intellectual disability

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Information
Disease name
intellectual disability
Disease ID
DOID:1059
Description
"A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills." [url:http\://aaidd.org/intellectual-disability/definition#.WsPDT2VvqaU, url:https\://en.wikipedia.org/wiki/Intellectual_disability]
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
WDR35 2 19,910,263 19,990,105 8
SZT2 1 43,389,899 43,454,247 8
SETD1B 12 121,804,009 121,832,656 8
KDM5C X 53,192,158 53,225,207 4
AGO1 1 35,883,209 35,930,532 4
NFIX 19 13,024,581 13,094,755 4
NALCN 13 101,053,815 101,416,447 4
CSNK2B 6 31,666,355 31,670,070 4
STARD9 15 42,575,606 42,720,998 4
POGZ 1 151,404,802 151,459,155 4
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT05451238 Active, not recruiting A Computerized Testing System for Measuring Motor and Sensory Integrative Functions in Children August 1, 2020 December 31, 2022
NCT04337697 Active, not recruiting Neonatal Seizure Registry - Developmental Functional EValuation March 15, 2020 September 29, 2024
NCT04154891 Active, not recruiting N/A Genome Sequencing Strategies for Genetics Diagnosis of Patients With Intellectual Disability March 13, 2020 December 2024
NCT05940168 Active, not recruiting N/A Internet-delivered ACT (I-Navigator ACT) for Parents of Children With Disabilities February 1, 2021 November 30, 2023
NCT05851937 Active, not recruiting N/A Written Language Intervention for Adults With Intellectual and Developmental Disabilities May 1, 2023 December 31, 2024
NCT05336487 Active, not recruiting N/A Physical Activity, Sports and Health in Adults With Intellectual Disabilities August 1, 2019 December 31, 2022
NCT06199362 Active, not recruiting Early Life Anemia and Children's Risk of Neurodevelopmental Disorders: National and Regional Register-based Studies August 15, 2023 December 2024
NCT04529226 Active, not recruiting Phase 2 Study to Compare Clozapine vs Treatment as Usual in People With Intellectual Disability & Treatment-resistant Psychosis November 26, 2020 December 30, 2025
NCT03548779 Active, not recruiting N/A North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 September 28, 2018 September 8, 2024
NCT02504502 Completed N/A Enhancing Genomic Laboratory Reports to Enhance Communication and Empower Patients August 2015 January 1, 2017
NCT02513277 Completed Diabetes Screening & Prevention for People With Learning (Intellectual) Disabilities:STOP Diabetes Study February 2013 September 2015
NCT02561754 Completed N/A Weight Management for Adolescents With IDD March 2015 May 5, 2021
NCT02591446 Completed Transcranial Magnetic Stimulation Studies in Autism Spectrum Disorders October 2014 August 7, 2017
NCT02616796 Completed Phase 1/Phase 2 Effects of Social Gaze Training on Brain and Behavior in Fragile X Syndrome April 2015 December 2020
NCT02714868 Completed N/A Evaluation of Project TEAM (Teens Making Environmental and Activity Modifications) October 2012 July 31, 2017
NCT02746614 Completed N/A Psychomotor Therapy Effects in Adaptive Behavior and Motor Proficiency in Intellectual Disability September 2014 March 2016
NCT02836405 Completed TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders May 2015 July 2020
NCT02889068 Completed Targeted Next Generation Sequencing and Intellectual Disability July 2015 January 30, 2017
NCT02919826 Completed N/A Dialectical Behaviour Group Therapy for Adults With Intellectual Disabilities August 2016 March 2018
NCT03135236 Completed N/A Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome March 6, 2017 June 1, 2018
NCT03139760 Completed N/A POWERSforID: A Telehealth Weight Management System for Adults With Intellectual Disability September 2016 October 2018
NCT03203226 Completed N/A The Feldenkrais Method for People With Intellectual Disability January 1, 2016 January 30, 2017
NCT03212092 Completed N/A Reducing Aggression Among People With an Intellectual Disability January 15, 2018 March 1, 2021
NCT03218462 Completed N/A Effect of Sensory Adapted Dental Environment on Dental Anxiety of Children With Intellectual and Developmental Disabilities July 10, 2017 March 30, 2018
NCT01695395 Completed Mental Health Care Provision for Adults With Intellectual Disability and a Mental Disorder February 2012 July 2014
NCT01915381 Completed N/A Improving Adherence Healthy Lifestyle With a Smartphone Application Based on Adults With Intellectual Disabilities March 2013 December 2017
NCT02099773 Completed Support Staff-client Interactions With Augmentative and Alternative Communication March 2014 May 2017
NCT02225041 Completed Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood August 2014 December 2018
NCT02270736 Completed Phase 3 Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability February 9, 2015 May 7, 2019
NCT02304302 Completed Phase 2 Down Syndrome Memantine Follow-up Study October 2014 July 22, 2020
NCT02414438 Completed N/A Establishing the Clinical Utility of First StepDx PLUS and NextStepDx PLUS Study August 2014 January 2015
NCT02451761 Completed Apparently Balanced Chromosomal Translocation/ Next-generation Sequencing/ Intellectual Disability April 2015 February 2017
NCT02486081 Completed Development and Application-Smart Football for Movement Evaluation and Training in the Special Education Population April 2016 May 2019
NCT03426059 Completed Mapping the Phenotype in Adults With Phelan-McDermid Syndrome May 22, 2018 December 31, 2020
NCT03479476 Completed Phase 2/Phase 3 A Trial of Metformin in Individuals With Fragile X Syndrome April 30, 2018 May 1, 2024
NCT03501914 Completed N/A A Pilot Trial of Mindfulness Based Intervention Program for People With Intellectual Disabilities in a Low Income Setting April 25, 2018 January 25, 2019
NCT03522337 Completed N/A Oral Health Promotion Among Preschool Children With Special Needs April 12, 2016 September 30, 2018
NCT03525431 Completed N/A Clinical Utility of Pediatric Whole Exome Sequencing August 1, 2017 May 13, 2022
NCT03558815 Completed Psychotropic Medication and Psychotherapeutic Treatment of Adults With Intellectual Disabilities May 1, 2017 May 31, 2019
NCT03586375 Completed Intensive Support Teams Study August 31, 2018 April 30, 2021
NCT03683706 Completed N/A Learning Through Play (LTP) in My Own Way Plus CBT March 15, 2019 October 8, 2020
NCT03684512 Completed N/A Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities January 7, 2019 October 28, 2022
NCT03722212 Completed N/A Early Diagnosis of the GLUT1 Deficiency Syndrome With a Blood Based Test September 24, 2018 July 9, 2021
NCT03989388 Completed N/A Occupational Self-Analysis Programme October 2014 July 2016
NCT04020302 Completed N/A Self-Monitoring Shopping Intervention September 6, 2019 December 20, 2019
NCT04102683 Completed N/A The Effects of Therapeutic Recreation Activities on Emotional Adjustment of Individuals With Intellectual Disabilities March 4, 2019 May 20, 2019
NCT04158960 Completed N/A Motor Skill Proficiency After Equine-assisted Activities and Brain-building Tasks February 1, 2015 May 31, 2018
NCT04182347 Completed N/A Research Engagement With People With Intellectual and Developmental Disabilities January 1, 2020 October 31, 2020
NCT04250701 Completed Postural Control, Grip Strength and Body Posture in Children With Intellectual Disability and Dyslexia February 15, 2017 June 26, 2018
NCT04254666 Completed N/A New Skills - No Scores Research Study January 24, 2020 August 1, 2022
NCT04277130 Completed N/A Effectiveness of Active Video Games in Children With Intellectual Disabilities September 1, 2016 August 31, 2018
NCT04436692 Completed N/A Dietary Intervention and Adults With Intellectual Disabilities September 1, 2020 December 31, 2023
NCT04518358 Completed N/A Expert Guiding Technology to Help Individuals With Developmental Challenges Build Life and Vocational Skills September 1, 2019 August 31, 2022
NCT04546464 Completed N/A The Effects of Therapeutic Recreation Activities on Aberrant Behaviours of Individuals With Intellectual Disabilities May 1, 2019 June 30, 2019
NCT04554355 Completed N/A Effects of a PA Intervention for Fatness and Fitness in Adolescents With Intellectual Disability September 1, 2018 June 30, 2019
NCT04557488 Completed N/A Effectiveness of Music Therapy in Social Skill Intervention for Children With ASD/ID October 1, 2020 February 28, 2023
NCT04565509 Completed N/A Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic November 20, 2020 March 29, 2024
NCT04616638 Completed N/A Effects of Guided Exercise on Functional Performance and Independence in Adults With Intellectual Disability January 17, 2018 July 31, 2019
NCT04728074 Completed N/A Effects of Vocational Rehabilitation Group Intervention on Motivation and Occupational Self-Awareness in Individuals With Intellectual Disabilities February 6, 2020 May 12, 2020
NCT04769011 Completed N/A Motor Impairments in Children With Autism Spectrum Disorder: a Multimodal Approach January 2, 2018 December 31, 2023
NCT04790461 Completed N/A The Quality of Life, Perceived Stress and Coping Ways of Caregivers of Mentally Handicapped Individuals November 25, 2020 January 30, 2022
NCT04917666 Completed N/A Process and Outcomes of Horticultural Therapy for People With Disabilities September 1, 2019 January 29, 2021
NCT04929106 Completed N/A Physical Activity, mHealth and Intellectual Disability - a Pilot Study May 7, 2021 June 1, 2022
NCT04962659 Completed N/A Telehealth Mindfulness-Based Music and Songwriting for Parents of Children With Intellectual/Developmental Disabilities June 29, 2021 August 16, 2022
NCT05149443 Completed N/A Move it, Move ID! Promotion of Physical Activity in Adolescents With Intellectual Disability January 1, 2022 October 10, 2023
NCT05193890 Completed Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte June 1, 2019 May 31, 2021
NCT05334498 Completed N/A Motor and Cognitive Dual-task Gait Training Effect Functional Outcome in Intellectual Disability August 1, 2021 January 1, 2022
NCT05339191 Completed N/A Compassionate Imagery for People With An Intellectual Disability July 1, 2020 April 30, 2021
NCT05451459 Completed N/A Fit Families Multisite April 20, 2022 August 26, 2022
NCT05472571 Completed N/A Pilot Project of Forest Bathing for Promoting Health May 1, 2021 March 15, 2022
NCT05587647 Completed N/A The Effect of Transition to Adulthood Education Program on Family Quality of Life and Perceived Stress Level January 1, 2023 September 1, 2023
NCT05822596 Completed N/A Tablet-based Interactive Games in Elderly With Cognitive Impairment and Persons With Intellectual Disability June 12, 2023 November 10, 2023
NCT06097819 Completed N/A Therapy-Based Games' Effects on Motor and Cognitive Skills in Intellectual Disabilities September 1, 2023 February 10, 2024
NCT06317506 Completed Methylation Pattern and Pain Sensation in Children With Intellectual Disability May 30, 2022 October 10, 2023
NCT02914951 Enrolling by invitation N/A Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability October 2016 December 2024
NCT05301361 Enrolling by invitation Phase 1 Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities February 1, 2023 September 29, 2026
NCT06291532 Enrolling by invitation N/A Feasibility and Usability of a Virtual Reality System April 1, 2023 September 30, 2025
NCT05473377 Not yet recruiting Computerized Testing System for Measuring Motor and Sensory Integrative Functions in Intellectual Disabilities January 1, 2024 December 31, 2024
NCT06063239 Not yet recruiting N/A Probiotics in Special Needs Patients at High Risk for Tooth Decay: a Randomized Controlled Trial. October 1, 2023 May 1, 2024
NCT06107829 Not yet recruiting Phase 4 Valbenazine Treatment of Tardive Dyskinesia in Adults With Intellectual/Developmental Disabilities August 2024 August 2026
NCT06403969 Not yet recruiting N/A Sleep in Children With Autism and Intellectual Disability May 14, 2024 June 30, 2026
NCT06392113 Not yet recruiting Developing a Falls Management Tool for Adults With ID-POC July 2024 January 2025
NCT06444659 Not yet recruiting N/A Effects of Adaptive Physical Activity on Health-related Fitness of Students With Intellectual Disabilitiesdisability June 2024 December 2024
NCT05935722 Recruiting N/A Evaluation of a Home-based Parenting Support Program: Parenting Young Children September 8, 2022 June 30, 2025
NCT05295277 Recruiting Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort November 30, 2020 June 30, 2024
NCT03492060 Recruiting A Natural History Study of hnRNP-related Disorders June 13, 2018 April 2024
NCT05273320 Recruiting Phase 1 Clinical Trial of Nabilone for Aggression in Adults With Intellectual and Developmental Disabilities March 17, 2022 March 31, 2024
NCT02461420 Recruiting Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome May 2015 December 2026
NCT04781452 Recruiting Evaluating the Treatment in the MZEB Aachen July 1, 2019 July 1, 2029
NCT06019182 Recruiting MEHMO Natural History and Biomarkers June 23, 2024 September 1, 2053
NCT04821856 Recruiting Phase 2 Evaluation of the Effectiveness of Cannabidiol in Treating Severe Behavioural Problems in Children and Adolescents With Intellectual Disability May 11, 2021 July 2024
NCT06065527 Recruiting N/A Future Planning and Well-Being for Individuals With Intellectual Disabilities and Family Caregivers December 22, 2023 April 30, 2029
NCT06086951 Recruiting N/A Pai.ACT - An Artificial Intelligence Driven Chatbot Assisted ACT October 1, 2023 September 30, 2025
NCT05131425 Recruiting N/A Facing Your Fears: Adolescents With ASD and Intellectual Disability September 1, 2021 August 2024
NCT05214859 Recruiting N/A Enhancing Mother-Child Ties and Psychosocial Wellness Through Arts Among Children With Intellectual Disability and Their Mothers July 9, 2022 December 31, 2025
NCT06259201 Recruiting N/A Vagus Nerve Stimulator for Autism and Other Developmental Disorders March 1, 2024 December 2026
NCT05471232 Recruiting Mental Health Crises in Youth With IDDs March 29, 2023 July 1, 2027
NCT03862950 Recruiting Phase 2 A Trial of Metformin in Individuals With Fragile X Syndrome (Met) May 24, 2019 June 2026
NCT04025398 Recruiting N/A A Computer-based Cognitive Remediation Program for Adults With Intellectual Disability June 17, 2020 December 31, 2025
NCT05473429 Recruiting N/A Characterization of Nociception Phenotype in Individuals With Intellectual Disability June 23, 2024 December 15, 2025
NCT05657860 Recruiting Phase 4 Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome December 17, 2020 January 18, 2024
NCT04199299 Recruiting Sensors for Communication for Persons Who Cannot Communicate Unequivocally February 1, 2020 December 31, 2032
NCT05696912 Recruiting N/A Functional Tests to Resolve Unsolved Rare Diseases. Rares. January 30, 2023 February 2025
NCT05738278 Recruiting N/A Heart Rate Informed Changes in Care for Non-Communicating Patients February 27, 2023 December 30, 2025
NCT05743439 Recruiting N/A Early Augmentative and Alternative Communication (AAC) Intervention Delivered Via Hybrid Telehealth July 1, 2022 December 31, 2025
NCT05744479 Recruiting Phase 4 Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability February 28, 2023 December 1, 2026
NCT05751525 Recruiting Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome July 1, 2016 December 31, 2025
NCT05767203 Recruiting N/A Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin September 1, 2022 December 31, 2032
NCT02461459 Recruiting Autism Spectrum Disorder (ASD) and Intellectual Disability (ID) Determinants in Tuberous Sclerosis Complex (TSC) May 2015 December 2026
NCT05867940 Recruiting N/A Effects of Physical Activity on Prescription (PAP) as a Health-enhancing Intervention in People With Disabilities June 5, 2023 December 2026
NCT04573530 Recruiting N/A We Walk Plus Study for Older Adults With Intellectual Disabilities June 15, 2021 October 30, 2024
NCT05872737 Recruiting N/A FAB Programme for Parents of Children With NDD June 5, 2023 September 8, 2026
NCT06238089 Recruiting Anti-psychotic Drug Prescribing Patterns Within Specialist Adult ID Services in England and Wales December 19, 2023 April 2024
NCT05432349 Recruiting Rett Syndrome Registry August 2, 2022 July 2028
NCT04079439 Terminated N/A Physical Activity With Tailored E-health Support for Individuals With Intellectual Disability January 1, 2020 January 1, 2022
NCT05445596 Terminated N/A Improving Treatment for Children With Intellectual and Developmental Disabilities and Problem Behavior in Schools September 1, 2022 December 20, 2022
NCT05290051 Unknown status N/A Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities. CHROmosome MAPping and Sequencing (CHROMAPS) April 2022 April 2024
NCT03234231 Unknown status N/A Supervised Brushing Programme for Intellectual Disabled Students May 1, 2018 December 31, 2018
NCT03644797 Unknown status Second Molecular Event Identification by Exome Sequencing for Intellectually Disabled Patients Carrying 16p13.11 CNVs September 2018 March 2019
NCT02721394 Unknown status N/A FCT With Young Children With ID in the UK: A Feasibility Project V.1 February 2016 December 2018
NCT04919213 Unknown status Safer Online Lives: Use of the Internet & Social Media by People With Intellectual Disabilities May 20, 2021 March 1, 2023
NCT04635969 Unknown status N/A Determining the Effectiveness of Sexual Health and Development Education for Children With Intellectual Disability February 15, 2021 August 2022
NCT04938999 Unknown status N/A Music-visual Guided Physical Activity Promotion for Adults With Intellectual Disabilities January 5, 2022 September 30, 2023
NCT03424772 Unknown status Whole Genome Sequencing in the Detection of Rare Undiagnosed Genetic Diseases in Children in China January 18, 2018 March 2019
NCT03348124 Unknown status N/A Prevention Among Young People With Intellectual Disability January 1, 2018 July 31, 2021
NCT04726371 Unknown status N/A Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental Disabilities in Congregate Living Settings January 8, 2021 October 2022
NCT03033797 Unknown status N/A Augmentative and Alternative Communication in Games With Virtual Reality in Intellectual Disabilities March 8, 2016 March 24, 2018
NCT02881333 Unknown status Various Type of Genetic Events in Patients With Intellectual Disability September 2016 December 2017
NCT01867554 Unknown status Research and Characterization of New Genes Involved in Intellectual Disability December 2012 December 2022
NCT04294082 Withdrawn Study of Mindfulness Course for Parents of Adults With Intellectual Disabilities April 1, 2020 October 1, 2021
NCT02934854 Withdrawn Biomarker for Creatine Deficiency Syndromes (BioCDS) August 20, 2018 February 28, 2021
Disase is a (Disease Ontology)
DOID:0060038
Cross Reference ID (Disease Ontology)
NCI:C84392
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:1855002
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0025362
Disase Synonym (Disease Ontology)
mental retardation
HPO alt_id (Human Phenotype Ontology)
HP:0000730
HPO alt_id (Human Phenotype Ontology)
HP:0001267
HPO alt_id (Human Phenotype Ontology)
HP:0001286
HPO alt_id (Human Phenotype Ontology)
HP:0002122
HPO alt_id (Human Phenotype Ontology)
HP:0002192
HPO alt_id (Human Phenotype Ontology)
HP:0002316
HPO alt_id (Human Phenotype Ontology)
HP:0002382
HPO alt_id (Human Phenotype Ontology)
HP:0002386
HPO alt_id (Human Phenotype Ontology)
HP:0002402
HPO alt_id (Human Phenotype Ontology)
HP:0002458
HPO alt_id (Human Phenotype Ontology)
HP:0002482
HPO alt_id (Human Phenotype Ontology)
HP:0002499
HPO alt_id (Human Phenotype Ontology)
HP:0002543
HPO alt_id (Human Phenotype Ontology)
HP:0003767
HPO alt_id (Human Phenotype Ontology)
HP:0006833
HPO alt_id (Human Phenotype Ontology)
HP:0007154
HPO alt_id (Human Phenotype Ontology)
HP:0007176
HPO alt_id (Human Phenotype Ontology)
HP:0007180
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0001249
MeSH unique ID (MeSH (Medical Subject Headings))
D008607