hypertrophic cardiomyopathy

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Information
Disease name
hypertrophic cardiomyopathy
Disease ID
DOID:11984
Description
"An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause." [url:http\://en.wikipedia.org/wiki/Hypertrophic_cardiomyopathy, url:http\://www.mayoclinic.org/diseases-conditions/hypertrophic-cardiomyopathy/basics/definition/con-20030747, url:http\://www.nhlbi.nih.gov/health/health-topics/topics/cm/]
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
KARS1 16 75,627,474 75,647,665 8
TNNT2 1 201,359,014 201,377,680 4
SCN5A 3 38,548,062 38,649,687 4
TNNI3 19 55,151,767 55,157,732 2
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT01915615 Active, not recruiting HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy April 2014 December 2024
NCT06031519 Active, not recruiting Impact of Liwen Procedure in Obstructive Hypertrophic Cardiomyopathy on Arrhythmias August 22, 2023 August 31, 2024
NCT06434415 Active, not recruiting Prognostic Value of Coronary Angiography-Derived Index of Microcirculatory Resistance in Hypertrophic Cardiomyopathy Patients January 1, 2017 May 31, 2024
NCT04706429 Active, not recruiting Phase 2 The Efficacy and Mechanism of Trientine in Patients With Hypertrophic Cardiomyopathy December 1, 2020 October 31, 2024
NCT04036799 Active, not recruiting PRecIsion Medicine in CardiomyopathY January 1, 2017 December 2023
NCT03723655 Active, not recruiting Phase 2/Phase 3 A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM October 5, 2018 March 15, 2030
NCT00001878 Completed Factors Contributing to Increased Left Ventricle Size in Patients With Abnormally Enlarged Hearts February 1999 August 2002
NCT00001894 Completed Phase 2 A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy August 1999 September 2002
NCT00001960 Completed Phase 2 Studying the Effectiveness of Pacemaker Therapy in Children Who Have Thickened Heart Muscle November 1999 December 2002
NCT00011076 Completed Phase 2 Pirfenidone to Treat Hypertrophic Cardiomyopathy February 2001 April 2003
NCT00035386 Completed Phase 2 Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study April 2002 April 2003
NCT00001225 Completed Family Studies of Inherited Heart Disease April 1987 August 2002
NCT06397092 Completed Anesthetic Management for TA-BSM in HOCM April 1, 2022 March 31, 2024
NCT00317967 Completed Phase 3 Study to Determine if Atorvastatin Reduces Size and Stiffness of Muscle in the Left Ventricle of the Heart April 2007 November 2010
NCT00319982 Completed Phase 2/Phase 3 Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem January 2006 December 2013
NCT06354413 Completed Outcomes of Concomitant Bypass Surgery in Septal Myectomy January 2009 December 2023
NCT00500552 Completed Phase 2 Perhexiline Therapy in Patients With Hypertrophic Cardiomyopathy December 2006 August 2010
NCT06048562 Completed N/A Incidence of Hypertrophic Cardiomyopathy in Infants of Diabetic Mothers Attending in NICU at Assiut University Children Hospital During One Year March 20, 2019 October 20, 2022
NCT00589836 Completed Assessment of Left Ventricular Torsion by Echocardiography Study June 2005 April 2008
NCT05510180 Completed CVD Risk Profile in Children With HCM May 21, 2019 February 28, 2023
NCT05459467 Completed N/A Exercise Training in Hypertrophic Cardiomyopathy: (SAFE-HCM) January 1, 2018 March 3, 2020
NCT00821353 Completed Phase 3 Antiarrhythmic Therapy Versus Catheter Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy January 2009 June 2012
NCT00879060 Completed Phase 4 Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy November 2007 November 2012
NCT01081093 Completed N/A Biventricular Pacing in Hypertrophic Cardiomyopathy After Aortic Valve Replacement April 2010 August 2014
NCT05366101 Completed Phase 2/Phase 3 Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy April 1, 2019 March 31, 2022
NCT01150461 Completed Phase 2 Effect of Losartan in Patients With Nonobstructive Hypertrophic Cardiomyopathy February 2007 July 2010
NCT05135871 Completed Phase 1 Study Evaluating the Pharmacokinetics of Mavacamten in Healthy Adult Chinese Subjects October 31, 2021 February 28, 2022
NCT01334801 Completed Biomarkers in Aortic Stenosis - B.A.S.S. July 2010 January 31, 2020
NCT01447654 Completed Phase 2 Inhibition of the Renin Angiotensin System With Losartan in Patients With Hypertrophic Cardiomyopathy November 2011 June 2014
NCT04830787 Completed Correlation Between Myocardial Deformation and Coronary Artery Tortuosity in Patients With Hypertrophic Cardiomyopathy December 1, 2017 August 1, 2022
NCT01537926 Completed Phase 1 Hypertrophic Regression With N-Acetylcysteine in HCM January 2012 December 31, 2016
NCT01559714 Completed A Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy April 2012 May 1, 2019
NCT04712136 Completed N/A Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations February 1, 2021 June 20, 2023
NCT01721967 Completed Phase 4 Ranolazine for the Treatment of Chest Pain in HCM Patients November 2012 May 2016
NCT01873963 Completed Genotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES) April 2013 March 31, 2018
NCT01912534 Completed Phase 2 Valsartan for Attenuating Disease Evolution In Early Sarcomeric HCM March 2014 July 2019
NCT02234336 Completed Assessment of Wall Thickness in Hypertrophic Cardiomyopathy October 2014 July 25, 2017
NCT04650009 Completed Physical Activity in Children With Inherited Cardiac Diseases May 1, 2020 February 1, 2021
NCT02329184 Completed Phase 1 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-461 December 2014 April 2016
NCT04439942 Completed 4D-flow MRI to Assess Left Ventricular Obstruction in Hypertrophic Cardiomyopathy June 17, 2020 June 1, 2023
NCT04402268 Completed Efficacy of Risk Assessment for Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy October 1, 2014 February 28, 2019
NCT04133532 Completed Phase 4 Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy March 5, 2020 February 23, 2023
NCT04129905 Completed N/A Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies October 22, 2019 December 14, 2021
NCT04112511 Completed Study of Myocardial Deformation Parameters in Patients With Hypertrophic Cardiomyopathy March 1, 2015 May 5, 2022
NCT02549664 Completed Exercise in Genetic Cardiovascular Conditions May 1, 2015 November 14, 2022
NCT02559726 Completed N/A Hyper-synchronicity in Hypertrophic Cardiomyopathy (HCM) : Description, Mechanism and Origin With a Multi-imaging Approach to Predict Dual Chamber Pacing Response June 22, 2015 January 19, 2019
NCT04056715 Completed Extended ECG Monitoring in HCM Patients January 14, 2020 April 18, 2022
NCT02590809 Completed Phase 2 Hypertrophic Cardiomyopathy Symptom Release by BX1514M October 7, 2015 July 6, 2016
NCT02619825 Completed N/A Non-Invasive Evaluation of Myocardial Stiffness by Elastography in Pediatric Cardiology (Elasto-Pédiatrie) November 2015 July 2017
NCT02806479 Completed Hypertrophic Cardiomyopathy Pilot Study September 2016 September 2020
NCT03496168 Completed Phase 2 Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER April 26, 2018 November 9, 2023
NCT00001396 Completed Phase 1 Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic Cardiomyop... October 6, 1993 July 23, 2008
NCT00001534 Completed Long Term Effects of Enalapril and Losartan on Genetic Heart Disease September 1996 April 2003
NCT00001631 Completed Phase 2 Study of Blood Flow in Heart Muscle August 1997 January 2003
NCT00001632 Completed Investigation Into the Use of Ultrasound Technique in the Evaluation of Heart Disease September 1997 August 2002
NCT00001746 Completed Screening for Inherited Heart Disease April 1998 April 2003
NCT03532802 Completed Phase 2 The Effect of Metoprolol in Patients With Hypertrophic Obstructive Cardiomyopathy. May 1, 2018 September 1, 2020
NCT03271385 Completed Differentiation HHD From HCM (EARLY-MYO-HHD) July 1, 2017 December 31, 2021
NCT03335332 Completed N/A High Intensity Exercise for Increasing Fitness in Patients With Hypertrophic Cardiomyopathy January 31, 2018 December 20, 2022
NCT03906734 Completed N/A Mitral Valve Management During Septal Myectomy January 10, 2016 March 20, 2019
NCT02994615 Completed Evaluating Microvascular Dysfunction in Symptomatic Patients With HypertroPhic CaRdiomyopathy January 2017 June 2020
NCT03043209 Completed Genomic Sequencing in Patients With HCM Undergoing Septal Myectomy August 30, 2018 December 28, 2022
NCT03832660 Completed Phase 2 Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy May 3, 2019 June 30, 2022
NCT03607669 Completed Manganese-Enhanced Magnetic Resonance Imaging of the Myocardium June 1, 2018 February 1, 2020
NCT03092843 Completed Functional Capacity and Quality of Life Following Septal Myectomy in Patients With HCM March 20, 2017 March 30, 2023
NCT03550573 Completed N/A 3D Non-invasive Myocardial Electrical Propagation Mapping as a New Tool to Predict Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy January 28, 2019 September 23, 2022
NCT03537183 Completed N/A Will Elevated Left Ventricle Filling Pressures Decrease by a Group Exercise Program in Patients With Hypertrophic CardioMyopathy? September 1, 2018 April 1, 2023
NCT04050579 Enrolling by invitation N/A OPIE in the Thin Interventricular Septum September 15, 2020 May 30, 2025
NCT05100420 Enrolling by invitation Hypertrophic Cardiomyopathy Registry, Biobank and Imaging Data Repository February 23, 2021 August 23, 2027
NCT03527342 Enrolling by invitation Sahlgrenska Cardiomyopathy Project June 1, 2018 January 2029
NCT06461468 Not yet recruiting Hypertrophic Cardiomyopathy Federated Learning Implementation Platform June 2024 January 2026
NCT06210607 Not yet recruiting Phase 1 A Trial of HS-10511 in Healthy Subjects January 31, 2024 December 31, 2024
NCT06269640 Not yet recruiting N/A NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study June 23, 2024 October 1, 2027
NCT06169358 Recruiting Screening Patients With Fabry Disease in Patients With Hypertrophic Cardiomyopathy or Left Ventricular Hypertrophy October 1, 2023 September 1, 2024
NCT03846297 Recruiting Optimisation of Decision Making for Defibrillator Implantation in Hypertrophic Cardiomyopathy September 23, 2020 March 2027
NCT02804269 Recruiting Molecular and Imaging Studies of Cardiovascular Health and Disease July 2013 July 2033
NCT04112290 Recruiting A Prospective Incident Study of Arrhythmias in Hypertrophic Cardiomyopathy November 5, 2019 December 2027
NCT02432092 Recruiting Pediatric Cardiomyopathy Mutation Analysis April 2014 December 31, 2030
NCT04157205 Recruiting N/A Prospective Evaluation Of Exercise-Induced Cardiac Conduction Instability In Predicting Ventricular Fibrillation Events In Hypertrophic Cardiomyopathy November 10, 2019 November 1, 2024
NCT04464655 Recruiting A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease December 12, 2019 January 31, 2025
NCT04649034 Recruiting Intraventricular Stasis In Cardiovascular Disease November 24, 2020 December 31, 2024
NCT04684290 Recruiting N/A Surgical Septal Myectomy vs Percutaneous Transluminal Alcohol Septal Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy June 30, 2021 May 1, 2026
NCT05081115 Recruiting Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging April 1, 2021 December 31, 2030
NCT05182658 Recruiting Phase 3 Empagliflozin in Hypertrophic Cardiomyopathy June 1, 2022 August 1, 2024
NCT05257772 Recruiting N/A Electromechanically Optimised Right Ventricular Pacing In Hypertrophic Cardiomyopathy (EMORI-HCM) March 14, 2022 October 1, 2025
NCT01091480 Recruiting French Hypertrophic Cardiomyopathy Observatory January 2010 December 2028
NCT05577208 Recruiting N/A Renal Denervation in Hypertrophic Cardiomyopathy November 26, 2022 December 31, 2024
NCT05645939 Recruiting Association of Obesity and Cardiovascular Outcomes in Hypertrophic Cardiomyopathy July 1, 2022 December 31, 2024
NCT05750147 Recruiting The SMARTER Cardiomyopathy Study March 1, 2023 August 1, 2027
NCT05754489 Recruiting Exercise Oxygen Kinetic and Cardiac Output in Hypertrophic Cardiomyopathy April 20, 2022 April 2024
NCT05818605 Recruiting N/A Exercise Intolerance in Non-obstructive Hypertrophic Cardiomyopathy February 17, 2023 March 1, 2027
NCT05836259 Recruiting Phase 1 Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM August 10, 2023 December 2029
NCT05884892 Recruiting Egyptian Hypertrophic Cardiomyopathy Program January 1, 2014 January 1, 2030
NCT05938283 Recruiting N/A Pilot Study of Hypertrophic Cardiomyopathy & Implantable Cardioverter Defibrillator Assessment: (Subcutaneous vs Transvenous) January 10, 2024 January 10, 2026
NCT05939700 Recruiting Mavacamten Pregnancy Surveillance Program November 19, 2023 April 2027
NCT06181617 Recruiting A Study to Assess Health-Related Quality of Life in Patients With Hypertrophic Cardiomyopathy in Japan December 6, 2023 June 30, 2025
NCT06256913 Recruiting Machine Learning Approach Based on Echocardiographic Data to Improve Prediction of Cardiovascular Events in Hypertrophic Cardiomyopathy May 6, 2023 May 6, 2024
NCT06287892 Recruiting Diagnosis of HCM With AI-ECG January 1, 2024 December 31, 2024
NCT06290570 Recruiting A Study of Artificial Intelligence ECG With ECG Devices to Detect Hypertrophic Cardiomyopathy Distinct From Athlete's Heart May 7, 2024 September 2025
NCT06347159 Recruiting Phase 2 A Study of EDG-7500 in Adult Patients With Obstructive Hypertrophic Cardiomyopathy (CIRRUS-HCM) April 11, 2024 March 2025
NCT06368518 Recruiting Austrian HCM Registry March 8, 2024 March 2034
NCT06381778 Recruiting Taiwan Registry of Hypertrophic Cardiomyopathy (THIC) Research Synopsis February 6, 2023 December 1, 2027
NCT06400524 Recruiting Assessment of Cardiac Function, Microvascular Function and Cardiac Perfusion in Different Disease Stages of Hypertrophic Cardiomyopathy May 2024 May 2026
NCT06401343 Recruiting Phase 4 Use of SGLT2i in noHCM With HFpEF August 1, 2022 August 1, 2025
NCT06409585 Recruiting Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition May 1, 2023 January 1, 2026
NCT03327623 Recruiting Sleep Apnea and Hypertrophic Cardiomyopathy (HCM) November 13, 2017 June 2030
NCT03362164 Recruiting Evaluation of HEArt invoLvement in Patients With FABRY Disease January 2001 March 2032
NCT04231032 Terminated N/A Paced Dyssynchrony and Myocardial Perfusion IN apiCal Hcm June 2, 2021 February 20, 2023
NCT00156429 Terminated Genetic Predictors of Outcome in HCM Patients April 22, 2009 July 30, 2020
NCT02291237 Terminated Phase 2/Phase 3 Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy February 5, 2015 February 17, 2017
NCT03249272 Terminated Phase 4 Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve September 5, 2017 March 31, 2019
NCT01230918 Terminated Phase 2 Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis May 2011 April 20, 2017
NCT03150342 Unknown status Presentations of Hypertrophic Cardiomyopathy on Myocardial Perfusion Imaging May 8, 2017 June 30, 2018
NCT03572569 Unknown status Risk Stratification in Children and Adolescents With Primary Cardiomyopathy January 2013 December 2020
NCT03076580 Unknown status An Integrative-"Omics" Study of Cardiomyopathy Patients for Diagnosis and Prognosis in China July 1, 2015 December 31, 2021
NCT03706001 Unknown status N/A Efficacy of Psychotherapy for Improving Quality of Life in Patients With Hypertrophic Cardiomyopathy and Depression October 20, 2018 December 31, 2019
NCT03061994 Unknown status Metabolomic Study of All-age Cardiomyopathy October 2016 October 2020
NCT03726424 Unknown status Outcome of Different Pathogenic Mutations in Hypertrophic Cardiomyopathy February 25, 2011 December 31, 2019
NCT03049995 Unknown status Stress Echo 2020 - The International Stress Echo Study November 2016 December 2021
NCT03278457 Unknown status Risk Stratification Using PET in HCM May 3, 2017 June 3, 2018
NCT02948998 Unknown status Phase 4 Evaluating the Effect of Spironolactone on Hypertrophic Cardiomyopathy May 14, 2018 July 2020
NCT02922517 Unknown status Predictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy June 2014 December 2021
NCT00315783 Unknown status Comparison of Data Obtained by Echocardiography and Magnetic Resonance Imaging in Hypertrophic Cardiomyopathy April 2006 June 2006
NCT02560467 Unknown status N/A Perfusion Imaging With Myocardial Contrast Echocardiography in HCM December 1, 2015 September 15, 2019
NCT04090437 Unknown status N/A HCM-AF Ablation With ACUTUS October 1, 2019 February 1, 2021
NCT00221832 Unknown status Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases October 2003 December 2011
NCT02520856 Unknown status New Diagnostic Strategy in Hypertrophic Cardiomyopathy July 2015 July 2018
NCT02500420 Unknown status N/A Study of Hypertrophic Cardiomyopathy Under Stress Conditions. Concordance Between Two Complementary Tests: Stress MRI and Exercice Stress Echocardiography December 2014 August 2017
NCT04153162 Unknown status N/A Non-Invasive Radiation Ablation in Patients With Hypertrophic CardioMyopathy: NIRA-HOCM January 2, 2020 January 2, 2023
NCT00698074 Unknown status Phase 3 Diastolic Ventricular Interaction and the Effects of Biventricular Pacing in Hypertrophic Cardiomyopathy
NCT04426578 Unknown status Phase 2 Role of Perhexiline in Hypertrophic Cardiomyopathy December 1, 2020 August 1, 2022
NCT02424994 Unknown status Morbidity and Mortality in Patients With Hypertrophic Cardiomyopathy: a CALIBER Study April 2015 December 2015
NCT00430833 Unknown status Phase 2 CHANCE - Candesartan in Hypertrophic Cardiomyopathy
NCT01518114 Unknown status N/A Exercise Training in Patients With Hypertrophic Cardiomyopathy December 2011
NCT00504647 Unknown status Phase 1 Biventricular Pacing in Hypertrophic Cardiomyopathy June 2006 August 2008
NCT01225978 Unknown status Refining Information Technology Support for Genetics in Medicine September 2009 December 2014
NCT03259113 Unknown status N/A Insertable Cardiac Monitors in Hypertrophic Cardiomyopathy August 16, 2017 April 16, 2019
NCT03182153 Unknown status Extended Ambulatory Monitoring Improves Risk Stratification in Hypertrophic Cardiomyopathy November 2016 December 31, 2018
NCT01873976 Unknown status Cardiac Biomarkers in Pediatric Cardiomyopathy (PCM Biomarkers) June 2013 June 2022
NCT01696370 Unknown status Phase 2 Trimetazidine Therapy in Hypertrophic Cardiomyopathy April 2012 April 2014
NCT00574821 Withdrawn Use of Magnetic Field Mapping in the Evaluation of Patients With Hypertrophic Heart Disease (Thick Heart Muscle) July 2007 December 2009
NCT04905173 Withdrawn N/A Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy November 2021 May 2022
NCT02431221 Withdrawn Phase 3 Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failure
NCT00703443 Withdrawn The Genetics of Cardiomyopathy and Heart Failure April 2007 April 2007
Disase is a (Disease Ontology)
DOID:0060036
Cross Reference ID (Disease Ontology)
ICD9CM:425.1
Cross Reference ID (Disease Ontology)
KEGG:05410
Cross Reference ID (Disease Ontology)
MESH:D002312
Cross Reference ID (Disease Ontology)
NCI:C34449
Cross Reference ID (Disease Ontology)
ORDO:217569
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:389998005
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0007194
Exact Synonym (Disease Ontology)
hypertrophic obstructive cardiomyopathy
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0001639