dry eye syndrome

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Information
Disease name
dry eye syndrome
Disease ID
DOID:10140
Description
"A lacrimal apparatus disease that is characterized by persistent irritation or burning of the coreneal surface." [url:https\://pubmed.ncbi.nlm.nih.gov/29498987/]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
NCT ID Status Phase Summary Start date Completion date
NCT01579539 Completed Phase 3 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy June 27, 2013 May 18, 2017
NCT02974907 Completed Phase 3 Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2 November 2016 March 2018
NCT03066219 Completed Phase 2 Safety and Efficacy of BRM421 for Dry Eye Syndrome February 7, 2017 June 28, 2017
NCT03074344 Completed N/A Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye May 2016 November 2016
NCT03085290 Completed N/A Allogeneic Versus Autologous Serum Eye Drops June 26, 2017 October 8, 2018
NCT03088605 Completed Phase 2 Safety and Efficacy of TOP1630 for Dry Eye Syndrome February 20, 2017 June 15, 2017
NCT03223909 Completed Phase 4 Efficacy and Safety of the Ophthalmic Solution PRO-087 Versus Systane ® Ultra and Ultra Preservative Free (087LATAMFIV) October 13, 2016 December 16, 2018
NCT03364322 Completed Influencing Factors on Dry Eye Syndrome and Ocular Surface Disease June 1, 2016 June 30, 2017
NCT03396913 Completed N/A Effectiveness of Intense Pulsed Light for Improving Dry Eye Syndrome January 10, 2018 August 15, 2019
NCT03404115 Completed Phase 2 A Multi-Center, Randomized, Double Masked, Parallel-Group, Vehicle-Controlled, Clinical Study to Assess the Safety and Efficacy of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease January 2, 2018 July 11, 2018
NCT03461575 Completed Phase 3 Efficacy and Safety of HU007 Eye Drops in Patients With Dry Eye Syndrome January 22, 2018 July 12, 2018
NCT03569202 Completed N/A Piiloset Trehalose Emulsion Eye Drop Study in Moderate or Severe Dry Eye May 21, 2018 November 8, 2018
NCT03576300 Completed Comparison of Ocular Surface Features in Patients With Diabetes and Dry Eye Syndrome February 1, 2018 August 1, 2018
NCT03622619 Completed N/A The Effect of Manuka Eye Drops on Tear Film Properties August 13, 2018 October 30, 2018
NCT03666884 Completed Phase 4 The Comparison of 50% AS Versus PFAT+ 0.05 % COE in Severe Dry Eye Syndrome October 10, 2015 October 25, 2016
NCT03723798 Completed Phase 2 Clinical Study to Investigate the Efficacy and Safety of Orally Administered SA001 in Patients With Dry Eye Syndrome. November 8, 2017 October 8, 2018
NCT03764735 Completed Phase 3 Study of SkQ1 as Treatment for Dry-eye Syndrome December 6, 2018 February 9, 2019
NCT03830359 Completed N/A Efficacy, Safety of T2769 in Dry Eye Disease September 1, 2018 February 18, 2019
NCT03833388 Completed Phase 2/Phase 3 Study of TOP1630 for Dry Eye Syndrome February 13, 2019 May 14, 2019
NCT03923244 Completed N/A Dry Eye Syndrome Description During Cataract Surgery, With Multimodal Analysis of the Ocular Surface April 1, 2019 March 6, 2020
NCT03982368 Completed Phase 2 A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe Dry Eye June 10, 2019 July 15, 2020
NCT04030962 Completed Phase 2 A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease March 4, 2020 March 18, 2022
NCT04139122 Completed Phase 1/Phase 2 Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease October 5, 2019 March 3, 2020
NCT04147650 Completed Phase 2/Phase 3 Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye Syndrome October 14, 2019 October 8, 2020
NCT04206020 Completed Phase 3 Vehicle-Controlled Study of SkQ1 as Treatment for Dry-eye Syndrome December 20, 2019 October 6, 2020
NCT04343287 Completed Phase 2/Phase 3 Safety and Efficacy of BRM421 for Dry Eye Syndrome Treatment January 15, 2020 June 23, 2020
NCT04938908 Completed Phase 2 Probiotic in Dry Eye Syndromes July 1, 2021 July 30, 2022
NCT05136170 Completed Phase 3 Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease January 27, 2022 May 24, 2023
NCT05656196 Completed N/A VGH-DESJS-1 in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome and Sjögren's Syndrome April 1, 2023 December 31, 2023
NCT05878067 Completed Phase 3 A Study to Assess Symptom Relief and Product Tolerability of ABBV-444 Drops in Adult Participants June 27, 2023 October 6, 2023
NCT06288945 Completed N/A Effect of an Educational Program on Health-related Outcomes of Patients With Dry Eye Syndrome January 15, 2023 September 14, 2023
NCT00442273 Completed N/A Comparison of Autologous Serum and Umbilical Cord Serum Eyedrops for Dry Eye Syndrome
NCT00514852 Completed N/A Safety and Efficacy of an Artificial Tear for the Treatment of Dry Eye October 2007 January 2008
NCT00522600 Completed Eye Drop Use in Glaucoma Patients Through Patient Surveys and Video Observations February 2007 July 2007
NCT00535054 Completed N/A Study to Assess the Safety and Patients' Satisfaction of Tears Again* in the Treatment of Dry Eye Symptoms September 2007 February 2010
NCT00544713 Completed N/A Evaluate the Safety and Efficacy of a New Artificial Tear for Use After LASIK Surgery September 2007 June 2008
NCT00565669 Completed N/A Evaluation of Blink Tears and Systane Concomitant With Restasis for the Treatment of Dry Eye Symptoms October 2007 October 2008
NCT00735865 Completed N/A Lid Margin And Conjunctival Microbial Flora Following Punctum Occlusion July 2003 May 2009
NCT00765804 Completed Phase 2 Safety and Efficacy Study of Iontophoresis and Dexamethasone Phosphate to Treat Dry Eye October 2008 February 2009
NCT00799552 Completed Phase 2 Safety and Efficacy Study of RX-10045 on the Signs and Symptoms of Dry Eye November 2008 June 2009
NCT00818909 Completed Phase 4 Systane Clinical Experience Study January 2009 October 2009
NCT00893243 Completed Efficacy Comparative Study Between Tears Again®, Opticol® and Optive®
NCT00932477 Completed N/A Safety and Tolerability of Artificial Tears in Dry Eye Subjects August 2009 September 2009
NCT00991679 Completed CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome February 2008 December 2008
NCT01010282 Completed N/A Safety and Efficacy of Two Artificial Tears in Dry Eye Subjects November 2009 April 2010
NCT01013077 Completed N/A The Effect of a New Emulsion in Dry Eye Patients on Tear Layer Aberrometry, Contrast Sensitivity, and Reading Ability November 2009 August 2011
NCT01107964 Completed N/A Oral Omega-3 Fatty Acids in the Treatment of Dry Eye Syndrome July 2010 June 15, 2015
NCT01162954 Completed Phase 1 Phase I Study to Evaluate the Tolerability of Eye Drop DA-6034 in Healthy Volunteers September 2008 March 2009
NCT01163643 Completed Phase 2 Study to Assess the Safety and Efficacy of BOL-303242-X Ophthalmic Suspension in Dry Eye Syndrome July 2010 July 2011
NCT01198782 Completed Phase 4 Evaluating Safety and Efficacy of FID 112903 Post Discontinuation of Long-term Use of RESTASIS® (Cyclosporine Ophthalmic Emulsion) 0.05% September 2010 May 2011
NCT01212471 Completed Phase 3 A Dose Ranging Study to Evaluate Safety and Efficacy of Bromfenac Ophthalmic Solution in Dry Eye Disease September 2010 December 2011
NCT01223040 Completed N/A An Open-Label, Single-Center Study Evaluating the Effect of Systane Balance on Video Ocular Protection Index (OPI) and Blink Patterns in Patients Diagnosed With Dry Eye August 2010
NCT01252121 Completed N/A Residence Time Evaluation of Systane Ultra Lubricant Eye Drops vs. Hialid and Saline October 2010 June 2011
NCT01339936 Completed Phase 2/Phase 3 Evaluation of the Effect of Repeated Usage on the Tear Film Characteristics of an Investigational Eye Drop in Dry Eye Sufferers March 2011 May 2012
NCT01382225 Completed Phase 3 Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome July 2011 May 2012
NCT01387347 Completed Phase 2 Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry Eye August 2011 December 2011
NCT01483989 Completed N/A In Vivo Measurement of Corneal Epithelial Changes in Dry Eye Patients February 2011 June 2011
NCT01541891 Completed Phase 2 Efficacy and Safety of PRO-148 Ophthalmic Solution Versus SYSTANE® in the Treatment of Patients With Dry Eye Syndrome October 2011 May 2012
NCT00344721 Completed N/A A Placebo Controlled Double Masked Clinical Assessment Study of Essential Fatty Acid Supplement and Its Effect on Patients With Apparent Aqueous Deficient Dry Eye Syndrome September 2004 October 2008
NCT01614600 Completed N/A Clinical Evaluation of a Daily Disposable Contact Lens in Symptomatic Weekly/Monthly Lens Wearers June 2012 September 2012
NCT01632137 Completed Phase 3 Efficacy and Safety of Rebamipide in Subjects With Dry Eye Syndrome June 2012
NCT01670357 Completed Phase 2 Phase II Study of DA-6034 Eye Drops in Dry Eye Syndrome April 2012 March 2013
NCT01675570 Completed Phase 2 A Study of RX-10045 in the Treatment of Dry Eye Disease August 2012 November 2012
NCT01688726 Completed N/A Evaluation of SYSTANE® BALANCE in Dry Eye Subjects With Lipid Deficiency December 2012 November 2013
NCT01733732 Completed N/A SYSTANE® BALANCE Symptoms (OSDI) & Inflammatory Biomarkers March 2013 October 2013
NCT01733745 Completed N/A SYSTANE® Family - Meibomian Deficiency February 2013 June 2013
NCT01744457 Completed N/A Reproducibility of Tearfilm Osmolarity Measurements Using TearLab® in Patients With Dry Eye Syndrome and Healthy Subjects February 2011 June 2012
NCT01745887 Completed Phase 1 A Multi-Center Study Subjects With Dry Eye Syndrome November 2012 November 2012
NCT01747616 Completed Phase 1 Assessment of Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Subjects While Wearing Contact Lenses and Before Insertion of Contact Lenses July 2011 December 2012
NCT01753687 Completed N/A Correlation of Different Signs for Assessment of Dry Eye Syndrome September 2011 September 2013
NCT01753752 Completed Phase 2 Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation September 2012 March 2013
NCT01776658 Completed Phase 1/Phase 2 Pilot Study to Evaluate SYL1001 Safety and Effect in Patients With Ocular Pain November 2012
NCT01797822 Completed Phase 4 Effects of Dry Eye Treatments on the Ocular Surface February 2013 December 2015
NCT01808560 Completed N/A Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery March 2013 January 2015
NCT01850979 Completed Phase 4 Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops February 2010 November 2011
NCT01863368 Completed N/A Clinical Evaluation of Systane® ULTRA Compared to OPTIVE® in Ocular Surface Staining September 2013 June 2014
NCT01864330 Completed Phase 4 Influence of Lachrymal Substitutes on Tear Film Thickness in Patients With Moderate Dry Eye Syndrome May 2013 September 2013
NCT01942226 Completed Investigation on Medical Management of Dry Eye Patients August 2013 December 2013
NCT01970917 Completed Phase 4 Effect of Olixia Pure® Eye Drops on Tear Film Thickness in Healthy Subjects October 2013 November 2013
NCT02023268 Completed Phase 3 Efficacy and Safety of T2762 and Vismed® in Dry Eye Syndrome December 2013 February 2015
NCT02066051 Completed N/A IPL and Meibomian Gland Expression to Treat Ocular Rosacea Ocular GVHD October 2013 November 2014
NCT02078661 Completed Phase 1/Phase 2 Safety and Efficacy of PG101 for Dry Eye Syndrome December 2013 January 2014
NCT02092207 Completed Phase 2 Phase 2 Study to Evaluation the Safety and Efficacy of Orally Administered KL7016 in Patients With Dry Eye Syndrome October 2012 July 2014
NCT02100787 Completed N/A Changes in Tear Osmolarity Over Time With Sustained Use of TheraTears April 10, 2014 June 30, 2016
NCT02101281 Completed Phase 2 Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye January 20, 2014 January 2015
NCT02315079 Completed Point of Care Testing of Inflammatory Markers in Tears January 2015 January 2017
NCT02326090 Completed Phase 2 Phase 2 Study With Cis-UCA Ophthalmic Solutions in Subjects With Dry Eye December 2014 April 2015
NCT02369861 Completed Phase 1 Study of ST266 Eye Drops in Treating Dry Eye March 2015 December 2015
NCT02376556 Completed The Effect of Eyelid Surgery on Dry Eye - a Prospective Study March 2015 March 2018
NCT02446015 Completed N/A Clinical Evaluation Following Use of SYSTANE® ULTRA in the Management of Dry Eye June 19, 2015 June 21, 2016
NCT02455999 Completed Phase 2 Dose-finding Study to Assess the Safety and Effect of SYL1001 in Patients With Ocular Pain June 2015
NCT02492412 Completed Phase 3 Efficacy and Safety of HE10 for Dry Eye Syndrome May 2013 September 2014
NCT02507934 Completed N/A Tolerability, Safety and Efficacy of Lubricin (150 µg/ml) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops in Patients With Moderate Dry Eye (DE) June 2015 September 2015
NCT02510235 Completed N/A Tolerability, Safety and Efficacy of Lubricin Eye Drops vs Sodium Hyaluronate Eye Drops in Subjects With Mod. Dry Eye March 2015 June 2015
NCT02522312 Completed A Retrospective Analysis of Restasis® Benefits in Dry Eye Contact Lens Patients September 2015 December 2015
NCT02597803 Completed Phase 2/Phase 3 Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-1 September 2015 July 2016
NCT02645045 Completed Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness December 11, 2015 February 10, 2016
NCT02680158 Completed N/A A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye Syndrome January 31, 2016 March 31, 2016
NCT02715323 Completed Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome May 2016 November 2019
NCT02758327 Completed Phase 4 Evaluation of Tear Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Drops October 2015 March 2016
NCT02798289 Completed N/A Acute Tear Production Following Single Use of the Oculeve Intranasal Neurostimulator June 2016 August 2016
NCT02917512 Completed Phase 2 Efficacy and Safety Study of HU00701/HU007 Eye Drops in Patients With Dry Eye Syndrome March 2016 December 2016
NCT02958514 Completed N/A Efficacy Comparison of Two Kinds of Treatment in Treating Dry Eye Caused by Meibomian Gland Dysfunction November 2016 March 2017
NCT06240364 Not yet recruiting N/A Effects of AffronEye®/ Crocuvis+® on Dry Eye Syndrome October 10, 2024 April 30, 2025
NCT03938207 Not yet recruiting Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank October 1, 2022 December 31, 2027
NCT06375499 Not yet recruiting N/A Comparison of the Performance and Safety of T2769 Versus Hylo-Forte® in the Treatment of Moderate to Severe Dry Eye Syndrome. August 1, 2024 April 28, 2025
NCT06172530 Recruiting Observational Study on the Improvement of Dry Eye Syndrome, Treatment Satisfaction, and Intraocular Tolerance With Diquasol Eye Drops February 8, 2023 December 2024
NCT04747288 Recruiting Objective Measurement With TCM Pattern for AIDDES February 1, 2021 December 31, 2024
NCT06190028 Recruiting N/A Evaluation of Performance and Safety of Carbopol 980 NF 0.2%- Based Medical Device in the Management of Patients With Glaucomar or Ocular Hypertension and Concomitant Dry Eye Syndrome on Multiple Long-term Topical Hypotensive Therapy June 14, 2023 December 2024
NCT04198740 Recruiting Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface February 1, 2020 January 2035
NCT04877483 Recruiting N/A To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome December 6, 2022 December 31, 2024
NCT02617095 Terminated N/A Comparison of the Efficacy and Safety of T2762 Versus Optive® in the Treatment of Moderate to Severe Dry Eye Syndrome February 2015 October 2016
NCT03803722 Terminated N/A To Demonstrate the Non-inferiority of Eyestil Protection® Compared to Vismed® in Terms of Clinical Performance July 8, 2019 June 30, 2020
NCT01228929 Terminated N/A Non-invasive Ocular Surface Measurements Before and After Interventions July 2010 January 2014
NCT05245604 Unknown status Phase 3 Evaluating the Efficacy and Safety of TJO-087 in Moderate to Severe Dry Eye Disease Patients June 19, 2020 April 2023
NCT01561040 Unknown status Phase 4 Oral Nutrition Impact on Tear Film March 2012 December 2012
NCT02849093 Unknown status Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. June 2016 December 2017
NCT03652415 Unknown status DRy Eye Outcome and Prescription Study August 23, 2018 August 23, 2021
NCT04711642 Unknown status Phase 3 Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery January 15, 2021 July 15, 2023
NCT03162094 Unknown status Phase 1/Phase 2 Assessing the Safety and Efficacy of AVX-012 in Subjects With Mild-to-moderate Dry Eye Syndrome April 3, 2017 December 2018
NCT03403023 Unknown status N/A Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy January 30, 2018 December 30, 2018
NCT04884217 Unknown status Phase 2 Treatment of Dry Eye Disease Using Pro-ocular™ - A Proof of Concept, Safety, and Efficacy Study May 20, 2021 December 30, 2021
NCT04025801 Unknown status Heidelberg In Vivo Confocal Microscopy to Evaluate the Ocular Surface Disorders of Healthy and Diseased Individuals July 31, 2019 June 2020
NCT03464357 Unknown status N/A Functional MRI Study of Cortical Modifications to Light Stimulation in Patients With Photophobia March 13, 2018 March 2019
NCT03539159 Unknown status N/A Assessment of the Mu-Drop System for Serum Eye Drops December 6, 2018 February 1, 2020
NCT02774707 Unknown status Comparing the Quality of Topical Autologous Serum in Different Etiologies of Dry Eye Syndrome January 2016 January 2017
NCT02777723 Unknown status Phase 3 Study to Evaluate the Efficacy and Safety of CKD-350 May 2016 September 2016
NCT01917539 Withdrawn N/A Efficacy of Pulsed Light Therapy for Meibomian Gland Dysfunction and Dry Eye Syndrome June 2013 May 2015
NCT00812721 Withdrawn N/A Tears Substitutions and Their Effects on Higher Order Aberrometery January 2009 July 2009
NCT01957670 Withdrawn N/A Pilot Study to Clinical Evaluate Device Prototypes in Dry Eye Patients February 2014 April 2016
NCT00355459 Withdrawn N/A A Prospective Clinical Study Assessing the Effects of Tetracycline Antibiotic on Tear Film and Tear Lipid Composition Within a Population of Patients Diagnosed With Blepharitis and Dry Eye Disease August 2005 April 2007
NCT01753596 Withdrawn Phase 3 Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease December 2014 February 2015
NCT03937271 Withdrawn Objective Measurement Methods for Autoimmune Disease and Dry Eye Syndrome April 1, 2019 December 31, 2020
Disase is a (Disease Ontology)
DOID:1400
Cross Reference ID (Disease Ontology)
ICD10CM:H04.12
Cross Reference ID (Disease Ontology)
MESH:D015352
Cross Reference ID (Disease Ontology)
NCI:C34553
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:193980001
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0013238
Exact Synonym (Disease Ontology)
dry eye disease
Exact Synonym (Disease Ontology)
Tear film insufficiency
MedGen concept unique identifier (MedGen Concept name)
C0013238
MedGen unique identifier (MedGen Concept name)
4411