keratoconus
Information
- Disease name
- keratoconus
- Disease ID
- DOID:10126
- Description
- "A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape." [url:http\://en.wikipedia.org/wiki/Keratoconus, url:http\://ghr.nlm.nih.gov/glossary=keratoconus]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT05596838 | Active, not recruiting | Long-term Result of Placing Intracorneal Rings in Keratoconus Using Laser | January 20, 2023 | January 2026 | |
| NCT01152541 | Active, not recruiting | Phase 3 | Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic Riboflavin | June 2010 | December 2025 |
| NCT04698590 | Active, not recruiting | N/A | Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism | January 15, 2021 | December 31, 2025 |
| NCT01112072 | Active, not recruiting | Phase 3 | Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia | April 2010 | December 2025 |
| NCT01604135 | Active, not recruiting | Phase 3 | Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial | May 2012 | April 2025 |
| NCT04594512 | Active, not recruiting | N/A | Fresh Corneal Lenticule Implantation and Autologous Serum - Case Report | May 8, 2019 | May 8, 2024 |
| NCT02649738 | Active, not recruiting | N/A | Corneal Tissue Inlay for Keratoconus | December 2015 | December 2025 |
| NCT04668924 | Active, not recruiting | N/A | Epi-on PiXL for the Treatment of Progressive Keratoconus. | March 20, 2019 | February 5, 2026 |
| NCT04895514 | Active, not recruiting | N/A | Gamma-Irradiated Corneal Inlay for Keratoconus | February 1, 2021 | November 1, 2023 |
| NCT04667572 | Active, not recruiting | Phase 1 | Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution | February 1, 2021 | August 31, 2024 |
| NCT01464268 | Active, not recruiting | Phase 3 | Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia | November 2011 | December 2025 |
| NCT05604443 | Completed | Keratoconus Detection Using MS39 and Pentacam | December 28, 2022 | May 1, 2023 | |
| NCT00777322 | Completed | N/A | T-Cat Laser & Cross-linking for Keratoconus | October 2008 | October 2010 |
| NCT00802776 | Completed | N/A | Femtosecond Laser Assisted Keratoplasty | October 2007 | January 2016 |
| NCT00832897 | Completed | N/A | Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring | March 2008 | October 2010 |
| NCT05457647 | Completed | N/A | Theranostic Guided Riboflavin/UV-A Corneal Cross-linking | April 27, 2022 | January 26, 2024 |
| NCT00850148 | Completed | N/A | Comparison of Anwar and Melles Techniques in Deep Anterior Lamellar Keratoplasty (DALK) for Keratoconus Patients | May 2008 | September 2009 |
| NCT00863876 | Completed | Comparison of WaveLight Analyzer and Alcon LadarWave | March 2009 | ||
| NCT00887900 | Completed | Phase 3 | Deep Anterior Lamellar Keratoplasty (DALK) | January 2006 | December 2008 |
| NCT00890266 | Completed | N/A | Corneal Collagen Cross-linking With Hypotonic Riboflavin in Corneas Thinner Than 400 Microns | April 22, 2009 | April 22, 2010 |
| NCT05279157 | Completed | Phase 2 | Autologous Adipose-Derived Adult Stem Cell Implantation for Corneal Diseases (ADASCs-CT-CD) | April 19, 2022 | February 5, 2023 |
| NCT01069848 | Completed | N/A | Feasibility Study of the Vedera KXS for Treatment of Keratoconus | January 2010 | March 2011 |
| NCT05241145 | Completed | Phase 1/Phase 2 | Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients | February 8, 2019 | July 8, 2020 |
| NCT05114928 | Completed | Correlation Between Q-value Changes and Progression of Pediatric Keratoconus. | October 9, 2021 | October 28, 2021 | |
| NCT01143389 | Completed | Phase 2 | Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia | May 2010 | August 30, 2017 |
| NCT05073601 | Completed | Thyroid Gland Dysfunction and Vitamin D Polymorphism in Keratoconus | March 6, 2021 | September 1, 2021 | |
| NCT01181219 | Completed | Phase 2 | Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus | July 2010 | December 2014 |
| NCT05019768 | Completed | N/A | Topo-pachimetric Accelerated Epi-On Cross-linking Compared to Dresden Protocol Using Riboflavin With Vitamin E TPGS | September 1, 2017 | December 31, 2020 |
| NCT01261013 | Completed | Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different Stages | January 2008 | March 2010 | |
| NCT04748198 | Completed | N/A | Effect of Intracorneal Ring Segments on Posterior Corneal Tomography in Eyes With Keratoconus | June 10, 2018 | June 15, 2020 |
| NCT01344187 | Completed | Phase 3 | Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus | July 2012 | June 2016 |
| NCT01403129 | Completed | Keratoconus Detection by Ultrasound | December 2010 | January 2020 | |
| NCT01448408 | Completed | Corneal Biomechanical Properties and Anterior Segment Parameters, in Forme Fruste Keratoconus | May 2007 | July 2011 | |
| NCT01471873 | Completed | Variability of Pentacam-derived Back Elevation Measurements in Keratoconus and Cross-linked Corneas | March 2011 | November 2011 | |
| NCT01510392 | Completed | CEI Van Outreach Screening Study | January 2012 | February 2, 2017 | |
| NCT01527708 | Completed | Accuracy of Curvature and Wavefront Aberrations of Posterior Corneal Surface, in Keratoconic and Post-CXL Corneas | September 2011 | December 2011 | |
| NCT01527721 | Completed | N/A | Blurring Strength & Aberrometric Changes Following Corneal Cross-linking (CxL) and CxL Combined With Photorefractive Keratectomy (PRK) in Keratoconus | September 2010 | January 2012 |
| NCT01643226 | Completed | Phase 3 | Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus | July 2012 | September 2016 |
| NCT01672814 | Completed | Phase 3 | Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus | August 2012 | June 1, 2017 |
| NCT04649177 | Completed | N/A | Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting | December 15, 2020 | March 23, 2022 |
| NCT01691651 | Completed | N/A | Botulinum Toxin A for the Treatment of Keratoconus | September 2012 | October 2014 |
| NCT01695811 | Completed | Femtosecond Laser-Assisted Keratoplasty | November 2007 | December 2013 | |
| NCT01743443 | Completed | Phase 2/Phase 3 | Corneal Sensitivity Cross-linking Keratoconus | March 2009 | October 2012 |
| NCT03187912 | Completed | Phase 3 | Accelerated Corneal Cross-linking With Different Riboflavin Solutions | September 19, 2016 | March 30, 2020 |
| NCT03127163 | Completed | N/A | Intraestromal Corneal Ring in Mild Keratoconus | January 10, 2015 | January 10, 2017 |
| NCT00347191 | Completed | Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. | January 2006 | June 2006 | |
| NCT06312163 | Completed | Validation of Innovative Scheimpflug Topography Derived RGP Contact Lens Designs In Optometry Network | June 6, 2022 | December 15, 2023 | |
| NCT06267495 | Completed | Epithelium-on Cross-linking Versus Observation of Fellow Eyes of Patients With Unilateral Clinically Evident Keratoconus | January 1, 2017 | January 31, 2024 | |
| NCT06243991 | Completed | The Effect Of High And Low Molecular Weight Sodium Hyaluronic Acid Eye Drops After Crosslinking | March 1, 2021 | February 1, 2023 | |
| NCT00409955 | Completed | Phase 2 | Lamellar Transplant With Lyophilized Corneas | December 2005 | December 2006 |
| NCT05756062 | Completed | N/A | Supplementation With a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients With Keratoconus | February 1, 2019 | January 10, 2022 |
| NCT05748847 | Completed | N/A | Pocket Versus Tunnel ICRS for Treatment of Keratoconus | June 1, 2019 | April 15, 2023 |
| NCT00584285 | Completed | Corneal Topographer Fluorescein Patterns | September 15, 2007 | September 14, 2009 | |
| NCT00626717 | Completed | Phase 2/Phase 3 | Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus | August 2007 | December 2012 |
| NCT03071302 | Completed | N/A | Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas | August 1, 2015 | December 31, 2016 |
| NCT03220529 | Completed | N/A | A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Cornea | November 2016 | September 2020 |
| NCT03091101 | Completed | N/A | Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus | March 15, 2017 | March 21, 2018 |
| NCT03184610 | Completed | Distinguishing Healthy and Keratoconic Eyes Using Ultrahigh-Resolution OCT | December 2014 | ||
| NCT01809977 | Completed | Phase 2 | Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus | July 2012 | December 2012 |
| NCT01843101 | Completed | Phase 2 | Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea With Optical Coherence Tomography (OCT) - A Pilot Study | March 14, 2014 | October 24, 2016 |
| NCT01845714 | Completed | N/A | Impact of Keratoconus, Cross-linking and Cross-linking Combined With Topo-guided Photorefractive Keratectomy on Self-reported Quality of Life. A Three-year Update. | April 2009 | October 2012 |
| NCT04532788 | Completed | N/A | Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking | March 1, 2021 | June 5, 2024 |
| NCT04517903 | Completed | N/A | Validation Study on Eye Rubbing Questionnaire in Patients With or Suspected of Having a Keratoconus (KC) | March 16, 2021 | October 13, 2021 |
| NCT04475900 | Completed | Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics | July 9, 2020 | July 31, 2022 | |
| NCT02008175 | Completed | N/A | Conventional Collagen Crosslinking in Young Keratoconus | January 2012 | November 2013 |
| NCT04457063 | Completed | Phase 2/Phase 3 | Endothelial Cell Loss After Penetrating Keratoplasty | July 1, 2018 | June 15, 2020 |
| NCT02023619 | Completed | Corneal Epithelial and Stromal Thickness Distribution in Keratoconus | July 2013 | September 2013 | |
| NCT04433936 | Completed | Corneal Tomographic Parameters in TGD | February 1, 2018 | June 1, 2018 | |
| NCT02119039 | Completed | Phase 4 | Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus | July 2014 | December 2015 |
| NCT04422080 | Completed | Retrospective Observational Study of Posterior Keratometry Measured | November 1, 2019 | June 3, 2020 | |
| NCT02173847 | Completed | N/A | Laser Assisted Procedures in Penetrating Keratoplasty | January 2011 | September 2013 |
| NCT02189447 | Completed | N/A | Photorefractive Keratectomy and Corneal Cross-linking in Keratoconus | January 2011 | September 2013 |
| NCT02208089 | Completed | N/A | Simultaneous TransPRK and Corneal Collagen Cross-Linking | August 2014 | July 2017 |
| NCT02301598 | Completed | N/A | Femtosecond Laser-assisted Anterior Lamellar Keratoplasty | January 2012 | September 2013 |
| NCT02349165 | Completed | N/A | Standard Versus Transepithelial Corneal Crosslinking | May 2011 | September 2014 |
| NCT02425150 | Completed | N/A | Treatment of Keratoconus With Advanced Corneal Crosslinking | October 2009 | October 2014 |
| NCT02428166 | Completed | Corneal Changes After Crosslinking in Keratoconus Patients Compared to the Untreated Fellow Eye | February 2015 | March 31, 2017 | |
| NCT02444923 | Completed | N/A | Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders | October 25, 2015 | January 29, 2019 |
| NCT02456961 | Completed | N/A | Standard Corneal Collagen Crosslinking Versus Transepithelial Corneal Crosslinking by Iontophoresis of Riboflavin | January 2010 | December 2014 |
| NCT04418999 | Completed | Early Phase 1 | Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus | September 1, 2020 | December 31, 2021 |
| NCT04392349 | Completed | N/A | Clinical Study - ES 900 - 2020-2 | July 1, 2020 | December 10, 2020 |
| NCT02485951 | Completed | N/A | Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty) | January 2014 | |
| NCT04383366 | Completed | Agreement and Accuracy of Different Devices Corneal Measurements | October 21, 2019 | February 6, 2020 | |
| NCT00347074 | Completed | A Clinical Study of Keratoconus in Asian Patients and Assessment of Different Topographic Patterns of Keratoconus in Asian Patients | September 2003 | March 2005 | |
| NCT04383301 | Completed | N/A | Combined Corneal Wavefront-guided TPRK and ACXL Following ICRS Implantation in Management of Moderate Keratoconus | October 1, 2018 | April 30, 2020 |
| NCT02590549 | Completed | N/A | MyoRing Implantation With Corneal Collagen Crosslinking for Keratoconus | January 2011 | December 2014 |
| NCT04177082 | Completed | Phase 1 | Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution | January 10, 2020 | May 5, 2022 |
| NCT02617368 | Completed | Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus | November 2014 | November 2015 | |
| NCT02625467 | Completed | Phase 1 | Treatment of Keratoconus With PALK Versus PK | June 2013 | November 2015 |
| NCT04174209 | Completed | N/A | CHOICE OF SUBJECTIVE OCULAR REFRACTION TECHNIQUE AND CORNEAL TOPOGRAPHY OF KERATOCONUS | November 18, 2019 | March 6, 2020 |
| NCT02698709 | Completed | Astigmatic Vector Analysis of Posterior Cornea - a Comparison Among Healthy, Forme Fruste and Overt Keratoconus Corneas | May 2015 | September 2015 | |
| NCT04062435 | Completed | N/A | Corneal Uptake of Riboflavin Eye Drops | December 1, 2019 | March 1, 2020 |
| NCT03990506 | Completed | N/A | Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus | April 2, 2019 | January 24, 2023 |
| NCT02806921 | Completed | N/A | Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes | August 2016 | February 15, 2018 |
| NCT02812563 | Completed | Familial Analysis of Keratoconus Risk | November 25, 2014 | September 19, 2017 | |
| NCT03753009 | Completed | Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric Patients. Three Year Follow up. | January 1, 2013 | June 30, 2015 | |
| NCT03661164 | Completed | Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients | May 1, 2013 | June 30, 2015 | |
| NCT02834260 | Completed | Phase 2 | Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study | January 10, 2017 | August 8, 2019 |
| NCT02849808 | Completed | Long Term Cornea Graft Survival Study | January 15, 2015 | August 3, 2017 | |
| NCT03647046 | Completed | N/A | Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus | October 8, 2018 | January 20, 2020 |
| NCT02861339 | Completed | N/A | Prevalence of Keratoconus in Inflammatory Bowel Diseases | February 2014 | July 2014 |
| NCT02875145 | Completed | Impact of Cataract Surgery on Keratoplasty Graft Survival | August 2014 | August 2015 | |
| NCT03598634 | Completed | N/A | Epi Off Versus Epi on Corneal Collagen Cross-linking in Keratoconus Patients | June 1, 2014 | December 31, 2017 |
| NCT02883881 | Completed | Correlation Between Eye Rubbing and Keratoconus Severity in a Treatment-naive Keratoconic Population | October 2015 | April 2016 | |
| NCT03531047 | Completed | N/A | Refractive Corneal Cross-linking for Progressive Keratoconus | November 1, 2018 | November 27, 2019 |
| NCT02891655 | Completed | KERatoconus and Metalloproteinases InvesTigation | December 2, 2016 | November 26, 2020 | |
| NCT03511495 | Completed | Reliability of Topography Measurements in Keratoconus | September 11, 2017 | March 31, 2019 | |
| NCT03462355 | Completed | Tobacco Smoking Among Crosslinked-keratoconus Patients | March 1, 2014 | January 30, 2018 | |
| NCT03288116 | Completed | Objective and Subjective Diagnostic Parameters in the Fellow Eye of Unilateral Keratoconus | January 2, 2014 | February 5, 2015 | |
| NCT02979054 | Completed | N/A | Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated Crosslinking | December 2016 | March 2018 |
| NCT03245853 | Completed | Phase 4 | Epi-On Corneal Crosslinking for Keratoconus | July 18, 2017 | September 30, 2019 |
| NCT03235856 | Completed | Retrospective Digital Computer Analysis of Keratoconus Evolution - REDCAKE | September 1, 2017 | December 31, 2018 | |
| NCT04598932 | Enrolling by invitation | Corneal Biomechanical Analysis Using Brillouin Microscopy | June 1, 2021 | December 2024 | |
| NCT06235567 | Enrolling by invitation | Phase 1/Phase 2 | Dextenza for Corneal Crosslinking | April 2024 | December 2024 |
| NCT04591587 | Enrolling by invitation | N/A | Corneal Lenticule Implantation in Keratoconus Disease With Relex Smile Surgery | January 1, 2018 | December 15, 2024 |
| NCT01384773 | No longer available | Progressive Keratoconus or Ectasia Treatment Plan | |||
| NCT03858036 | Not yet recruiting | Phase 3 | Corneal Collagen Cross-Linking (CXL) Performed With "Epi-ON" Versus "Epi-OFF" in Eyes With Keratoconus and Other Corneal Ectatic Disorders | March 8, 2019 | December 31, 2024 |
| NCT02512432 | Not yet recruiting | N/A | INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia | December 2025 | June 2029 |
| NCT04584125 | Not yet recruiting | N/A | A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used for Keratoplasty in Keratoconus Patients | December 1, 2023 | November 30, 2028 |
| NCT05134909 | Not yet recruiting | N/A | Customized Contact Lenses | November 2021 | December 2024 |
| NCT05345652 | Not yet recruiting | Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography | May 1, 2022 | September 29, 2024 | |
| NCT05395650 | Not yet recruiting | Cyanocobalamin as Photosensitizing Agent | September 1, 2023 | December 1, 2023 | |
| NCT05905978 | Not yet recruiting | N/A | Donors Predisposed by Corneal Collagen Cross-linking in Deep Lamellar Keratoplasty for the Patients With Keratoconus | June 2023 | July 2027 |
| NCT06288737 | Not yet recruiting | Assessing Patient Engagement in Keratoconus Clinical Research | March 2025 | March 2027 | |
| NCT02118922 | Recruiting | A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia | June 2013 | September 2026 | |
| NCT02138669 | Recruiting | N/A | Intacs Prescription Inserts for Keratoconus Patients | January 2011 | July 31, 2025 |
| NCT04251143 | Recruiting | Dresden Corneal Disease and Treatment Study | March 12, 2018 | December 31, 2030 | |
| NCT03115710 | Recruiting | The K-Map Study, Global Prevalence of KC | December 28, 2015 | February 1, 2025 | |
| NCT02921009 | Recruiting | N/A | McNeel Eye Center Corneal Crosslinking Study | September 2016 | December 2022 |
| NCT03504800 | Recruiting | OCT in Diagnosis of Irregular Corneas | May 1, 2018 | April 2026 | |
| NCT06159881 | Recruiting | N/A | Customized Crosslinking: Safety and Efficacy in an Epithelium-off Accelerated-pulsated Protocol for Thin Keratoconus | March 1, 2023 | May 15, 2024 |
| NCT06100952 | Recruiting | Phase 3 | Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus | November 1, 2023 | November 2025 |
| NCT03560609 | Recruiting | N/A | Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus | November 15, 2018 | July 31, 2024 |
| NCT06100939 | Recruiting | Phase 3 | Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus | October 30, 2023 | October 2025 |
| NCT00560651 | Recruiting | German Corneal Cross Linking Register | November 2007 | November 2027 | |
| NCT05693740 | Recruiting | N/A | Accelerated Corneal Collagen Crosslinking Protocols | August 1, 2022 | March 1, 2024 |
| NCT05676580 | Recruiting | N/A | Risk Factors and Progression of Keratoconus | June 5, 2023 | May 2028 |
| NCT03030755 | Recruiting | Corneal Elastography and Patient Specific Modeling | May 2016 | May 2024 | |
| NCT05516004 | Recruiting | Phase 2 | Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning | July 1, 2024 | June 1, 2034 |
| NCT06451718 | Recruiting | N/A | First in Human Study to Assess the Safety and the Efficacy of an Implantable Nitinol Device in the Treatment of Keratoconus | May 7, 2024 | December 2025 |
| NCT06264024 | Recruiting | N/A | Simultaneous pHototherapeutic Keratectomy and corneAl Collagen cRosslinking in Eyes With Keratoconus: a Randomized Trial (SHARK) | February 12, 2024 | February 1, 2034 |
| NCT03760432 | Recruiting | N/A | Collagen Cross-linking in Keratoconus | June 20, 2018 | December 2025 |
| NCT05027295 | Recruiting | Phase 3 | Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light | July 30, 2021 | July 2025 |
| NCT04918316 | Recruiting | N/A | Initial Correction Keratoconus | July 23, 2021 | June 2025 |
| NCT04905108 | Recruiting | Phase 3 | Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia | June 2, 2021 | December 2025 |
| NCT04897503 | Recruiting | Phase 3 | Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulose | April 16, 2021 | December 2025 |
| NCT03922542 | Recruiting | Phase 2/Phase 3 | Comparison of Standard vs. Accelerated Corneal Crosslinking | April 16, 2019 | May 1, 2026 |
| NCT03923101 | Recruiting | The Homburg Keratoconus Center (HKC) | January 1, 2011 | January 1, 2032 | |
| NCT03095235 | Recruiting | N/A | Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking | May 1, 2017 | July 1, 2025 |
| NCT04741230 | Recruiting | N/A | Investigator Initiated, Prospective Study of Xenia Corneal Lenticule | May 15, 2024 | April 1, 2026 |
| NCT04653922 | Recruiting | N/A | Evaluation of Safety and Efficacy of a Bioengineered Corneal Implant for Treatment of Keratoconus | November 2016 | July 31, 2024 |
| NCT04570020 | Recruiting | Scleral Lens Fitting Using Wide-Field OCT | September 23, 2020 | December 2026 | |
| NCT04094090 | Recruiting | Phase 2 | Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia | October 19, 2019 | December 19, 2024 |
| NCT04562064 | Recruiting | Pentacam Findings After Implantation of Intrastromal Corneal Rings in Keratoconus. | December 1, 2020 | November 2022 | |
| NCT04439552 | Recruiting | fMRI and IVCM Cornea Microscopy of CXL in Keratoconus | October 4, 2021 | December 2025 | |
| NCT01295164 | Terminated | N/A | Measurement of High Order Aberrations in Late Stages Keratoconus | October 2011 | November 2012 |
| NCT02857881 | Terminated | N/A | Corneal De-epithelization Associated With a Therapeutic Photokeratectomy in Patients With Evolutive Keratoconus | October 13, 2015 | February 7, 2019 |
| NCT02762253 | Terminated | Phase 2 | Study of the Safety and Effectiveness of Photochemically Induced Collagen Cross-Linking in Eyes With Keratoconus. | September 2012 | April 2016 |
| NCT04240457 | Terminated | Phase 2 | Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Conditions | July 8, 2020 | February 18, 2023 |
| NCT01972854 | Terminated | Phase 3 | Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus | November 2013 | April 2017 |
| NCT01956474 | Terminated | Phase 2 | CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas | January 2013 | February 3, 2017 |
| NCT01901614 | Terminated | N/A | OCT-guided LALAK for KCN | August 2013 | August 31, 2017 |
| NCT00384501 | Terminated | N/A | Management of Patients With Keratoconus With Intacs | January 2000 | July 2006 |
| NCT01682993 | Terminated | Phase 3 | Corneal Cross Linking and Topography Guided Excimer Laser Treatment | January 2010 | December 2015 |
| NCT01459679 | Terminated | Phase 3 | Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery | July 2012 | August 2016 |
| NCT01416272 | Terminated | N/A | Twelve Month Clinical Evaluation of KeraSoft IC Soft Contact Lenses | April 2011 | February 2013 |
| NCT04811924 | Terminated | Phase 2 | The Effect of Mitomycin C on Corneal Haze and Scarring After Corneal Crosslinking in Keratoconus Patients | July 26, 2021 | February 22, 2023 |
| NCT01190306 | Terminated | Phase 3 | Safety Study of the VEGA UV-A System to Treat Keratoconus | August 2010 | December 2011 |
| NCT01189864 | Terminated | Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas | February 1, 2010 | February 3, 2017 | |
| NCT01145937 | Terminated | N/A | PENTACON Trial: Partial ENdothelial Trepanation in Addition to Anterior Lamellar Keratoplasty in keratoCONus | March 2011 | May 2015 |
| NCT01097447 | Terminated | Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2) | December 1, 2009 | April 30, 2017 | |
| NCT01024322 | Terminated | Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas | October 1, 2009 | February 3, 2017 | |
| NCT03029104 | Terminated | Phase 2 | Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas | December 21, 2016 | December 27, 2020 |
| NCT04130334 | Unknown status | Phase 2/Phase 3 | Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refractive Outcomes in Patients With KCN | June 1, 2018 | March 1, 2020 |
| NCT03619434 | Unknown status | N/A | Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty | February 1, 2019 | December 26, 2021 |
| NCT00566605 | Unknown status | Phase 1 | Outcomes in a Comparison of Manual Penetrating Keratoplasty and the IntraLase® Enabled Keratoplasty | August 2007 | August 2008 |
| NCT02883478 | Unknown status | Phase 1/Phase 2 | Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL). | August 2012 | August 2016 |
| NCT04129021 | Unknown status | N/A | Multimodal Ophthalmic Imaging | July 15, 2019 | June 30, 2023 |
| NCT04092426 | Unknown status | Prevelance of Keratoconus | October 1, 2019 | October 1, 2021 | |
| NCT04578184 | Unknown status | N/A | Epithelial Thickness Map | October 15, 2020 | March 2021 |
| NCT00347230 | Unknown status | N/A | Intacs for Keratoconus | October 2005 | |
| NCT01869517 | Unknown status | Phase 2 | Myoring Versus Keraring Implantation for Keratoconus | May 2013 | |
| NCT02475343 | Unknown status | N/A | A Novel Method to Assess the Cornea Biomechanical Properties With Schiotz Tonometer | February 2015 | June 2016 |
| NCT02638376 | Unknown status | Phase 3 | Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus | March 2013 | June 2016 |
| NCT04430244 | Unknown status | N/A | Deep Anterior Lamellar Keratoplasty Using Dehydrated Versus Standard Organ Culture Stored Donor Corneas | June 17, 2020 | May 2023 |
| NCT04164407 | Unknown status | Keratoconus, Corneal Diseases and Transplant Registry | December 1, 2019 | December 30, 2021 | |
| NCT02009709 | Unknown status | Phase 1 | Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2 | October 2013 | |
| NCT01746823 | Unknown status | Identification and Validation of Functional Biomarkers for Keratoconus | April 2013 | December 2015 | |
| NCT03584243 | Unknown status | N/A | Transepithelial Corneal Collagen Crosslinking in Eyes With Progressive Keratoconus | December 21, 2017 | June 2019 |
| NCT02736877 | Unknown status | N/A | Corneal Transplantation Guided by OCT RESCAN | April 2016 | March 2017 |
| NCT02887326 | Unknown status | Keratoconus - Biomarkers and Questionnaire | November 2016 | March 2019 | |
| NCT02894489 | Unknown status | N/A | Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear | August 2016 | August 2019 |
| NCT01325298 | Unknown status | Phase 2 | UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia | March 2011 | May 2014 |
| NCT03249233 | Unknown status | N/A | Corneal Thickness Changes With Scleral Contact Lenses | June 22, 2017 | December 2020 |
| NCT04763785 | Unknown status | Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Images | May 11, 2021 | December 1, 2023 | |
| NCT00435799 | Unknown status | Phase 2/Phase 3 | Evaluating Collagen Cross-Linking (CCL) Treatment in Norway | February 2007 | January 2010 |
| NCT04820608 | Unknown status | N/A | Transepithelial Customized Cross-linking | February 1, 2018 | January 1, 2022 |
| NCT03450213 | Unknown status | N/A | Astigmatism in Keratoconus Patients | October 1, 2019 | October 1, 2021 |
| NCT03890718 | Unknown status | N/A | Topography Versus Non-Topography-Guided PRK With CXL in Keratoconus | March 30, 2017 | December 15, 2023 |
| NCT03879421 | Unknown status | N/A | Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking. | October 1, 2016 | May 30, 2019 |
| NCT00000155 | Unknown status | The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study | June 1995 | ||
| NCT03429569 | Unknown status | Phase 4 | Cross-Linking ACcéléré Iontophorèse Confocal kératocONE | August 12, 2015 | June 30, 2018 |
| NCT03760770 | Unknown status | N/A | Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients | February 1, 2018 | February 1, 2019 |
| NCT05055349 | Unknown status | N/A | Intrastromal Corneal Ring Segments and Toric Phakic Posterior Intra-ocular Lenses Implantation in Keratoconus | November 28, 2019 | November 22, 2021 |
| NCT03080077 | Unknown status | Phase 3 | Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia | June 2016 | June 2019 |
| NCT03229239 | Unknown status | N/A | Corneal Stroma Implantation for the Treatment of Keratoconus | August 11, 2017 | December 2018 |
| NCT05161052 | Unknown status | N/A | Assessment of Corneal Stiffness in Keratoconus After Crosslinking by Corvis ST and OCT. | January 1, 2022 | February 1, 2023 |
| NCT05176171 | Unknown status | N/A | Surface Ablation With Corneal Cross Linking in Mild Keratoconus | March 5, 2018 | July 5, 2023 |
| NCT01081561 | Unknown status | Phase 2/Phase 3 | Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs | January 21, 2009 | June 30, 2021 |
| NCT02932852 | Unknown status | Early Phase 1 | Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases | November 2015 | |
| NCT00371202 | Unknown status | Phase 3 | Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus | July 2006 | August 2006 |
| NCT03732599 | Unknown status | N/A | Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior Lamellar Keratoplaty (IE-DALK) | April 8, 2015 | May 31, 2021 |
| NCT00841386 | Unknown status | Phase 2/Phase 3 | Treatment of Keratoconus Using Collagen Cross-Linking | September 2008 | December 2011 |
| NCT02833649 | Unknown status | N/A | Comparative Analysis of the Visual Performance After TICL Implantation in Patients With Stable Keratoconus | December 2011 | December 2016 |
| NCT00816569 | Unknown status | N/A | Orthokeratology for Keratoconus | February 2009 | August 2009 |
| NCT00642044 | Unknown status | N/A | Corneal Collagen Crosslinking With Riboflavin for Keratoconus Treatment: A Brazilian Study | February 2007 | December 2009 |
| NCT04180111 | Unknown status | Cross Linking Corneal Biomechanical Evaluation of CATS Tonometer Prism | May 5, 2019 | December 30, 2019 | |
| NCT03637673 | Unknown status | The Possible Role of Thyroxine in Keratoconus Development | June 1, 2018 | September 15, 2018 | |
| NCT02613780 | Unknown status | Phase 3 | Refractive Treatment of Early Keratoconus | January 2016 | January 2019 |
| NCT04299399 | Unknown status | Corneal Biomechanical Changes of Allergic Conjunctivitis | November 10, 2019 | June 30, 2021 | |
| NCT04343326 | Unknown status | Phase 2/Phase 3 | The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressive Keratoconus. A Randomized Clinical Trial | January 1, 2020 | June 1, 2020 |
| NCT02514200 | Unknown status | Phase 2 | Treatment of Keratoconus With Advanced CXL-II | March 2014 | October 2019 |
| NCT02507362 | Unknown status | Phase 1/Phase 2 | Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus | August 2014 | February 2016 |
| NCT02476149 | Unknown status | Biomechanical Properties of Keratoconic Eyes | June 2015 | January 2020 | |
| NCT04401865 | Unknown status | Phase 1/Phase 2 | Safety and Effectiveness of the PXL-Platinum 330 System | June 1, 2020 | June 30, 2023 |
| NCT01789333 | Withdrawn | N/A | Higher Irradiance in Keratoconus Ectasia | September 1, 2010 | December 30, 2022 |
| NCT02827747 | Withdrawn | Phase 2 | The Role of Antioxidant Supplementation in Keratoconus Patients | August 1, 2021 | March 2023 |
| NCT04249180 | Withdrawn | Eye Rubbing and Keratoconus in Montpellier CHU | July 1, 2019 | July 1, 2020 | |
| NCT03990740 | Withdrawn | Myofibroblastic Transformation Secondary to Epithelial-stromal Interactions in the Keratoconus | November 1, 2019 | May 12, 2020 | |
| NCT05489510 | Withdrawn | Phase 1/Phase 2 | PXL-Platinum 330 in Eyes With Corneal Thinning Conditions | August 15, 2023 | December 31, 2031 |
- Disase is a (Disease Ontology)
- DOID:10124
- Cross Reference ID (Disease Ontology)
- GARD:6824
- Cross Reference ID (Disease Ontology)
- ICD10CM:H18.6
- Cross Reference ID (Disease Ontology)
- ICD9CM:371.6
- Cross Reference ID (Disease Ontology)
- MESH:D007640
- Cross Reference ID (Disease Ontology)
- MIM:148300
- Cross Reference ID (Disease Ontology)
- MIM:608586
- Cross Reference ID (Disease Ontology)
- MIM:608932
- Cross Reference ID (Disease Ontology)
- MIM:609271
- Cross Reference ID (Disease Ontology)
- MIM:614622
- Cross Reference ID (Disease Ontology)
- MIM:614623
- Cross Reference ID (Disease Ontology)
- MIM:614628
- Cross Reference ID (Disease Ontology)
- MIM:614629
- Cross Reference ID (Disease Ontology)
- NCI:C26806
- Cross Reference ID (Disease Ontology)
- ORDO:156071
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:267733008
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0022578
- Exact Synonym (Disease Ontology)
- conical cornea
- HPO Human Phenotype ID (Human Phenotype Ontology)
- HP:0000563
- OMIM Phenotype Series Number (OMIM)
- PS148300
- ICD10 preferred id (Insert disease from ICD10)
- D0006079
- ICD10 class code (Insert disease from ICD10)
- H18.6
- MeSH unique ID (MeSH (Medical Subject Headings))
- D007640