Different Irrigation System in Retrograde Intrarenal Surgery September 24, 2020 December 24, 2021
NCT05059808 Completed European Sepsis Care Survey August 1, 2021 October 30, 2022
NCT05060679 Completed Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction January 1, 2018 February 29, 2020
NCT05065333 Completed N/A Implementation Trial of Predictive Modeling to Enhance Diagnosis and Improve Treatment in Pediatric Septic Shock March 16, 2022 March 31, 2023
NCT05072145 Completed Evaluating Tele-Emergency Care in Costs and Outcomes for Rural Sepsis Patients April 1, 2022 December 31, 2023
NCT05076435 Completed Phase 2 Restrictive Fluid Administration vs. Standard of Care in Emergency Department Sepsis Patients November 3, 2021 March 19, 2022
NCT05076721 Completed N/A Effectiveness of Simulation Based Training in Implementing One Hour Bundle Sepsis August 22, 2020 October 24, 2020
NCT05094154 Completed Phase 4 Effect of Antibiotic Choice On ReNal Outcomes (ACORN) November 10, 2021 October 21, 2022
NCT05094856 Completed Effects of Fluid Therapy on Peripheral TIssse Perfusion During Sepsis/Septic Shock February 23, 2022 March 16, 2023
NCT05095220 Completed Integration of NAVOY® Sepsis in an Electronic Health Record System May 27, 2022 March 8, 2023
NCT05139459 Completed Sepsis Characterization in Kilimanjaro January 17, 2022 November 3, 2023
NCT05140213 Completed A STUDY BEFORE/AFTER THE IMPLEMENTATION OF AN ANTI-INFECTIOUS PRESCRIPTION AID December 12, 2020 August 30, 2021
NCT05143645 Completed A New Protocol for Continuous Vancomycin Infusion Dosing. September 1, 2013 March 31, 2020
NCT05172479 Completed Prognostic Accuracy of qSOFA, SIRS, and EWSs for In-hospital Mortality in Emergency Department December 12, 2021 September 11, 2023
NCT05208112 Completed Phase 1 Intravenously Administered M6229 in Critically Ill Sepsis Patients April 5, 2022 September 28, 2023
NCT05213923 Completed N/A ED Tracking Sheet Implementation July 1, 2021 June 1, 2022
NCT05244018 Completed Phase 4 Outcome of High Dose Vitamin D on Prognosis of Sepsis Requiring Mechanical Ventilation March 1, 2022 October 31, 2022
NCT05246969 Completed Detecting Sepsis in Patients With Severe Subarachnoideal Hemorrhage June 1, 2017 February 1, 2022
NCT05259683 Completed Febrile Infant Diagnostic Assessment and Outcome Study August 1, 2022 December 31, 2023
NCT05273034 Completed N/A Effect of the 1-hour Sepsis Bundle on In-hospital Mortality in Patients With Sepsis in the Emergency Department June 13, 2022 October 13, 2023
NCT05283083 Completed Phase 2 Decatecholaminisation of Septic Shock With Dexmedetomidine and In-hospital Mortality March 25, 2022 March 1, 2023
NCT05283317 Completed Phase 1/Phase 2 Effect of Mesenchymal Stromal Cells on Sepsis and Septic Shock March 11, 2018 November 13, 2019
NCT05283733 Completed N/A Open to Laparoscopic Reverse Conversion of Perforated Appendicitis January 18, 2018 December 25, 2021
NCT05293132 Completed Phase 2/Phase 3 Effect of Montelukast Versus Co Enzyme in Sepsis February 1, 2022 June 1, 2023
NCT05310812 Completed Evaluation of Candidate Biomarkers to Predict Disease Severity and Acute Kidney Injury in Sepsis Patients December 1, 2021 November 29, 2022
NCT05314816 Completed N/A Rapid Blood Culture Identification Panel in Pediatric Patients in Guatemala April 7, 2022 November 28, 2022
NCT05367986 Completed N/A Electro-acupuncture at Zusanli, Qihai, and Guanyuan Acupoints Regulate Immune Function in Patients With Sepsis July 1, 2019 January 30, 2022
NCT05374759 Completed NGAL and Renal Resistive Index in the Diagnosis and Prognosis of Sepsis-associated AKI May 11, 2022 December 11, 2022
NCT05394961 Completed Factors Associated With Decisions to Withhold or Withdraw Intensive Care August 26, 2021 August 26, 2021
NCT05448534 Completed Electroencephalographic Patterns of Septic Patients and Its Correlation With Cognitive Outcomes November 1, 2021 February 24, 2023
NCT05459389 Completed N/A Early Targeted Antibiotic Therapy in Patients With Sepsis May 1, 2022 September 1, 2023
NCT05469048 Completed Near Patient Molecular Testing in Sepsis March 12, 2020 October 31, 2022
NCT05495438 Completed Impact and Safety of AI in Decision Making in the ICU: a Simulation Experiment July 22, 2022 October 31, 2022
NCT05495607 Completed Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants December 1, 2018 January 1, 2022
NCT05496816 Completed Coagulation Disturbances in COVID-19 Septic Patients January 1, 2021 December 31, 2021
NCT05558098 Completed Phase 3 Dapagliflozin in Patients With Critical Illness November 1, 2022 October 20, 2023
NCT05584098 Completed N/A Modified Early Warning Score (MEWS) and Quick Sequential Organ Failure Assessment (qSOFA) in the Emergency Room March 20, 2022 November 23, 2023
NCT05596942 Completed Phase 3 Evaluating the Efficacy of Channa Striata in Stabilizing eNOS in Patients With Septic. July 1, 2021 September 30, 2021
NCT05605275 Completed CRP and PCT as Predictors of Sepsis Cause January 5, 2022 July 10, 2023
NCT05610020 Completed Heparin Binding Protein as a Prognostic Biomarker of Sepsis Severity October 1, 2021 October 1, 2022
NCT05625464 Completed N/A Effect of Automated Real-time Feedback on Early Sepsis Care December 1, 2020 November 30, 2021
NCT05627076 Completed Analytical Validation of the abioSCOPE Device With the IVD CAPSULE PSP Test: Comparison of PSP Values Measured With Venous Whole Blood and Those Measured With Arterial Whole Blood. August 29, 2022 October 31, 2022
NCT05636202 Completed The Role of NLR in the Diagnosis and Prognosis of Sepsis December 1, 2022 December 30, 2022
NCT05640037 Completed Urine Interleukin-37 as a Biomarker of Mortality Risk in Patients With Sepsis March 23, 2022 March 20, 2024
NCT05663164 Completed N/A Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS) October 1, 2022 December 1, 2022
NCT05684133 Completed REMISE Study: REMnant Biospecimen Investigation in SEpsis October 25, 2022 December 31, 2023
NCT05691309 Completed Optimizing Vancomycin Therapy in Children December 12, 2022 November 22, 2023
NCT05703802 Completed Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia. February 1, 2022 November 1, 2022
NCT05739604 Completed Serum Free Amino Acid Concentrations in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy (CRRT) June 19, 2020 December 15, 2022
NCT05774054 Completed N/A The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension May 1, 2021 March 10, 2023
NCT05849831 Completed Optic Nerve Sheath Diameter for Prediction of Sepsis Associated Encephalopathy May 3, 2023 May 30, 2024
NCT05849935 Completed abioSCOPE PSP Reference Range Study; Extension of AB-PSP-003 July 17, 2023 July 31, 2023
NCT05909384 Completed Management of Sepsis in Resource Limited Settings Using a Delphi Method. May 16, 2023 September 30, 2023
NCT05953441 Completed N/A Artificial Intelligence Versus Human-controlled Doctor in Virtual Reality Simulation for Sepsis Team Training August 8, 2022 November 13, 2022
NCT05961137 Completed N/A Orange Park Out-of-Hospital Quality Improvement Study for Improving CMS Sepsis Core Measures April 1, 2021 August 31, 2022
NCT05968287 Completed Can Measurement of Neutrophil-derived ROS Production be a Novel Biomarker of Sepsis? June 28, 2022 January 31, 2023
NCT05999682 Completed Phase 1/Phase 2 Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis September 1, 2023 January 5, 2024
NCT06008223 Completed N/A Clinical Analysis of Vitamin B6 in Sepsis November 1, 2021 November 30, 2022
NCT06076980 Completed Phase 4 Heamodynamic Effects of Paracetamol in Septic Shock Patients November 1, 2020 January 24, 2023
NCT06231862 Completed Gene Expression Objective Definition of Early Sepsis In Children March 1, 2019 March 1, 2023
NCT06265714 Completed The IndONEsia ICCU Registry: a Multicenter Cohort of Intensive Cardiovascular Care Units Patients in Indonesia July 23, 2021 September 23, 2023
NCT06354452 Completed Effect of Statin Therapy on Sepsis-related Mortality in Intensive Care Unit Patients January 1, 2018 January 31, 2020
NCT06360770 Completed Assessement of Microcirculation With NIRS Predicts Sepsis Development in Patients With Severe Covid-19 Pneumonia December 1, 2021 April 30, 2023
NCT06368336 Completed Health Related Quality of Life After Intensive Care for Sepsis, a National Cohort Study. January 1, 2008 December 31, 2022
NCT06390748 Completed Phase 2 Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient Outcomes January 1, 2021 December 31, 2023
NCT06404424 Completed Combined Hemoperfusion and Therapeutic Plasma Exchange for Treatment of Patients With Septic Shock May 1, 2022 March 1, 2024
NCT00001303 Completed Phase 1 Effects of Endotoxin in Normal Human Volunteers April 6, 1992 May 17, 2018
NCT05604430 Enrolling by invitation Pre-hospital Ventilation Clinical Study June 30, 2022 June 30, 2024
NCT05900284 Enrolling by invitation Phase 2 Safety and Feasibility of Metformin for Sepsis Induced AKI November 8, 2023 December 21, 2026
NCT06117605 Enrolling by invitation N/A Sepsis Electronic Prompting for Timely Intervention and Care for Emergency Department Patients November 14, 2023 July 2024
NCT05602584 Enrolling by invitation Effect of Immunophenotype on Prognosis of Sepsis October 1, 2021 December 1, 2023
NCT03146546 Enrolling by invitation STUDY00015328: Sepsis Endotypes August 6, 2020 June 30, 2025
NCT05634057 Enrolling by invitation N/A Efficacy of Anisodamine Hydrobromide Combined With Low-molecular-weight Heparin in the Treatment of Patients With Sepsis January 25, 2024 November 2025
NCT04178915 Enrolling by invitation Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections July 1, 2019 December 31, 2023
NCT06117618 Enrolling by invitation N/A Sepsis Electronic Prompting for Timely Intervention and Care for Inpatients November 14, 2023 July 2024
NCT05052203 Enrolling by invitation Researching the Effects of Sepsis on Quality Of Life, Vitality, Epigenome and Gene Expression During RecoverY From Sepsis September 28, 2021 December 2023
NCT06063707 Not yet recruiting The Effect of rTEM in the Prognosis and Severity of Sepsis Induced ARDS October 1, 2023 September 1, 2024
NCT06068192 Not yet recruiting Registration of Sepsis Patients in the Emergency Department January 1, 2024 October 1, 2026
NCT06072430 Not yet recruiting Phase 3 A Phase III, Open Label, Randomized, Controlled Study of VBI-S in the Treatment of Hypovolemia in Patients With Septic Shock (VBI-S-02) July 2024 July 2025
NCT05718804 Not yet recruiting Gut Microbiota and Sepsis-associated Acute Kidney Injury February 1, 2023 December 31, 2024
NCT06329518 Not yet recruiting Phase 1 Rezafungin PK in Patients on ECMO April 2024 April 2025
NCT05612893 Not yet recruiting Discover the Immune Signature of Sepsis Caused by Acute Pulmonary Infection: A Cohort Study November 16, 2022 September 10, 2025
NCT06156072 Not yet recruiting Ultrasound-guided Blood Sampling Drawing for Microbiological Analysis in the Critically Ill April 2024 December 31, 2025
NCT03278730 Not yet recruiting Phase 2 Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis February 2025 February 28, 2027
NCT05953142 Not yet recruiting Phase 2 Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation. February 1, 2024 March 31, 2026
NCT06007352 Not yet recruiting Phase 2 Use of Antibiotic Based Irrigation for Ureteroscopic Treatment of Urolithiasis May 2024 June 2025
NCT05826223 Not yet recruiting Novel Sepsis Sub-phenotypes Based on Trajectories of Vital Signs July 2024 December 2024
NCT06258252 Not yet recruiting Effect of Metabolic Dysfunction in Branched-chain Amino Acids on Cardiac Function in Patients With Sepsis June 15, 2024 March 15, 2026
NCT05921825 Not yet recruiting Red Cell Distribution Width and Lactate Albumin Ratio as Prognostic Markers for Mortality in Sepsis and Septic Shock July 1, 2023 January 30, 2024
NCT05507957 Not yet recruiting Impact of Blood Culture Positivity Time on Clinical Management of Pediatric ICU Patients January 1, 2023 March 1, 2025
NCT05647096 Not yet recruiting N/A Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating cfDNA/NETs in Subjects With Sepsis August 1, 2024 May 28, 2026
NCT06124105 Not yet recruiting N/A Can Urinary Partial Oxygen Pressure be an Indicator of Acute Kidney Injury in Patients With Sepsis? March 6, 2024 December 15, 2024
NCT05361135 Not yet recruiting N/A 18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in S. Aureus Bacteraemia September 2023 July 2026
NCT06220929 Not yet recruiting Phase 4 Mecobalamin Combined With Ceftriaxone Sodium in the Treatment of Sepsis Liver Injury January 15, 2024 January 1, 2025
NCT06124092 Not yet recruiting Outcomes of Children After Hospitalization in Intensive Care Unit March 2024 March 2029
NCT05748301 Not yet recruiting AI Clinician XP2 - A Study of the AI Clinician Running in Real Time in the ICU February 28, 2023 June 30, 2023
NCT06253585 Not yet recruiting N/A Precision Resuscitation With Crystalloids in Sepsis June 3, 2024 May 31, 2025
NCT06375616 Not yet recruiting Phase 4 Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI April 2024 April 2027
NCT06305403 Not yet recruiting VEXUS and NGAL in the Diagnosis and Prognosis of Sepsis-associated Acute Kidney Injury May 1, 2024 May 18, 2025
NCT06256198 Not yet recruiting Role of PCO2 Gap as Predictor of Clinical Outcome in ICU Septic Patients February 2024 June 2024
NCT06271031 Not yet recruiting Process Mapping and Data Collection to Inform a Computer Simulation Model of Hospitalised Patients With Bloodstream Infection, Sepsis and Systemic Infection March 1, 2024 March 31, 2026
NCT05914480 Not yet recruiting Sepsis in ICU:Causes and Outcomes in Diabetics and Non Diabetics July 2023 August 2024
NCT06289179 Not yet recruiting Thyroid and Cortisol Hormone Response to Sepsis March 1, 2024 October 25, 2026
NCT05606627 Not yet recruiting Correlation Between Antibiotic Resistance and Incidence of Sepsis in Community Acquired Pneumonia December 2022 April 2024
NCT06078839 Not yet recruiting Phase 4 Nafamostat Mesilate in the Treatment of Severe Infection-associated Coagulopathy October 1, 2023 October 1, 2026
NCT06307509 Not yet recruiting Adiposity and Immunometabolism in Sepsis March 2024 July 31, 2025
NCT05265130 Not yet recruiting Phase 4 The Efficacy of YiQiFuMai Injection as an Adjunctive Treatment for Sepsis February 28, 2022 October 31, 2024
NCT06013033 Not yet recruiting DDX17 Orchestrate Septic Vascular Endothelial Pyroptosis by Controlling Gasdermin D Pore Formation September 1, 2023 December 31, 2025
NCT06377397 Not yet recruiting Phase 3 Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates April 15, 2024 April 14, 2028
NCT06116656 Not yet recruiting Changes in Host Gene Expression to Differentiate Between Systemic Inflammation and Infection After Major Surgery January 1, 2024 June 1, 2026
NCT06302998 Not yet recruiting Phase 2 Dexmedetomidine and Vasopressin in Septic Shock June 2024 January 2026
NCT05759494 Not yet recruiting The Clinical and Pharmacoeconomic Impact of Rapid Diagnostic Test (Multiplex PCR FilmArray) on Antimicrobial Decision Making Compared to Conventional Decision Making Among Critically Ill Patients May 1, 2023 February 1, 2024
NCT05591924 Not yet recruiting Early Severe Illness TrAnslational BioLogy InformaticS in Humans January 11, 2024 December 31, 2024
NCT05692011 Not yet recruiting AN69ST Verse PS in CBP in Septic Children May 1, 2024 December 31, 2024
NCT06446947 Not yet recruiting Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis July 1, 2024 January 11, 2026
NCT06028178 Not yet recruiting Droplet Digital PCR Combines With Transcriptome Analysis in Early Warning of Sepsis in the Emergency Department May 1, 2024 December 31, 2026
NCT03473769 Not yet recruiting N/A Sepsis Pre-Alert Monitoring Intervention: Study to Investigate Targeted Enhanced Monitoring for Sepsis September 1, 2024 June 2025
NCT06045130 Not yet recruiting PUFAs in Preterm Infants September 21, 2023 August 31, 2026
NCT05148117 Not yet recruiting Mitochondrial Dysfunction Contributes to Sepsis Induced Cardiac Dysfunction December 10, 2024 May 7, 2025
NCT06338124 Not yet recruiting Value of Laboratory Biomarkers in Prediction of Outcome in Septic Patients April 1, 2024 April 1, 2025
NCT05524376 Not yet recruiting Regulatory Network and Diagnostic Value of Key Autophagy-related Genes in Sepsis September 1, 2022 December 31, 2022
NCT06447441 Not yet recruiting N/A Clinical Outcomes Of Mega-dosage Supplementations Of Cholecalciferol In Critically Ill Patients With Sepsis July 1, 2024 December 31, 2029
NCT06326112 Not yet recruiting Phase 2 Role of Active Deresuscitation After Resuscitation: May 1, 2024 June 30, 2025
NCT05943938 Not yet recruiting Comparison of Sepsis Prediction Algorithms August 2024 December 2024
NCT06103500 Not yet recruiting N/A Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis July 1, 2024 March 31, 2025
NCT06209268 Not yet recruiting N/A The Impact of Selective Vitamin D Receptor Activation on Clinical Outcomes in Septic Patients October 1, 2024 February 1, 2025
NCT05770622 Not yet recruiting Phase 4 Improving Therapeutic Drug Monitoring and Dosing for Vancomycin in Young Infants With Infections (VANCAPP) (Part 2) April 2024 March 2025
NCT06381661 Not yet recruiting Phase 3 Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Bayesian Basket Trial April 1, 2026 April 1, 2032
NCT06045780 Not yet recruiting HO-1/CREB3 Modulates Golgi Stress in Patients With Sepsis September 15, 2023 November 15, 2024
NCT06440317 Not yet recruiting Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS Membrane June 2024 July 2025
NCT05595239 Not yet recruiting N/A Blood Purification in Septic Children May 1, 2024 December 31, 2025
NCT06326385 Not yet recruiting Machine Learning Predictive Models for Sepsis Risk in ICU Patients With Intracerebral Hemorrhage March 30, 2024 May 30, 2024
NCT06372444 Not yet recruiting Mechanisms of Acute Kidney Injury in Severe Infections May 1, 2024 June 30, 2026
NCT06184659 Not yet recruiting Phase 4 Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis August 1, 2024 March 30, 2029
NCT06278675 Not yet recruiting N/A Multiple Study of Electroaccpuncture in ARDS May 10, 2024 December 31, 2026
NCT04843982 Recruiting Phase 4 Immunoinflammatory Regulation of Esketamine in Septic Patients July 28, 2021 December 31, 2024
NCT05194189 Recruiting Phase 2 Clinical Efficacy of Megadose Vitamin C in Sepsis February 8, 2022 December 4, 2024
NCT04103281 Recruiting Expression Profiles of Integrin αDβ2 on Neutrophils in Sepsis September 1, 2020 December 31, 2024
NCT04861922 Recruiting Phase 3 Unfractioned Heparin for Treatment of Sepsis Caused by Abdominal Infection May 11, 2021 July 30, 2024
NCT04870125 Recruiting Phase 1 Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS) December 6, 2023 September 2025
NCT05336851 Recruiting Emergency PWAS in Respiratory Infectious Disease April 11, 2023 May 1, 2025
NCT05741801 Recruiting Digital Alerts for Sepsis: a Qualitative Study November 4, 2022 August 2023
NCT05758246 Recruiting Phase 2 Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial August 23, 2023 August 23, 2026
NCT05623722 Recruiting N/A Erector Spinae Plane Block Improves Organ Dysfunction in Septic Patients With Acute Gastrointestinal Injury December 29, 2022 June 2024
NCT05624619 Recruiting The Diagnostic and Prognostic Value of Speckle Tracking Imaging in Septic Cardiomyopathy December 18, 2022 December 31, 2025
NCT04904289 Recruiting Early Recognition and Dynamic Risk Warning System of Multiple Organ Dysfunction Syndrome Caused by Sepsis April 21, 2022 December 31, 2023
NCT02654561 Recruiting Phase 3 Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation April 12, 2018 June 2025
NCT06253325 Recruiting Early Detection of At-risk Septic Patients January 12, 2024 August 6, 2024
NCT04910464 Recruiting Phase 3 Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis June 5, 2021 June 30, 2024
NCT05181696 Recruiting Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia January 1, 2020 May 2024
NCT06219135 Recruiting Evaluation of the Performance of the IDBIORIV Method in Pathogen Identification and Antibiotic Susceptibility Testing in Patients With Sepsis March 21, 2024 May 2026
NCT05179499 Recruiting Phase 3 Early Vasopressors in Sepsis October 11, 2022 September 2025
NCT02707497 Recruiting Phase 2/Phase 3 The Effect of REcombinant Human Thrombopoietin (rhTPO) on Sepsis Patients With aCUte Severe thrombocytopEnia April 1, 2019 September 30, 2024
NCT05544903 Recruiting Point of Care Ultrasound to Predict Intensive Care Unit Admission of Patients Presenting With Sepsis to the Emergency Department September 1, 2022 September 2024
NCT04140578 Recruiting Phase 4 Antibiotic Prophylaxis in Patients Undergoing GVO January 28, 2017 December 31, 2030
NCT05311046 Recruiting Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool January 9, 2023 June 2024
NCT06080282 Recruiting Role of the Kallikrein-kinin System in Septic Cardiomyopathy October 15, 2023 October 14, 2025
NCT06187168 Recruiting Risk Factors of Post-ERCP Sepsis December 23, 2023 April 2024
NCT04961580 Recruiting PK/PD of Ceftazidime Avitbatan Sodium in Children With Severe Infection October 1, 2022 June 1, 2024
NCT06082154 Recruiting A Prognostic Model Based on POCUS at ICU Admission in Critically Ill Patients With Sepsis April 26, 2023 April 30, 2024
NCT06087315 Recruiting Evaluation of a Multi-country Medical Oxygen Program November 27, 2023 December 2027
NCT05557461 Recruiting Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help? September 20, 2022 March 30, 2023
NCT06099756 Recruiting Discharge Readmission Analysis and Management in Sepsis (DReAMS-2) October 26, 2023 October 2024
NCT04103268 Recruiting Neutrophil Phenotypic Profiling and Organ Injury Assessment in Patients With Sepsis August 4, 2020 December 1, 2024
NCT06323226 Recruiting The Impact of Sepsis on Long-term Outcomes in Critical Ill Children With Sepsis January 1, 2019 June 1, 2025
NCT03754257 Recruiting N/A Effects of Electrical Stimulation for Preventing Loss of Muscle Mass in Patients With Sepsis October 1, 2018 July 31, 2024
NCT06238180 Recruiting Personalised Real-time Interoperable Sepsis Monitoring (PRISM) November 29, 2023 March 31, 2024
NCT05955612 Recruiting Phase 3 Use of Procalcitonin, a Blood Test to Guide Antibiotic Therapy for Sepsis in Adults July 26, 2023 June 30, 2025
NCT01904188 Recruiting Clinical Microbial Species & Antibiotic Resistance ID in ED Patients Presenting With Infection - is Rapid ID Possible & Accurate? June 2015 July 2027
NCT03760315 Recruiting mNGS vs Culture Critically Ill Patients April 1, 2022 December 30, 2022
NCT06294730 Recruiting COronary Microcirculation and Troponin Elevation in Septic Shock June 13, 2019 December 2024
NCT06368388 Recruiting Bacteriophage Therapy for Difficult-to-treat Infections: the Implementation of a Multidisciplinary Phage Task Force June 1, 2021 June 1, 2025
NCT04565691 Recruiting N/A Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis February 25, 2019 December 31, 2027
NCT05969275 Recruiting Phase 2 Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock February 14, 2024 March 31, 2027
NCT03990467 Recruiting N/A Observed Pharmacokinetic of Piperacillin/Tazobactam Compared to Amikacin in ICU January 28, 2021 January 28, 2023
NCT05971979 Recruiting Therapeutic Drug Monitoring - Targeting IMproved Effectiveness December 14, 2023 July 31, 2024
NCT04571801 Recruiting N/A Optimization of Sepsis Therapy Based on Patient-specific Digital Precision Diagnostics March 16, 2022 August 31, 2024
NCT05688774 Recruiting Study of Progression of Community Acquired Pneumonia in the Hospital in Patients With More Severe Preexisting Diseases and Immunosuppression February 28, 2022 February 28, 2028
NCT04576819 Recruiting Role and Mechanisms of Lipid and Lipoprotein Dysregulation in Sepsis November 20, 2020 April 1, 2025
NCT04580680 Recruiting Extracorporeal Blood Purification Therapy in Critically Ill Patients (GlobalARRT) November 1, 2020 September 30, 2024
NCT04580888 Recruiting N/A Emergency Echocardiography in Sepsis July 23, 2021 August 23, 2025
NCT05608096 Recruiting European Registry for Hemadsorption in Sepsis With the Seraph Filter October 25, 2022 December 30, 2025
NCT05975671 Recruiting N/A Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis August 21, 2023 January 2026
NCT03379402 Recruiting Sepsis-3 Study in Northeast Thailand February 1, 2018 December 31, 2024
NCT04610853 Recruiting Rotational Thromboelastometry Versus DIC Score in Sepsis November 2, 2020 May 31, 2024
NCT05978154 Recruiting Thigh Muscle Mass and Muscle Wasting in Patients in the Emergency Department July 28, 2023 March 31, 2025
NCT00901602 Recruiting Lebanese Interhospital Pneumococcal Surveillance Program October 2005 October 2030
NCT04615065 Recruiting Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine September 1, 2020 September 1, 2030
NCT04618198 Recruiting Phase 3 Early Empiric Anti-Mycobacterium Tuberculosis Therapy for Sepsis in Sub-Saharan Africa December 10, 2021 June 25, 2025
NCT05979038 Recruiting Phase 3 Clinical Evaluation of the Effect of Metformin in Sepsis September 10, 2023 July 10, 2024
NCT05349370 Recruiting N/A Lactate Kinetics in Septic Shock December 28, 2022 December 31, 2024
NCT04624945 Recruiting DetectIon of Severe Sepsis In PATients With Neurological haemorrhagE (The DISSIPATE Study) November 25, 2020 December 2024
NCT05402553 Recruiting Phase 1/Phase 2 The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic Shock April 24, 2022 June 2023
NCT05691621 Recruiting Galectin-3 in Septic and Non-septic Acute Kidney Injury January 1, 2023 August 31, 2023
NCT05502107 Recruiting N/A Impact of a Prehospital Sepsis Protocol on Timely Antibiotic Administration and Subsequent Adverse Events June 27, 2023 December 2024
NCT06295393 Recruiting Renin Angiotensin Aldosterone System In Septic Kids January 24, 2024 June 1, 2025
NCT05980494 Recruiting N/A Lung Ultrasound Score and Inferior Vena Cava Diameter Compared to Pulse Pressure Variation September 13, 2022 June 20, 2024
NCT05985525 Recruiting Microvascular Monitoring in Circulatory Shock and Sepsis (MiMICSS) May 27, 2022 May 31, 2025
NCT05997420 Recruiting N/A Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up January 16, 2024 September 2025
NCT05410665 Recruiting The Roles of IL-9/E-cadherin and Ferroptosis in Intestinal Mucosal Barrier Injury in Sepsis May 31, 2022 June 30, 2024
NCT05998733 Recruiting The Impact of Coagulation Disorders on the Diagnosis and Prognosis of Sepsis June 1, 2022 June 1, 2024
NCT04033224 Recruiting Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure July 16, 2019 December 2024
NCT06001294 Recruiting We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury. July 3, 2022 December 31, 2023
NCT05694455 Recruiting N/A Micro and Macro Circulation in Sepsis July 1, 2022 December 31, 2024
NCT05208242 Recruiting Phase 2/Phase 3 Strong Albumin Solutions in Patients With Septic Shock November 10, 2023 February 28, 2026
NCT06006325 Recruiting N/A Electroacupuncture Modulates SPMs Metabolism and Respiratory Symptoms in Patients With Sepsis Complicating ARDS August 20, 2023 October 2, 2024
NCT05707494 Recruiting N/A Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis January 1, 2023 April 30, 2025
NCT04059263 Recruiting HFIP Ex-vivo Study August 5, 2019 March 1, 2025
NCT05208216 Recruiting N/A Neuromuscular Stimulation Versus Intermittent Compression for Venous Thromboembolism Prophylaxis in Critical Care November 1, 2022 May 1, 2024
NCT05616130 Recruiting Pathological Myeloid Activation After Sepsis and Trauma September 1, 2022 September 30, 2028
NCT06009445 Recruiting Renal Resistive Index as a Predictor of Acute Kidney Injury and Evaluation of Fluid Administration in Sepsis July 1, 2023 July 1, 2024
NCT04063332 Recruiting Functionality of Endogenous Biological Clock in Sepsis June 3, 2019 June 2024
NCT06010186 Recruiting N/A Evolution of Muscle Function, Breathlessness and Quality of Life Following Intra or Extra-Abdominal Sepsis in ICU Patients July 28, 2023 December 31, 2025
NCT05725837 Recruiting Phase 2 Effects of Paroxetine on Cardiovascular Function in Septic Patients June 10, 2023 July 15, 2024
NCT06193980 Recruiting Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness December 15, 2023 July 2025
NCT05386199 Recruiting The Role of Serotonin in Intensive Care Patients May 25, 2022 December 31, 2024
NCT06018792 Recruiting Molecular Culture for the Diagnosis of Pediatric Sepsis March 10, 2024 November 1, 2027
NCT04758676 Recruiting N/A BIA Assessment of Polymyoneuropathy in Critically Ill Patients March 1, 2021 May 31, 2024
NCT06021743 Recruiting The Role of Immune Semaphorins in Steatotic Liver Disease and Sepsis January 1, 2022 March 1, 2024
NCT05730452 Recruiting N/A Smart Discharges to Improve Post-discharge Health Outcomes in Children July 16, 2017 March 31, 2024
NCT04794595 Recruiting Clinical Features and Outcomes of CBP Versus Non-CBP in Septic Children December 1, 2020 December 30, 2024
NCT05731349 Recruiting N/A Impact of Early Sepsis Care Guided by the National Early Warning Score 2 in the Emergency Department April 1, 2023 May 31, 2025
NCT06226441 Recruiting N/A Aminoglycoside Administration in Septic Patients June 2, 2023 December 2026
NCT04094818 Recruiting HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections and Suspected Sepsis February 28, 2020 May 15, 2024
NCT04803955 Recruiting Phase 2 Efficacy and Safety of Kukoamine B Mesilate in Sepsis Patients May 15, 2021 June 30, 2024
NCT06061224 Recruiting N/A The Influences of Early Mobilization on Myokines, Body Composition and Outcomes in ICU Septic Patients January 1, 2022 September 30, 2025
NCT06061575 Recruiting Phase 4 Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients October 31, 2023 December 1, 2024
NCT05383963 Recruiting Evaluation of Parameters Collected From Routine Data for the Diagnosis of Sepsis and Septic Shock and Their Influence on Time to Diagnosis and Patient Outcome July 15, 2022 December 2027
NCT06067516 Recruiting Effects of Fluid Resuscitation on Capillary Refilling Time and Organ Functions in Septic Shock October 25, 2023 September 1, 2024
NCT06072508 Recruiting N/A Prognostic Interest of Vasorin in Septic Shock July 3, 2023 March 2025
NCT04829188 Recruiting N/A Comparative Effectiveness of Readmission Reduction Interventions for Individuals With Sepsis or Pneumonia March 30, 2021 October 2025
NCT06157320 Recruiting N/A Clinical Research on Shenfu Injection in Septic Patients December 1, 2023 January 1, 2026
NCT05833412 Recruiting Molecular Early Sepsis Identification Study April 12, 2023 April 30, 2024
NCT06178822 Recruiting Towards Novel BIOmarkers to Diagnose SEPsis on the Emergency Room October 25, 2022 October 1, 2026
NCT05842616 Recruiting N/A Cerebral Pulsatility Index Compared To Mean Arterial Blood Pressure Guided Protocol In Sepsis Induced Encephalopathy: May 1, 2023 September 1, 2024
NCT05110937 Recruiting Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis January 4, 2022 April 2026
NCT05842980 Recruiting BIomarkers to Predict the Outcomes of Sepsis June 1, 2020 June 1, 2025
NCT05565222 Recruiting Phase 3 Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit March 11, 2023 June 2026
NCT06261164 Recruiting Population Pharmacokinetic Model of Amikacin and Vancomycin in Critically Ill Patients January 31, 2024 January 31, 2025
NCT03044223 Recruiting Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis August 2014 December 2026
NCT05630716 Recruiting N/A Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock July 31, 2023 November 30, 2025
NCT05127109 Recruiting Phase 4 The PASTDUe Nutrition Ecosystem Project (PASTDUe) April 25, 2022 January 1, 2026
NCT05849194 Recruiting N/A Role of Early Point of Care Ultrasound in Management of Sepsis in Emergency Department August 1, 2023 January 2024
NCT05136560 Recruiting Phase 1/Phase 2 Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis January 15, 2021 June 30, 2024
NCT05143736 Recruiting Nasal and Gut Microbiota Combined Clinical Events Predicts the Prognosis of Septic Patients January 10, 2022 January 31, 2025
NCT06181422 Recruiting Phase 2/Phase 3 Metformin and Lactoferrin in Sepsis in Icu April 2024 June 9, 2024
NCT04280497 Recruiting N/A Rapid Recognition of Corticosteroid Resistant or Sensitive Sepsis April 10, 2020 October 2024
NCT06344819 Recruiting Phase 2 An Acupuncture Study for People At High Risk for Sepsis March 20, 2024 March 20, 2028
NCT06242561 Recruiting Quantification of Dilutional Anemia in the Initial Phase of Sepsis Management: Preliminary Retrospective Study January 1, 2024 March 1, 2024
NCT05874895 Recruiting N/A MAnual Lymphatic DrAinage to iMprove the outcomE of Patients After Septic Shock June 1, 2023 December 31, 2024
NCT05875740 Recruiting Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective, Non-interventional, Observational Study February 24, 2024 May 31, 2025
NCT05578196 Recruiting N/A Fecal Microbial Transplantation in Critically Ill Patients With Severe Infections. September 4, 2022 December 31, 2025
NCT06287684 Recruiting Molecular Endotype-Specific Dynamics of Lung Endothelial Barrier Integrity in Sepsis September 13, 2023 December 30, 2025
NCT05469347 Recruiting Phase 1 Alirocumab in Patients With Sepsis January 4, 2023 May 2024
NCT05633290 Recruiting CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis. March 1, 2023 February 2024
NCT03720860 Recruiting Inflammatory Mediators of Acute Kidney Injury in Intensive Care January 1, 2018 May 2026
NCT06267742 Recruiting Clinical Trial to Evaluate MDW for Early Detection of Sepsis June 23, 2022 September 30, 2024
NCT05305469 Recruiting Early Identification and Prognosis Prediction of Sepsis Through Multiomics January 1, 2022 December 31, 2025
NCT05882708 Recruiting Phase 4 Effect of Heart Rate Control With Ivabradine on Hemodynamic in Patients With Sepsis June 1, 2023 March 31, 2025
NCT04306419 Recruiting Observational Trial on Cytokine Adsorption in Sepsis November 15, 2020 May 31, 2024
NCT05893420 Recruiting N/A A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning December 1, 2022 June 30, 2025
NCT05304221 Recruiting A Prospective Cluster-Randomized, Controlled Crossover Trial to Validate an Electronic "Resistance Calculator" July 3, 2023 January 2025
NCT06241248 Recruiting Evaluation of the Performance of a New Rapid Bacteremia Test in the Intensive Care Patient May 13, 2024 June 2025
NCT03334006 Recruiting Phase 2 Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis (PEPPER Trial). November 20, 2017 March 2028
NCT05897151 Recruiting Phase 4 Continuous Spinal Anesthesia Versus General Anesthesia in Sepsis June 10, 2023 November 30, 2023
NCT05229328 Recruiting Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Sepsis October 26, 2021 December 31, 2024
NCT05908162 Recruiting Algorithm for Predicting the Unfavorable Course of Sepsis in Children July 1, 2021 July 1, 2024
NCT05909683 Recruiting Phase 3 Assessing the Procalcitonin-guidance and Molecular-guided Diagnosis for Therapy of Severe Infections (the MODIFY Trial) September 14, 2023 July 25, 2025
NCT05634733 Recruiting Change in MAPSE During Treatment of Sepsis April 1, 2023 December 1, 2025
NCT05911711 Recruiting Identification and Clinical Efficacy Analysis of Biomarkers in Sepsis Patients July 7, 2023 June 7, 2024
NCT03892174 Recruiting N/A Cytokine REmoval in CRitically Ill pAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE) November 14, 2019 December 1, 2024
NCT05912413 Recruiting Predicton of Sepsis Recovery Performance Subtypes Pilot Study July 11, 2023 October 15, 2024
NCT05914428 Recruiting Biomarkers to Predict Acute Respiratory Distress Syndrome(ARDS) in Patients With Sepsis June 13, 2023 July 15, 2023
NCT01670383 Recruiting Repository for Sepsis and Postresuscitation Samples July 2006 December 2028
NCT01713205 Recruiting Prediction Study of Complications After Severe Trauma October 2012 December 2023
NCT05428423 Recruiting Reliability of PVI Changes During Tidal Volume Challenge in ICU Patients June 6, 2022 November 2022
NCT05922371 Recruiting ObsErvational Study of the Practical Cinical UTility of the NuQ.® H3.1 Nucleosome Levels in Adult Patients With Sepsis to Facilitate Early Diagnosis and Prognostication. (EPICETUS) December 18, 2023 March 1, 2025
NCT05930418 Recruiting N/A Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis May 20, 2023 July 31, 2025
NCT04448951 Recruiting Immune Homeostasis in Sepsis and Septic Shock September 1, 2020 December 31, 2027
NCT05941624 Recruiting N/A Comparison Between HA330 Hemoperfusion Filter Hemodialysis and Conventional High-Flux Hemodialysis Filter June 16, 2023 March 31, 2024
NCT04470973 Recruiting Pharmacokinetics of Amikacin and Cefuroxime in Critically Ill Patients. July 15, 2020 December 15, 2023
NCT05942157 Recruiting N/A Therapeutic Drug Monitoring in Patients With Difficult-to-Treat Gram-Negative Bacterial Infections March 29, 2023 December 31, 2025
NCT05287477 Recruiting Passive Evaluation in Operational Environment of the AI Clinician Decision Support System for Sepsis Treatment March 24, 2022 August 31, 2024
NCT05950984 Recruiting Medical Device (MD) Derived Pharmacokinetic (PK) Parameters for Vancomycin (MD-PK) October 30, 2023 August 2024
NCT04513288 Recruiting N/A ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock May 20, 2022 June 20, 2024
NCT06312488 Recruiting N/A Point of Care Evaluation of Fibrinolysis in Sepsis January 22, 2024 August 31, 2025
NCT06319248 Recruiting Phase 2/Phase 3 Use of Midodrine in Septic Shock Patients June 12, 2024 July 30, 2029
NCT04529655 Recruiting Digital Capillary Refill for Monitoring of Sepsis August 12, 2020 November 1, 2023
NCT05671159 Recruiting N/A COMPArative Study of the Consequence on innaTe Immune Response du to Bacterial or Viral Infection in Patients Admitted to Intensive Care Unit February 19, 2023 February 20, 2026
NCT05681442 Recruiting Phase 4 Beta-lactam Intermittent Versus Continuous Infusion and Combination Antibiotic Therapy in Sepsis November 13, 2023 January 1, 2025
NCT05784740 Recruiting N/A Precision Exercise to Improve Outcomes in Sepsis April 17, 2023 August 2025
NCT01315782 Recruiting Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis December 2016 December 2024
NCT05787184 Recruiting Sepsis Early EvaluatioN Through Rapid Ultrasound and veNous Gas Analysis January 1, 2023 June 1, 2024
NCT02829060 Recruiting N/A Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2 January 2016 January 2025
NCT06109506 Recruiting Towards a Tailored Approach for Patients With Acute Diverticulitis and Abscess Formation. A Multicenter Cohort Analysis June 1, 2023 November 30, 2023
NCT05806762 Recruiting Prediction of Rehospitalization Following a Sepsis Admission Using a Wearable Biopatch May 1, 2023 May 2, 2027
NCT04995835 Recruiting Phase 1 Cefiderocol PK in Patients on ECMO July 16, 2021 July 16, 2024
NCT05807217 Recruiting A Pharmacokinetics Study of Meropenem and Piperacillin in Patients With Sepsis October 26, 2022 December 31, 2023
NCT04166331 Recruiting Phase 3 Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion September 20, 2020 December 20, 2024
NCT05807555 Recruiting Longitudinal Evolution of Biomarkers of Dysautonomia and Inflammation During Sepsis in Children March 29, 2023 January 1, 2025
NCT05033808 Recruiting Phase 2 Epirubicin for the Treatment of Sepsis & Septic Shock October 19, 2022 December 2024
NCT05808946 Recruiting Phase 2/Phase 3 Alpha-Lipoic Acid in Patients With Sepsis March 10, 2023 October 2024
NCT05048888 Recruiting Symphony IL-6 Reference Range Study August 31, 2021 March 30, 2024
NCT06280872 Recruiting N/A Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns February 19, 2024 July 2026
NCT05059795 Recruiting Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension February 1, 2020 September 10, 2024
NCT05146336 Recruiting CytOSorb TreatMent Of Critically Ill PatientS Registry June 22, 2022 September 2032
NCT06210425 Recruiting Is Re-examination of Urine Culture Necessary for Patients With Preoperative Positive Results in Predicting Infectious Complications Related to Mini-Percutaneous Nephrolithotomy? March 1, 2021 November 10, 2024
NCT06122987 Recruiting Phase 4 Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic Shock December 4, 2023 January 2025
NCT02936232 Recruiting Severe Sepsis and Septic Shock Registry August 2014 March 2028
NCT06142162 Recruiting To Develop an Algorithm for Predicting the Unfavorable Course of Sepsis in Children Based on a Comprehensive Assessment of Immunological, Biochemical and Molecular Genetic Markers July 1, 2021 June 30, 2024
NCT05810415 Recruiting Use of Renin Versus Lactic Acid as Tissue Perfusion Biomarkers for Mortality Prediction in Hypotensive Critically Ill Patients June 21, 2022 January 25, 2024
NCT06150092 Recruiting Use of Presepsin in the Emergency Department October 10, 2023 April 10, 2025
NCT04203979 Recruiting Sepsis: From Syndrome to Personalized Care January 6, 2020 December 31, 2026
NCT05825118 Recruiting N\L Ratio Versus L\A Ratio as a Predictor of Morbidity and Mortality in Sepsis and Septic Shock May 2023 October 2023
NCT02979951 Recruiting Fosfomycin i.v. for Treatment of Severely Infected Patients December 2016 December 2030
NCT05453695 Recruiting Phase 1 Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI) January 17, 2023 September 2025
NCT05830669 Recruiting N/A Remote Ischemic Preconditioning in Septic Patients May 11, 2023 January 2025
NCT01182974 Suspended Phase 3 Paracetamol Toxicity in Septic Patients August 2010 August 2011
NCT00563134 Suspended N/A A Randomised Trial on the Saftely and Efficacy of GR270774 in the Treatment of Gram-negative Sepsis in Adult October 2005 December 2006
NCT03562689 Suspended Cognitive Processing in Patients Surviving Delirium. Neuropsychological, EEG and Structural Brain Correlates. March 1, 2019 December 2020
NCT00793078 Suspended Arterial Blood Pressure-complexity in Septic Patients January 2009 December 2012
NCT01705808 Terminated Phase 3 Administration of Protein C Concentrates in Adult Critically Ill Septic Patients September 2012 October 2014
NCT02704871 Terminated The Ward Study for SeptiCyte® Lab to Distinguish Between Infection-positive and Infection-negative SIRS June 2015 February 2018
NCT02159222 Terminated N/A Sepsis Trial of Early Physical Therapy Outside the ICU April 2014 September 2019
NCT01087450 Terminated The Effect of Erythropietin on Microcircualtory Alteration in Intensive Care Unit Patients With Severe Sepsis August 12, 2009 March 7, 2018
NCT03489577 Terminated The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients June 2014 June 1, 2016
NCT00299949 Terminated Thrombin Generation and Thromboelastography in Non-overt DIC October 2006 December 2008
NCT04134624 Terminated N/A EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock September 11, 2019 July 8, 2021
NCT04434209 Terminated Phase 4 A Study Looking at the Use of Biomarkers to Provide Early Indication of Acute Kidney Injury in Patients With Sepsis (Limiting AKI Progression In Sepsis) January 19, 2021 February 14, 2022
NCT00698542 Terminated Evaluation of the Patient Safety Screening Tool (PSST) for Sepsis May 2008 March 2010
NCT04280354 Terminated Molecular Biomarkers for Sepsis February 16, 2022 July 31, 2022
NCT00016523 Terminated Phase 3 Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure January 2001 May 2006
NCT01359813 Terminated Phase 3 Albumin Administration in Cirrhotic Patients With Bacterial Infection and a Systemic Inflammatory Response Syndrome Unrelated to Spontaneous Bacterial Peritonitis December 2008 June 2012
NCT02871024 Terminated N/A Efficacy of Polymyxin B Hemoperfusion on Severe Sepsis Secondary to Pneumonia or Urinary Tract Infection August 2016 March 26, 2019
NCT00428051 Terminated Colombia Epidemiologic Surveillance Study September 2006 October 2011
NCT01214473 Terminated N/A Probiotics for Prevention Neonatal Infection June 2007 November 2013
NCT02872792 Terminated N/A Early Mobilisation in Intensive Care Unit : Interest of Cyclo-ergometry in Patients With Septic Chock December 14, 2016 April 21, 2020
NCT01784159 Terminated Phase 2 ASpirin for Patients With SEPsis and SeptIc Shock March 27, 2019 January 5, 2023
NCT00395161 Terminated Phase 3 The CRISIS Prevention Study April 2007 November 2009
NCT01365312 Terminated N/A Safety and Efficacy Study of Ethanol Locking to Prevent Central Line Infection in Premature Neonates February 2010
NCT01371929 Terminated Plasma Inducible Nitric Oxide Synthase (iNOS) Assay and Sepsis Study February 4, 2013 September 30, 2015
NCT00511186 Terminated Phase 2 A Study in Sepsis Patients With Renal Failure May 2008 December 2009
NCT01449916 Terminated N/A Simplified Severe Sepsis Protocol in Zambia February 2012 November 2012
NCT03846596 Terminated Flow Cytometry Analysis of the Reactive Oxygen Species in Immature Granulocytes in Septic Patient March 26, 2019 March 10, 2020
NCT04117568 Terminated The Role of Emergency Neutrophils and Glycans in Postoperative and Septic Patients September 4, 2019 April 1, 2020
NCT00407147 Terminated Phase 4 Procalcitonin Level to Discontinue Antibiotics on ICU Patients With no Obvious Site of Infection July 2008 June 2009
NCT00318331 Terminated Phase 2/Phase 3 Enteral Glutamine in Critical Illness May 2006 September 2007
NCT02568189 Terminated N/A Utility of Ultrasound Assessment of the Inferior Vena Cava in Patients With Sepsis and Dehydration October 1, 2015 December 31, 2016
NCT02130388 Terminated N/A The Impact of Zinc Supplementation on Innate Immunity and Patient Safety in Sepsis May 2014 March 2019
NCT02424721 Terminated Sepsis Assessment in Belgian Emergency Rooms May 2015 December 2018
NCT01146821 Terminated Phase 2 Fish OIL Optimal dosE Determination Study October 2013 April 2017
NCT05192213 Terminated Phase 3 Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock August 1, 2021 September 19, 2022
NCT00528580 Terminated Phase 2 Statins for the Early Treatment of Sepsis February 2008 September 2011
NCT02203630 Terminated Phase 4 Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill Patients August 2014 January 2016
NCT02367170 Terminated Phase 1/Phase 2 Project 4A: Inspiratory Muscle Training and Diaphragm Strength March 2015 July 2015
NCT00524394 Terminated Characteristics of Cord Blood Immunologic Parameters of Infants <32 Weeks Gestation August 2007 January 2012
NCT00037687 Terminated Phase 3 Safety and Efficacy of Recombinant Human Platelet-Activating Factor Acetylhydrolase for the Treatment of Severe Sepsis April 2001 December 2004
NCT00159510 Terminated Phase 1 Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome April 2004 September 2014
NCT02523690 Terminated Phase 1/Phase 2 Evaluating Muscle Weakness Improvement With Lorcaserin in ICU December 2015 December 2017
NCT05210387 Terminated N/A Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections January 27, 2022 December 31, 2023
NCT00303082 Terminated Phase 3 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity January 2006 August 2009
NCT00545831 Terminated N/A Effect of Taurolidin on Prevention of Bloodstream Infection October 2007 December 2011
NCT00979121 Terminated Phase 3 Statins for Acutely Injured Lungs From Sepsis January 2010 November 2013
NCT00837421 Terminated The Ohio State University Sepsis Registry December 2006 November 2011
NCT00835874 Terminated N/A Probiotic Administartion to Mothers of Preterm Infants to Prevent Necrotizing Enterocolitis and Sepsis June 2007 July 2009
NCT03320785 Terminated Circulating Markers in Preterm Infants With Perinatal and Neonatal Inflammation September 1, 2017 December 31, 2021
NCT01906229 Terminated Lung and Systemic Inflammation in the Critically Ill Patient July 2013 December 2018
NCT00633477 Terminated Phase 3 Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure February 2008 February 2009
NCT03335124 Terminated Phase 4 The Effect of Vitamin C, Thiamine and Hydrocortisone on Clinical Course and Outcome in Patients With Severe Sepsis and Septic Shock September 26, 2017 December 1, 2018
NCT01683747 Terminated Phase 2 Single Dose Enteral Tranexamic Acid in Critically Ill Patients June 2012 November 2014
NCT04759989 Terminated N/A Fluid Resuscitation in Septic Shock Patients With BMI Elevation June 1, 2021 May 25, 2022
NCT01275976 Terminated Phase 3 Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture April 2012 February 2015
NCT05118048 Terminated StatStrip Lactate, Hemoglobin, and Hematocrit Meter in Whole Blood January 18, 2021 October 22, 2021
NCT02734147 Terminated Phase 2 High Dose Intravenous Ascorbic Acid in Severe Sepsis April 1, 2016 November 23, 2017
NCT05157360 Terminated Phase 1/Phase 2 HAT for the Treatment of Sepsis Associated With NASTI September 10, 2021 May 16, 2023
NCT02731144 Terminated Phase 4 Optimized Caloric-proteic Nutrition in Septic and Septic Shock Patients June 2016 February 2018
NCT03178578 Unknown status A Prospective Observational Study of the Expectations and Physiological Effects of Fluid Bolus Therapy May 18, 2017 January 2020
NCT05443854 Unknown status Phase 3 Impact of Aminoglycosides-based Antibiotics Combination and Protective Isolation on Outcomes in Critically-ill Neutropenic Patients With Sepsis: (Combination-Lock01) September 2022 June 2024
NCT03531515 Unknown status Predictors of Reactive Thrombocytosis in Critically Ill Septic Patients April 11, 2018 April 2019
NCT03540797 Unknown status Myeloid-derived Suppressor Cells in Sepsis July 1, 2015 December 31, 2023
NCT03598127 Unknown status Vitamin A Status in Critically Ill Children With Sepsis and Its Association With Illness Severity June 1, 2018 December 31, 2021
NCT03601767 Unknown status Derivation and Validation of a Prognostic Model for Septic Patients at Hospital Admission September 20, 2017 August 1, 2019
NCT03621618 Unknown status N/A Clinical Assessment of Arterial Dynamic Elastance in ICU Patients, Dependent on Inotropic or Vasopressor Drugs. March 31, 2019 December 31, 2020
NCT03634293 Unknown status Phase 2/Phase 3 Treatment of Severe Infection With Antihyperlipidemia Drug January 2019 February 2021
NCT03654456 Unknown status Impact of Sleep Apnea on Sepsis Mortality May 28, 2018 May 27, 2019
NCT03683693 Unknown status N/A Procalcitonin to Guide Antibiotic Stop in Neurocritical Care Patients. May 7, 2018 September 2020
NCT03685214 Unknown status N/A Comparison of Balanced Crystalloids and Normal Saline in Septic Patients March 1, 2019 May 2021
NCT03714841 Unknown status N/A C-reactive Protein Information and Blood Cultures for Emergency Department Patients With Sepsis January 21, 2017 May 15, 2021
NCT03715556 Unknown status Phase 3 Control Versus Liberal Cardiac Frequency in Patients in Sepse With Atrial Fibrillation of High Ventricular Response December 1, 2018 December 1, 2021
NCT03717350 Unknown status Phase 2/Phase 3 suPAR to Guide Antibiotics in Emergency Department October 27, 2018 August 31, 2021
NCT03727243 Unknown status Molecular Diagnosis and Risk Stratification of Sepsis in India December 6, 2018 June 11, 2021
NCT03734978 Unknown status Association Between Different Blood Groups and Sepsis in Preterm Infants December 15, 2018 October 31, 2019
NCT03752489 Unknown status Phase 2 Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment April 1, 2022 March 31, 2024
NCT03777670 Unknown status nSeP: Detecting Neonatal Sepsis by Immune-Metabolic Network Analysis February 26, 2020 February 28, 2024
NCT03782454 Unknown status Quantification of Bacterial DNA in Sepsis January 7, 2019 May 31, 2022
NCT03788096 Unknown status N/A Peer Support for Post Intensive Care Syndrome Self-Management April 20, 2020 January 27, 2021
NCT03788772 Unknown status N/A Systems Analysis of Antigen Presenting Cells in Human Sepsis July 15, 2019 July 15, 2022
NCT03791866 Unknown status N/A The Th9/IL-9 and Early Enteral Nutrition in Sepsis October 1, 2018 June 30, 2020
NCT00389337 Unknown status Sepsis: Prognosis and Evaluation of Early Diagnosis and Intervention (SPEEDI Study) January 2005 December 2006
NCT03802136 Unknown status Multiple Biomarkers in ICU Sepsis Patients December 30, 2018 June 2019
NCT00187824 Unknown status Regulation of Endocrine, Metabolic, Immune and Bioenergetic Responses in Sepsis July 2004 August 2007
NCT00384644 Unknown status Skeletal Muscle Oxygenation in Critically Ill April 2004 December 2010
NCT03811483 Unknown status SepsisFLAGS ( FLuidAndGender) June 2020 June 1, 2021
NCT03831685 Unknown status Blood Lactate Level for Pre-hospital Orientation of Septic Shock March 1, 2018 March 1, 2022
NCT03837730 Unknown status Citrulline and Arginase Activity in Severe Sepsis and Septic Shock February 10, 2019 August 10, 2019
NCT03844542 Unknown status N/A Therapeutic Plasma Exchange in the Treatment of Sepsis Associated Multi-Organ Failure [SAMOF-TPE] June 2019 June 2023
NCT03847493 Unknown status Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death April 15, 2019 December 31, 2023
NCT00628381 Unknown status Phase 3 L-citrulline Supplementation During Sepsis January 2011 January 2013
NCT03847961 Unknown status N/A Efficacy and Safety Study of CA330 Hemoadsorption Device on IL-6 Removal in Septic Patients December 17, 2018 October 2020
NCT00641355 Unknown status Acute Phase Proteins as Early Markers in Sepsis April 2008 September 2012
NCT00697944 Unknown status Phase 4 Ambisome® Preemptive Treatment of Multiple Candida Colonization in Sepsis Patients March 2008 March 2009
NCT00698919 Unknown status Bacterial Infection Diagnosis Using Blood DNA September 2008 November 2010
NCT00711789 Unknown status Phase 2 Angiotensin in Septic Kidney Injury Trial February 2010
NCT03869073 Unknown status Phase 2 Evolocumab for PCSK9 Lowering in Early Acute Sepsis (The PLEASe Study) February 11, 2019 February 11, 2021
NCT03870789 Unknown status Field Paramedic Application of Sepsis Triage December 11, 2016 December 31, 2019
NCT03876704 Unknown status Phase 3 Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants January 29, 2019 December 31, 2020
NCT03877081 Unknown status Phase 3 Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients January 4, 2019 February 4, 2023
NCT00745888 Unknown status Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit May 2007
NCT03884595 Unknown status Early Identification of Sepsis in Children December 1, 2019 January 2022
NCT03913403 Unknown status Study of Treatment's Echocardiographic Mechanisms April 30, 2019 May 1, 2021
NCT03914586 Unknown status The Membrane Adsorbing OXiris Filter in Septic Patients With AKI January 10, 2019 July 30, 2020
NCT00800631 Unknown status The Biomarker and Cardiac Function in Sepsis January 2008 December 2009
NCT03935477 Unknown status Surrogate of Adequate Perfusion: Bladder Tissue Oxygen Monitoring April 10, 2019 March 2020
NCT03950778 Unknown status Early Phase 1 The Effect of Albumin Supplementation on the Inflammatory and Oxidative Stress Markers in Septic Patients April 1, 2019 April 1, 2022
NCT03953404 Unknown status POC SPLA2-IIA as a Biomarker for Sepsis and Septic Shock May 14, 2019 April 30, 2022
NCT03966664 Unknown status Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients June 3, 2019 June 2021
NCT00854386 Unknown status N/A Effect of Intraoperative Fluid Restriction on Postoperative Outcomes in Video-assisted Thoracic Surgery (VATS) May 2009 September 2011
NCT00854932 Unknown status N/A Neonatal Procalcitonin Intervention Study June 2009 August 2016
NCT03982628 Unknown status ICU Sarcopenia Rates by Abdominal CT: Sepsis vs. Trauma August 1, 2020 December 30, 2020
NCT03991793 Unknown status Granzyme A in Patients With E. Coli Bacteremic Urinary Tract Infections June 20, 2019 December 31, 2020
NCT00452608 Unknown status Phase 2 Statin for Immunomudulation in Sepsis December 2006 December 2009
NCT03996759 Unknown status Early Prediction of Sepsis by Using Metabolomics July 10, 2019 December 31, 2022
NCT00908635 Unknown status The Role of Angiopoietin, Tie-2, and Vascular Endothelial Growth Factor (VEGF) in Sepsis-Induced Multiple Organ Dysfunction Syndrome (MODS) July 2008 August 2010
NCT04005001 Unknown status Phase 2 Machine Learning Sepsis Alert Notification Using Clinical Data September 25, 2021 August 31, 2022
NCT04015752 Unknown status Sepsis in ICU:Causes and Outcomes of Sepsis in Diabetics Versus Non Diabetics in Assiut University Hospital August 2019 October 2020
NCT04028102 Unknown status Ultrasound Optimization of Initial Fluid Challenge in Sepsis October 1, 2016 September 1, 2020
NCT04032743 Unknown status Risk Factors and Treatment Outcome of Oncology Children Hospitalized in the Intensive Care Unit Due to Sepsis October 16, 2018 December 2022
NCT00948558 Unknown status Citrate Pharmacokinetics and Regional Citrate Anticoagulation in CRRT March 2009 September 2011
NCT04032938 Unknown status Multi-omics Study on Gut Microbiota in Critical Ill Patients After Cardiopulmonary Bypass August 1, 2018 December 31, 2019
NCT04055727 Unknown status Sepsis at Södersjukhuset-Adherence to Treatment Guidelines March 7, 2019 September 1, 2022
NCT01045252 Unknown status Study of Hemodynamics of Neonates by Echocardiography and USCOM October 2008 December 2011
NCT01080950 Unknown status Vitamin D Zinc Fever March 2010 March 2011
NCT01085994 Unknown status Procalcitonin Monitoring May Decrease Antibiotic Use in the Intensive Care Unit January 2010 March 2010
NCT04068298 Unknown status Temperature Gradients for Sepsis Severity and Fluid Resuscitation September 1, 2019 September 1, 2022
NCT01104857 Unknown status N/A Respiratory Muscle Dysfunction in Critically Ill Patients April 2010 April 2016
NCT04079426 Unknown status Tetracycline to Limit the Innate Immune Response in Acute Respiratory Distress Syndrome January 4, 2019 January 2022
NCT04092621 Unknown status Phase 4 Rapid Atrial Fibrillation Treatment Strategy September 16, 2019 September 15, 2020
NCT01155674 Unknown status Innate Immune Functions of Immature Neutrophils May 2010 October 2011
NCT01157299 Unknown status Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO September 2009 September 2010
NCT01169168 Unknown status Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU) April 2010
NCT01174966 Unknown status Assessment of Transcutaneous Oxygen Tension/Oxygen Challenge Test in Intensive Care Unit (ICU) Patients September 2009 October 2010
NCT00357123 Unknown status Phase 2 Effect of Rosuvastatin in Abdominal Sepsis August 2006 September 2011
NCT04127968 Unknown status N/A Efficacy and Safety of Vitamin A Treatment for Children With Sepsis November 1, 2022 May 31, 2024
NCT01207531 Unknown status MiRNAs Evaluate the Prognosis of Sepsis July 2010 April 2011
NCT04130789 Unknown status Personalized Swiss Sepsis Study November 15, 2019 June 2023
NCT01244178 Unknown status N/A Hyperinsulinemic Therapy in Sepsis November 2010
NCT04141410 Unknown status Global Longitudinal Strain Assessment in Cardiogenic Shock During Sepsis October 21, 2019 January 21, 2021
NCT04146701 Unknown status Metabolomics and Microbiomics in Cardiovascular Diseases February 1, 2019 December 31, 2022
NCT01312688 Unknown status N/A Early Goal-directed Therapy and Myocardial Dysfunction July 2011 December 2013
NCT04182737 Unknown status Phase 3 Efficacy and Safety of Therapy With IgM-enriched Immunoglobulin With a Personalized Dose vs Standard Dose in Patients With Septic Shock. May 1, 2020 March 31, 2022
NCT04189549 Unknown status Preclinical Detection of Sepsis Early in Hospitalized Patients Following Surgery, Injury or Severe Illness December 9, 2019 April 30, 2021
NCT04199962 Unknown status Genomics in Infection and Sepsis to Predict Organ Dysfunction and Outcomes in Sepsis December 12, 2019 December 31, 2023
NCT04203524 Unknown status N/A Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients With Sepsis August 21, 2019 September 21, 2023
NCT01379547 Unknown status Phase 3 Procalcitonin to Shorten Antibiotics Duration in ICU Patients June 2011 June 2013
NCT01397474 Unknown status Phase 4 Peripheral Perfusion Targeted Fluid Management October 2011 January 2014
NCT04239937 Unknown status Insulin Resistance in Stress-metabolic Medical Patients February 18, 2020 August 27, 2020
NCT00335907 Unknown status N/A Protocol-driven Hemodynamic Support for Patients With Septic Shock September 2006 January 2011
NCT04257838 Unknown status Monitoring of Piperacillin-Tazobactam and Meropenem Plasmatic Levels in Critical Patients February 15, 2020 March 15, 2021
NCT04260230 Unknown status N/A Remote Monitoring of Patients at Risk of Sepsis March 2020 October 2020
NCT01447836 Unknown status Indocyanine Clearance Rate and Septic Liver Injury July 2011 November 2012
NCT01459822 Unknown status MiRNAs Evaluate the Prognosis of Sepsis by Dynamic Study August 2011 September 2013
NCT04289506 Unknown status Validation of Molecular and Protein Biomarkers in Sepsis February 25, 2020 November 2021
NCT01493466 Unknown status Serum Proteomics Analysis for Sepsis May 2010 March 2012
NCT01493492 Unknown status Urinary Proteomics Analysis for Sepsis and Prognosis May 2010 January 2012
NCT01494389 Unknown status The Changes of CD4+T Lymphocyte Subsets in Septic Patients August 2011 March 2012
NCT04300530 Unknown status Monocyte Distribution Width (MDW) in Hospital Practice July 15, 2020 December 31, 2021
NCT01501097 Unknown status N/A The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis December 2011
NCT01503684 Unknown status Biomarkers in Exhaled Breath Condensates of Septic Patients to Predict Development of Multi-organ Dysfunction Syndrome August 2011
NCT01504243 Unknown status Association Between cd163 Gene Polymorphisms and Sepsis Among Chinese Han Population May 2010 May 2012
NCT04304456 Unknown status Epidemiology and Determinants of Outcomes of Hospital Acquired Blood Stream Infections in the Intensive Care in Turkey June 2020 April 2022
NCT01535534 Unknown status Mediators of Inflammation, Prognostic Markers and Genetic Polymorphisms in Patients With Sepsis January 2012 December 2021
NCT01539551 Unknown status Investigation of the Role of Brain Natriuretic Peptide and Lactate in Early Goal-directed Therapy for Patients With Severe Sepsis and Septic Shock February 2012 January 2013
NCT04322942 Unknown status Sepsis Prediction by Monocyte Distribution Width and Procalcitonin April 16, 2019 September 30, 2020
NCT01619462 Unknown status Phase 3 Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children November 2011 November 2016
NCT04372472 Unknown status SQuISH-COVID: A Pilot Study April 7, 2020 April 30, 2022
NCT04397640 Unknown status N/A Myocardial Contrast Echocardiography in Septic Patients January 31, 2020 December 31, 2023
NCT01652404 Unknown status Phase 3 PROcalcitonin to SHORTen Antibiotics Duration in PEDiatricICU Patients (ProShort-Ped) Trial March 2011 December 2012
NCT04427371 Unknown status The Effect and Mechanism of lncRNA NBR2 Regulating Endothelial Pyroptosis by Targeting GSDMD in Sepsis May 22, 2020 December 31, 2023
NCT01709565 Unknown status Lactate Clearance According to the Presence of Hepatic Dysfunction July 2012 June 2014
NCT01724463 Unknown status Electronic Application of a Severe Sepsis Screening Tool and Management Bundle March 2013 October 2018
NCT04445220 Unknown status Phase 1/Phase 2 A Study of Cell Therapy in COVID-19 Subjects With Acute Kidney Injury Who Are Receiving Renal Replacement Therapy November 19, 2020 September 2022
NCT01788956 Unknown status Comparison of Central Venous Oxygen Saturation Measurements by Non-invasive Mespere Venous Oximeter and Central Venous Catheter October 2014 October 2016
NCT04513795 Unknown status EARLY-MYO-SEPSIS Registry September 1, 2020 August 31, 2023
NCT04516395 Unknown status N/A Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae September 2020 April 2021
NCT04525677 Unknown status Gut Microbiome Dysbiosis in Sepsis-induced Coagulopathy July 15, 2020 July 15, 2021
NCT01807858 Unknown status N/A The Effects of Synbiotics on Morbidity and Mortality in Preterm Infants October 2012 December 2013
NCT01818830 Unknown status Amino Acids Expression Profiling of Patients With Sepsis March 2012
NCT01828372 Unknown status N/A Quantification of Drugs and Their Degradation Products May 2013 March 2017
NCT01828853 Unknown status Maternal and Neonatal Outcomes After Membrane Sweeping April 2013 December 2013
NCT01838525 Unknown status Alpha-1-acid Glycoprotein as a Biomarker of Developmental Diagnosing and Monitoring Effectiveness in Sepsis April 2011 June 2013
NCT04529733 Unknown status N/A Evaluation of the IB10 Sphingotest PCT+ in a Point-of-Care Setting September 15, 2020 March 30, 2021
NCT04537767 Unknown status N/A The Effect of Esmolol on Patients With Sepsis October 1, 2020 September 30, 2023
NCT04540094 Unknown status Phase 3 Feasibility of 5% Albumin Compared With Balanced Crystalloid, as Intravenous Fluid Resuscitation in Adult Patients With Sepsis, Presenting as an Emergency to Hospital June 1, 2021 April 30, 2023
NCT04541771 Unknown status Phase 2 The Role of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis (NEC) in Pre-term Infants October 2020 January 2021
NCT01891253 Unknown status Inert Gas Rebreathing in Ventilated Patients March 2013 December 2020
NCT01905033 Unknown status Molecular Diagnosis and Risk Stratification of Sepsis January 2011 June 2018
NCT01920217 Unknown status Identification Sepsis Related Single Nucleotide Polymorphism (SNP) by Whole Exome Sequencing January 2013 December 2015
NCT04548414 Unknown status Homocysteine in Patients With Sepsis September 20, 2020 September 19, 2022
NCT04568746 Unknown status N/A Implementation of a qSOFA Score in the Emergency Department October 12, 2020 November 1, 2021
NCT02002676 Unknown status Prevalence and Outcome of Hypermetabolism in Initial Prevalence and Outcome of Hypermetabolism in Initial Phase of Intensive Care Unit Patient: a Prospective Observational Study December 2013 June 2014
NCT02019992 Unknown status Investigation of Plasma Mitochondrial DNA Level in Septic Patients September 2013 February 2015
NCT02020811 Unknown status N/A Safety and Efficacy of Immages System in Patients Recieving IV Therapy November 2013 April 2014
NCT04582188 Unknown status The Early Coagulopathy for the Prognosis in Sepsis November 5, 2020 December 31, 2022
NCT04606862 Unknown status N/A A Clinical Trial to Evaluate the Efficacy of the Morley Medical Sepsis (MMS) Software Device in Predicting Sepsis in Adult Patients Using Artificial Intelligence (AI) Machine Learning Algorithms October 31, 2020 December 31, 2020
NCT02069028 Unknown status Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis February 2014 September 2014
NCT00294697 Unknown status Genetic Variation and Immune Responses After Injury August 2003 October 2011
NCT02094248 Unknown status Phase 2/Phase 3 rhTPO in Critical Patients With Thrombocytopenia March 2014 April 2016
NCT02114853 Unknown status Oxidative Monitoring in ICU Patients. April 2014 April 2016
NCT04632017 Unknown status Computerized Cardiotocography Monitoring of Fetuses With pPROM June 15, 2020 July 30, 2021
NCT04635878 Unknown status INFLAmmasomes NLRP3 in Platelets and Leukocytes During SEPSIS in Intensive Care Unit July 27, 2020 July 2022
NCT02135055 Unknown status Phase 4 Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status May 2014 March 2015
NCT02143986 Unknown status Glycosylated Ferritin in Macrophagic Activation Syndromes May 2014 December 2020
NCT04638738 Unknown status Outcomes of Digital Alerting Systems in Secondary Care October 1, 2017 September 2021
NCT04646629 Unknown status N/A Effect of Electroacupuncture on Sepsis-induced Intestinal Dysfunction November 23, 2020 June 30, 2022
NCT02180399 Unknown status Serial Measurement of Capillary Blood Lactate in the Management of Sepsis February 2014 September 2017
NCT02185118 Unknown status N/A Effects of Subanesthetic Isoflurane/Sevoflurane in 60% Oxygen on Clinical In-vitro Experimental Sepsis June 2014 July 2018
NCT04647201 Unknown status Study of Biomarkers in Patients of Sepsis Complicated With Gastrointestinal Dysfunction November 23, 2020 June 30, 2022
NCT02195830 Unknown status N/A Inferior Vena Cava Collapsibility Index in Severe Sepsis July 2014 July 2015
NCT04695119 Unknown status Sepsis in the ICU-II September 17, 2018 December 31, 2023
NCT02204215 Unknown status N/A Electric Acupuncture for ICU-acquired Weakness in Mechanical Ventilation Patients January 2014 December 2015
NCT02213237 Unknown status The Application of SERS and Metabolomics in Sepsis July 2011 December 2018
NCT04716842 Unknown status Evaluation of Plasma Angiotensin II and Angiotensin II Receptor Levels in Patients With Sepsis and Septic Shock: a Prospective Observational Study. January 1, 2021 April 2021
NCT04717037 Unknown status Phase 2/Phase 3 Olive Oil Massage Effect for Reduction of Preterm Sepsis (OMEPS) September 1, 2020 August 1, 2022
NCT04721275 Unknown status Evaluation of the Performance of Sepsis Predictive Scores on the Elderly Population in the Emergency Department. January 18, 2021 August 1, 2021
NCT02276066 Unknown status N/A Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS February 2015 November 2022
NCT00451373 Unknown status N/A Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF (NSARF) Study July 2006 December 2012
NCT02285257 Unknown status Epidemiology of Sepsis at Yuetan Subdistrict in Beijing July 2013 June 2016
NCT04728438 Unknown status Effect of Targeted Temperature Management on Cerebral Autoregulation in Patients With Neurocritical Diseases January 22, 2021 July 1, 2021
NCT02304224 Unknown status N/A the Relationship of the Use of Eye Masks and Outcomes of Patients With Sepsis in Intensive Care Unit December 2014 February 2016
NCT02312024 Unknown status International Registry on the Use of the CytoSorb Adsorber January 2015 December 2020
NCT02319876 Unknown status Expression of TIM-3 on Lymphocytes in Sepsis February 2014 December 2015
NCT04771429 Unknown status A Machine Learning Predictive Model for Sepsis April 1, 2019 April 1, 2021
NCT04774705 Unknown status N/A Effectiveness of Non-invasive Vagus Nerve Stimulation as an Adjuvant Treatment in Patients With Sepsis in Intensive Care. March 29, 2021 March 29, 2023
NCT02359240 Unknown status HO-1 and Muscle Mitochondrial Dysfunction in Sepsis December 2014 August 2016
NCT00258869 Unknown status Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests December 2005 July 2010
NCT02366650 Unknown status Help in the Emergency Room to Detect Organ Dysfunction February 2015 August 2016
NCT02370030 Unknown status Phase 1/Phase 2 Effect of Citrulline on the Clinical and Biochemical Evolution of Patients With Sepsis. November 2014 December 2016
NCT04800952 Unknown status N/A Pharmacokinetics of Antibiotics in Critically Ill Patients Receiving CVVHF April 2021 April 2023
NCT04803942 Unknown status Clinical Intuition for PRedicting Evolution in Sepsis in the Emergency Department - CIPRES-ED Study January 19, 2021 October 31, 2022
NCT02426645 Unknown status Microcirculatory Alteration and Biomarkers: New Approach for Early Assessment of Septic Multi-organ Dysfunction April 2015 April 2019
NCT02452138 Unknown status Endotoxin Activity Assay and Microcirculation in Severe Sepsis January 2016 June 2017
NCT04839653 Unknown status N/A Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria May 1, 2021 April 2023
NCT02478073 Unknown status Piperacillin Pharmacokinetics in ICU Patients June 2015 May 2016
NCT00254176 Unknown status Phase 2/Phase 3 Cysteine Supplementation in Critically Ill Neonates September 2006 July 2011
NCT02530359 Unknown status Phase 4 Pirfenidone Effect on the Recovery of Renal Function in Septic Acute Kidney Injury October 2015 July 2016
NCT04872010 Unknown status Construction of a Database for the Life-cycle Sepsis-specific Disease Cohort June 1, 2021 September 30, 2022
NCT04873479 Unknown status N/A Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery May 10, 2021 October 30, 2023
NCT02545478 Unknown status Biomarkers in Infection April 2006 April 2023
NCT04876937 Unknown status N/A Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients May 28, 2021 April 2024
NCT02565251 Unknown status N/A Volemic Resuscitation in Sepsis and Septic Shock September 2015 September 2017
NCT02567305 Unknown status Neutrophil Extracellular Traps and Neonatal (PV4991) & Pediatric Sepsis (PV5063) September 2015 January 2020
NCT04898322 Unknown status Phase 2 SY-005 （Recombinant Human Annexin A5）in Patients With Sepsis January 2, 2022 July 1, 2023
NCT02589535 Unknown status Circulating Stem Cells, SDF-1, HIF-1 and Sepsis's Indices in Emergency Abdominal Surgical Patients December 2015 June 2018
NCT04903405 Unknown status Immune Function Monitoring and Immunotherapy in Sepsis June 1, 2021 July 30, 2021
NCT02611271 Unknown status Elimination of Antibiotics During Renal Replacement Therapy and Cytosorb Adsorptive Therapy December 1, 2017 December 31, 2020
NCT02616354 Unknown status Phase 4 Preliminary Research On Two-step Dosing Of Imipenem/Cilastatin January 2015 December 2015
NCT04904523 Unknown status Blood Markers for Identifying & Investigating Infection With COVID19 & Sepsis in Children. December 16, 2020 June 30, 2023
NCT04921319 Unknown status N/A De-resuscitation Informed by Ultrasound for Patients With Sepsis April 26, 2021 July 30, 2022
NCT02697513 Unknown status N/A The 'Bekele Afessa Scan-Teach-Treat Approach' March 2016 December 2017
NCT02701725 Unknown status Compensatory Reserve Index as a Hemodynamic Status Evaluation Tool in Patients March 2016 September 2016
NCT04933760 Unknown status CV-SQuISH-ED: Clinical Validation Study May 18, 2021 May 1, 2022
NCT04934943 Unknown status "Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools" October 22, 2021 September 1, 2022
NCT00449800 Unknown status Phase 4 Pharmacokinetic of Ceftriaxone in Septic ICU Patients July 2006 March 2007
NCT04940676 Unknown status Phase 2 Oral Administration or Nasal Feeding of Huzhangxiefei Decoction for Treatment in Sepsis Induced Acute Lung Injury March 10, 2021 December 31, 2022
NCT02743585 Unknown status N/A Impact of Rapid Pathogen Identification From Blood Cultures (RABbIT) March 20, 2017 July 2, 2020
NCT04974411 Unknown status Establishment of Early Diagnosis and Monitoring Model for Sepsis Patients February 2, 2021 March 20, 2024
NCT02764359 Unknown status N/A Study of Obese Patients Comparing Two Vancomycin Loading Dose Regimens August 1, 2016 January 22, 2021
NCT02768324 Unknown status the Effect of Gut Microbiota on the Prognosis of Sepsis May 1, 2017 September 1, 2019
NCT04979767 Unknown status Function of Circulating Exosomes in Sepsis-induced Immunosuppression April 15, 2021 June 30, 2022
NCT02796794 Unknown status Phase 4 Effect of Enteral Genistein Supplementation in Sepsis June 2015 September 2016
NCT02820142 Unknown status Plasticity and Regeneration of Renal Epithelial Cells July 2016 December 2019
NCT04985110 Unknown status Phase 2 Administration of Antibiotic Prophylaxis for Transperineal Prostate Biopsy in Cipto Mangunkusumo Hospital July 6, 2021 July 6, 2023
NCT00197899 Unknown status N/A Low-Dose Endotoxemia and the Acute Phase Response March 2004 January 2005
NCT04999137 Unknown status Phase 2 Evaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa September 1, 2021 December 29, 2021
NCT02858778 Unknown status N/A Timing of Acute Palliative Care Consultation in Critically Ill Patients June 2016
NCT05023954 Unknown status mSEP: Testing of Physiological and Immune-metabolic Blood Markers for Maternal Sepsis October 12, 2020 September 1, 2022
NCT05024565 Unknown status N/A Prolonged Intravenous Infusion of β-lactam Antibiotics in Early Septic Patients September 20, 2021 September 1, 2023
NCT02871895 Unknown status Application of Biomarkers Change to Predict Outcome of Patient With Severe Sepsis July 2013 December 2018
NCT05036928 Unknown status Study of MDW Levels Predicting the Development of Sepsis in Hospitalized HIV-infected Patients and Correlation With Prognosis December 2021 October 2022
NCT02887274 Unknown status Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis July 2013 December 2018
NCT05042622 Unknown status N/A Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure January 1, 2021 December 31, 2023
NCT05044403 Unknown status Phase 4 Evaluation of the Efficacy and Safety of Extracorporeal Support With Hemoperfusion in Critical Patients With Multiorgan Dysfunction Syndrome by Septic Origin October 1, 2021 December 31, 2022
NCT02899143 Unknown status Phase 2 Short-course Antimicrobial Therapy in Sepsis September 2016 October 2021
NCT02910765 Unknown status Phase 4 Methylene Blue and Ozone in Early Sepsis October 2016 April 2017
NCT02920736 Unknown status Value of Urine sTREM-1 on Early Predicting AKI in Sepsis January 2016 December 2018
NCT02922998 Unknown status CD64 and Antibiotics in Human Sepsis September 2016 June 2019
NCT02930070 Unknown status qSOFA in General Wards: the Accuracy in Diagnosis of Sepsis September 2016 April 2017
NCT02957279 Unknown status Dendritic Cells-Derived Exosomes in Human Sepsis November 2016 October 2017
NCT05082168 Unknown status Capnodynamic Monitoring of Cardiorespiratory Function in Critically Ill Patients February 1, 2021 July 1, 2023
NCT05083520 Unknown status Incidence of Cereblon in Intensive Care Patients December 1, 2021 April 1, 2022
NCT05090930 Unknown status N/A Innovative Technologies for the Treatment of Pulmonary and Heart Failure January 1, 2021 December 1, 2023
NCT02980588 Unknown status N/A The Effects of SGC on Glucose Control in Critically Ill Patients With Sepsis December 2016 September 2017
NCT03001687 Unknown status N/A Impact of Vitamin D Supplementation on Hepcidin Levels and Transfusion Requirements in Surgical and Septic Patients January 2017 December 2017
NCT03010410 Unknown status Platelet Immune Responses in Aging and Influenza and Sepsis (INVACS) December 21, 2014 December 2019
NCT05095324 Unknown status The Biomarker Prediction Model of Septic Risk in Infected Patients September 7, 2021 September 14, 2022
NCT05109156 Unknown status Preoperative Sepsis Timeline, Profile and Its Association With Recipient Outcome Following Live Donor Liver Transplant November 5, 2021 April 2022
NCT05111769 Unknown status N/A Preliminary Study on the Clinical Effect of Recombinant Human Brain Natriuretic Peptide on Sepsis Complicated With Heart Failure December 1, 2021 December 1, 2023
NCT05112406 Unknown status Early Diagnostic Biomarkers of Sepsis December 2021 March 2023
NCT05118646 Unknown status N/A Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock December 1, 2020 December 30, 2021
NCT03048903 Unknown status Phase 2 The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure February 2016 July 2018
NCT05133310 Unknown status Phase 4 Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia November 19, 2021 June 23, 2023
NCT03095625 Unknown status Role of Thromboelastography in Septic Shock October 1, 2015 December 31, 2017
NCT03113721 Unknown status Assessment of Heparin Binding Protein for the Prediction of Severe Sepsis March 27, 2017 March 1, 2019
NCT00174122 Unknown status Procalcitonin in Diagnosing Bacteremia in the Emergency Department July 2005 June 2006
NCT05142813 Unknown status A Blood Test to Diagnose Sepsis in Symptomatic Adults and Children May 2022 December 2023
NCT03133910 Unknown status Pharmacokinetics and Pharmacodynamics of Ceftazidime in Pediatric ICU Patients March 9, 2017 January 2019
NCT03139955 Unknown status Bodytrak® Feasibility Study August 1, 2019 December 1, 2019
NCT03153306 Unknown status Phase 4 Importance of the Infusion Rate for the Plasma Expanding Effect of 5% Albumin in the Septic Patient June 2016 March 2018
NCT03178292 Unknown status N/A Conventional Antibiotic Prophylaxis Versus Add-On 5 Days Levofloxacin Before Percutaneous Nephrolithotomy June 15, 2017 June 15, 2017
NCT05391789 Unknown status Phase 3 Clinical Efficacy of Ulinastatin for Treatment of Sepsis With Systemic Inflammatory Response Syndrome July 2022 December 2023
NCT03179189 Unknown status Investigation of The Prevalence of Sepsis in Adults in Multicenter Intensive Care Unıts in Turkey October 1, 2017 March 1, 2018
NCT00197847 Unknown status Infection Surveillance in Intensive Care Patients December 2002 September 2005
NCT03208725 Unknown status Childhood Acute Illness and Nutrition Network November 30, 2016 October 31, 2020
NCT03214913 Unknown status N/A Controlled Fluid Resuscitation in Sepsis January 1, 2018 June 30, 2021
NCT03217552 Unknown status The Performance of the Mologic Biomarker Panel in Infection November 26, 2017 July 2019
NCT03217981 Unknown status Sepse: Critical Analysis of New Sepse Definitions and Retrospective Evaluation of Sepse Protocol at a Tertiary Hospital in Brazil August 2, 2017 August 8, 2017
NCT05171699 Unknown status N/A Effect of Electroacupuncture in Patients With Sepsis Associated Brain Injury April 25, 2022 December 30, 2022
NCT03226626 Unknown status Phase 2/Phase 3 Tumescent Anesthesia Antibiotic Delivery (TAAD) December 1, 2021 July 31, 2022
NCT03231956 Unknown status CLEAR Sepsis Clinical Study June 29, 2017 June 30, 2022
NCT03237403 Unknown status Hospital Orientation Since SAMU Regulation Centre Call January 1, 2017 January 1, 2019
NCT05186480 Unknown status N/A Evaluation of the Effect of Immune Modulating Enteral Nutrition Formula October 3, 2021 March 28, 2022
NCT05190861 Unknown status N/A Evaluation of Droplet Digital PCR Rapid Detection Method and Precise Diagnosis and Treatment for Suspected Sepsis November 29, 2021 June 1, 2023
NCT03252613 Unknown status Translational Approaches to Septic Cardiomyopathy May 19, 2017 October 27, 2019
NCT03253146 Unknown status The Role and Mechanism of Vimentin in Sepsis Patients July 1, 2016 December 31, 2017
NCT03256461 Unknown status N/A Lactate Clearance Goal-directed Therapy in Sepsis August 21, 2017 December 2021
NCT03289312 Unknown status Dissecting How Peripheral Lymphocytes Are Lost During Sepsis January 11, 2018 December 31, 2018
NCT03309423 Unknown status Is Venous to Arterial Conversion (v-TAC) of Blood Gas Reliable in Critical Ill Patients in the ICU? October 9, 2017 March 30, 2018
NCT05217485 Unknown status N/A Continuous Ambulatory Cardiac Monitoring for Recurrent Atrial Fibrillation After Sepsis March 2022 March 2024
NCT05217836 Unknown status Iron Metabolism Disorders in Patients With Sepsis or Septic Shock. September 24, 2021 December 31, 2022
NCT03340649 Unknown status The Predictive Value of Hepatocyte Growth Factor and Soluble Receptor s-Met in Sepsis November 9, 2017 March 1, 2018
NCT03341572 Unknown status N/A The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance November 13, 2017 December 30, 2017
NCT05267483 Unknown status Evaluation of Usage Patterns and Outcomes in Patients Receiving Ceftolozane/Tazobactan (C/T) in Brazilian Hospitals April 1, 2022 March 30, 2023
NCT03363646 Unknown status Italian National Study on the Critically Ill Liver Transplant Patient With an Infection July 1, 2018 August 30, 2019
NCT03369275 Unknown status Phase 2 Cellular Immunotherapy for Septic Shock March 2018 October 2020
NCT03372330 Unknown status Peripheral Artery Disease and Sepsis Outcomes September 11, 2017 September 10, 2019
NCT03379896 Unknown status Study on Antigen-presenting Function of Gamma Delta T Cells in Sepsis and Its Molecular Mechanisms January 4, 2018 December 30, 2020
NCT00189384 Unknown status Phase 3 Efficacy Study of Community-Based Treatment of Serious Bacterial Infections in Young Infants November 2003 December 2005
NCT03406494 Unknown status N/A Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis March 2018 April 30, 2021
NCT03406598 Unknown status Bedside Visual Analysis of Sublingual Microcirculation in Shock Patients March 2, 2018 October 10, 2021
NCT05309889 Unknown status A Prospective Observational Study of Sepsis May 12, 2022 June 2023
NCT03438214 Unknown status Phase 4 Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients April 28, 2018 December 1, 2022
NCT05312034 Unknown status N/A Application of an Antimicrobial Stewardship Program in Brazilian ICUs Using Machine Learning Techniques and an Educational Model April 1, 2022 December 29, 2023
NCT03464071 Unknown status N/A Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation March 23, 2018 December 20, 2019
NCT05357339 Unknown status N/A Microcirculation Properties of Albumin for Fluid Resuscitation in Septic Shock September 1, 2021 November 30, 2022
NCT00136370 Unknown status Phase 3 Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn April 2004 November 2007
NCT03497741 Unknown status Predictive Value of Procalcitonin for Bacteremia in the ICU October 1, 2017 April 1, 2019
NCT00368381 Withdrawn Phase 4 Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis September 2006 September 2009
NCT01601938 Withdrawn Phase 2 Selenium Replacement and Serum Selenium Level in Severe Sepsis and Septic Shock Patients September 2012 May 2014
NCT00304772 Withdrawn Phase 4 Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients August 2006 December 2008
NCT01505478 Withdrawn Comparing an Automated to a Conventional Sepsis Clinical Prediction Rule July 2012
NCT01472952 Withdrawn System-level Monitoring of Immune Activation Concerning Susceptibility to Sepsis in Trauma Patients February 2012 December 2013
NCT03644940 Withdrawn Phase 2 Subpopulation-Specific Sepsis Identification Using Machine Learning December 2020 July 2021
NCT03835286 Withdrawn Phase 3 Vitamin C to Reduce Vasopressor Dose in Septic Shock March 1, 2019 December 2022
NCT03090919 Withdrawn N/A The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis January 3, 2017 May 31, 2021
NCT01382394 Withdrawn Impact of Clinical, Demographic and Laboratory Variables on Brain Natriuretic Peptide Levels July 2009 June 2010
NCT02929160 Withdrawn N/A Percutaneous Nephrostomy Versus Stent In Sepsis Trial January 1, 2017 January 2020
NCT03167788 Withdrawn Phase 2 Red Cell Rejuvenation for the Attenuation of Transfusion Associated Organ Injury in Cardiac Surgery December 2020 December 2020
NCT01234285 Withdrawn Phase 2 Safety of Heparin in Patients With Septic Shock December 2010 October 2013
NCT01229046 Withdrawn Phase 1 Pharmacokinetics and Safety of Ticarcillin-clavulanate in Infants September 2010
NCT03734484 Withdrawn Phase 2 Gram Type Infection-Specific Sepsis Identification Using Machine Learning May 1, 2022 March 1, 2023
NCT00247468 Withdrawn N/A Strict Glucose Control of Pediatric Intensive Care Unit (ICU) Patients December 2004 December 2004
NCT04110912 Withdrawn Improving Outcomes After Time Sensitive Prehospital Interventions: Rescu Epistry January 2015 December 2040
NCT04088591 Withdrawn Phase 3 High-dose Intravenous Vitamin C as an Adjunctive Treatment for Sepsis in Rwanda October 2022 December 2023
NCT02771158 Withdrawn Phase 4 Midodrine During Recovery From Septic Shock August 2017 November 1, 2017
NCT00583206 Withdrawn Muscle Atrophy in Sepsis December 2007 December 2009
NCT03817281 Withdrawn Collective Accuryn Physiologic Signals and Signatures March 29, 2020 March 29, 2020
NCT00486174 Withdrawn N/A Methylene Blue in Sepsis: A Randomized Controlled Trial June 2007
NCT00987818 Withdrawn N/A Procalcitonin Guided Versus Conventional Antibiotic Therapy in Patients With Sepsis in the ICU
NCT04961151 Withdrawn N/A Working Toward the Advancement of Recovery Using Modulated Therapeutic Hyperthermia (WARMTH) in Sepsis - Pilot August 25, 2021 July 1, 2022
NCT00889083 Withdrawn Hepatic Mitochondrial Function in Sepsis April 2009 April 2012
NCT03673891 Withdrawn N/A Evaluation of Fluid Infusion With LifeFlow for Patients With Suspected Septic Shock January 1, 2019 December 31, 2019
NCT02699905 Withdrawn Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis August 2016 November 2017
NCT03968484 Withdrawn N/A Platelet Transfusion in Sepsis Trial August 1, 2020 February 1, 2023
NCT02684487 Withdrawn Phase 3 Vitamin D Status in Patients With Severe Sepsis December 2017 December 2022
NCT05639504 Withdrawn Sepsis Prognosis and Diagnosis in the Emergency Department (SPEED) December 2022 May 2023
NCT02578667 Withdrawn N/A Gorbly Compression Device for Use in Image-guided Procedures December 2015 January 2016
NCT03882476 Withdrawn Phase 2 RCT of Sepsis Machine Learning Algorithm January 1, 2020 February 28, 2021
NCT04881097 Withdrawn Cognitive Function and Health-related Quality of Life After Neuro-intensive Care August 1, 2021 August 1, 2025
NCT00472628 Withdrawn Multi-marker INDex for the Risk Assessment of Sepsis in the Emergency departmenT (MINDSET) May 2007 August 2007
NCT00750516 Withdrawn Lactic Acid Levels In Hypotensive Patients Without(Standard) and With Tourniquet September 2008 June 2009
NCT00739089 Withdrawn Presep and Vascath Interaction Study August 2008 December 2009
NCT04850469 Withdrawn Study of MSC-Exo on the Therapy for Intensively Ill Children September 1, 2022 December 31, 2024
NCT02319265 Withdrawn Phase 1/Phase 2 Dose Assessment of Melatonin in Sepsis Trial April 2017 December 2019
NCT02277977 Withdrawn N/A Evaluation of Impaired Microcirculation During Septic Shock With Contrast Enhanced Ultrasound November 2014 December 2015
NCT02266654 Withdrawn N/A Early Goal Directed Therapy in Sepsis by Emergency Medical Services October 2014 May 2017
NCT04698382 Withdrawn Impact of COVID-19 on the Incidence, Characteristics, Management and Outcome of Sepsis August 1, 2020 December 31, 2023
NCT03654287 Withdrawn Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children October 30, 2018 October 30, 2021
NCT04576806 Withdrawn N/A Physiological Effects of 38°C vs. 22°C Fluid Therapy in Critically Ill Patients April 30, 2021 October 30, 2021
NCT01903668 Withdrawn Determination of the Nature of the Endogenous Ligand of TREM-1 and Its Use as a New Diagnostic Biomarker in Sepsis April 2012
NCT05602896 Withdrawn N/A Reducing 30-Day Sepsis Readmissions: Impact of a Post Discharge Education Program March 31, 2024 July 31, 2025
NCT01801020 Withdrawn Phase 3 Different Modes of Temperature Measurement in the Emergency Department March 2013 January 2015
NCT03488940 Withdrawn N/A Effect of Different Feeding Method on Gastrointestinal Function of Septic Patients (DFM-GF Trial) January 1, 2019 August 31, 2020
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0100806
MeSH unique ID (MeSH (Medical Subject Headings))
D018805