Alzheimer's disease

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Information
Disease name
Alzheimer's disease
Disease ID
DOID:10652
Description
"A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." [url:http\://en.wikipedia.org/wiki/Alzheimer%27s_disease, url:http\://www.merriam-webster.com/medical/alzheimer%27s%20disease, url:http\://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet] {comment="ls:IEDB"}
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
PSEN2 1 226,870,600 226,896,088 114
APP 21 25,880,550 26,170,770 76
PSEN1 14 73,136,763 73,223,685 46
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04241068 Active, not recruiting Phase 3 A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205 March 2, 2020 August 28, 2024
NCT02380573 Active, not recruiting Phase 2 Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease July 2015 July 2023
NCT02114372 Active, not recruiting Cognitive Health in Ageing Register: Investigational, Observational and Trial Studies in Dementia Research: Prospective Readiness Cohort Study February 5, 2014 June 28, 2024
NCT02485730 Active, not recruiting Early Identification of Markers in Alzheimer's Families / ALFA October 25, 2016 December 31, 2025
NCT01767311 Active, not recruiting Phase 2 A Study to Evaluate Safety, Tolerability, and Efficacy of Lecanemab in Subjects With Early Alzheimer's Disease December 20, 2012 February 20, 2025
NCT03269149 Active, not recruiting N/A Tango for Alzheimer's Disease Patients' Caregivers September 19, 2017 December 2024
NCT05476783 Active, not recruiting Phase 2 A Long Term Extension Study to Assess the Safety of TB006 in Participants With Alzheimer's Disease September 14, 2022 October 2024
NCT04603482 Active, not recruiting N/A Dementia Caregiver Career Study January 8, 2021 June 30, 2024
NCT02685969 Active, not recruiting Brain Characterization of Amyloid Protein and Glucose Metabolism of ALFA Project Participants March 1, 2017 December 31, 2024
NCT05310071 Active, not recruiting Phase 3 A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease June 2, 2022 October 31, 2026
NCT01903421 Active, not recruiting N/A Inhalational Anesthesia and Precipitation of Dementia: is There a Link? March 2014 July 2023
NCT03817684 Active, not recruiting Phase 2 Tetra PICASSO AD Trial: Study to Evaluate Effects of BPN14770 in Early Alzheimer's Subjects April 30, 2019 February 2020
NCT05267535 Active, not recruiting Phase 2/Phase 3 Piromelatine 20 mg in Participants With Mild Dementia Due to Alzheimer's Disease May 12, 2022 June 2025
NCT03672201 Active, not recruiting N/A Standardizing Care for Neuropsychiatric Symptoms and Quality of Life in Dementia November 1, 2018 December 31, 2024
NCT04141150 Active, not recruiting Phase 2 Evaluation of [18F]APN-1607 PET Uptake in Alzheimer's Disease Patients Compared With Healthy Subjects March 22, 2022 February 2025
NCT01208675 Active, not recruiting The Swedish BioFINDER Study September 2010 December 2024
NCT05352763 Active, not recruiting Phase 2 Open-Label Extension of the PTI-125-04 Study in Mild-to-Moderate Alzheimer's Disease May 12, 2022 November 29, 2025
NCT04867616 Active, not recruiting Phase 2 A Study to Test the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Patients With Mild Cognitive Impairment or Mild Alzheimer's Disease (AD) June 9, 2021 July 28, 2025
NCT02899091 Active, not recruiting Phase 1/Phase 2 Evaluation of the Safety and Potential Therapeutic Effects of CB-AC-02 in Patients With Alzheimer's Disease September 2016 December 2024
NCT05619692 Active, not recruiting Phase 2 A Study to Evaluate the Effects of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD) December 27, 2022 January 2025
NCT00051909 Completed Phase 2 Efficacy and Safety of LY451395 in Patients With Probable Alzheimer's Disease November 2002 June 2003
NCT00056225 Completed Phase 3 VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study) January 2003 June 2007
NCT00056524 Completed Phase 3 Safety Study of AVP-923 in the Treatment of IEED (Involuntary Emotional Expression Disorder) Also Known as Pseudobulbar Affect (Episodes of Uncontrolled Crying and/or Laughter) February 2003 June 2007
NCT00065689 Completed Phase 3 High Intensity Light Therapy in Alzheimer's Disease March 2003 September 2005
NCT05787028 Completed Phase 1 Safety, Tolerability and Pharmacokinetics of AD16 Tablets in Adult Healthy Subjects After Single Administration January 30, 2019 May 31, 2020
NCT00074529 Completed Phase 2 Study of MK0677 for the Treatment of Alzheimer's Disease (0677-030)(COMPLETED) October 2003 January 2006
NCT00082602 Completed Phase 3 Safety and Tolerability Study of Extended Release (ER) Galantamine in Alzheimer's Disease May 2004 April 2005
NCT00083421 Completed Phase 2 Effects of ONO-2506PO in Patients With Alzheimer's Disease June 2004 July 2007
NCT00086138 Completed Phase 2/Phase 3 Depression in Alzheimer's Disease-2 July 2004 July 2009
NCT00087789 Completed Phase 1 CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease June 2004 May 2010
NCT00090116 Completed Phase 3 The Safety and Efficacy of Neramexane in Patients With Moderate to Severe Alzheimer's Disease March 2003 March 2005
NCT00090402 Completed Phase 1/Phase 2 Fish Oil and Alpha Lipoic Acid in Treating Alzheimer's Disease April 2004 August 2007
NCT00093951 Completed Phase 2 SGS742 in Patients With Mild to Moderate Alzheimer's Disease (AD) April 2004 September 2007
NCT05519137 Completed N/A Using a Wireless Controller to Deliver a Lighting Intervention to Persons With Dementia January 6, 2022 May 1, 2023
NCT00095719 Completed Phase 3 Intramuscular Aripiprazole in Acutely Agitated Patients Diagnosed With Dementia December 2003 March 2005
NCT00096473 Completed Phase 3 Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease January 2001 September 2005
NCT00097916 Completed Phase 3 An Evaluation of the Safety and Efficacy of Memantine in Agitated Patients With Moderate to Severe Alzheimer's Disease September 2004 April 2006
NCT00099242 Completed Phase 3 Efficacy and Safety of the Rivastigmine Transdermal Patch in Patients With Probable Alzheimer's Disease November 2003 January 2006
NCT00099710 Completed Phase 2 Curcumin in Patients With Mild to Moderate Alzheimer's Disease July 2003 December 2007
NCT00100282 Completed Phase 1 Safety Study of PPI-1019 in Patients With Mild-Moderate Alzheimer's Disease May 2003 June 2005
NCT00100334 Completed Phase 1/Phase 2 Safety Study of PPI-1019 in Subjects With Mild-Moderate Alzheimer's Disease December 2004 August 2005
NCT00104273 Completed Phase 2 Rasagiline 1 mg and 2 mg Added to Aricept 10 mg Daily in Patients With Mild to Moderate Alzheimer's Disease (AD) August 2004
NCT00104442 Completed Phase 4 Study of the Effects of Current Drug Treatments on Levels of Certain Brain Chemicals in Alzheimer's Disease October 2003 April 2006
NCT00105612 Completed N/A Memory Aid for Informed Consent in Alzheimer's Research September 2004 March 2007
NCT00106899 Completed ADNI: Alzheimer's Disease Neuroimaging Initiative July 2005 June 2011
NCT00112073 Completed Phase 2 AAB-001 in Patients With Mild to Moderate Alzheimer's Disease April 2005 December 2008
NCT00117403 Completed Phase 1 Anti-Oxidant Treatment of Alzheimer's Disease January 2006 September 2007
NCT00120874 Completed Phase 4 Memantine and Comprehensive, Individualized Management of Alzheimer's Disease and Caregiver Training August 2006 November 2011
NCT00130429 Completed Phase 2 Safety and Effect on Memory of PYM50028 in Mild Alzheimer's Disease January 2004 September 2005
NCT05363293 Completed Phase 1/Phase 2 Multiple Ascending Dose Safety, Tolerability, PK Study of AL001 in Alzheimer's Disease Patients & Healthy Adult Subjects May 4, 2022 May 15, 2023
NCT00142805 Completed Phase 2 Tricaprilin in Mild to Moderate Alzheimer's Disease November 4, 2004 January 7, 2007
NCT00151333 Completed Phase 2 Study Evaluating SRA-333 in Mild to Moderate Alzheimer's Disease (AD) February 2005 April 2005
NCT00151502 Completed Phase 3 To Evaluate the Safety and Effectiveness of Atorvastatin Plus a Cholinesterase Inhibitor in AD Patients. November 2002 July 2007
NCT00164749 Completed Phase 1/Phase 2 A Pilot Study of Curcumin and Ginkgo for Treating Alzheimer's Disease October 2004 July 2006
NCT00165724 Completed Phase 4 Alzheimer's Disease Long-term Follow-up Study (ALF Study) June 30, 2004 December 31, 2006
NCT05350410 Completed N/A "Healthy Actions and Lifestyles to Avoid Dementia or Hispanos y el ALTo a la Demencia Program" April 5, 2022 August 24, 2022
NCT00182897 Completed N/A PACT: Providers and Alzheimer's Caregivers Together October 2000 November 2005
NCT00182988 Completed Alzheimer's Caregiver Communication Study October 2004 December 2007
NCT00190372 Completed N/A AIDMA: A Psycho-educational Program Designed to Support and Train Carers of Alzheimer's Disease (AD) Patients October 2004 May 2008
NCT00202124 Completed Phase 4 Double Blind Study of Trp01 in Patients With Alzheimer's Disease April 2001 March 2002
NCT00203320 Completed Phase 1 TNF-Alpha Inhibition for Treatment of Alzheimer's Disease April 2005 January 2006
NCT00203359 Completed Phase 1 TNF-Alpha Inhibition for Treatment of Alzheimer's Disease September 2004 April 2006
NCT00205179 Completed Phase 2 Alzheimer's Disease: Potential Benefit of Isoflavones January 2005 December 2009
NCT05227118 Completed Phase 1 MK-8189 Safety and Tolerability in Participants With Alzheimer's Disease With or Without Symptoms of Agitation-Aggression and/or Psychosis (MK-8189-017) July 1, 2022 January 10, 2023
NCT00211159 Completed N/A OmegAD (Omega-3 and Alzheimer's Disease) December 2000
NCT05074498 Completed Phase 1/Phase 2 Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of TB006 in Participants With Alzheimer's Disease October 8, 2021 October 13, 2022
NCT00219232 Completed Phase 3 An Open-label Extension to Evaluate the Efficacy and Safety of the Rivastigmine Transdermal Patch in Patients With Probable Alzheimer's Disease February 2003 July 2006
NCT00224497 Completed Phase 2 A Dose Ranging Study To Investigate The Efficacy And Safety Of SB-742457 In Alzheimer's Disease September 2005
NCT00230568 Completed Phase 4 EARTH 413: A Study of Aricept in Hispanic Patients With Mild to Moderate Alzheimer's Disease (AD) December 2005 December 2007
NCT00231946 Completed Phase 3 ALADDIN Study - Phase III: Antigonadotropin-Leuprolide in Alzheimer's Disease Drug INvestigation (VP-AD-301) September 2005
NCT05040048 Completed Taxonomy of Neurodegenerative Diseases : Observational Study in Alzheimer's Disease and Parkinson's Disease September 4, 2015 February 2018
NCT00234637 Completed Phase 4 Rivastigmine Monotherapy and Combination Therapy With Memantine in Patients With Moderately Severe Alzheimer's Disease Who Failed to Benefit From Previous Cholinesterase Inhibitor Treatment November 2003 June 2005
NCT00235716 Completed Phase 3 A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease August 2007 October 2012
NCT04983368 Completed Phase 1/Phase 2 A Double-Blind, Placebo-Controlled, Dose Ranging Study of Xanamem® in Healthy Elderly Volunteers June 30, 2021 February 11, 2022
NCT00239759 Completed MIRAGE: Multi-Institutional Research in Alzheimer's Genetic Epidemiology September 2002 June 2008
NCT00241293 Completed Influence of Age on Hemispheric Lateralization of Language : a Longitudinal Study
NCT00244322 Completed Phase 2 Effects of LY450139 Dihydrate on Subjects With Mild to Moderate Alzheimer's Disease October 2005 December 2006
NCT00245206 Completed Phase 4 Side Effects of Newer Antipsychotics in Older Adults August 2005 October 2010
NCT00246896 Completed N/A Care Management for Patients With Alzheimer Disease and Their Family Caregivers August 2001 August 2005
NCT00257673 Completed Phase 2 Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease November 2005 October 2007
NCT00259467 Completed Phase 1 Project TAP: Tailored Activities Project February 2004 January 2007
NCT00259480 Completed Phase 3 Project ACT: Advancing Caregiving Techniques August 2001 March 2015
NCT00260624 Completed Phase 4 Escitalopram Treatment of Patients With Agitated Dementia February 2003 December 2006
NCT00265148 Completed Phase 2 Brain Imaging Study Of Rosiglitazone Efficacy And Safety In Alzheimer's Disease May 18, 2004 July 10, 2008
NCT00267124 Completed Brain Aging Project--Kansas University November 2004 August 2009
NCT00283725 Completed Use of Different Treatment Care Methods in Patients With Dementia Associated With Alzheimer's Disease June 2003 December 2006
NCT04973189 Completed Phase 1 A Study of SHR-1707 in Healthy Young Adult and Elderly Subjects May 8, 2021 January 13, 2022
NCT00303277 Completed Phase 4 Do HMG CoA Reductase Inhibitors Affect Abeta Levels? August 2002 April 2005
NCT00305903 Completed Phase 4 Safety and Tolerability of Rivastigmine With Add-on Memantine in Patients With Probable Alzheimer's Disease March 2006 August 2007
NCT04761497 Completed N/A Effects of Group Music Therapy Interventions on Alzheimer's Disease Patients: a Three-arm Randomized Controlled Blind Study. September 12, 2018 January 7, 2019
NCT00309725 Completed Phase 3 A Cardiac Safety Study of Galantamine in the Treatment of Alzheimer's Disease. October 1999
NCT04730635 Completed Phase 1 Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413) March 23, 2021 February 6, 2023
NCT00315575 Completed Memory Imaging of Normal Aging August 2005 July 2008
NCT00319891 Completed Phase 1 Computer-Based Training for Mild Alzheimer's Disease September 2004 October 2006
NCT00329082 Completed Phase 2 Effects of LY2062430 in Subjects With Mild-to-Moderate Alzheimer's Disease and in Healthy Volunteers May 2006 May 2008
NCT00334906 Completed Phase 4 Study of Memantine in Assessment of Selected Measures of Volumetric Magnetic Resonance Imaging (MRI) and Cognition in Moderate AD (Alzheimer's Disease) July 2005
NCT00338117 Completed Phase 3 Safety and Efficacy of High Dose, Rapid Titration Galantamine in Patients With Alzheimer's Disease August 1995 May 1997
NCT00348140 Completed Phase 3 Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy In Subjects With Mild To Moderate Alzheimer's Disease July 12, 2006 March 20, 2009
NCT00348192 Completed Phase 2 SB-742457 And Donepezil In Alzheimer's Disease May 2006
NCT00348309 Completed N/A Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease July 6, 2006 January 28, 2009
NCT00355498 Completed Amyloid Plaque and Tangle Imaging in Aging and Dementia September 2005 May 2010
NCT00357357 Completed Phase 2 European Study of HF0220 in Mild to Moderate Alzheimer's Disease Patients July 2006 August 2008
NCT00359944 Completed Phase 2 Safety and Efficacy Study of AC-3933 in Adults With Mild to Moderate Alzheimer's Disease February 2006 September 2008
NCT04584138 Completed Autobiographical Memory April 15, 2021 November 25, 2022
NCT04445831 Completed Phase 1/Phase 2 A Study to Evaluate the Safety, Tolerability and Immunogenicity of Tau Targeted Vaccines in Participants With Early Alzheimer's Disease July 31, 2019 September 5, 2023
NCT04308304 Completed Phase 1 MK-1942/Donepezil Interactions in Participants With Alzheimer's Disease (MK-1942-005) February 16, 2021 May 18, 2022
NCT00377715 Completed Phase 2 Double-blind, Placebo-controlled Study of Oral Dimebon in Subjects With Mild to Moderate Alzheimer's Disease September 2005
NCT00381238 Completed Phase 2 Open-Label Extension Assessing Long-Term Safety Of Rosiglitazone In Subjects With Mild To Moderate Alzheimer's Disease June 20, 2006 February 3, 2009
NCT00381381 Completed Phase 4 The Clinical Response of Choline Acetyltransferase and Apolipoprotein Epsilon Gene Polymorphisms to Donepezil in Alzheimer's Disease May 31, 2006 December 31, 2008
NCT00384423 Completed Phase 2 Short Term Effects of PRX-03140 in Patients With Mild Alzheimer's Disease Being Treated With Aricept October 2006
NCT00388544 Completed Phase 2 Enhancing Quality of Life for Nursing Home Residents May 2005 February 2010
NCT00391794 Completed N/A Efficacy of Early Stage Alzheimer's Support Groups September 2006 May 2011
NCT00391833 Completed Phase 1/Phase 2 Effect of Panax Ginseng on the Cognitive Performance in Alzheimer's Disease April 2004 October 2005
NCT00392912 Completed N/A Effect of Testosterone Therapy in Men With Alzheimer's Disease and Low Testosterone April 2007 July 2010
NCT00401167 Completed Phase 4 Memantine for Agitation and Aggression in Severe Alzheimer's Disease November 2006 January 2010
NCT00403520 Completed Phase 4 Hippocampus Study: Comparative Effect of Donepezil 10mg/d and Placebo on Clinical and Radiological Markers November 2006 August 2010
NCT00407576 Completed Phase 1 PET Imaging of Brain Amyloid Using [11C]MeS-IMPY December 1, 2006
NCT00408525 Completed Phase 1 Donepezil and Brain Activity Patterns in Those at Risk For Alzheimer's Disease December 2006 August 24, 2012
NCT00411580 Completed Phase 1 Safety and Tolerability Study in Patients With Mild to Moderate Alzheimer's Disease (AD) June 2005 December 2008
NCT00413621 Completed MRI of Alzheimer's Disease Imaging Amyloid Plaques in Persons With and Without Memory Problems December 14, 2006
NCT00416078 Completed Phase 2/Phase 3 Online Caregiver Psychoeducation and Support for Alzheimer's August 2007 December 2012
NCT00420420 Completed Phase 2 MK0249 for the Symptomatic Treatment of Alzheimer's Disease (MK0249-011) November 2006 August 2008
NCT00423085 Completed Phase 3 Efficacy and Safety of Rivastigmine Transdermal Patch in Patients With Mild to Moderate Alzheimer's Disease January 2007 April 2010
NCT00428090 Completed Phase 3 Rosiglitazone (Extended Release Tablets) As Monotherapy In Subjects With Mild To Moderate Alzheimer's Disease February 27, 2007 September 5, 2008
NCT00428389 Completed Phase 3 Safety of Switching From Donepezil to Rivastigmine Patch in Patients With Probable Alzheimer's Disease January 2007 February 2008
NCT00438568 Completed Phase 2 SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days) June 2006 December 2011
NCT00439166 Completed Phase 3 Effects of Doxycycline and Rifampicin on Biomarkers of Alzheimer's Disease in the Cerebrospinal Fluid February 2007 December 2010
NCT00440050 Completed Phase 3 DHA (Docosahexaenoic Acid), an Omega 3 Fatty Acid, in Slowing the Progression of Alzheimer's Disease February 2007 May 2009
NCT00443417 Completed Phase 2 A Trial of SK-PC-B70M in Mild to Moderate Alzheimer's Disease April 2007 January 2009
NCT03938870 Completed CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease August 18, 2015 July 6, 2023
NCT00454870 Completed Phase 2 Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease February 2007 October 2007
NCT00455000 Completed Phase 1 A Phase I, Single IV Dose Of PF-04360365 In Adults With Mild To Moderate Alzheimer's Disease March 2007 September 2009
NCT00459355 Completed Phase 1 Home Safety Clinical Trial for Alzheimer's Disease July 2007 December 2011
NCT00459550 Completed Phase 1 A Clinical Study to Assess Single and Repeat Doses of a New Medication (GSK933776) in Patients With Alzheimer's Disease March 12, 2007 May 30, 2011
NCT00468897 Completed Phase 1 A Study To Demonstrate The Bioequivalence Of Rosiglitazone XR (BRL-049653) 8mgs XR Manufactured At Two Different Sites. March 21, 2007 May 2, 2007
NCT00469456 Completed Phase 4 Effect of Memantine on Functional Communication in Patients With Alzheimer's Disease April 2007 November 2008
NCT00471211 Completed Phase 2 Study Evaluating the Safety, Tolerability and Efficacy of PBT2 in Patients With Early Alzheimer's Disease December 2006 December 2007
NCT00476008 Completed Phase 4 Delaying the Progression of Driving Impairment in Individuals With Mild Alzheimer's Disease July 2007 October 2012
NCT00477659 Completed Phase 4 Neural Correlates In Mild Alzheimer's Disease July 23, 2007 August 15, 2008
NCT00478166 Completed Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease July 2005 October 2007
NCT00478205 Completed Phase 3 Comparison of 23 mg Donepezil Sustained Release (SR) to 10 mg Donepezil Immediate Release (IR) in Patients With Moderate to Severe Alzheimer's Disease June 2007
NCT00478491 Completed fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease January 2003 July 2011
NCT00479843 Completed N/A Nutritional Programme for Dementia Elderly Patient July 2005 July 2007
NCT00480220 Completed N/A Specific Care and Assistance Plan for Alzheimer's Disease August 2003 August 2007
NCT00483028 Completed N/A A Randomized, Placebo-Controlled Trial to Examine the Efficacy of Oral Donepezil in Subjects With MCI June 2004 January 2007
NCT03884023 Completed Effect of REST in the Alzheimer Disease Continuum June 28, 2019 November 30, 2020
NCT00495417 Completed Phase 1 Tolerability and Safety of Subcutaneous Administration of Affitope AD01 in Mild to Moderate Alzheimer's Disease July 2007 August 2009
NCT00495820 Completed Phase 4 Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study August 2007 June 2010
NCT00499200 Completed Phase 1 Study Evaluating Safety, Tolerability, Pharmacokinetics and 5 HT1A Receptor Occupancy October 2007 June 2008
NCT03856359 Completed Phase 2 Trial of Rifaximin in Probable Alzheimer's Disease April 9, 2019 November 19, 2020
NCT00531804 Completed Phase 1 A Multiple Ascending Dose Study of R1450 in Patients With Alzheimer Disease. December 2006 September 2010
NCT00539305 Completed Phase 3 Hormone and Information Processing Study July 2009 May 2012
NCT00544856 Completed N/A Effects of a Complex Cognitive Training in Mild Cognitive Impairment and Mild Alzheimer's Disease October 2007 October 2008
NCT00546767 Completed N/A Home-Based Assessment for Alzheimer Disease Prevention September 2007 June 2013
NCT00549601 Completed Phase 4 Convenience, Tolerability, and Safety of Change in the Administration of Rivastigmine From Capsules to a Transdermal Patch in Patients With Mild to Moderate Alzheimer's Disease September 2007 April 2009
NCT03838185 Completed Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetics of Single Ascending Oral Doses of J147 January 22, 2019 February 1, 2020
NCT00551772 Completed Phase 1 A Study To Assess The Pharmacokinetics Of SB-742457 Formulated As A Capsule And A Tablet In Healthy Elderly Volunteers. August 2007
NCT03828747 Completed Phase 2 A Study of Semorinemab in Patients With Moderate Alzheimer's Disease January 25, 2019 August 30, 2023
NCT00558402 Completed Phase 2 Meditation or Education for Alzheimer Caregivers November 2007 July 2011
NCT00561392 Completed Phase 4 Clinical Effectiveness of 10 cm^2 Rivastigmine Patch in Patients With Alzheimer's Disease November 2007 November 2008
NCT00566397 Completed Phase 2 A Phase 2 Study Evaluating The Efficacy And Safety Of PF 04494700 In Mild To Moderate Alzheimer's Disease December 2007 December 2010
NCT00566501 Completed Phase 3 Open-Label Extension Study of 23 mg Donepezil SR in Participants With Moderate to Severe Alzheimer's Disease December 14, 2007 April 1, 2010
NCT00571025 Completed N/A Risk Evaluation and Education for Alzheimer's Disease August 2000 April 2004
NCT00574132 Completed Phase 3 Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Non-Carrier) December 2007 June 2012
NCT00575055 Completed Phase 3 Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease (ApoE4 Carrier) December 2007 April 2012
NCT00580931 Completed Phase 1/Phase 2 Safety Study of Nicotinamide to Treat Alzheimer's Disease January 2008 July 2014
NCT00581867 Completed Phase 1/Phase 2 Memory and Insulin in Early Alzheimer's Disease October 2007 May 2012
NCT00582127 Completed Evaluation of the COGNISION(TM) System as an Event-related Potential (ERP) Collection System. January 2008 November 2010
NCT00586430 Completed N/A The Impact of Lorazepam on Cognition in APOE e4 Carriers December 2005 July 2007
NCT00594568 Completed Phase 3 Effect of LY450139 on the Long Term Progression of Alzheimer's Disease March 2008 May 2011
NCT03828383 Completed N/A In-Home Technology for Dementia Caregivers February 26, 2019 November 27, 2020
NCT03710642 Completed Phase 2 Prazosin for Agitation in Alzheimer's Disease October 23, 2018 January 5, 2022
NCT00607308 Completed Phase 1 A Phase I, Single Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's Disease February 2008 October 2010
NCT00611312 Completed Phase 2 Effects of Delivery Mode of Cognition Intervention in Early Alzheimer's Disease February 2008 September 2012
NCT00621010 Completed Phase 1 Safety Study of CTS21166 to Treat Alzheimer Disease June 2007 February 2008
NCT00621647 Completed Phase 3 Seroquel- Agitation Associated With Dementia September 2002 November 2003
NCT00622713 Completed Phase 4 A 24 Week, Multicenter, Open, Evaluation of the Clinical Effectiveness of the Once-daily 10 cm^2 Rivastigmine Patch Formulation in Patients With Probable Alzheimer's Disease (EXTRA) January 2008 January 2009
NCT00624026 Completed Phase 3 Memantine - Communication Study November 2007 December 2008
NCT03656042 Completed Phase 2 To Evaluate the Efficacy and Safety/Tolerability Profiles of G-CSF in Subjects With Mild to Moderate Alzheimer's Disease March 2009 August 2014
NCT03625128 Completed Early Phase 1 18F-PM-PBB3 PET Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls January 2, 2018 December 3, 2018
NCT00628017 Completed N/A Preliminary Study of Fish Oil and Dementia January 2003 March 2005
NCT00633841 Completed Phase 1 Tolerability and Safety of Subcutaneous Administration of AFFITOPE AD02 in Mild to Moderate Alzheimer's Disease February 2008 September 2009
NCT03594123 Completed Phase 3 A 12-week Extension Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type October 11, 2018 September 19, 2022
NCT00646269 Completed Phase 3 Efficacy Assessment of Three Non Pharmacological Therapies in Alzheimer's Disease March 2008 December 2012
NCT00647478 Completed System-IGF-1 Pathway and Alzheimer's Disease October 2007 July 2012
NCT03503669 Completed N/A Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training May 1, 2018 February 1, 2021
NCT00654563 Completed Memory Disorders Registry August 2007 March 2012
NCT00660088 Completed Safety of Three Formulations of Ketasyn Administered for 14 Days in Healthy Elderly April 2008 August 2008
NCT00663936 Completed Phase 2 Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease April 2008 June 2011
NCT00666445 Completed Improved Diagnosis of Alzheimer's Disease Using the Synchronous Neural Interaction™ Test April 2008 December 2009
NCT03456349 Completed Phase 1 Multi-centre Study of HTL0018318 in Patients as an add-on to Standard-of-care November 10, 2017 July 16, 2018
NCT00675090 Completed Phase 1 Bridging Study With GSK239512 In Patients With Mild To Moderate Alzheimer's Disease February 21, 2008 June 16, 2009
NCT00675623 Completed Phase 3 A Safety and Efficacy Study of Oral Dimebon in Patients With Mild-To-Moderate Alzheimer's Disease May 2008
NCT00678431 Completed Phase 3 Randomized Trial of a Nutritional Supplement in Alzheimer's Disease January 2008 June 2011
NCT03438604 Completed Phase 1 A Study to Evaluate the Effect of Heat Application on the Delivery Profile of Corplex™ Donepezil Transdermal Delivery System (TDS) February 13, 2018 June 30, 2018
NCT00684281 Completed N/A Early Diagnosis of Alzheimer's Disease: Clinical, Neuropsychological and Neuroimaging Follow-up of a Cohort of Patients With an Isolated Memory Impairment July 2008 December 2011
NCT00684944 Completed Phase 2 Open Label Study of TRx0014 in Alzheimer's Disease September 13, 2007 December 2, 2010
NCT00687141 Completed Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD0328 in Elderly Healthy Subjects November 2007 June 2008
NCT00688207 Completed Phase 1 Mild Alzheimer''s Disease to Assess the of Extended Release Formulation of Rosiglitazone (RSG XR) April 2008 September 2008
NCT00689559 Completed Phase 1 Drug Interaction Study Between AZD3480 and Aripiprazole in Healthy Subjects March 2008 April 2009
NCT00689637 Completed Phase 1 Drug Interaction Study Between AZD3480 and Warfarin September 2007 February 2009
NCT03432195 Completed Phase 1 A Clinical Study to Evaluate the Pharmacokinetics (PK) of Corplex™ Donepezil Transdermal Delivery System (TDS) Applied to Different Body Locations January 31, 2018 June 28, 2018
NCT00692510 Completed Phase 1 Drug Interaction Study Between AZD3480 and Cytochrome P450 November 2007 September 2008
NCT00692588 Completed MRI to Measure Treatment With Antibiotics in Alzheimer's Disease June 2008 June 2010
NCT03422250 Completed N/A Non-invasive Stimulation of Brain Networks and Cognition in Alzheimer's Disease and Frontotemporal Dementia June 8, 2015 November 3, 2018
NCT00698165 Completed Observational Study on Costs and Caregiver Burden in Alzheimer's Disease June 2007 January 2009
NCT00702143 Completed Phase 2 A Phase II Trial of 18F-AV-45 Positron Emission Tomography (PET) Imaging in Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD) June 2008 December 2008
NCT00702780 Completed N/A Progression Delaying Effect of Escitalopram in Alzheimer's Disease November 2008 September 2011
NCT03411291 Completed Statins in Cerebral Blood Flow and Neuronal Activity--A Pilot Study April 2007 September 2010
NCT03325205 Completed N/A MR Guided tDCS in Alzheimer's Disease August 22, 2017 March 10, 2020
NCT00708552 Completed Phase 2 Study of SB-742457 or Donepezil Versus Placebo in Subjects With Mild-to-moderate Alzheimer's Disease July 4, 2008 March 9, 2010
NCT00710684 Completed Phase 2 A Study of SB-742457, Added to Donepezil for the Treatment of Mild-to-moderate Alzheimer's Disease July 1, 2008 November 16, 2010
NCT00711139 Completed Long-term Safety and Tolerability of AFFITOPE AD01 June 2008 November 2009
NCT00711321 Completed Long-term Safety and Tolerability of AFFITOPE AD02 November 2008 April 2010
NCT00714571 Completed Phase 1 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI) July 2008 September 2014
NCT03259958 Completed Phase 1 A Bioequivalence Study of Corplex™ Donepezil Transdermal Delivery System Compared to Aricept® October 30, 2017 March 14, 2018
NCT00721383 Completed N/A Telephone Resources and Assistance for Caregivers (TRAC) May 2007 February 2013
NCT00722046 Completed Phase 2 Multiple IV Dose Study Of PF-04360365 In Patients With Mild To Moderate Alzheimer's Disease December 5, 2008 August 16, 2011
NCT00731224 Completed Phase 4 Compliance and Tolerability of Rivastigmine Transdermal Patch 10 cm² in Patients With Probable Alzheimer's Disease. July 2008 October 2011
NCT00733642 Completed Phase 1 Single Dose Escalation Study of PF-04360365 In Subjects With Mild To Moderate Alzheimer's Disease August 2008 July 2009
NCT00733785 Completed Phase 1 PK, Dose Proportionality, Food Effect And Repeat Dose Study Of Rosiglitazone XR In Healthy Volunteers August 13, 2008 November 28, 2008
NCT00736775 Completed Phase 1 A Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Anti-Abeta (MABT5102A) in Patients With Alzheimer's Disease August 2008
NCT00742417 Completed Phase 2 Efficacy and Safety of Plasma Exchange With 5% Albumin in Beta-amyloid Peptide Clearance in Cerebral Spinal Fluid July 2007 March 2011
NCT00744978 Completed Phase 2 Evaluation of the Efficacy of Varenicline on Cognition, Safety, Tolerability and Pharmacokinetics in Subjects With Mild-to-Moderate Alzheimer's Disease July 2009 November 2010
NCT00749216 Completed Phase 2 Solanezumab Safety Study in Japanese Patients With Alzheimer's Disease September 2008 July 2009
NCT00750529 Completed Phase 1 Alzheimer and Sleep November 2008 September 2013
NCT00751907 Completed Phase 2 Cerebral and Peripheral Perfusion Pilot Study June 2006 April 2007
NCT03172117 Completed Phase 1/Phase 2 Follow-up Study of Safety and Efficacy in Subjects Who Completed NEUROSTEM® Phase-I/IIa Clinical Trial. May 19, 2017 March 18, 2022
NCT00757939 Completed Phase 1 A Study to Assess Regional Cerebral Blood Flow as an Alzheimer's Disease Biomarker Compared to Positron Emission Tomography in Patients With Mild-to-Moderate Alzheimer's Disease and Cognitively Normal Elderly Subjects (Study MK-0000-068)(COMPLETED) September 2008 October 2010
NCT00759863 Completed Phase 2 LifeZig Personalized Reminiscence Video With Slideshows and Music for Individuals With Alzheimer's and Dementia August 2006 April 2009
NCT00762411 Completed Phase 3 Effects of LY450139, on the Progression of Alzheimer's Disease as Compared With Placebo September 2008 April 2011
NCT00766363 Completed Phase 1 Safety, Tolerability, and Pharmacokinetic Study of EVP-6124 in Patients With Alzheimer's Disease October 2008 March 2009
NCT03113812 Completed Phase 1 Repeated Subcutaneous Administration of ABvac40 in Mild to Moderate Alzheimer's Disease Patients January 1, 2014 July 30, 2015
NCT00777608 Completed Phase 1 A Study to Test the Performance of the CogState Computerized Neuropsychological Battery in Patients With Alzheimer's Disease (0000-086)(COMPLETED) December 2008 April 2010
NCT00785759 Completed Phase 2 Brain Uptake and Safety With Probable Alzheimer's Disease, Amnestic Mild Cognitive Impairment and Healthy Volunteers September 2008 December 2009
NCT03075241 Completed Phase 3 Z-Drugs for Sleep Disorders in Alzheimer's Disease October 2016 April 2020
NCT00795418 Completed Phase 2 Safety and Tolerability of Repeated Subcutaneous Injections of CAD 106 in Mild Alzheimer's Patients October 2008
NCT00800709 Completed Phase 4 Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease July 2008 October 2010
NCT00804271 Completed Phase 3 Memantine and Validation of a New Alzheimer's Disease Scale December 2008 November 2009
NCT03061474 Completed Phase 2 Nicotinamide as an Early Alzheimer's Disease Treatment July 12, 2017 August 30, 2022
NCT00810147 Completed Phase 2 A Phase II, Multicenter, Double Blind, Placebo-Controlled Safety, Tolerability Study of BMS-708163 in Patients With Mild to Moderate Alzheimer's Disease February 2009 June 2010
NCT03056729 Completed Phase 1 Single-Ascending-Dose Study of BIIB076 in Healthy Volunteers and Participants With Alzheimer's Disease February 17, 2017 March 3, 2020
NCT00812565 Completed Phase 2 Study of Octagam (Intravenous Immunoglobulin [IVIG]) 10% on the Treatment of Mild to Moderate Alzheimer's Disease February 2009 September 2010
NCT00814346 Completed Phase 2 Effect of EGb761® on Brain Glucose Metabolism in Three Groups of Elderly Defined by Cognitive Functions October 2008 July 2012
NCT00814697 Completed Phase 2 Effect of Repetitive Transcranial Magnetic Stimulation on Language in Alzheimer's Disease December 2008 August 2012
NCT00814801 Completed Phase 3 An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease February 2007 September 2008
NCT00824590 Completed Phase 1 A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function February 2009 October 2009
NCT00825084 Completed Phase 1 A Phase 1 Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF-01913539] In Japanese And Western Healthy Subjects February 2009 May 2009
NCT00827034 Completed Phase 1 A Phase 1, Randomized, Open-Label, Two-Way Crossover Study To Evaluate The Steady-State Effect Of Dimebon (PF 01913539) On The Single-Dose Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects February 2009 April 2009
NCT00829374 Completed Phase 3 Safety and Efficacy Study Evaluating Dimebon in Patients With Mild to Moderate Alzheimer's Disease on Donepezil March 2009 December 2011
NCT00829816 Completed Phase 1 Safety and Tolerability of Dimebon in Patients on Memantine, and Memantine Plus Donepezil December 2008 August 2010
NCT00838084 Completed Phase 1 A Safety Study of LY2811376 Single Doses in Healthy Subjects December 2008 June 2009
NCT00838110 Completed Phase 3 A Phase 3 Study To Evaluate The Safety And Tolerability Of Dimebon Patients With Mild To Moderate Alzheimer's Disease February 2009 January 2010
NCT00838877 Completed Phase 1 Positron Emission Tomography (PET) Study With [18F]AZD4694 and [11C]AZD2184, Candidate PET Ligands for Aβ Amyloid January 2009 October 2009
NCT00842673 Completed Phase 2 Preliminary Efficacy and Safety Study of ST101 in Alzheimer's Disease February 2009 September 2010
NCT00842816 Completed Phase 2 Preliminary Efficacy and Safety Study of ST101 Plus Aricept in Alzheimer's Disease February 2009 May 2011
NCT03002142 Completed N/A Auditory Rehabilitation and Cognition in Alzheimer Patients March 31, 2017 May 3, 2020
NCT00843518 Completed Phase 2 Treatment for Aggression and Agitation in Patients With Alzheimer's Disease February 2009 June 2011
NCT00855868 Completed Phase 2 Ability Of ([18F]-AV-45) PET Scan to Distinguish Alzheimer's Disease Subjects From Cognitively Normal Individuals March 2009 January 2011
NCT02989402 Completed Phase 4 A Phase IV Study to Evaluate Safety, Tolerability and Effectiveness of Rivastigmine Patch 15cm2 in Patients With Severe Dementia of the Alzheimer's Type. December 31, 2018 December 8, 2022
NCT00857415 Completed Phase 3 Phase III Study of the Correlation Between Florbetapir F18 PET Imaging and Amyloid Pathology in the Brain December 2008 May 2010
NCT00857506 Completed Phase 2 Observational Study of Cognitive Outcomes for Subjects Who Have Had Prior PET Amyloid Imaging With Florbetapir F 18 (18F-AV-45) January 2009 December 2011
NCT02968875 Completed N/A Alzheimer's Disease and Physiological, Cognitive Function and BDNF Levels of Plasma Adaptation After Exercise Training July 2015 February 2018
NCT00862940 Completed Phase 4 A Clinical Study Evaluating the Effects of Memantine on Brain Atrophy in Patients With Alzheimer's Disease September 2005 April 2009
NCT00867399 Completed Phase 1 A Safety and Tolerability Study of ABT-126 in Elderly March 2009
NCT02925650 Completed Phase 1/Phase 2 Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease March 2, 2017 December 31, 2021
NCT02921672 Completed N/A Feasibility Trial of a Mediterranean Diet Pattern to Prevent Cognitive Decline March 2016 December 2018
NCT02910739 Completed Phase 1 An Open-Label Study Investigating MK-8931 in Participants With Mild and Moderate Hepatic Insufficiency (MK-8931-016) October 11, 2016 April 12, 2017
NCT00876863 Completed Phase 2 Randomized, Controlled Study Evaluating CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease November 2008 August 13, 2015
NCT00880347 Completed N/A Blood Gene Expression Signature in Patients Diagnosed With Probable Alzheimer's Disease Compared to Patients Suffering From Other Types of Dementia February 2008 February 2011
NCT00880412 Completed Phase 2 A Study to Determine the Clinical Safety/Tolerability and Exploratory Efficacy of EHT 0202 as Adjunctive Therapy to Acetylcholinesterase Inhibitor in Mild to Moderate Alzheimer's Disease April 2008 August 2009
NCT00880451 Completed Development and Decline of Brain and Cognition Through the Life Span March 2009
NCT00884507 Completed Phase 2 A Study of RO5313534 as Add-on to Donepezil Treatment in Patients With Mild to Moderate Alzheimer's Disease May 2009 November 2010
NCT02910102 Completed Phase 2 Study Evaluating Intepirdine (RVT-101) on Gait and Balance in Subjects With Dementia October 2016 November 2017
NCT02907567 Completed Phase 1/Phase 2 Clinical Trial of CT1812 in Mild to Moderate Alzheimer's Disease September 2016 September 2017
NCT00889603 Completed Non-Interventional Study With Aricept® Evess May 2009 March 2010
NCT02880956 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Participants With Early Alzheimer's Disease January 26, 2017 July 28, 2021
NCT00898807 Completed Phase 3 Citalopram for Agitation in Alzheimer's Disease July 2009 September 2013
NCT02860338 Completed COMPARATIVE EFFECTIVENESS OF MCI and DEMENTIA TREATMENTS IN A COMMUNITY-BASED DEMENTIA PRACTICE January 2009 December 2015
NCT00901498 Completed Phase 1 Relative Bioavailability Study of Four Experimental Formulations for Alzheimer's Disease May 2009 July 2009
NCT02849639 Completed Early Phase 1 The INCREASE Study - Delaying the Onset of Alzheimer's Symptomatic Expression April 4, 2017 April 21, 2021
NCT00904683 Completed Phase 3 Effect of LY2062430 on the Progression of Alzheimer's Disease May 2009 June 2012
NCT00905372 Completed Phase 3 Effect of LY2062430 on the Progression of Alzheimer's Disease May 2009 April 2012
NCT00908999 Completed Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) April 2008 September 2011
NCT00921297 Completed N/A Cataract Removal and Alzheimer's Disease June 2009 March 30, 2017
NCT02848404 Completed N/A Therapeutic Efficacy of Categorical Language Fluency Smartphone Game Application June 2016 February 2017
NCT00930059 Completed Phase 2 A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease September 10, 2009 September 22, 2010
NCT00931073 Completed Phase 1 A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 Metabolizers July 2009 October 2009
NCT00933608 Completed Phase 4 Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease July 2009 September 2011
NCT00934050 Completed Phase 2 ELND005 Long-Term Follow-up Study in Subjects With Alzheimer's Disease June 2009 June 2011
NCT02840279 Completed Phase 1 A Multiple Ascending Dose Study of BPN14770 in Healthy Young and Elderly Male or Female Subjects June 2016 December 2016
NCT00939822 Completed Phase 2 Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease March 2009 September 2013
NCT00940589 Completed Phase 2 Efficacy of Circadin® 2 mg in Patients With Mild to Moderate Alzheimer Disease Treated With AChE Inhibitor September 2009 May 2013
NCT00945672 Completed Phase 2 A Multiple Dose Study of PF-04360365 In Patients With Mild to Moderate Alzheimer's Disease August 6, 2009 June 1, 2011
NCT00948766 Completed Phase 4 Effects of Rivastigmine Patch on Activities of Daily Living and Cognition in Patients With Severe Dementia of the Alzheimer's Type (ACTION) (Study Protocol CENA713DUS44, NCT00948766) and a 24 Week Open-label Extension to Study CENA713DUS44 July 2009 June 2012
NCT00948909 Completed Phase 2 Efficacy and Safety Study for Subjects With Mild-to-Moderate Alzheimer's Disease October 2009 November 2010
NCT00951834 Completed Phase 2/Phase 3 Sunphenon EGCg (Epigallocatechin-Gallate) in the Early Stage of Alzheimer´s Disease October 2009 February 2015
NCT00954252 Completed Phase 1 Safety, Pharmacokinetics and Pharmacodynamics Study of Treatment With CHF 5074 in Healthy Young Male Subjects October 2009 May 2010
NCT00954369 Completed Early Phase 1 Exploratory and Safety Study of [F-18]W372 August 2009 February 2010
NCT00954538 Completed Phase 1 Safety, Radiation Dosimetry, Biokinetics, and Effectiveness of [18F]MK3328 (MK-3328-001) August 2009 May 2011
NCT00954616 Completed Inappropriate Medications Associated With Anticholinesterase and/or Memantine Treatment in the Elderly January 2009 January 2012
NCT00955422 Completed Screening and Evaluation of Patients With Signs and Symptoms of Alzheimer's Disease July 31, 2009 July 6, 2017
NCT00959192 Completed Phase 2 Safety, Tolerability, And Immunogenicity Study Of ACC-001 In Japanese Subjects With Mild To Moderate Alzheimer's Disease August 2009 January 2013
NCT00965588 Completed Phase 1 Study to Evaluate Safety, Tolerability and Immunogenicity of Vaccine (UB 311) in Subjects With Alzheimer's Disease February 2009 April 2011
NCT02820896 Completed Phase 1 A Study of RO7105705 in Healthy Participants and Participants With Mild-to-Moderate Alzheimer's Disease June 29, 2016 June 26, 2017
NCT02814045 Completed Role of Hypoxia Ans Sleep Fragmentation in Alzheimer's Disease. and Sleep Fragmentation. November 2015 July 2017
NCT02813070 Completed Phase 2 Comparison of PET Amyloid Imaging in Japanese and Western Subjects October 2012 May 2013
NCT00973518 Completed Improved Diagnosis of Alzheimer's Disease Using Magnetoencephalography (MEG) September 2009 June 2010
NCT00975481 Completed Phase 1 A Study To Evaluate The Abuse Potential Of Single Oral Doses Of Dimebon (Latrepirdine) In Healthy Recreational Polydrug Users October 2009 February 2010
NCT00976118 Completed Phase 2 Activity of Masitinib (AB1010) in Mild to Moderate Alzheimer's Disease February 2006 February 2009
NCT00979446 Completed N/A Passport to Brain Wellness in Sedentary Adults June 2008 August 2009
NCT00980785 Completed Phase 4 Studying the Effects of Antihypertensives on Individuals at Risk for Alzheimer's April 9, 2009 July 26, 2011
NCT02795780 Completed Phase 2 Follow up 18F-AV-1451 Scan in Confirmatory Cohort Subjects From Study 18F-AV-1451-A05 August 2016 August 28, 2017
NCT00987220 Completed Effect of Aricept on Biomarkers (Acetylcholine, sAPP Alpha) In Cerebrospinal Fluid October 2009 February 2010
NCT00988598 Completed Phase 1 A Brief Study To Evaluate The Safety, Tolerability, And Blood Levels Of Multiple Doses Of PF-044467943 Or Placebo In Combination With Donepezil In Subjects With Mild To Moderate Alzheimer's Disease October 26, 2009 July 5, 2010
NCT00988624 Completed Phase 1 A Study In Healthy Volunteers To Estimate The Pharmacokinetics Of Four Modified-Release Formulations Of Dimebon (Latrepirdine) October 2009 December 2009
NCT00990613 Completed Phase 1 A Study Evaluating The Absorption Of Dimebon Into The Body From A Dimebon Solution Applied To The Skin October 2009 January 2010
NCT00991419 Completed Phase 2 To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden February 2010 August 2011
NCT01000038 Completed N/A Wii-fit for Activity, Balance and Gait in Assisted Living March 30, 2009 July 7, 2011
NCT01005862 Completed Phase 1 Effect of PF-04360365 On ABETA In Patients With Alzheimer's Disease And Healthy Volunteers March 2010 September 2012
NCT01009255 Completed Phase 2 Study to Evaluate the Efficacy and Safety of GSK239512 in Alzheimer's Disease November 2, 2009 November 10, 2010
NCT01018875 Completed Phase 2 Efficacy and Safety Study of ABT-288 in Subjects With Mild-to-Moderate Alzheimer's Disease December 2009 February 2011
NCT01019421 Completed Phase 2 Lu AE58054 Added to Donepezil for the Treatment for Moderate Alzheimer's Disease December 2009
NCT01021644 Completed N/A Genes, Exercise, Memory and Neurodegeneration October 2009 December 2013
NCT01023425 Completed N/A Clinical Trial of Donepezil Between the Naive Group and the Switching Group February 2008 April 2009
NCT01023867 Completed N/A Clinical Trial of Donepezil Between the Patients With Alzheimer's Disease and Mixed Dementia March 2007 June 2010
NCT01024660 Completed Early Phase 1 The Effect of Cognitive Function as Measured by Repeated Cognitive Measures After 12 Weeks Treatment With Donepezil December 2009 January 2011
NCT01025466 Completed Phase 4 Exelon Patch and Combination With Memantine Comparative Trial December 2008 April 2010
NCT01028053 Completed Phase 3 Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects With Amnestic Mild Cognitive Impairment Who Will Convert to Clinically Probable Alzheimer's Disease December 2009 January 2014
NCT02792257 Completed Phase 2 Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease March 1, 2017 May 31, 2024
NCT01035138 Completed Phase 3 A Study of Semagacestat for Alzheimer's Patients December 2009 April 2011
NCT01035164 Completed Phase 1 Evaluation of ZK 6032924 in Probable Alzheimer's Disease Patients Versus Healthy Volunteers and the Radiation Dosimetry of ZK 6032924 in Healthy Volunteers June 2007 January 2010
NCT01038726 Completed N/A Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults December 2009 September 2012
NCT01047579 Completed Phase 4 A 12 Week, Multicenter, Open Label Evaluation of Caregiver Preference, Safety and Tolerability of Exelon® Patch (Rivastigmine Transdermal) in Patients With Alzheimer's Disease April 2010 January 2012
NCT01049555 Completed N/A Contribution of Actigraphy and Recognition Video in Apathy Assessment of Alzheimer's Disease : Experimental Research September 2011 December 2012
NCT01054976 Completed Phase 4 The Efficacy of Galantamine Treatment on Attention in Patients With Alzheimer's Disease October 2006 February 2009
NCT01055561 Completed Phase 1 A Study of Acupuncture for Patients With Behavioural and Psychological Symptoms of Dementia January 2010 March 2011
NCT01058941 Completed Phase 1/Phase 2 Lipoic Acid and Omega-3 Fatty Acids for Alzheimer's Disease September 2010 December 2014
NCT02792179 Completed Phase 1 Evaluation of [18F]RO6958948 as Tracer for Positron Emission Tomography (PET) Imaging of Tau Burden in Alzheimer's Disease Participants July 19, 2016 September 28, 2016
NCT02789800 Completed N/A Patient-Centred Innovations for Persons With Multimorbidity - Quebec April 22, 2016 November 1, 2022
NCT01068353 Completed Phase 2 Safety and Tolerability of Etanercept in Alzheimer's Disease January 2011
NCT02787746 Completed Phase 4 Safety and Efficacy of Donepezil in Mild to Moderate Alzheimer's Disease April 2016 March 2019
NCT01073228 Completed Phase 2 Safety and Cognitive Function Study of EVP-6124 in Patients With Mild to Moderate Alzheimer's Disease April 2010 February 2012
NCT01075763 Completed Phase 2 A Pilot Trial of Interferon Beta-1a in Alzheimer's Disease November 2004 May 2008
NCT01078636 Completed Alzheimer's Disease Neuroimaging Initiative Grand Opportunity April 2010 October 2012
NCT01079819 Completed Phase 1 Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of BMS-708163 April 2010 December 2010
NCT02782975 Completed Phase 1 Absolute Bioavailability of a Single, Fixed Subcutaneous Dose of Aducanumab in Healthy Participants May 2016 November 2016
NCT01093664 Completed Phase 1 Safety/Tolerability, Immunological and Clinical Activity of a Boost Immunization With AFFITOPE AD02 October 2009 July 2010
NCT02778971 Completed Implications for Management of PET Amyloid Classification Technology June 2016 September 2022
NCT01095744 Completed Influence of Age on Amyloid Load in Alzheimer's Disease and in Atypical Focal Cortical Alzheimer's Disease March 2009 May 2012
NCT01097096 Completed Phase 2 Safety, Tolerability and Abeta-specific Antibody Response of Repeated i.m. Injections of Adjuvanted CAD106 in Mild Alzheimer Patients March 2010 December 2012
NCT02778438 Completed A Validation Study of the Novel Application of Telehealth in Clinical Drug Development in Subjects With Mild Cognitive Deficits February 2016 August 2016
NCT01117181 Completed Phase 2 Apathy in Dementia Methylphenidate Trial (ADMET) June 2010 August 2012
NCT01117818 Completed Phase 2 Clinical- and Immunological Activity, Safety and Tolerability of Different Doses / Formulations of AFFITOPE AD02 in Early Alzheimer's Disease September 2010 December 2013
NCT01119638 Completed Phase 4 Escitalopram Treatment for BPSD in Alzheimer's Disease in Comparison to Risperidone April 2008 May 2010
NCT02772523 Completed N/A Control and Intervention Programme on Alzheimer's Disease Risk Factors May 2016 May 2019
NCT01125631 Completed Phase 1 Multiple Intravenous Dose Study Of PF-04360365 In Japanese Patients With Mild To Moderate Alzheimer's Disease May 2010 August 2011
NCT01126099 Completed N/A Prazosin Treatment for Disruptive Agitation in Alzheimer's Disease March 2010 March 2014
NCT02769234 Completed EEG/ERP Longitudinal Study in Alzheimer's Disease (AD) May 2016 July 2017
NCT01128361 Completed N/A Pilot Study of Aerobic Exercise in Early Alzheimer's Disease(AD) May 2010 April 2015
NCT01129115 Completed Early Phase 1 Dose Response Study of Aerobic Exercise in Older Adults May 2010 April 2014
NCT01129596 Completed Post-marketing Surveillance of Long-term Administration of Donepezil Hydrochloride -Investigation of the Clinical Condition and Safety in Patients With Alzheimer's Disease- June 10, 2010 June 23, 2016
NCT01133405 Completed Phase 1 A Safety Study of LY2886721 Single Doses in Healthy Subjects June 2010 October 2010
NCT01137526 Completed Phase 2 Efficacy and Safety Study of ABT-384 in Subjects With Mild-to-Moderate Alzheimer's Disease May 2010 July 2011
NCT02767609 Completed N/A Measuring Cerebral Blood Flow Using Pseudo-continuous Arterial Spin Labeling Perfusion Magnetic Resonance Imaging May 2014 March 3, 2017
NCT01142258 Completed Phase 3 Trazodone for Sleep Disorders in Alzheimer's Disease March 2010 August 2012
NCT01142336 Completed Phase 4 Effects of Simvastatin on Biomarkers June 2010 October 2015
NCT02761707 Completed Biomarkers in Neural Disorders June 2016 July 16, 2019
NCT02756858 Completed Phase 2 An Extension Study of ANAVEX2-73 in Patients With Mild to Moderate Alzheimer's Disease March 2016 November 2020
NCT01148498 Completed Phase 2 A Biomarker Study of Solanezumab in Patients With and Without Alzheimer's August 2010 August 2012
NCT02754830 Completed Phase 1 A Study of LY3303560 in Healthy Participants and Participants With Alzheimer's Disease (AD) April 25, 2016 July 10, 2018
NCT01172145 Completed Phase 3 Treatment of Apathy in Alzheimer's Disease With Modafinil July 2005 September 2007
NCT01179373 Completed Phase 2 Deep Transcranial Magnetic Stimulation for Treatment of Alzheimer's Disease August 2010 June 2015
NCT01189084 Completed Observational Study to Monitor Long-term Immunogenicity and Efficacy of UB 311 Vaccine in Subjects With Alzheimer's Disease April 2010 July 2011
NCT01190800 Completed Capacity Assessment in Persons With Alzheimer's Disease June 2010 September 2014
NCT02750982 Completed N/A Laughter Therapy Effects on Mood, Stress and Self-efficacy in People With Neurological Diseases. July 2016 August 2018
NCT01193608 Completed Phase 1 Study Evaluating The Safety Of AAB-003 (PF-05236812) In Subjects With Alzheimer's Disease September 2010 October 2013
NCT02742597 Completed N/A Patient-Centred Innovations for Persons With Multimorbidity - Ontario January 12, 2016 October 19, 2022
NCT01202994 Completed Phase 2 Practice Effects and Amyloid Imaging Using 18F-PIB or Flutemetamol PET and FDG-PET May 2011 October 14, 2020
NCT01203384 Completed Phase 1 Study to Evaluate Safety, Pharmacokinetics and Pharmacodynamics of CHF5074 in Healthy Young Male Subjects September 2010 December 2010
NCT02719834 Completed Behavioral Expressions in Alzheimer's Disease April 2016 February 2018
NCT01217541 Completed N/A Collaboration Between Department of Old Age Psychiatry and Nursing Homes September 2010 March 2012
NCT01221259 Completed Phase 1 A Randomized, Double-blind, Placebo-controlled, Sequential Ascending, Single-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2212 in Healthy Subjects January 2010 November 2012
NCT01224106 Completed Phase 3 A Study of Gantenerumab in Participants With Prodromal Alzheimer's Disease November 30, 2010 September 10, 2020
NCT01227252 Completed Phase 1 A Safety Study of LY2886721 Multiple Doses in Healthy Subjects December 2010 April 2011
NCT01227564 Completed Phase 2 Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Early Alzheimer's Disease February 2011 February 2014
NCT01230853 Completed Phase 1 A Randomized, Double-blind, Placebo-controlled, Combined Single Ascending Dose and Multiple Ascending Dose Study August 2010 February 2013
NCT02719327 Completed Phase 2/Phase 3 Brain Amyloid and Vascular Effects of Eicosapentaenoic Acid June 8, 2017 September 29, 2023
NCT02711683 Completed DL-3-n-butylphthalide Treatment in Patients With Mild to Moderate Alzheimer's Disease Already Receiving Donepezil March 2016 December 2019
NCT01249196 Completed Phase 3 A Confirmatory Trial of SK-PC-B70M in Mild to Moderate Alzheimer's Disease May 2010
NCT01251718 Completed Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Clinical Safety and Effectiveness in Patients With Alzheimer's Disease December 1, 2010 February 18, 2016
NCT01253122 Completed Phase 1 Comparative Bioavailability in Healthy Elderly Volunteers February 2010 April 2010
NCT01253499 Completed Phase 1 Multiple Dose Study of TRx0037 March 2010 May 2010
NCT01254448 Completed Phase 1 Multiple Ascending Dose Study of TC-5619 in Healthy Elderly Subjects and Subjects With Alzheimer's Disease September 2010 May 2011
NCT01254773 Completed Phase 2 Amyloid Imaging And Safety Study Of Subcutaneous Bapineuzumab In Subjects With Mild to Moderate Alzheimer's Disease December 2010 March 2013
NCT02710188 Completed Phase 1 Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation February 2016 August 2016
NCT01258452 Completed Phase 1 Study to Evaluate the Effects of Food Ingestion on the Pharmacokinetics of CHF 5074 in Healthy Young Male Subjects February 2011 March 2011
NCT01264614 Completed N/A Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults December 2010 April 2011
NCT02709356 Completed N/A Medium Chain Triglycerides and Brain Metabolism in Alzheimer's Disease October 2015 February 2018
NCT01284387 Completed Phase 2 Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Mild to Moderate Alzheimer's Disease January 2011 February 2014
NCT01294540 Completed Phase 1 Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2609 in Healthy Subjects and an Elderly Cohort December 2010 December 2011
NCT01295957 Completed Phase 4 Alzheimer's Disease Reminiscence Quality of Life January 2010 November 2010
NCT01297114 Completed Imaging of Cognition, Learning, and Memory in Aging March 2011 October 1, 2017
NCT01303744 Completed Phase 2 Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 March 2011 April 2012
NCT01309763 Completed Phase 1 Safety and Tolerability of AFFITOPE AD03 October 2010 November 2011
NCT01311492 Completed N/A Exercise Trial for Alzheimer's Disease March 2011 April 2013
NCT01312363 Completed Study for the Tolerability of Exelon Patch (Rivastigmine) for Alzheimer's Disease (AD) Patients June 2009 July 2011
NCT02708485 Completed N/A Effect of Walking on Brain Fuel Consumption in Mild Alzheimer's Disease April 2009 July 2017
NCT02695004 Completed Phase 1 Safety, Tolerability and Pharmacokinetics of DKF-310 ( (Donepezil). February 2016 March 2017
NCT01314950 Completed N/A Alzheimer's Disease Multiple Intervention Trial July 2010 December 2015
NCT01315639 Completed N/A New Biomarker for Alzheimer's Disease Diagnostic September 3, 2010 March 16, 2018
NCT02694445 Completed Monetary Cost of Alzheimer's Disease in China October 2015 May 2016
NCT02690896 Completed N/A Caregiver Burden and Depression: Caring for Those Who Care for Others February 24, 2016 August 1, 2020
NCT01320527 Completed Phase 2 A Clinical Trial of a Vitamin/Nutriceutical Formulation for Alzheimer's Disease August 2008 April 2012
NCT02686216 Completed Phase 1 Biodistribution, Pharmacokinetics, and Safety of F-18 THK-5351 PET in Alzheimer's Disease Patients and Healthy Subjects.(Positron Emission Tomograph ) December 2015 November 2016
NCT01322568 Completed Research on Aging Project in Iceland: Second Stage January 31, 2003 February 11, 2014
NCT01324518 Completed Phase 2 Safety and Efficacy of ORM-12741 in Patients With Alzheimer's Disease April 2011 October 2012
NCT01325259 Completed Phase 2 FluoroAv45 Imaging Research-in Alzheimer's Disease April 2009 December 2013
NCT01325662 Completed A Study to Evaluate the Use of an Indwelling Catheter to Obtain Cerebrospinal Fluid (CSF) by Low-rate Continuous Sampling (MK-0000-211) March 2011 September 2011
NCT02686190 Completed N/A Effects of Light-therapy in Alzheimer's Disease July 2012 December 2014
NCT01329536 Completed The Occurrence of the ApoE4 Allele in Agitated In-Patients With Late-Onset Alzheimer's Disease December 2010 October 2011
NCT01343966 Completed Phase 2 A Study to Evaluate the Efficacy and Safety of MABT5102A in Patients With Mild to Moderate Alzheimer's Disease (ABBY) April 30, 2011 February 28, 2014
NCT01348737 Completed Phase 1 Assessment of Safety, Tolerability and Blood Concentrations of Single Doses of AZD3839 in Healthy Volunteers June 2011 November 2011
NCT01350362 Completed Phase 2 Efficacy, Safety and Tolerability of Tideglusib to Treat Mild-to-Moderate Alzheimer's Disease Patients April 2011 October 2012
NCT01351142 Completed N/A Cytokines and Cognitive Decline in Alzheimer's Disease November 2009
NCT01354444 Completed Phase 4 Trial of Carvedilol in Alzheimer's Disease June 2011 January 2017
NCT01354691 Completed Phase 2 Safety and Efficacy Study of Ladostigil in Mild to Moderate Probable Alzheimer's Disease February 2011 March 2013
NCT01366027 Completed PRISM Registry: Pseudobulbar Affect Registry Series May 2011 September 2012
NCT01369225 Completed Phase 1 Open Label Extension Study Evaluating Safety and Tolerability of AAB-003 (PF-05236812) in Subject With Mild to Moderate Alzheimer's Disease July 2011 August 2014
NCT01370954 Completed NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support) May 2011 December 2012
NCT01374438 Completed Phase 2 3-month Study of MSDC-0160 Effects on Brain Glucose Utilization, Cognition & Safety in Subjects With Alzheimer's Disease July 2011 May 2013
NCT01378195 Completed Phase 2 iCare Stress Management e-Training for Dementia Family Caregivers May 2011 July 2012
NCT01380288 Completed N/A Cognitive Changes in Alzheimer's Disease Patients Associated With or Without White Matter Changes After Rivastigmine June 2011 December 31, 2017
NCT02670993 Completed N/A Support by Singing Sessions on Physical and Moral Pain : Assessment of Its Effectiveness in Alzheimer's Disease January 2016 June 2016
NCT01388478 Completed Phase 2 Safety Study of R(+)Pramipexole to Treat Early Alzheimer's Disease July 2011 April 2014
NCT01397539 Completed Phase 1 Single Ascending Dose Study of BIIB037 in Participants With Alzheimer's Disease June 2011 August 2013
NCT01397578 Completed Phase 2 A Study to Evaluate the Impact of MABT5102A on Brain Amyloid Load and Related Biomarkers in Patients With Mild to Moderate Alzheimer's Disease August 31, 2011 April 30, 2014
NCT01399125 Completed Phase 3 A 24-Week Efficacy, Safety and Tolerability of Rivastigmine Patch Study in Patients With Probable Alzheimer's Disease July 2011 May 2013
NCT02656498 Completed Phase 2 [18F]THK-5351 Positron Emission Computed Tomography Study of Normal, Mild Cognitive Impairment, Alzheimer's Disease and Other Neurodegenerative Disease January 11, 2016 December 31, 2019
NCT01406145 Completed Phase 1 A Study of the Safety and Tolerability of ASP0777 in Subjects With Alzheimer's Disease (AD) Taking a Stable Dose of Donepezil June 16, 2011 November 4, 2011
NCT01409915 Completed Phase 2 Study of the Safety & Efficacy of Leukine® in the Treatment of Alzheimer's Disease March 2011 December 9, 2019
NCT01420315 Completed The Prevalence of Vitamin D Deficiency in Patients With Alzheimer's Disease August 2011 August 2012
NCT01421056 Completed Phase 2 Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Open Label Extension (CT04 OLEP) July 2011 November 2012
NCT02654574 Completed N/A Comparison of Two Modes of Administration of the IADL Questionnaire, Assessing the Level of Functional Autonomy of Patients to Carry Out the Tasks of Daily Living: Randomized Controlled Trial Among Patients of a Memory Clinic June 2014 April 2016
NCT01423396 Completed N/A Impact of Controlling Vascular Risk Factors on the Progression of Alzheimer's Disease March 15, 2010 May 2022
NCT01424436 Completed Phase 1 Modulation of Abeta Levels by GSK933776 in Alzheimer's Disease Patient May 19, 2010 December 8, 2011
NCT01428362 Completed Phase 2 VI-1121 for the Treatment Alzheimer's Disease August 2011 August 2013
NCT01428453 Completed Phase 2 A Phase 2a Study to Evaluate the Effect of Rilapladib (SB-659032) in Alzheimer's Disease October 1, 2011 February 18, 2013
NCT01436045 Completed Phase 2 Safety and Effectiveness Study of Intranasal Insulin Glulisine on Cognitive and Memory in Mild-Mod AD Patients. September 2011 June 2013
NCT01439555 Completed Phase 2 Endothelial Facilitation in Alzheimer's Disease November 2011 November 2017
NCT01447719 Completed Phase 3 Autopsy Follow-up of Subjects Previously Imaged With Florbetapir F 18 (18F-AV-45) PET in Trial 18F-AV-45-A07 March 2010 July 2011
NCT01454115 Completed Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Tolerability of BMS-708163 June 2007 March 2009
NCT02648672 Completed Phase 1 BPN14770 Single Ascending Dose Study in Healthy Male and Female Subjects December 2015 July 2016
NCT01459016 Completed Phase 1 A Non-drug Methods Study in Participants With Alzheimer's Disease December 2011 December 2014
NCT01463384 Completed Phase 2 Minocycline in Patients With Alzheimer's Disease September 2011 October 2012
NCT01465360 Completed Performance of AclarusDx™, a Blood-Based Transcriptomic Test for AD, in US Patients Newly Referred to a Memory Center November 2011
NCT01466088 Completed Phase 2 Efficacy, Safety, & Tolerability of AZD3480 Patients With Mild to Moderate Dementia of the Alzheimer's Type (AD) October 2011 May 2014
NCT01467726 Completed Phase 1 Safety, Pharmacokinetics and Pharmacodynamics of Velusetrag in Healthy Elderly Subjects November 2011 January 2012
NCT02640092 Completed Phase 1 Longitudinal Evaluation of [18F]GTP1 as a PET Radioligand for Imaging Tau in the Brain of Participants With Alzheimer's Disease Compared to Healthy Participants December 23, 2015 June 11, 2019
NCT01478204 Completed A Study to Evaluate Sleep Quality in Patients With Mild to Moderate Alzheimer's Disease June 2008 July 2009
NCT01478633 Completed Phase 4 Evaluation of Efficacy and Safety of Galantamine in Patients With Dementia of Alzheimer's Type Who Failed to Benefit From Donepezil September 2011 June 2013
NCT01481558 Completed Phase 2 Effects of Transcranial Direct Current Stimulation on the Apathy of Alzheimer's Disease January 2012 May 2012
NCT01481961 Completed N/A Study of Repetitive Transcranial Magnetic Stimulation (rTMS) as add-on Treatment for Early Alzheimer's Disease November 2010 May 2012
NCT01482845 Completed Phase 1 A Phase 1 Study of the Safety, Tolerability and Pharmacokinetics of ABT-126 in Subjects With Alzheimer's Disease November 2011 March 2012
NCT01485302 Completed Phase 1 Single and Repeated Dosing Study to Assess the Safety and the Concentration-time Profile of SAR228810 in Alzheimer's Patients January 2012 February 2015
NCT01492374 Completed Phase 1 Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease February 2012 October 2013
NCT01496170 Completed Phase 1 A Study of the Safety, Tolerability, and Pharmacodynamics of MK-8931 in Participants With Alzheimer's Disease (MK-8931-010 AM1 [P07820 AM1]) December 2011 June 2012
NCT01503944 Completed Phase 1/Phase 2 A Trial of 18F-AV-133 and 18F-AV-45 Positron Emission Tomography (PET) March 2010 July 2011
NCT01504854 Completed Phase 2 Resveratrol for Alzheimer's Disease May 2012 March 2014
NCT01504958 Completed N/A Effects of a Combined Transcranial Magnetic Stimulation (TMS) and Cognitive Training in Alzheimer Patients December 2010 May 2015
NCT01505504 Completed Mirtazapine in Alzheimer-associated Weight Loss January 2004 December 2011
NCT01527916 Completed Phase 2 Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease February 2012 November 2013
NCT01529619 Completed Phase 4 Efficacy, Safety and Tolerability of Rivastigmine Patch in Patients With Mild to Moderate Alzheimer's Disease Switched From Cholinesterase Inhibitors March 2012 December 2013
NCT01537757 Completed Phase 1 A Two-Part, Single-Dose Study of the Pharmacokinetics of MK-8931 in Subjects With Renal Insufficiency (MK-8931-009 [P08535]) March 2012 May 2012
NCT01538212 Completed Retrospective Cohort Study Of The Efficacy Of Axona® (Medium Chain Triglycerides) In Patients With Alzheimer's Disease January 2012 October 2012
NCT01547169 Completed Phase 2 Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 21 Days March 2011 December 2012
NCT02626572 Completed Phase 2 Efficacy and Safety of 3 Doses of S47445 Versus Placebo in Patients With Alzheimer's Disease at Mild to Moderate Stages With Depressive Symptoms February 2015 September 2017
NCT01548053 Completed N/A The Primary Care - Dementia Assessment and Treatment Algorithm March 2012 May 2016
NCT01548430 Completed Phase 1 A Safety Study of TTP4000 in Subjects With Alzheimer's Disease October 2011 February 2013
NCT01549834 Completed Phase 2 Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors March 2012 October 2013
NCT02621606 Completed Phase 1 [11C]MK-6884 Positron Emission Tomography (PET) Tracer Validation Trial (MK-6884-001) January 8, 2016 December 28, 2017
NCT02615002 Completed Phase 2 Safety and Efficacy of Piromelatine in Mild Alzheimer's Disease Patients (ReCOGNITION) November 2015 November 19, 2019
NCT01554683 Completed N/A Seizure Activity in Alzheimer's Disease February 2012 July 1, 2017
NCT01555827 Completed N/A Retinal Neurodegenerative Signs in Alzheimer's Diseases March 12, 2012 June 7, 2014
NCT01559220 Completed N/A Deep Brain Stimulation for the Treatment of Alzheimer's Disease March 2012 January 2016
NCT02600130 Completed Phase 1 Lomecel-B Infusion Versus Placebo in Patients With Alzheimer's Disease October 10, 2016 September 2021
NCT01561053 Completed Phase 2/Phase 3 A Study to Evaluate Albumin and Immunoglobulin in Alzheimer's Disease April 19, 2012 March 6, 2018
NCT02585934 Completed Phase 3 Study Evaluating Intepirdine (RVT-101) in Subjects With Mild to Moderate Alzheimer's Disease on Donepezil: MINDSET Study October 2015 September 2017
NCT01565343 Completed Phase 1 A Study of 18F-AV-45 in Alzheimer's Disease (AD) and Healthy Volunteers April 2008 April 2009
NCT01565356 Completed N/A Evaluation of PET Scan Timing Relative to AV-45 Injection Time March 2010 May 2010
NCT01565369 Completed N/A Evaluation of Physician Training Methods to Read Florbetapir-PET Scans January 2011 January 2011
NCT01565382 Completed Phase 3 Evaluation of Inter-reader Reliability Using Images From Subjects With Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI) February 2011 February 2011
NCT02585232 Completed N/A Optimizing Dementia Care October 1, 2016 October 22, 2020
NCT02580305 Completed Phase 2 SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study September 2015 November 7, 2019
NCT01574456 Completed Blood-brain Barrier Permeability in Alzheimer's Disease March 2012 December 2013
NCT01577394 Completed Phase 3 Oculomotor Testing in the Differential Diagnosis of Dementia June 2011 April 2016
NCT01584440 Completed Phase 2 Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Participants With Alzheimer's Disease August 13, 2012 July 30, 2014
NCT01592552 Completed A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery November 2011 March 2015
NCT01594346 Completed Phase 3 Multicenter Vitamin E Trial in Aging Persons With Down Syndrome September 2000 April 2010
NCT01595646 Completed Phase 2 Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120) November 2011 March 12, 2015
NCT01600469 Completed Phase 2 NMDA-enhancing Agent for Treatment of Mild Cognitive Impairment and Mild Alzheimer's Disease January 2012 May 2013
NCT01600859 Completed Phase 1 Evaluation of E2609 in Subjects With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (Study: E2609-A001-101 Amendment 02) July 2012 October 2013
NCT01602393 Completed Phase 2 Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Prolonged Open Label Extension Phase May 2012 October 2013
NCT01607476 Completed Phase 2 Bridging Study of C11 Pittsburgh Compound B (PiB) and F18 Flutemetamol Brain Positron Emission Tomography (PET) July 2012 March 2016
NCT01609335 Completed Phase 1 Normative Values for Cognitive Testing and Alzheimer's Imaging Biomarkers in Young Adults July 2012 August 2013
NCT01609348 Completed N/A Venlafaxine for Depression in Alzheimer's Disease (DIADs-3) April 2012 January 2017
NCT01614886 Completed Phase 3 Randomized, Double-blind Study to Evaluate the Tolerability of 2 Different Titration Methods of Rivastigmine Patch in AD Patients (MMSE 10-20) July 2012 May 2014
NCT02579252 Completed Phase 2 24 Months Safety and Efficacy Study of AADvac1 in Patients With Mild Alzheimer's Disease March 2016 June 2019
NCT01617577 Completed Phase 1/Phase 2 Efficacy and Safety of Filgrastim in Alzheimer's Disease June 2009 February 2012
NCT02576639 Completed Phase 2 Dose-ranging Safety and Tolerability Study in Subjects ≥60 Years of Age August 10, 2015 March 11, 2016
NCT02562989 Completed Phase 1 [18F]MK-6240 Positron Emission Tomography (PET) Tracer First-in-Human Validation Study (MK-6240-001) October 19, 2015 December 27, 2016
NCT01630525 Completed " The Eyes Have it " : Ocular Saccade Abnormalities in Prodromal Alzheimer's Disease December 2012 December 2015
NCT02560753 Completed Phase 1/Phase 2 Feasibility Study in Subjects With Mild to Moderate Alzheimer's Disease July 2015 June 30, 2016
NCT01638949 Completed N/A Multi-modal Neuroimaging in Alzheimer's Disease May 2012 September 20, 2022
NCT01652222 Completed N/A Experimental Study to Validate the "Therapeutic Game" CONEM-BETA January 2012 August 2012
NCT01656525 Completed Phase 1 A Multiple-dose Study of Gantenerumab in Japanese Alzheimer&Apos;s Disease Patients June 2012 June 2014
NCT02557464 Completed N/A Identification of Early Markers of Alzheimer's Disease by Using Eye Tracking in Reading. November 10, 2015 July 5, 2018
NCT01660815 Completed Phase 1 A Study of Florbetapir (18F) in Japanese Healthy Volunteers August 2012 January 2013
NCT01661673 Completed Phase 2 Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease November 2012
NCT01661894 Completed Phase 1 Effectiveness of a Brain-Computer Interface Based System for Cognitive Enhancement in the Normal Elderly April 2012 April 2014
NCT01662882 Completed Phase 2/Phase 3 A Phase II Trial of Florbetapir (18F) Positron Emission Tomography (PET) Imaging in Japan of Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD) October 2012 February 2013
NCT01672827 Completed Phase 3 Effectiveness of an Electronic Training Program for Orienting and Interpreting [18F]Flutemetamol Positron Emission Tomography (PET) Images July 2012 August 2012
NCT02551809 Completed Phase 2 Evaluate the Safety, Tolerability, Immunogenicity and Efficacy of UB-311 in Mild Alzheimer's Disease (AD) Patients October 2015 August 2018
NCT02550665 Completed Phase 3 Optimal Dose Escalation Strategy to Successful Achievement of High Dose Donepezil 23mg December 2014 October 2016
NCT01677754 Completed Phase 2 A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy October 24, 2012 June 12, 2015
NCT01687153 Completed A Study of Brain Aging in Vietnam War Veterans October 2012 September 21, 2021
NCT01689233 Completed Phase 3 Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild Alzheimer's Disease October 2012 May 2016
NCT01689246 Completed Phase 3 Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease January 2013 November 2015
NCT02547818 Completed Phase 3 Safety and Efficacy Study of ALZT-OP1 in Subjects With Evidence of Early Alzheimer's Disease September 15, 2015 November 18, 2020
NCT02546310 Completed Phase 1 Phase 1 Study Investigating Effects of HTL0009936 on Cognition and BOLD fMRI Signals in Healthy Elderly Subjects October 2015 February 2017
NCT01699503 Completed N/A Indiana University Dementia Screening Trial October 2012 November 22, 2017
NCT01702467 Completed Phase 1 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single, Oral Escalating Doses of GSK2647544 in Healthy Volunteers October 19, 2012 May 15, 2013
NCT01702480 Completed Phase 1 Effects of Triglycerides on Age-Related Cognitive Function Decline in Older Subjects November 5, 2012 July 3, 2015
NCT01703117 Completed Phase 2 Riluzole in Mild Alzheimer's Disease November 2013 May 26, 2020
NCT01703702 Completed Phase 4 Effectiveness of Florbetapir (18F) PET Imaging in Changing Patient Management and the Relationship Between Scan Status and Cognitive Decline October 2012 April 2015
NCT01708304 Completed N/A Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs) November 2012 June 2017
NCT02537938 Completed Phase 1 Neurogenetic Pharmaceuticals (NGP) 555 in Healthy Volunteers (14 Day Multiple Ascending Dose) January 2016 December 2016
NCT01713816 Completed Human Brain Antioxidants During Oxidative Stress June 2013 July 24, 2018
NCT01715181 Completed N/A Volunteers Adding Life in Dementia: VALID January 2013 March 2016
NCT01715350 Completed Phase 2 Study to Explore the Optimal Dosage/Administration in Alzheimer's Disease May 2012 June 2015
NCT01716637 Completed Phase 1 Short Term Efficacy and Safety of Perispinal Administration of Etanercept in Mild to Moderate Alzheimer's Disease February 2010 May 2016
NCT01716897 Completed Phase 1 An Study to Determine the Bioavailability of E2609 Tablets Compared to Capsules and the Effect of Food on Absorption October 2012 February 2013
NCT02537626 Completed N/A An Evaluation of Low Level Laser Light Therapy on Improving the Symptoms of Alzheimer's Disease March 15, 2018 October 15, 2020
NCT01723826 Completed Phase 2 A Long-Term Safety Extension of Studies ABE4869g and ABE4955g in Participants With Mild to Moderate Alzheimer's Disease Treated With Crenezumab December 7, 2012 February 8, 2017
NCT01724151 Completed Effects of Exercise Training in Patients With Mild Cognitive Impairment April 2009 April 2012
NCT01727622 Completed Arterial Spin Labeling (ASL) MRI for Cognitive Decline August 2012 May 31, 2018
NCT01729598 Completed Early Phase 1 Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study April 2012 October 2014
NCT01730430 Completed Cerebrospinal Fluid (CSF) Biomarkers Alzheimer's Disease (AD) and Non-AD Dementias July 2012 December 2013
NCT01734395 Completed A Study to Show That the Change of Attention Measure is Correlated With the Changes of Caregiver's Burden After Treatment With Galantamine in Patients With Alzheimer's Disease March 2007 January 2008
NCT01735630 Completed Phase 2 Efficacy and Safety Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease November 2012 May 2015
NCT02537496 Completed N/A Enhancing Working Memory in Patients With Early Alzheimer's Disease Through the Use of rTMS January 14, 2016 October 10, 2018
NCT01741194 Completed Phase 2/Phase 3 AC-1204 26-Week Long Term Efficacy Response Trial With Optional Open-label Ext March 2013 April 14, 2017
NCT01745198 Completed Effect of Cerefolin®/CerefolinNAC® on Biomarker Measurements December 2012 June 2014
NCT02534480 Completed Phase 1 Neurogenetic Pharmaceuticals (NGP) 555 in Healthy Young Volunteers (Single-ascending Dose) March 2015 November 2015
NCT01764243 Completed Phase 2 Safety and Efficacy of MT-4666 November 2012 July 2015
NCT02520232 Completed N/A Pathological and Non-pathological Aging, Physical Activity, Genotype and Cognition June 2015 May 11, 2018
NCT01767909 Completed Phase 2/Phase 3 The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF) January 8, 2014 December 11, 2018
NCT01775696 Completed Central and Systemic Inflammation in Alzheimer's Disease December 8, 2011 April 4, 2017
NCT02516046 Completed Phase 3 18F-AV-1451 Autopsy Study September 2015 July 15, 2018
NCT01779310 Completed Clinical Pathway for Alzheimer's Disease in China (CPAD) November 2012 April 2013
NCT01782742 Completed Phase 2 Bexarotene Amyloid Treatment for Alzheimer's Disease February 2013 December 2014
NCT01798199 Completed N/A Vanquishing Apathy Through E-inclusion Using Realistic Virtual Environment Project May 2013 September 2014
NCT02502253 Completed Phase 1 BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2DM) June 2015 June 1, 2022
NCT01825317 Completed N/A Effect of NeuroAD on Alzheimer Patients March 2013 December 2013
NCT01825330 Completed N/A Effect of NeuroAD on the Cognitive Function of Alzheimer Patients October 2013 March 2016
NCT01826110 Completed Phase 1 PET Imaging Study Using [11C]PIB in Subjects With AD & Healthy Volunteers September 2013 July 2018
NCT02502045 Completed N/A Effect of Therapeutic Light on Sleep, Circadian Rhythm, and Global Function in Women With Alzheimer's May 2012 January 2016
NCT01841125 Completed Phase 4 Escitalopram for the Treatment of Depression in Alzheimer's Disease November 2011 July 2014
NCT02492529 Completed N/A Knowing and Remembering: Cognitive and Neural Influences of Familiarity on Recognition Memory in Early Alzheimer's Disease July 21, 2015 December 31, 2017
NCT02489110 Completed N/A Webnovela for Hispanic Dementia Family Caregivers June 2015 September 2016
NCT01847586 Completed N/A Enhancing Neuroplasticity and Frontal Lobe Function in Patients With Mild Alzheimer's Disease April 2013 October 2017
NCT02278354 Completed Phase 1 Tau Imaging in Professional Fighters February 18, 2015 February 3, 2017
NCT00001235 Completed Genetic Studies in Alzheimer's Disease February 1988 February 2004
NCT00001480 Completed The Evaluation and Follow-up of Individuals With Memory Disorder March 21, 1995 March 31, 2007
NCT00001549 Completed Diagnosis and Natural History Study of Patients With Neurological Conditions October 1995 January 2006
NCT00001662 Completed Phase 2 Treatment of Alzheimer's Disease With CX516 (Ampalex) December 1996 November 2005
NCT00001917 Completed Brain Imaging in Elderly People and Individuals With Alzheimer's Disease April 1999 April 2005
NCT00001933 Completed Phase 2 Nefiracetam in the Treatment of Alzheimer's Disease July 1999 January 2002
NCT00001972 Completed PET Scan of Brain Metabolism in Relation to Age and Disease September 1994 August 2002
NCT00001977 Completed The Effect of Acetylcholine on Memory and Attention January 2000 April 2001
NCT00009217 Completed Phase 4 Treatment of Behavioral Symptoms in Alzheimer's Disease January 1999 December 2004
NCT00010803 Completed Phase 3 Ginkgo Biloba Prevention Trial in Older Individuals October 2000 July 2011
NCT00012831 Completed Nurse Managed Clinic for Dementia Patients and Family Caregivers June 2001
NCT00013182 Completed N/A Effect of Activity on Sleep of Cognitively-Impaired Veterans June 2001
NCT00013650 Completed Phase 1 Effects of an Anti-Inflammatory Drug in Alzheimer's Disease March 22, 2001 April 21, 2008
NCT00015548 Completed N/A CATIE-Alzheimer's Disease Trial March 2001 October 2004
NCT00018291 Completed N/A Specific Interventions for Agitation in Alzheimer's Disease January 2001 January 2005
NCT00018343 Completed Phase 2 Alzheimer's Disease and Aging: Therapeutic Potential of Estrogen April 1998 March 2001
NCT00018473 Completed Gene-Environment Interactions in Alzheimer's Disease April 1999 March 2004
NCT05888610 Completed N/A Caregiver Solutions for Dementia Patients June 12, 2023 July 12, 2023
NCT05792163 Completed Phase 1 A First Time in Human Study of SNP318 as a Treatment for Neurodegenerative Diseases Including Alzheimer's Disease March 20, 2023 November 29, 2023
NCT02260167 Completed N/A Treatment of Alzheimer's and Dementia With the Metabolism, Infections, Nutrition, Drug Elimination (MIND) Protocol September 2014 December 2017
NCT02260674 Completed Phase 2 A Safety and Tolerability Study of JNJ-54861911 in Participants With Early Alzheimer's Disease November 2014 June 2016
NCT02262975 Completed A Multi-national Study to Identify Treatment Discontinuation Rate in de Novo Alzheimer's Disease Patients Who Have Been Newly Prescribed With Donepezil (Aricept) in Asia (ADOS) July 2014 August 2016
NCT02278367 Completed Phase 2 Clinical Evaluation of Flortaucipir F 18 December 2014 June 26, 2019
NCT02474251 Completed N/A Brain Sleep Clearance of Amyloid-Beta Peptides October 1, 2015 July 31, 2019
NCT01859767 Completed Phase 1 Efficacy and Safety of MNI-672 SPECT for Detection/Exclusion of Cerebral B-amyloid in AD Subjects Compared to HVs. April 2013 April 2015
NCT01862640 Completed Phase 3 A Phase 3, 12-week, Multicenter, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of 2 Fixed Doses of Brexpiprazole in the Treatment of Alzheimer's Agitation July 11, 2013 March 15, 2017
NCT01864655 Completed Phase 1 Safety and Tolerability of AZD0530 (Saracatinib) in Alzheimer's Disease July 2013 November 6, 2014
NCT01867346 Completed Early Markers of Cognitive Change and Alzheimer s Disease March 19, 2003 January 2, 2015
NCT02472899 Completed Biomarker Study for Alzheimer's Disease February 2007 June 2016
NCT02471833 Completed Phase 1/Phase 2 Health Evaluation in African Americans Using RAS Therapy April 2015 April 15, 2022
NCT01876823 Completed Phase 2/Phase 3 Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment April 2006 March 2010
NCT02471196 Completed Phase 2 Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease August 14, 2015 December 4, 2017
NCT02462161 Completed Phase 1 Study of Nasal Insulin to Fight Forgetfulness - Short-Acting Insulin Aspart March 20, 2015 April 16, 2019
NCT02460783 Completed N/A Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function June 22, 2015 December 23, 2022
NCT01890343 Completed Phase 2 Imaging Characteristics of Florbetapir 18F in Patients With Frontotemporal Dementia, Alzheimer's Disease and Normal Controls. September 2009 April 2013
NCT01893398 Completed N/A Multistimulation Group Therapy for Alzheimer's Disease January 2010
NCT01894620 Completed N/A The Effect of rTMS Treatment on Alzheimer's and Sleep Quality May 2013 October 2014
NCT02453763 Completed In Vivo Imaging of Therapeutic Electric Current Flow June 2015 July 6, 2017
NCT01908010 Completed Phase 1 Safety, Tolerability, and Pharmacokinetics of ABT-354 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors July 2013 November 2013
NCT01920672 Completed N/A Disrupted Sleep, Neuroendocrine Status and the Behavioral Symptoms of AD September 2013 June 2015
NCT01921972 Completed Phase 4 The Efficacy of a Combination Regimen in Patients With Mild to Moderate Probable Alzheimer's Disease November 2004 May 2009
NCT01922258 Completed Phase 3 Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type September 2013 March 2017
NCT02434718 Completed Phase 1 Single and Multiple Ascending Dose Study of Aducanumab (BIIB037) in Japanese Participants With Alzheimer's Disease June 24, 2015 December 9, 2016
NCT01926691 Completed Predictors for Poststroke Outcomes: Tel Aviv Brain Acute Stroke Cohort Acute Stroke Cohort (TABASCO) April 1, 2008 December 31, 2015
NCT01928420 Completed Phase 2 A Single Site, Randomized, Double-blind, Placebo Controlled Trial of NIC5-15 in Subjects With Alzheimer's Disease April 2007 June 2014
NCT02431468 Completed Phase 2 A Study Assessing Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease November 2015 February 2017
NCT02423200 Completed Phase 2 Clinical Pharmacology of p38 MAP Kinase Inhibitor, VX-745, in Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD April 2015 November 2016
NCT01948791 Completed Phase 4 16w Interventional Study on Titration and Dose/Efficacy Assessment of Exelon in Chinese Alzheimer's Disease Patients August 2014 September 2015
NCT02423122 Completed Phase 2 A PET Study of the Effects of p38 MAP Kinase Inhibitor, VX-745, on Amyloid Plaque Load in Alzheimer's Disease (AD) April 2015 September 2016
NCT02420756 Completed Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) Study February 2016 December 2017
NCT01955161 Completed Phase 3 Study of Idalopirdine in Patients With Mild - Moderate Alzheimer's Disease Treated With Donepezil October 2013 July 2016
NCT01958437 Completed N/A Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation October 1, 2013 March 24, 2017
NCT01962779 Completed N/A Sleep, Aging and Risk for Alzheimer's Disease July 31, 2013 May 3, 2017
NCT01965756 Completed Phase 2 Effect of Insulin Sensitizer Metformin on AD Biomarkers January 2013 April 2017
NCT01966666 Completed Phase 1 A Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of TPI-287 in Alzheimer's Disease November 2013 September 2019
NCT02418806 Completed N/A Group Therapy for Caregivers of Alzheimer's Disease Patients in Spanish Elderly Persons Centres January 2014 September 2015
NCT02403752 Completed N/A Paired Integrative Home Exercise for Seniors With Dementia and Their Caregivers (PairedPLIE) March 2015 July 2018
NCT02389413 Completed Phase 2 Safety and Tolerability of PQ912 in Subjects With Early Alzheimer's Disease March 2015 April 2017
NCT02386306 Completed Phase 1 Study Evaluating Safety, Tolerability, and PK of Multiple Ascending Doses of GC021109 in Subjects With Mild to Moderate Alzheimer's Disease February 2015 October 2015
NCT01982578 Completed N/A Genistein as a Possible Treatment for Alzheimer's Disease. September 1, 2017 December 31, 2020
NCT01992380 Completed Phase 1 A Study of Flortaucipir PET in Healthy Volunteers and Cognitively Impaired Subjects November 13, 2013 May 30, 2014
NCT02384993 Completed N/A aeRobic Exercise and Cognitive Health April 28, 2015 July 19, 2016
NCT01998711 Completed N/A Impact of a Memory Group for Older Adults Reporting Memory Difficulties October 2004 November 2007
NCT01998841 Completed Phase 2 A Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers to Evaluate Efficacy and Safety in the Treatment of Autosomal-Dominant Alzheimer's Disease (AD), Including a Placebo-Treated Non-Carrier Cohort December 20, 2013 August 8, 2023
NCT02000583 Completed N/A Alzheimer's Prevention Through Exercise November 2013 December 31, 2019
NCT02002819 Completed Phase 2 Levetiracetam for Alzheimer's Disease-Associated Network Hyperexcitability October 16, 2014 July 21, 2020
NCT02380703 Completed N/A Aggression Prevention Training for Caregivers of Persons With Dementia (APT) February 5, 2015 October 23, 2018
NCT02005380 Completed Usability Study of Spaced Retrieval Exercise Using Mobile Devices for Alzheimer's Disease Rehabilitation November 2013 November 2013
NCT02006641 Completed Phase 3 Idalopirdine in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil February 2014 December 2016
NCT02006654 Completed Phase 3 Study of Idalopirdine in Patients With Mild - Moderate Alzheimer's Disease Treated With an Acetylcholinesterase Inhibitor March 2014 January 2017
NCT02010476 Completed Alzheimer's Disease Biomarkers in Cerebrospinal Fluid in Insulin-resistant Men November 2013 April 2016
NCT02016560 Completed Phase 2/Phase 3 Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI, and AD Subjects December 2013 July 28, 2017
NCT02017340 Completed Phase 3 A Phase III Trial of Nilvadipine to Treat Alzheimer's Disease April 24, 2013 December 16, 2016
NCT02021682 Completed CNS and Plasma Amyloid-Beta Kinetics in Alzheimer's Disease December 2013 July 2017
NCT02377713 Completed Phase 1 A Single Dose Study of KHK6640 in Japanese Patients With Alzheimer's Disease. March 2015 September 2016
NCT02365051 Completed N/A Translation of COPE for Publicly-Funded Home Care Clients and Their Families May 2015 September 30, 2019
NCT02031198 Completed Phase 1 18-months Safety Follow-up Study of AADvac1, an Active Tau Vaccine for Alzheimer's Disease January 2014 December 2016
NCT02360657 Completed Phase 1 Study Investigating the Effects of JNJ-54861911 on Amyloid-beta Processing in Cerebrospinal Fluid (CSF) and Plasma in Japanese Participants Asymptomatic at Risk for Alzheimer Dementia February 16, 2015 September 8, 2015
NCT02035982 Completed Phase 3 Discontinuation of Cholinesterase Inhibitors for the Treatment of Severe Alzheimer's Disease July 2010 September 2015
NCT02040987 Completed Phase 1 AZD3293 Thorough QT Study in Healthy Male Volunteers January 2014 May 2014
NCT02041728 Completed The Detection of Early Dementia With the Digital Game Memory January 2013 April 2013
NCT02359552 Completed Phase 2 Rasagiline Rescue in Alzheimer's Disease Clinical Trial May 2015 January 4, 2019
NCT02051335 Completed Phase 1 Roflumilast and Donepezil to Reverse Scopolamine Induced Cognitive Deficits in Healthy Adults January 2014 May 2014
NCT02051608 Completed Phase 3 A Study of Gantenerumab in Participants With Mild Alzheimer Disease March 27, 2014 April 16, 2021
NCT02356055 Completed N/A Mass Practice of Activities of Daily Living in Dementia (STOMP) October 2014 November 2016
NCT02051790 Completed Phase 4 Evaluation of Reader Training Processes March 2014 August 2014
NCT02353884 Completed Multi-modality MRI Study on Prediction for Mild Cognitive Impairment Conversion January 2010 December 2012
NCT02054208 Completed Phase 1/Phase 2 Safety and Exploratory Efficacy Study of NEUROSTEM® Versus Placebo in Patients With Alzheimer's Disease March 2014 December 2019
NCT02061878 Completed Phase 1 A Study to Evaluate the Effect of Bexarotene on Beta-Amyloid and Apolipoprotein E Metabolism in Healthy Subjects August 2014 November 2014
NCT02353845 Completed Construction of Diagnosis System for Early AD Based on Multi-Modality MRI Technology November 2013 August 2016
NCT02063308 Completed N/A Oxaloacetate Pharmacokinetics and Safety February 2014 June 2014
NCT02064920 Completed Phase 2 Computerized Cognition Testing in Participants With Mild Alzheimer's Disease (AD) Treated With Donepezil (MK-0000-318) April 22, 2014 July 13, 2016
NCT02074215 Completed N/A Effect of Exercises Training in Patients With Mild Cognitive Impairment and Early Alzheimer's Disease March 2011 December 2013
NCT02078310 Completed Phase 1/Phase 2 Study of ITI-007 in Healthy Geriatric Volunteers and in Geriatric Patients With Dementia February 2014 November 2014
NCT02079246 Completed Phase 3 Long-term Safety and Tolerability of Idalopirdine (Lu AE58054) as Adjunctive Treatment to Donepezil in Patients With Mild-moderate Alzheimer's Disease April 7, 2014 July 6, 2017
NCT02079909 Completed Phase 2 Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease (US202) March 2014 May 5, 2017
NCT02350634 Completed Phase 1 18F-AV-1451 High Resolution Autopsy Study June 2015 May 18, 2018
NCT02350127 Completed Phase 2/Phase 3 Preventing Loss of Independence Through Exercise (PLIE) in Persons With Dementia May 4, 2015 December 31, 2018
NCT02089555 Completed African American Alzheimer's Progression Markers - CSF and Neuro-Imaging September 2013 June 2016
NCT02094729 Completed Phase 1 A Randomized, Double-blind, Placebo-controlled Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamic Response of Repeated Intravenous Infusions of BAN2401 in Subjects With Mild Cognitive Impairment Due to Alzheimer's Disease and Mild Alzheimer's Disease September 2013 May 2015
NCT02097056 Completed Phase 4 Safety and Efficacy of Donepezil HCl 23 mg in Patients With Moderate to Severe Alzheimer's Disease February 2014 May 2015
NCT02107599 Completed Phase 4 The Feasibility of Florbetapir Quantitation in Europe March 2014 May 2014
NCT02109705 Completed Porphyromonas Gingivalis and Alzheimer's Disease March 2014 January 2021
NCT02119546 Completed N/A Effects of Exercise Training in Patients With Mild Cognitive Impairment and Early Alzheimer's Disease May 2010 December 2012
NCT02120664 Completed Phase 1 Florbetapir Calibration to the Centiloid Scale April 2014 September 2015
NCT02127476 Completed Phase 1 A Study of Single and Multiple Doses of KHK6640 in Subjects With Prodromal or Mild to Moderate Alzheimer's Disease July 2014 May 2017
NCT02129348 Completed Phase 2 Treatment of Psychosis and Agitation in Alzheimer's Disease June 2014 January 2020
NCT02347202 Completed N/A Tools for Distance Delivery of an Evidence-based AD Family Caregiver Intervention October 2015 March 4, 2020
NCT02137460 Completed Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease May 2014 January 2023
NCT02141971 Completed Down Syndrome Biomarker Initiative (DSBI) June 1, 2013 April 15, 2017
NCT02142777 Completed Phase 1 S-Equol in Alzheimer's Disease (SEAD) Trial July 2014 April 2016
NCT02346201 Completed Phase 3 Apathy in Dementia Methylphenidate Trial 2 January 2016 July 15, 2020
NCT02155946 Completed N/A Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment December 1, 2014 March 31, 2021
NCT02158910 Completed A Plan on Investigation and Collection of Aricept Safety Information With a Dose Increase on Alzheimer's Disease Patients March 2015 June 2016
NCT02162264 Completed Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Factors That Affect Aricept Medication Persistence Rate and the Safety and Efficacy in Patients With Alzheimer's Disease in Clinical Practice June 1, 2013 July 22, 2016
NCT02336360 Completed Phase 1 Augmenting Flortaucipir Dosimetry Estimates January 2015 June 2015
NCT02167256 Completed Phase 2 A Phase IIa Multi-Center Study of 18F-FDG PET, Safety, and Tolerability of AZD0530 in Mild Alzheimer's Disease December 2014 February 27, 2018
NCT02176629 Completed N/A Usability of Virtual Reality in Subjects With Mild Cognitive Impairment or Alzheimer's Disease August 2014 February 2015
NCT02185053 Completed Phase 2 A Phase II Study of CPC-201 to Treat Alzheimer's Disease Type Dementia July 31, 2014 July 31, 2016
NCT02198586 Completed Apoe Impact Study on Brain Structure and Function, in a Population 45 to 75 Years Old April 2014 September 2015
NCT02205424 Completed Cognition And Neocortical Volume After Stroke May 1, 2011 June 30, 2021
NCT02205710 Completed N/A Adaptive Cognitive Training in Healthy Older Adults August 2016 August 2018
NCT02210286 Completed N/A Magnesium L-Threonate for the Enhancement of Learning and Memory in People With Dementia July 2014 July 2016
NCT02317523 Completed N/A Alzheimer's Caregiver Coping: Mental and Physical Health September 2014 June 30, 2019
NCT02309723 Completed N/A Influence of Beta Amyloid Imaging on Care of Patients Cognitive Complaints. September 2013 November 2013
NCT02222181 Completed N/A Impact of Pharmacotherapy Management in Patients With Alzheimer's Disease April 2014 March 2016
NCT02300584 Completed N/A Distance Savvy: Testing Tele-Savvy, a Distance Dementia Family Caregiver Education Program November 2014 October 2015
NCT02228187 Completed Phase 2 Brain-Computer Interface System for Training Memory and Attention in Elderly July 2015 June 2017
NCT02244541 Completed Phase 2 Phase 2a Dose Finding, PK/PD and 12 Month Exploratory Efficacy Study of ANAVEX2-73 in Patients With Alzheimer's Disease December 2014 November 2016
NCT02292238 Completed Phase 2 Benfotiamine in Alzheimer's Disease: A Pilot Study February 15, 2015 September 8, 2020
NCT02291783 Completed Phase 1 Phase I, Healthy Subject, Safety, Tolerability and Pharmacokinetic Study of an M1 Agonist to Treat Cognitive Impairment November 2013 July 2014
NCT02290912 Completed N/A Gray Matters Alzheimer's Disease Prevention Intervention April 2014 December 2014
NCT02279511 Completed Phase 2 ATP in Alzheimer Disease December 2014 February 2016
NCT02256306 Completed N/A The PLasma for Alzheimer SymptoM Amelioration (PLASMA) Study September 2014 February 2017
NCT02752750 Enrolling by invitation Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease May 2016 May 2025
NCT00950430 Enrolling by invitation Phase 4 Imaging of Brain Amyloid Plaques in the Aging Population April 2008 June 2024
NCT00585572 Enrolling by invitation Wisconsin Brain Donor Program March 2007 August 2050
NCT02831283 Enrolling by invitation Phase 2 Imaging Inflammation in Alzheimer's Disease June 2016 June 2023
NCT06411561 Not yet recruiting N/A A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors July 1, 2024 May 31, 2027
NCT02438202 Not yet recruiting N/A Electroconvulsive Therapy for Treatment of Alzheimer´s Disease December 2026 January 2028
NCT06338397 Not yet recruiting N/A Social & Affective Cognition in Alzheimer's Disease & Associated Disorders May 2, 2024 May 2, 2027
NCT06380725 Not yet recruiting N/A The Treatment of High Intensity Transcranial Current Stimulation for Alzheimer's Disease April 2024 December 2024
NCT06384573 Not yet recruiting Phase 3 DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease June 2024 November 2029
NCT05463731 Recruiting Phase 3 A Study of Remternetug (LY3372993) in Participants With Alzheimer's Disease (TRAILRUNNER-ALZ 1) August 1, 2022 October 1, 2026
NCT05462106 Recruiting Phase 1/Phase 2 A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study) June 21, 2022 June 2026
NCT06245616 Recruiting N/A Attenuation of Postprandial Inflammatory Processes in Alzheimer's Disease Patients by Consumption of Pomace Oil May 1, 2024 June 30, 2025
NCT05965414 Recruiting Early Phase 1 Safety and Pharmacokinetics of Single Ascending Doses and Multiple Ascending Doses of CS6253 in Healthy Volunteers October 23, 2023 September 30, 2024
NCT02330510 Recruiting Amyloid and Glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment Patients With Significant White Matter Disease August 2014 December 2024
NCT06206824 Recruiting Phase 1 Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease January 18, 2024 August 2024
NCT05908695 Recruiting Phase 4 An Efficacy and Safety Study of Sodium Oligomannate (GV-971) for the Treatment of Alzheimer's Disease August 31, 2023 December 2029
NCT06199037 Recruiting Phase 2 Safety and Pharmacodynamics of SHR-1707 in Alzheimer's Disease Patients February 5, 2024 June 24, 2026
NCT05423522 Recruiting Phase 2 Clinical Safety and Efficacy Evaluation of NanoLithium® NP03 in Patients With Mild-to-severe Alzheimer's Disease May 20, 2022 April 2025
NCT05837819 Recruiting N/A Methodology Issues in a Tailored Light Treatment for Persons With Dementia - Aim 2 February 14, 2023 December 2025
NCT05811442 Recruiting Phase 2 Study of 50561 in Patients With Mild or Moderate Alzheimer's Disease April 18, 2023 June 2024
NCT05383833 Recruiting N/A Creatine to Augment Bioenergetics in Alzheimer's December 12, 2022 June 30, 2025
NCT05260177 Recruiting N/A Study on the Effect of 40 Hz Non-Invasive Light Therapy System September 20, 2022 December 1, 2026
NCT05256251 Recruiting Westlake Longevity Cohort November 15, 2021 November 14, 2031
NCT06356337 Recruiting N/A A Light Exposure Tracker Designed to Improve Circadian Rhythms - Aim 1 February 22, 2024 August 31, 2025
NCT06402838 Recruiting Phase 2 A Study to Evaluate the Safety and Biomarker Effects of RO7269162 in Participants at Risk for or at the Prodromal Stage of Alzheimer's Disease (AD) May 2, 2024 May 19, 2027
NCT05804383 Recruiting Phase 1 A Multiple Ascending Dose Study in Healthy Volunteers and Patients With Alzheimer's Disease March 28, 2023 July 15, 2024
NCT06337578 Recruiting Advances in Telephone-based Cognitive Screening Procedures October 25, 2023 October 25, 2026
NCT05744401 Recruiting Phase 2 A Long-term Extension Study to Evaluate Safety, Tolerability, and Efficacy of AL002 in Alzheimer's Disease January 4, 2023 December 2025
NCT02524405 Recruiting BEAM: Brain-Eye Amyloid Memory Study February 2016 March 2025
NCT05978830 Recruiting N/A Development of Multimodal Fusion Warning System and Non-invasive Techniques for Early Alzheimer's Detection. March 1, 2022 December 30, 2024
NCT05738486 Recruiting Phase 3 A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6) February 28, 2023 May 2025
NCT05176704 Recruiting Development and Validation of a Novel Functional Eye-Tracking Software Application for Alzheimer's Disease April 15, 2022 March 3, 2024
NCT05153941 Recruiting Diagnosis and Monitoring of Disease Progression Using Deep Neuro Signatures January 31, 2022 January 31, 2030
NCT05681819 Recruiting Phase 1 Safety, Tolerability and Pharmacodynamics of SHR-1707 in Alzheimer's Disease Patients. February 17, 2023 August 18, 2025
NCT05048966 Recruiting N/A Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons December 8, 2022 September 2025
NCT01421420 Recruiting Alzheimer's Disease Core Center July 2001 July 2025
NCT05040217 Recruiting Phase 1 A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment February 7, 2022 October 1, 2027
NCT05020106 Recruiting The Diagnostic Cut-off Value of Core Biomarkers of Alzheimer's Disease September 1, 2018 September 1, 2025
NCT06183658 Recruiting Greater-Bay-Area Healthy Aging Brain Study (GHABS) May 1, 2021 April 30, 2026
NCT05658913 Recruiting Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU) March 14, 2023 December 2029
NCT04926272 Recruiting Phase 2 Amyloid-beta PET Imaging With 18F-92 in Alzheimer's Disease July 1, 2021 July 1, 2024
NCT04850053 Recruiting Detection of Alzheimer's Disease (AD)-Related Seeds for AD Diagnosis August 26, 2020 December 31, 2024
NCT06322667 Recruiting A Post Marketing Study in Participants With Early Alzheimer's Disease Treated With Lecanemab February 14, 2024 December 31, 2027
NCT04820127 Recruiting N/A Personalized Management of Psycho-behavioral Symptoms in Alzheimer's Disease: Impact on Health Resources Use October 14, 2021 October 14, 2024
NCT04769024 Recruiting N/A Virtual Reality Intervention for the Reduction of Behavioral and Psychological Symptoms of Dementia December 2, 2022 July 2024
NCT04666077 Recruiting N/A Music Therapy Experiences in Patients With Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) August 27, 2019 December 2023
NCT04426539 Recruiting New IDEAS: Imaging Dementia-Evidence for Amyloid Scanning Study December 17, 2020 December 31, 2024
NCT04396873 Recruiting Phase 1 PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease August 17, 2021 October 3, 2030
NCT04073628 Recruiting N/A The Long-term Impact of a Light Intervention on Sleep and Cognition in Mild Cognitive Impairment June 14, 2021 April 2025
NCT03945968 Recruiting The Role of Concomitant Diseases in Postoperative Complications Risk Stratification. July 1, 2019 February 28, 2025
NCT06141356 Recruiting [18F]Florbetazine ([18F]92) for Beta Amyloid PET Imaging in Alzheimer's Disease January 30, 2023 December 31, 2025
NCT03360552 Recruiting N/A Evaluating the Effectiveness of a New Way of Organizing Primary Health Care to Improve the Management of Alzheimer's Disease January 16, 2019 January 15, 2026
NCT03233646 Recruiting Retinal Imaging in Neurodegenerative Disease July 20, 2017 December 31, 2025
NCT03140865 Recruiting Wake Forest Alzheimer's Disease Clinical Core January 2014 January 2031
NCT03019757 Recruiting Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease August 30, 2018 December 2024
NCT00869817 Recruiting Dominantly Inherited Alzheimer Network (DIAN) January 2009 July 2025
NCT06088121 Recruiting N/A Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Dementia May 15, 2023 June 30, 2025
NCT05655195 Recruiting N/A Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy December 14, 2022 September 1, 2026
NCT05607615 Recruiting Phase 2 A 6-Month Study to Evaluate the Safety & Potential Efficacy of Trappsol Cyclo in Patients With Early Alzheimer's Disease September 23, 2022 March 31, 2024
NCT05596994 Recruiting N/A 7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD February 28, 2023 July 2025
NCT05591027 Recruiting Phase 1 Safety and Target Engagement of Centella Asiatica in Cognitive Impairment December 1, 2022 March 31, 2026
NCT02022943 Recruiting Alzheimer's Prevention Registry: A Program to Accelerate Enrollment Into Studies May 2012 January 2030
NCT05578443 Recruiting Phase 2 Effect of Astragalus Membranaceus on the Improvement of Cognitive Function in Alzheimer's Disease October 1, 2022 July 30, 2025
NCT05551741 Recruiting Phase 1 A First in Human Study of IBC-Ab002 in Persons With Early Alzheimer's Disease (AD) February 23, 2023 November 1, 2025
NCT06079190 Recruiting Phase 2 Efficacy and Safety of GSK4527226 [AL101] in Participants With Early Alzheimer's Disease October 20, 2023 May 16, 2029
NCT06285240 Recruiting Phase 1 Efficacy and Safety of MK-1167 in Participants With Alzheimer's Disease Dementia Taking Stable Donepezil Treatment (MK-1167-007) March 28, 2024 August 16, 2024
NCT06043700 Recruiting A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology September 12, 2023 March 31, 2025
NCT05542953 Recruiting Phase 3 [18F]APN-1607 PET in Subjects With AD Compared to HC February 11, 2022 June 2023
NCT00205621 Suspended Phase 1 Positron Emission Tomography of Amyloid in Alzheimer's Disease October 2005 December 2009
NCT02033941 Suspended Phase 2 Phase 2 Study to Examine Grape Seed Extract as an Anti-Oligomerization Agent in Alzheimer's Disease (AD) July 3, 2018 March 2024
NCT02245568 Terminated Phase 3 Open-Label Study of Leuco-methylthioninium Bis(Hydromethanesulfonate) (LMTM) in Subjects With Alzheimer's Disease or Behavioral Variant Frontotemporal Dementia (bvFTD) August 2014 May 2017
NCT02303158 Terminated Relationship Between Protein Biomarkers in Cerebrospinal Fluid and Alzheimer&Apos;s Disease in Patients With Depression January 2014 October 2018
NCT02221947 Terminated Phase 1/Phase 2 Study to Evaluate the Preliminary Safety, Efficacy, PK and PD of Bryostatin 1 in Patients With Alzheimer's Disease June 2014 December 2014
NCT02220738 Terminated Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ABT-957 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors September 2014 March 2016
NCT02327182 Terminated Phase 3 Safety Study of MT-4666 in Subjects With Alzheimer's Disease December 2014 October 2015
NCT02166827 Terminated N/A Effects of a NeuroAD System, for the Treatment of Alzheimer Disease November 2014 November 2015
NCT02080364 Terminated Phase 3 Evaluation of the Efficacy and Safety of Azeliragon (TTP488) in Patients With Mild Alzheimer's Disease April 2015 June 1, 2018
NCT02353949 Terminated Phase 3 Investigating the Clinical Consequences of Flutemetamol-PET-scanning May 2015 December 10, 2019
NCT02051764 Terminated Phase 2 Imaging Characteristics of a Follow-up 18F-AV-1451 Scan May 2014 December 2016
NCT02359864 Terminated N/A Study of Low Dose Whole Brain Irradiation in the Treatment of Alzheimer's Disease October 1, 2019 February 3, 2021
NCT02004392 Terminated Phase 3 Study of the Safety and Clinical Effects of 2 Doses of EVP-6124 in Subjects With Alzheimer's Disease Who Complete Study EVP-6124-024 or EVP-6124-025 June 2014 August 2017
NCT01978327 Terminated Phase 1 GSK2647544 RD, DDI in Healthy Young and Elderly Volunteers November 22, 2013 March 3, 2014
NCT01969136 Terminated Phase 3 Study of the Safety and Effectiveness of Two Doses of Investigational Study Drug EVP-6124 in Subjects With Alzheimer's Disease October 2013 January 2017
NCT01969123 Terminated Phase 3 Study of the Safety and Effectiveness of Two Doses of Investigational Study Drug EVP-6124 in Subjects With Alzheimer's Disease October 2013 January 2017
NCT01953601 Terminated Phase 3 Efficacy and Safety Trial of Verubecestat (MK-8931) in Participants With Prodromal Alzheimer's Disease (MK-8931-019) November 5, 2013 April 17, 2018
NCT01924858 Terminated Phase 1 A Positron Emission Tomography (PET) Study to Investigate the Brain Biodistribution of 18F GSK2647544 in Healthy Subjects to Determine Its Ability to Cross the Blood-brain-barrier. August 19, 2013 March 3, 2014
NCT01900665 Terminated Phase 3 Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo July 2013 February 2017
NCT01883648 Terminated Phase 2/Phase 3 Study to Evaluate Coconut Oil for Alzheimer's Disease June 2013 February 1, 2017
NCT01867372 Terminated Early Markers of Alzheimer's Disease: Structural and Functional Brain Changes March 10, 2003 September 22, 2014
NCT01852110 Terminated Phase 2 Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012) October 22, 2013 April 11, 2016
NCT02477800 Terminated Phase 3 221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease August 13, 2015 August 8, 2019
NCT02484547 Terminated Phase 3 221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease September 15, 2015 August 5, 2019
NCT01832350 Terminated Phase 4 Nuedexta in the Treatment of Pseudobulbar Affect in Patients With Alzheimer's Disease August 28, 2012 December 1, 2016
NCT01777789 Terminated The Role of Mid-Life Adiposity in Functional Brain Connectivity December 2012 February 2016
NCT01766336 Terminated Phase 2 A 36-Week Safety Extension Study of ELND005 as a Treatment for Agitation and Aggression in Alzheimer's Disease January 2013 August 2015
NCT02521558 Terminated N/A Effectiveness of Home-based Electronic Cognitive Therapy in Alzheimer's Disease September 2015 June 30, 2020
NCT01739348 Terminated Phase 2/Phase 3 An Efficacy and Safety Trial of Verubecestat (MK-8931) in Mild to Moderate Alzheimer's Disease (P07738) November 30, 2012 April 14, 2017
NCT01712074 Terminated Phase 2 Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil November 2012 September 2015
NCT01690195 Terminated Phase 2 Safety and Tolerability Study Evaluating a New Treatment for Subjects With Mild to Moderate Alzheimer's Disease September 2012 February 2014
NCT01689948 Terminated N/A Alzheimer Disease : Rehabilitation's Intervention at Home October 2012 September 2014
NCT01677572 Terminated Phase 1 Multiple Dose Study of Aducanumab (BIIB037) (Recombinant, Fully Human Anti-Aβ IgG1 mAb) in Participants With Prodromal or Mild Alzheimer's Disease October 5, 2012 July 31, 2019
NCT01676935 Terminated Phase 2 This is a Safety and Tolerability Study Evaluating a New Treatment for Subjects With Mild to Moderate Alzheimer's Disease August 2012 March 2014
NCT01658722 Terminated Retrieval of Patient Information After Discontinuation December 2011 August 2012
NCT01626391 Terminated Phase 2 Safety Study of TRx0237 in Patients Already Taking Medications for Mild and Moderate Alzheimer's Disease September 2012 March 2013
NCT02573740 Terminated Phase 1 Safety, Tolerability and the Effects on Cerebrospinal Fluid Spectrin Breakdown Product-145 Levels of ABT-957 in Subjects With Mild Alzheimer's Disease and Mild Cognitive Impairment December 2015 June 2016
NCT01568086 Terminated Follow-up Study to Evaluate Long-term Safety and Tolerability of Immunization With AD03 Applied During AFF005A December 2011 October 2013
NCT01561430 Terminated Phase 1/Phase 2 Study of LY2886721 in Mild Cognitive Impairment Due to Alzheimer's Disease or Mild Alzheimer's Disease March 2012 August 2013
NCT02586909 Terminated Phase 3 12-Month Open-Label Extension Study of Intepirdine (RVT-101) in Subjects With Alzheimer's Disease: MINDSET Extension April 26, 2016 March 12, 2018
NCT01560585 Terminated Phase 1/Phase 2 Open Label Study of Isotretinoin in Mild to Moderate Alzheimer's Disease April 2012 August 2014
NCT02614131 Terminated Phase 1 A Study of LY2599666 in Healthy Participants and Participants With Mild Cognitive Impairment or Alzheimer's Disease (AD) December 2015 December 2016
NCT01553929 Terminated N/A Physical Training and Cognitive Activity on the Mild Cognitive Impairment (MCI) Patient March 2012 January 2015
NCT01454453 Terminated Phase 4 Optimisation of Antipsychotic Drug Use in Older People May 2012 July 2015
NCT02670083 Terminated Phase 3 A Study Evaluating the Efficacy and Safety of Crenezumab Versus Placebo in Participants With Prodromal to Mild Alzheimer's Disease (AD). March 22, 2016 May 31, 2019
NCT01385033 Terminated Phase 1 [18F]MK-3328 as a Possible Novel Positron Emission Tomography (PET) Tracer for the Detection of Brain Amyloid Plaques (MK-3328-002) August 19, 2011 May 15, 2012
NCT01362686 Terminated N/A Comparative Research of Alzheimer's Disease Drugs April 2011 October 2015
NCT01255163 Terminated Phase 2 A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease November 21, 2010 November 18, 2016
NCT01238991 Terminated Phase 2 Long Term Extension Study Evaluating Safety, Tolerability And Immunogenicity Of ACC-001 In Japanese Subjects With Mild To Moderate Alzheimer's Disease December 2010 December 2013
NCT01152216 Terminated Phase 3 An Extension of the CONCERT Protocol (DIM18) April 2010
NCT02760602 Terminated Phase 3 A Study of Solanezumab (LY2062430) in Participants With Prodromal Alzheimer's Disease June 2016 May 2017
NCT01143350 Terminated N/A Non Pharmacological Treatment in Alzheimer's Disease and Associated Disorders March 2010 March 2011
NCT01137799 Terminated Phase 1 The Effect of JNJ-39393406 on Event Related Potentials in Stable Schizophrenic Patients August 2009 March 2011
NCT02769000 Terminated N/A Low Dose RT to Reduce Cerebral Amyloidosis in Early Alzheimer's May 2016 March 15, 2019
NCT01127633 Terminated Phase 3 Continued Safety Monitoring of Solanezumab (LY2062430) in Alzheimer's Disease December 2010 February 2017
NCT01082965 Terminated N/A Acute Effects Of Donepezil On Brain Perfusion And Memory In Subjects With Cognitive Impairment And Mild Alzheimer's Disease July 2010 July 2012
NCT02783573 Terminated Phase 3 A Study of Lanabecestat (LY3314814) in Participants With Mild Alzheimer's Disease Dementia July 1, 2016 September 28, 2018
NCT01072812 Terminated Phase 1 Study of the Pharmacokinetics and Pharmacodynamics of POSIPHEN® in Subjects With Amnestic Mild Cognitive Impairment February 2010 July 2010
NCT01066546 Terminated Phase 3 An Extension To The B1451006 Protocol To Evaluate The Safety and Efficacy of Dimebon In Subjects With Moderate-to-Severe Alzheimer's Disease April 2010 July 2010
NCT02791191 Terminated Phase 2 A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia June 16, 2016 July 2, 2018
NCT01028911 Terminated Phase 1 A Study to Evaluate the Safety, Tolerability, and Blood Levels of PF-03654746 in Subjects With Mild to Moderate Alzheimer's Disease December 2009 May 2010
NCT00968097 Terminated Phase 1 Evaluation of [123I] MNI-340 and SPECT as a Marker of Beta-Amyloid Protein Deposition April 2008 July 2008
NCT00939783 Terminated Phase 3 An Extension To The B1451027 Protocol To Evaluate The Long Term Safety And Tolerability Of Dimebon In Patients With Alzheimer's Disease September 2009 August 2010
NCT00937352 Terminated Phase 3 A Long-Term Safety and Tolerability Study in Subjects With Mild to Moderate Alzheimer's Disease July 2009 September 2012
NCT02864303 Terminated N/A Use of Saliva for Alzheimer's Disease Diagnosis June 21, 2012 October 11, 2018
NCT00890890 Terminated Phase 2 A Multicenter, Double Blind, Placebo-Controlled, Safety and Tolerability Study of BMS-708163 in Patients With Prodromal Alzheimer's Disease May 2009 July 2013
NCT02884492 Terminated Phase 2 Imaging Tau in Alzheimer's Disease and Normal Aging July 2016 June 30, 2017
NCT00886951 Terminated Phase 1 Single Photon Emission Computed Tomography (SPECT) Imaging Study to Develop a Biomarker for Alzheimer's Disease March 2009 March 2009
NCT00874939 Terminated Phase 1 A Study to Evaluate the Effects of MK-0249 and an Alzheimer's Disease Medication on Cognitive Function in Adults With Alzheimer's Disease (MK-0249-023) April 6, 2009 April 20, 2009
NCT02916056 Terminated Phase 3 2-Year Extension Study of Azeliragon in Subjects With Alzheimer's Disease (STEADFAST Extension) December 2016 June 1, 2018
NCT00870519 Terminated Phase 1 Brain Imaging Study in Subjects With Alzheimer Disease in Comparison to Healthy Subjects January 2009 December 2010
NCT02956486 Terminated Phase 3 A 24-Month Study to Evaluate the Efficacy and Safety of Elenbecestat (E2609) in Participants With Early Alzheimer's Disease October 20, 2016 January 15, 2020
NCT00857649 Terminated Phase 3 Efficacy and Safety of Memantine in Moderate to Severe Alzheimer's Disease December 2003 September 2010
NCT02972658 Terminated Phase 3 A Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease Dementia March 15, 2017 October 2, 2018
NCT00857233 Terminated Phase 3 Safety and Tolerability of Memantine in Moderate to Severe Alzheimer's Disease June 2004 October 2010
NCT00843115 Terminated Observational Study Of Donepezil In Routine Clinical Practice February 2007 April 2008
NCT00811122 Terminated Early Phase 1 Biodistribution of 11C-PIB PET in Alzheimer's Disease, Frontotemporal Dementia, and Cognitively Normal Elderly November 2009 December 2021
NCT00809510 Terminated Phase 2 A Study of the Long-term Safety of ABT-089 for Subjects With Mild-to-moderate Alzheimer's Disease Who Participated in the M06-876 Study January 2009
NCT00777361 Terminated Phase 1 Study of Uptake, Break Down and Elimination of an Investigational Drug in Healthy Volunteers October 2008 October 2009
NCT03114657 Terminated Phase 3 A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD) March 29, 2017 June 11, 2019
NCT00713765 Terminated Phase 1 Pharmacokinetic Interaction Between AZD3480 and Donepezil December 2008 December 2008
NCT03289143 Terminated Phase 2 A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients With Prodromal to Mild Alzheimer's Disease October 4, 2017 January 15, 2021
NCT03307993 Terminated Phase 1 Positron Emission Tomography (PET) Study in Patients With Alzheimer's Disease September 22, 2017 February 19, 2018
NCT00704782 Terminated Phase 2 Study of Combination Therapy With Dimebon and Donepezil (Aricept) in Patients With Alzheimer's Disease April 2008 August 2010
NCT03352557 Terminated Phase 2 Phase 2 Study of BIIB092 in Participants With Early Alzheimer's Disease May 3, 2018 August 30, 2021
NCT00693004 Terminated Phase 2 Study of PRX-03140 Monotherapy in Subjects With Alzheimer's Disease May 2008
NCT00679627 Terminated Phase 3 A Study of Galantamine Used to Treat Patients With Mild to Moderate Alzheimer's Disease June 2008 May 2012
NCT00672945 Terminated Phase 2 A Study of PRX-03140 in Subjects With Alzheimer's Disease Receiving a Stable Dose of Donepezil April 2008
NCT03491150 Terminated Phase 3 An Open-Label Crenezumab Study in Participants With Alzheimer's Disease April 11, 2018 May 31, 2019
NCT00649220 Terminated Phase 4 Memantine and Antipsychotics Use July 2008 June 2009
NCT03531710 Terminated Phase 2 An Extension Study of V203-AD Study to Evaluate the Safety, Tolerability, Immunogenicity, and Efficacy of UB-311 August 10, 2018 October 31, 2019
NCT03639987 Terminated Phase 2 A Study of Aducanumab in Participants With Mild Cognitive Impairment Due to Alzheimer's Disease or With Mild Alzheimer's Disease Dementia to Evaluate the Safety of Continued Dosing in Participants With Asymptomatic Amyloid-Related Imaging Abnormalities December 20, 2018 July 30, 2019
NCT03668405 Terminated Phase 1 A Study to Evaluate the Long-term Safety and Tolerability of Lu AF20513 and the Antibody Response in Patients With Alzheimer's Disease (AD) June 26, 2018 May 27, 2019
NCT00606476 Terminated Phase 2 AAB-001 (Bapineuzumab) Open-Label, Long-Term Extension Study in Patients With Mild to Moderate Alzheimer's Disease December 2006 September 2012
NCT03712787 Terminated Phase 2 An Extension Study of ABBV-8E12 in Early Alzheimer's Disease (AD) March 22, 2019 September 30, 2021
NCT00602680 Terminated Phase 2 Effect on Cognitive Performance and Safety/Tolerability of SSR180711C in Mild Alzheimer's Disease January 2008 July 2008
NCT00596024 Terminated Phase 2 Lutein and Alzheimer's Disease Study December 2007 July 2009
NCT00555204 Terminated Phase 2 Safety and Efficacy Study of ABT-089 in Adults With Mild to Moderate Alzheimer's Disease November 2007
NCT00550420 Terminated Phase 3 Study Of Rosiglitazone XR In Subjects With Mild-to-Moderate Alzheimers October 1, 2007 February 12, 2009
NCT00490568 Terminated Phase 3 Open-Label Extension Study Of Rosiglitazone XR As Adjunctive Therapy In Subjects With Mild-to-Moderate Alzheimers August 8, 2007 June 1, 2009
NCT03935568 Terminated Phase 1 A Single and Multiple Ascending Dose Study to Evaluate the Safety and Pharmacokinetics of PU-AD in Healthy Subjects June 24, 2019 December 23, 2019
NCT00380276 Terminated Phase 3 Open-Label Treatment With MPC-7869 for Patients With Alzheimer's Who Previously Participated in an MPC-7869 Protocol September 2006 December 2008
NCT00369603 Terminated Phase 4 Functional Brain Imaging of Medication Treatment Response in Mild Alzheimer's Disease Patients October 2006 November 2007
NCT00362024 Terminated Phase 2 MK0952 in Patients With Mild-to-Moderate Alzheimer's Disease (0952-004)(COMPLETED) November 2006 November 2007
NCT00334568 Terminated Phase 2 Effects Of Rosiglitazone (Extended Release Tablets) On Cerebral Glucose Utilisation And Cognition Alzheimers Disease December 2004 July 2007
NCT00299988 Terminated Phase 2 Phase II Study of Intravenous Immunoglobulin (IVIg) for Alzheimer's Disease February 2006 April 2010
NCT00287742 Terminated Phase 3 A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Patients With Hallucinations and Delusions Associated With Alzheimer's Disease March 2002 March 2003
NCT00165750 Terminated Phase 4 Correlation Between Regional Brain Volume and Response to Donepezil Treatment in AD Patients March 2005 November 2008
NCT00105105 Terminated Phase 2 Mifepristone as Adjunctive Therapy in Alzheimer's Disease April 2003 November 2005
NCT05602727 Terminated Phase 2 Efficacy and Safety of MK-1942 as an Adjunct Therapy in Participants With Mild to Moderate Alzheimer's Disease Dementia (MK-1942-008) December 2, 2022 September 27, 2023
NCT00087724 Terminated Phase 2 A Randomized Study to Evaluate FK962 in Subjects With Mild to Moderate Alzheimer's Disease July 2004 September 2006
NCT00069849 Terminated Phase 2 A Study of the Safety and Efficacy of Multiple Doses of ABT-089 in Subjects With Alzheimer's Disease July 2003
NCT00021723 Terminated Phase 2 Randomized Safety, Tolerability and Pilot Efficacy of AN-1792 in Alzheimer's Disease September 2001 September 2003
NCT00001178 Terminated Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders January 19, 1981 December 17, 2012
NCT00172900 Unknown status MRS and DTI of White Matter in Alzheimer's Disease June 2005
NCT00174525 Unknown status Phase 2 Safety Study of Passive Immunization for Patients With Mild to Moderate Alzheimer's Disease April 2005 April 2008
NCT00902499 Unknown status Evolution of Memory Related Activity May 2006 May 2011
NCT00900770 Unknown status Implications of Amyloid Pathology November 2008 March 2014
NCT00715858 Unknown status Phase 3 A Pilot Study of Inflammatory Markers in Alzheimer's Disease May 2008 October 2009
NCT02868905 Unknown status N/A Identification of Epigenetic Markers Common to Obesity and Alzheimer's Disease in Women September 2016 September 2018
NCT02873546 Unknown status N/A tDCS Effect on Cognitive Functions From Patients With Alzheimer's Disease or Progressive Primary Aphasia July 19, 2013 July 31, 2018
NCT02147652 Unknown status N/A Personalized Music Therapy and Agitation in Dementia October 14, 2014 June 2020
NCT00888056 Unknown status Phase 1/Phase 2 Chronic Electrical Stimulation of Hypothalamus/Fornix in Alzheimer's Disease June 2009
NCT00149175 Unknown status Clinical and Genetic Study of Neurodegenerative Disorders With Cognitive Impairment December 2002 October 2007
NCT02908815 Unknown status N/A Investigating the Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) as a Treatment for Alzheimer's Disease November 2016 July 2022
NCT00142324 Unknown status Phase 4 CALM-AD November 2003 December 2005
NCT02912936 Unknown status N/A A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease September 2016 December 2019
NCT01624389 Unknown status N/A Establish Taiwan Alzheimer's Disease Neuroimaging Initiative - a Three-year Pilot Study January 2012 January 2015
NCT01192529 Unknown status N/A Evaluation of a Diet in Patients With Senile Dementia October 2010 December 2012
NCT02928211 Unknown status Phase 1 Aftobetin-HCl and Fluorescence Detection Measured by Sapphire II to Determine the Number and Timing of Administrations July 2016 January 2019
NCT02941289 Unknown status N/A Visuospatial Attention, Eye Movements and Instrumental Activities of Daily Living (IADLs) in Alzheimer's Disease November 2016 May 2019
NCT02947893 Unknown status Phase 2 Impact of Nilotinib on Safety, Biomarkers and Clinical Outcomes in Mild to Moderate Alzheimer's Disease January 2017 February 2020
NCT02964611 Unknown status Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration January 2013 December 2019
NCT01746706 Unknown status N/A Can the Assessment of the Subhippocampal Region Contribute to the Detection of Early Diagnosis of Alzheimer's Disease? A Validation Study Using PET With Florbetapir (AV-45). October 2011 November 2017
NCT02227953 Unknown status N/A A Pilot Study of tDCS for Mild to Moderate Alzhemier's Disease August 2014 December 2014
NCT00094952 Unknown status Biomarkers and Early Alzheimer's Disease April 2003 March 2008
NCT02522091 Unknown status N/A Cerebral Substrates of Prospective Memory in Young and Its Disruption in Normal Aging and in Alzheimer's Disease: A Study in Anatomical MRI, Diffusion Tensor MRI and Functional MRI November 2010
NCT01198093 Unknown status Clinical Research Center for Dementia of South Korea (CREDOS)(or CRCD) November 2005 August 2015
NCT01819545 Unknown status The Study of microRNA 107 (miRNA 107) and Beta-amyloid Precursor Protein-cleaving Enzyme 1 (BACE1) Messenger Ribonucleic Acid (mRNA) Gene Expression in Cerebrospinal Fluid and Peripheral Blood of Alzheimer's Disease January 2012 December 2015
NCT01841905 Unknown status Detection of Disease-Related Changes in Pre-Symptomatic Alzheimer's Disease July 2013 December 2016
NCT00753662 Unknown status Phase 2 Deep Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease November 2008 November 2012
NCT01843075 Unknown status Phase 2 Evaluating Liraglutide in Alzheimer's Disease January 2014 December 2019
NCT02253043 Unknown status N/A The Safety and Efficacy of Long-term Treatment of PINS Stimulator System for Patients With Alzheimer's Disease May 2014 December 2018
NCT01849042 Unknown status Phase 4 Effect of Memantine Oral Pump on Language in Patients With Probable Alzheimer's Disease January 2013 August 2015
NCT01867775 Unknown status Phase 3 Mirtazapine for Sleep Disorders in Alzheimer's Disease May 2012 May 2014
NCT01238458 Unknown status Phase 2 Phase II Study for Amyloid Binding Imaging Study of [18F]AV-45 in Patients With Mild Cognitive Impairment, Alzheimer's Disease and Healthy Volunteers November 2009 June 2013
NCT00703430 Unknown status N/A Memantine on Aggression and Agitation of Alzheimer's Disease (AD) March 2008 June 2014
NCT01885806 Unknown status Phase 2 Repetitive Transcranial Magnetic Stimulation for Apathy Treatment in Alzheimer's Disease June 2013 December 2015
NCT03441516 Unknown status Phase 4 Effect of Choline Alphoscerate on Cognitive Function in Alzheimer's Dementia April 19, 2018 December 31, 2021
NCT01886820 Unknown status Phase 3 A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of [18F]NAV4694 PET for Detection of Cerebral Beta-Amyloid When Compared With Postmortem Histopathology June 2013 September 2018
NCT02247180 Unknown status N/A Cognitive Rehabilitation in Alzheimer's Disease September 2014 December 2015
NCT00031018 Unknown status Phase 2 Prevention of Cognitive Decline in Alzheimer's Disease by Ingested Interferon Alpha
NCT02439099 Unknown status Retinoic Acid Homeostasis in Neuropsychiatric Diseases March 2015 December 2022
NCT00637442 Unknown status N/A Continuous Arterial Spin Labeling (CASL) MRI for Monitoring and Prediction of Drug Therapy in Alzheimers Disease (AD) February 2008
NCT00627029 Unknown status N/A Evaluation of Programs of Coordinated Care and Disease Management September 2000 December 2016
NCT01935024 Unknown status N/A Benefits of Exercise in Alzheimer's Disease August 1, 2013 April 2020
NCT00626613 Unknown status Phase 4 The Relationship Between Risperdal Treatment and Quality of Life in Patients With Alzheimer's Disease and Behavioural and Psychological Symptoms of Dementia (BPSD)
NCT01940952 Unknown status Phase 3 Zydena on Cognitive Function of Alzheimer's Disease Patients September 2013
NCT00606164 Unknown status Phase 2 Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics Study of Bryostatin 1 in Patients With Alzheimer's Disease April 2008 December 2008
NCT01953705 Unknown status Phase 2 n-3 PUFA for Vascular Cognitive Aging May 2014 June 2021
NCT03740178 Unknown status Phase 1 Multiple Dose Trial of MK-4334 in Participants With Alzheimer's Clinical Syndrome (MK-4334-005) September 27, 2019 February 28, 2020
NCT03790982 Unknown status Phase 2 Evaluate the Safety and Efficacy of AD-35 Tablet in Subjects With Mild to Moderate Alzheimer's Disease December 1, 2018 July 30, 2021
NCT02397980 Unknown status N/A Intervention Programs for Decreasing Caregiver Burden in Caregivers of Patients With Dementia March 2015 December 2016
NCT01979419 Unknown status Korea Alzheimer's Disease Neuroimaging Initiative November 2012 October 2020
NCT01993628 Unknown status N/A Construction-LBD (Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD)) October 2013 November 2016
NCT02018913 Unknown status Blood-brain Barrier Leakage in Dementia. A Dynamic Contrast-enhanced MRI Study April 2014 April 2018
NCT00523666 Unknown status Phase 4 Diffusion Tensor Weighted MRI in Alzheimer's Disease Modifying Treatment Effects of Galantamine (Reminyl®) September 2006 September 2008
NCT02363504 Unknown status The Locus Coeruleus and Memory February 1, 2017 December 2020
NCT00448318 Unknown status Phase 2/Phase 3 Evaluating the Effects of Music Interventions on Hospitalised People With Dementia March 2007 October 2008
NCT03942341 Unknown status Sleep in Adults With Down Syndrome and Alzheimer's Disease May 8, 2019 December 2020
NCT01282619 Unknown status Phase 2/Phase 3 Study of Huperzine A Sustained-Release Tablets in Patients With Alzheimer's Disease May 2010 June 2012
NCT04137926 Unknown status N/A A Multicenter Study on the Diagnosis and Intervention of New Biomarkers on the Prodromal Stage of Alzheimer's Disease March 1, 2020 November 30, 2022
NCT04169126 Unknown status Phase 2 Topography Staging and Dual Phase Image Quantification of Tau PET in Cognitive Impairment Subjects April 1, 2019 September 30, 2023
NCT04174287 Unknown status Phase 2 Modeling the Relationships Between Functional Connectivity and Amyloid Deposition in Alzheimer's Disease March 28, 2019 September 27, 2023
NCT02051244 Unknown status Measurement of Retinal Nerve Fiber Layer Thickness - a Biomarker for the Early Detection of Alzheimer's Disease? February 2014 February 2015
NCT04248270 Unknown status Phase 1/Phase 2 A Noval Tau Tracer in Young Onset Dementia February 20, 2020 November 30, 2023
NCT04271163 Unknown status Phase 1/Phase 2 Transcranial Electromagnetic Treatment (TEMT) Against Alzheimer's Disease February 10, 2020 March 31, 2021
NCT04305210 Unknown status Phase 2 Alzheimer's Disease: Clinical Investigation and Neuroimage Studies Including 18F-PM-PBB3 and 18F-florbetapir (AV-45) PET Examination December 1, 2019 January 23, 2021
NCT04368572 Unknown status N/A Efficacy of Hypnosis on Pain and Anxiety During Lumbar Puncture for Etiological Diagnosis of Cognitive Impairment August 1, 2019 June 2020
NCT01314131 Unknown status N/A Use of Autobiographical and Interest Assessment for a Better Stimulation of Patients in Nursing Home March 2011 June 2012
NCT01315704 Unknown status Alzheimer's Disease and Related Disorders November 2009 November 2017
NCT02052947 Unknown status N/A Co-LEsions in Alzheimer Disease and Related Disorders January 2014 October 2020
NCT04476303 Unknown status Phase 1 A Study to Evaluate the Pharmacokinetics and Safety of BEY2153 in Healthy Participants August 28, 2020 October 2021
NCT02063269 Unknown status N/A Brain Changes by Rivastigmine According to Butyrylcholinesterase Alleles February 2014 June 2017
NCT02085265 Unknown status Phase 2 Telmisartan vs. Perindopril in Mild-Moderate Alzheimer's Disease Patients March 2014 September 2023
NCT01316562 Unknown status Predictive Value of Cognitive Tests Performed for the Diagnosis of Alzheimer's Disease and Related Disorders July 2009 July 2012
NCT00314912 Unknown status Phase 3 Open-Label Extension of the Phase III Study With Tramiprosate (3APS) in Patients With Mild to Moderate Alzheimer's Disease May 2006
NCT00306124 Unknown status Phase 4 Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dementia/Mild Cognitive Impairment January 2006 March 2008
NCT01322373 Unknown status A Study of Alzheimer's Disease Using Magnetoencephalography (MEG) and the Synchronous Neural Interaction™ Test March 2011 August 2011
NCT01329484 Unknown status N/A Computerized Personal Interventions for Alzheimer's Patients March 2011 September 2012
NCT02685787 Unknown status N/A Early Counseling and Support for Alzheimer's Disease Caregivers April 2012 December 2017
NCT02349191 Unknown status N/A Omental Transposition Surgery for Mild Alzheimer's Disease March 2016 May 2019
NCT02672306 Unknown status Phase 1/Phase 2 Safety and Exploratory Efficacy Study of UCMSCs in Patients With Alzheimer's Disease October 20, 2017 October 2019
NCT01163825 Unknown status Phase 1 Encapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer´s Disease Patients January 2008
NCT04954534 Unknown status N/A Exploratory Efficacy Study of NEUROSTEM® in Subjects Who Control Group of NEUROSTEM® July 12, 2021 June 30, 2022
NCT01147679 Unknown status Study of Social Behavior and Emotion in Frontotemporal Dementia, Alzheimer's Disease and Controls January 2010 July 2014
NCT02759159 Unknown status N/A The Study of Mechanism of Alzheimer's Disease Using Acupuncture Based on fMRI June 2016 December 2018
NCT00239746 Unknown status Phase 1 BONSAI: Biomarkers of Nonsteroidal Anti-Inflammatories October 2005 August 2009
NCT02664584 Unknown status The Trinity, Ulster and Department of Agriculture Cohort Study December 2008 December 2018
NCT00232570 Unknown status N/A Quetiapine for the Treatment of Insomnia in Alzheimer's Disease November 2005 January 2010
NCT01403519 Unknown status Innovative Biomarkers in Alzheimer's Disease and Frontotemporal Dementia (FTD): Preventative and Personalized July 2011 January 2014
NCT02772185 Unknown status Phase 2/Phase 3 Neurostimulation and Cognitive Intervention in Alzheimer's Disease May 2016 May 2019
NCT01120002 Unknown status Phase 2 Efficacy and Safety of Tamibarotene (OAM80) for Alzheimer's Disease May 2010 December 2012
NCT01099332 Unknown status Phase 1/Phase 2 Trial of Novel Oral Zinc Cysteine Preparation in Alzheimer's Disease November 2009 January 2011
NCT01094340 Unknown status Phase 2/Phase 3 Thalidomide for Patients With Mild to Moderate Alzheimer's Disease March 2010 January 2013
NCT02781220 Unknown status Implications for Management of PET Amyloid Classification Technology in the Imaging Dementia(IDEAS) Trial July 2016 July 2021
NCT02649985 Unknown status Phase 1/Phase 2 Microglial Activation Positron Emission Tomography (PET) Brain Imaging in Multiple Sclerosis and Alzheimer's Disease May 2, 2016 December 31, 2021
NCT00217763 Unknown status Phase 3 European Study of 3APS in Mild to Moderate Alzheimer's Disease Patients September 2005 December 2007
NCT05113732 Unknown status Association of Cognition With Functional Mobility in People With Alzheimer's Disease November 1, 2021 May 1, 2022
NCT01476228 Unknown status N/A EEG Objectification in Neuropsychiatry November 2011 December 2015
NCT01547689 Unknown status Phase 1/Phase 2 Safety and Efficiency of Umbilical Cord-derived Mesenchymal Stem Cells(UC-MSC) in Patients With Alzheimer's Disease March 2012 December 2016
NCT01554202 Unknown status N/A Multi-modal Neuroimaging in Alzheimer's Disease January 2008
NCT00987090 Unknown status N/A Early-onset and Late-onset Sporadic Alzheimer's Disease (AD) October 2009
NCT01569516 Unknown status Phase 2 Study of Octohydroaminoacridine Succinate Tablets in Patients With Alzheimer's Disease June 2011 October 2012
NCT00966017 Unknown status Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia July 2009 February 2014
NCT00965835 Unknown status Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome August 2009 May 2011
NCT02836054 Unknown status N/A Study of Degenerescence CSF Hallmarks in Older Bipolar Patients November 2013 December 2019
NCT02319681 Withdrawn N/A Reminiscence, Anxiety and Early Alzheimer's Disease January 2015 June 2017
NCT04353947 Withdrawn Induction and Recognition of Emotions March 2, 2020 November 30, 2020
NCT00884533 Withdrawn Phase 1 QTc Study of Rosi XR in Healthy Volunteers June 2009 August 2009
NCT03316898 Withdrawn Phase 1 A FDG-PET Study of AGN-242071 Added to Standard-of-Care (Donepezil ± Memantine) for the Treatment of Participants With Mild to Moderate Alzheimer's Disease September 30, 2018 November 4, 2018
NCT02860065 Withdrawn Phase 2 CPC-201 Alzheimer's Disease Type Dementia: PET Study September 30, 2016 June 30, 2017
NCT02500784 Withdrawn Phase 2 Improving Beta-2 Adrenergic Signaling in Alzheimer's Disease January 2023 July 2025
NCT02912169 Withdrawn Phase 1/Phase 2 Study to Assess the Safety and Effects of Autologous Adipose-Derived Stromal Cells in Patients With Alzheimer's Disease November 1, 2015 November 15, 2017
NCT02029547 Withdrawn N/A Evaluation of Electronic Florbetapir (18F) Interpretation Training in Japanese Physicians October 2014 May 2015
NCT02467413 Withdrawn Phase 2 BAC in Patient With Alzheimer's Disease or Vascular Dementia January 30, 2017 November 1, 2018
NCT00691340 Withdrawn Cellular Proteome From Leukocytes of Glaucoma Patients in Comparison With Patients With Alzheimer's Disease June 2008 August 2011
NCT02130661 Withdrawn Phase 1 Study to Determine the Effect of Itraconazole on the Pharmacokinetics of Rilapladib (SB659032) in Healthy Volunteers October 2017 January 2018
NCT01066481 Withdrawn Phase 2 A Study Of Oral PF-01913539 In Patients With Mild To Moderate Alzheimer's Disease April 2010 April 2012
NCT01723670 Withdrawn Phase 2 Evaluation of Effects of Multiple Dose Regimens of CHF 5074 on Potential Biomarkers of Neurodegeneration in Subjects With Mild Cognitive Impairment December 2012 March 2016
NCT01211782 Withdrawn Phase 2/Phase 3 AC-1204 Long-term Efficacy Response Trial (ALERT Protocol)
NCT01313806 Withdrawn N/A Study of Magnetic Fields to Treat Alzheimer's Disease September 2011 September 2012
NCT05332678 Withdrawn Phase 2 SLS-005 (Trehalose Injection) in the Treatment of Alzheimer's Disease March 3, 2023 April 10, 2023
NCT00412048 Withdrawn N/A Functional Magnetic Resonance Imaging - Synthetic Aperture Magnetometry (fMRI-SAM) and Alzheimer's Disease April 2012 February 2018
NCT01636596 Withdrawn N/A Efficacy of Pulsatile IV Insulin on Cognition and Amyloid Burden in Patients With Alzheimer's Disease September 2013 January 2015
NCT02506374 Withdrawn Development of Therapeutic Intervention for Sleep in Alzheimer/Caregiver Dyads November 2014 January 2016
NCT04187547 Withdrawn Phase 3 A Phase III Multi Regional Clinical Trial (MRCT) of Tricaprilin in Mild to Moderately Severe Probable Alzheimer's Disease With Optional Open Label Extension June 30, 2022 February 28, 2024
NCT01615666 Withdrawn A Composite MR Neuroimaging Marker for Alzheimer's Disease March 2009 January 2016
NCT02246075 Withdrawn Phase 2 Study of the Safety of Two Doses of Investigational Study Drug EVP-6124 in Subjects With Alzheimer's Disease Currently Receiving Memantine July 2015
NCT02741505 Withdrawn N/A Brain Sleep Deprivation MRI Effects (BEDTIME) June 2019 December 1, 2019
NCT00792662 Withdrawn Phase 4 Improving Function, Quality of Life, Glycemia in Diabetics With Dementia November 18, 2008 December 20, 2011
NCT00927108 Withdrawn Phase 2 Rajavtihi Neuronal Adult Stem Cells Project July 2009 December 2011
NCT00375557 Withdrawn Phase 4 Safety and Efficacy of Divalproex and Quetiapine in Elderly Alzheimer's Dementia Patients October 2006 September 2007
Disase is a (Disease Ontology)
DOID:680
Cross Reference ID (Disease Ontology)
GARD:10254
Cross Reference ID (Disease Ontology)
ICD10CM:G30
Cross Reference ID (Disease Ontology)
ICD9CM:331.0
Cross Reference ID (Disease Ontology)
KEGG:05010
Cross Reference ID (Disease Ontology)
MESH:D000544
Cross Reference ID (Disease Ontology)
NCI:C2866
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:73768007
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0002395
Exact Synonym (Disease Ontology)
Alzheimer disease
Exact Synonym (Disease Ontology)
Alzheimers dementia