dilated cardiomyopathy

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Information
Disease name
dilated cardiomyopathy
Disease ID
DOID:12930
Description
"An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently." [url:http\://en.wikipedia.org/wiki/Dilated_cardiomyopathy]
Disease area statistics
Chromosome band
Gene symbol Chromosome Start Stop The number of variant
MYH7 14 23,412,740 23,435,660 4
TBX5 12 114,353,931 114,408,442 4
MYBPC3 11 47,331,406 47,352,702 2
TNNI3 19 55,151,767 55,157,732 2
MYPN 10 68,109,488 68,212,017 2
LMNA 1 156,114,711 156,140,081 2
MYH7 14 23,412,740 23,435,660 2
Annotation
NCT ID Status Phase Summary Start date Completion date
NCT05973591 Active, not recruiting The Impact of Ivabradine on Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy (NIDCM) on Current Medical Therapy Era July 15, 2023 December 31, 2024
NCT00180323 Completed N/A ACC - Atrial Contribution to CRT November 2004 December 2008
NCT00208806 Completed Resynchronization Therapy in Young Patients With and Without CHD June 2004 December 2006
NCT00282789 Completed N/A BiPAP for Cardiomyopathy With Central Sleep Apnea June 2000
NCT00333827 Completed Phase 3 Cell Therapy In Dilated Cardiomyopathy January 2006 February 2013
NCT00454818 Completed Phase 1/Phase 2 Efficacy and Safety Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure March 2007 August 2012
NCT02479776 Completed N/A A Trial of Autologous Bone Marrow Derived Stem Cells in Paediatric Heart Failure May 2008 March 2015
NCT02115581 Completed Phase 4 Coenzyme Q10 Supplementation in Children With Idiopathic Dilated Cardiomyopathy September 2006 March 2008
NCT02133911 Completed Phase 2 A Pilot Trial of Ranolazine to Treat Patients With Dilated Cardiomyopathy May 1, 2014 April 2, 2016
NCT02148926 Completed Clinical and Genetic Examinations of Dilated Cardiomyopathy February 2014 June 2018
NCT02248532 Completed Phase 2/Phase 3 Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy (REMEDIUM) January 2014 December 2017
NCT00505154 Completed Phase 3 Effect of Rosuvastatin on Left Ventricular Remodeling July 2007 July 2013
NCT00001313 Completed Evaluation of Patients With Known or Suspected Heart Disease May 10, 1992 January 6, 2009
NCT00541268 Completed N/A Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality February 2008 July 2016
NCT00542945 Completed N/A Danish ICD Study in Patients With Dilated Cardiomyopathy March 2008 June 2016
NCT00558584 Completed N/A Multicenter Study of Immunoadsorption in Dilated Cardiomyopathy (IMPACT-DCM) December 2007 April 2023
NCT04957147 Completed Reverse Remodelling and Remission Markers in the Serial Evaluation of Recent-onset Dilated Cardiomyopathy August 1, 2019 May 1, 2023
NCT00615394 Completed Phase 1/Phase 2 Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells by Mini-Thoracotomy April 2004 December 2006
NCT00629018 Completed Phase 2 Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy May 2006 April 2013
NCT00629096 Completed Phase 2 Intracoronary Infusion of Autologous Bone Marrow Cells for Treatment of Idiopathic Dilated Cardiomyopathy February 2008 December 2010
NCT04712136 Completed N/A Healthy-related Quality of Life and Physical Activity of Children With Cardiac Malformations February 1, 2021 June 20, 2023
NCT00709163 Completed N/A Nesiritide - Dilated Cardiomyopathy December 2003 November 2005
NCT00743639 Completed Phase 2/Phase 3 Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy July 2005 June 2008
NCT00765518 Completed Phase 2 Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM) September 2008 September 5, 2012
NCT04650009 Completed Physical Activity in Children With Inherited Cardiac Diseases May 1, 2020 February 1, 2021
NCT00847964 Completed Phase 2 Safety and Feasibility of Algisyl-LVR™ as a Method of Left Ventricular Restoration in Patients With DCM Undergoing Open-heart Surgery February 2009 November 2012
NCT00934609 Completed N/A Training Study to Evaluate the Benefit of Exercise for Patients With Chronic Heart Failure
NCT00958087 Completed Cardiac Sarcoidosis and FDG-PET March 2004 July 2010
NCT04307823 Completed N/A Respiratory Muscles Training in Patients With Dilated Cardiomyopathy August 15, 2019 January 30, 2020
NCT01015144 Completed The Influence of Atorvastatin on the Parameters of Inflammation and the Function of Left Ventricle February 2007 February 2009
NCT01020968 Completed Phase 2 Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy December 2009 December 5, 2013
NCT04159454 Completed N/A PITA-HF: Feasibility, Safety, and Tolerability November 20, 2020 February 1, 2023
NCT03893760 Completed Assessment of Right Ventricular Function in Advanced Heart Failure October 2016 June 2017
NCT01223703 Completed Phase 3 PUFAs and Left Ventricular Function in Heart Failure November 2007 June 2009
NCT03775070 Completed Phase 2 Simvastatin Therapy in Patients With Dilated Cardiomyopathy. January 17, 2019 July 31, 2022
NCT01293903 Completed Phase 4 Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy January 2012 September 30, 2016
NCT01302171 Completed Phase 2 Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy August 2010 July 2013
NCT01311791 Completed Phase 2/Phase 3 A Randomized, Controlled Study to Evaluate Algisyl-LVR™ as a Method of Left Ventricular Augmentation for Heart Failure August 2012 May 2016
NCT01350310 Completed Phase 2 Safety and Efficacy Study of Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy March 2011 December 2014
NCT03607669 Completed Manganese-Enhanced Magnetic Resonance Imaging of the Myocardium June 1, 2018 February 1, 2020
NCT01399801 Completed N/A Optimizing Left Ventricular Lead To Improve Cardiac Output December 2010 September 25, 2014
NCT01557140 Completed Phase 4 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy May 2003 December 2006
NCT03447990 Completed Phase 1/Phase 2 v4 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491 February 6, 2018 October 24, 2019
NCT01739777 Completed Phase 1/Phase 2 Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy December 2012 June 2015
NCT03415789 Completed Intraventricular Stasis in Non Ischemic Dilated Myocardiopathy February 10, 2018 November 24, 2020
NCT01873963 Completed Genotype-Phenotype Associations in Pediatric Cardiomyopathy (PCM GENES) April 2013 March 31, 2018
NCT03235063 Completed Pregnancy and Dilated Cardiomyopathy January 2, 2013 June 30, 2021
NCT03129568 Completed Phase 1 Transcoronary Infusion of Cardiac Progenitor Cells in Pediatric Dilated Cardiomyopathy April 14, 2017 December 9, 2020
NCT01917149 Completed Phase 4 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy March 2005 December 2013
NCT01919983 Completed Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death March 2012 September 2014
NCT03062956 Completed Phase 1 A Single Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of MYK-491 January 16, 2017 November 28, 2017
NCT02018835 Completed N/A Exercise Stress MRI to Evaluate Aortic Function (Compliance, Distensibility, Pulse Wave Velocity) and Left Ventricular Function : Validation in Healthy Volunteers and in Selected Patients. A Pilot Study. December 5, 2013 October 28, 2022
NCT02619825 Completed N/A Non-Invasive Evaluation of Myocardial Stiffness by Elastography in Pediatric Cardiology (Elasto-Pédiatrie) November 2015 July 2017
NCT02064192 Completed Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe May 2014 November 2019
NCT06072937 Not yet recruiting N/A IntelliStent for Pulmonary Flow Adjustment in Congenital Heart Disease and Dilated Cardiomyopathy June 4, 2024 June 4, 2026
NCT06464588 Not yet recruiting Phase 1 A Phase 1 Open-Label Study of the Safety of Intravenous Allogeneic Neonatal Mesenchymal Cells (nMSCs) in Young Adult (1A) and Pediatric (1B) Patients With Dilated Cardiomyopathy (DCM) July 2024 July 2027
NCT04703751 Not yet recruiting N/A Evaluation of the CIRCULATE Catheter for Transcoronary Administration of Pharmacologic and Cell-based Agents September 2022 November 2022
NCT03993730 Not yet recruiting N/A Cardiovascular Magnetic Resonance GUIDEd Insertion of Implantable Cardiac Defibrillator in Dilated CardioMyopathy June 2020 June 2026
NCT05026112 Recruiting The Arrhythmogenic Potential of Midwall Septal Fibrosis in Dilated Cardiomyopathy October 1, 2021 October 1, 2024
NCT02432092 Recruiting Pediatric Cardiomyopathy Mutation Analysis April 2014 December 31, 2030
NCT02804269 Recruiting Molecular and Imaging Studies of Cardiovascular Health and Disease July 2013 July 2033
NCT03057002 Recruiting UTSW HP [13-C] Pyruvate Injection in HCM May 1, 2018 November 8, 2024
NCT03572660 Recruiting Phase 2 Use of Bone Marrow Derived Stem Cell and G-CSF With Circulatory Assistance in the Treatment of DCM December 24, 2018 March 30, 2025
NCT03843255 Recruiting Defining the Genetics, Biomarkers and Outcomes for Dilated Cardiomyopathy January 9, 2020 July 22, 2027
NCT04246450 Recruiting N/A Arrhythmic Risk Stratification in Nonischemic Dilated Cardiomyopathy September 1, 2020 May 1, 2025
NCT04331769 Recruiting N/A Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study December 21, 2020 December 21, 2030
NCT04464655 Recruiting A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease December 12, 2019 January 31, 2025
NCT04638621 Recruiting Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Ancillary Study April 1, 2021 April 2026
NCT04649034 Recruiting Intraventricular Stasis In Cardiovascular Disease November 24, 2020 December 31, 2024
NCT04982081 Recruiting Phase 1 Treating Congestive HF With hiPSC-CMs Through Endocardial Injection September 21, 2021 July 31, 2023
NCT04990297 Recruiting Cardiac Magnetic Resonance for Risk Stratification in Dilated Cardiomyopathy December 24, 2019 December 31, 2031
NCT05410873 Recruiting Phase 2 Examining the Effects of Mitochondrial Oxidative Stress in DCM July 26, 2022 July 3, 2025
NCT05564689 Recruiting Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy September 29, 2022 September 30, 2024
NCT05645952 Recruiting Association of Obesity and Cardiovascular Outcomes in Dilated Cardiomyopathy July 1, 2022 December 31, 2024
NCT05750147 Recruiting The SMARTER Cardiomyopathy Study March 1, 2023 August 1, 2027
NCT05799833 Recruiting Low QRS Voltages in Young Healthy Individuals and Athletes October 9, 2023 November 1, 2025
NCT05837143 Recruiting Early Phase 1 Myocardial Telomere Recapping Study for Dilated Cardiomyopathy April 6, 2023 July 2025
NCT05849766 Recruiting Phase 3 Effect of Dapagliflozin on Secondary Mitral Regurgitation April 27, 2023 May 1, 2024
NCT06236022 Recruiting Phase 4 The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi Sarcoma-associated Virus January 1, 2024 December 31, 2028
NCT06250257 Recruiting Phase 3 Bromocriptine in Dilated Cardiomyopathy Among Women of Reproductive Age December 1, 2023 August 30, 2024
NCT06381466 Recruiting Phase 1 A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants. April 1, 2024 March 6, 2025
NCT03071653 Suspended Phase 2 Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study November 24, 2016 February 2022
NCT03439514 Terminated Phase 3 A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation April 17, 2018 October 13, 2022
NCT00585546 Terminated Phase 1 Harefield Recovery Protocol Study for Patients With Refractory Chronic Heart Failure July 2007 March 2010
NCT01583114 Terminated Phase 3 PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors December 2011 January 2014
NCT04176458 Terminated N/A Methacetin Breath Test in Patients With Liver Disease Secondary to Heart Disease April 21, 2019 March 19, 2021
NCT00466713 Terminated N/A Defining the Role of Insulin Resistance in 'Idiopathic' Dilated Cardiomyopathy March 2007 December 2007
NCT01290822 Terminated Phase 1/Phase 2 Optimized Biventricular Pacing Allograft Recipients January 2007 March 2011
NCT02770443 Terminated N/A Withdrawal of Medication in Recovered DCM February 19, 2016 November 2019
NCT04174456 Unknown status N/A Combination of Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy December 1, 2019 December 31, 2021
NCT00962364 Unknown status Long-term Evaluation of Patients Receiving Bone Marrow-derived Cell Administration for Heart Disease October 2001 December 2021
NCT00518817 Unknown status The Cardiovascular Genetic and Therapeutic Implications of Muscular Dystrophy August 2007 August 2009
NCT04405804 Unknown status Phase 2 Early Administration of Ivabradine in Children With Heart Failure June 20, 2020 May 2021
NCT05193838 Unknown status Effect of Allopurinol on Left Ventricular Function in Children With Dilated Cardiomyopathy May 1, 2022 July 2023
NCT05237323 Unknown status Phase 3 Micophenolate Mofetil Versus Azathioprine in Myocarditis October 1, 2020 May 29, 2023
NCT00374465 Unknown status Phase 4 Therapy With Verapamil or Carvedilol in Chronic Heart Failure January 2006 May 2008
NCT02226679 Unknown status N/A An Open Label Rollover Trial for Patients Randomized to the Control Group of Study LSH-10-001 January 2014 April 2016
NCT00819442 Unknown status N/A Relationship Between Abnormalities of Desmin Cytoskeleton, Mitochondrial Activity and Expression of Ubiquitin in Aspect of Pathogenesis of Heart Failure and Prognosis January 2009 June 2011
NCT02440217 Unknown status Myocardial Metabolism in Patients With Dilated Cardiomyopathy May 2015 June 2015
NCT02175836 Unknown status Arrhythmia Prediction Trial October 2007 June 2019
NCT02020954 Unknown status Prospective Becker-Heart-Study January 2013 June 2017
NCT02652728 Unknown status Phase 2/Phase 3 Orodispersible Minitablets of Enalapril in Children With Heart Failure Due to Dilated Cardiomyopathy January 2016 June 2017
NCT02654678 Unknown status Phase 2/Phase 3 Follow-up Safety Trial in Children With Chronic Heart Failure Therapy Receiving Orodispersible Minitablets of Enalapril March 2016 April 2018
NCT01756014 Unknown status Brain Function and Perfusion in Patients With Heart Failure January 2012
NCT03572569 Unknown status Risk Stratification in Children and Adolescents With Primary Cardiomyopathy January 2013 December 2020
NCT01378572 Unknown status Electrophysiologic and Morphologic Assessment of the Substrate to Guide Implantation of Defibrillators in Dilated Cardiomyopathy November 2009
NCT01219452 Unknown status Phase 1/Phase 2 Intramuscular Injection of Mesenchymal Stem Cell for Treatment of Children With Idiopathic Dilated Cardiomyopathy October 2010 December 2012
NCT01157299 Unknown status Hemodynamic Evaluation of Preload Responsiveness in Children by Using PiCCO September 2009 September 2010
NCT04055636 Unknown status Observational Trial of Cardiotoxicity in Patients Undergoing Chemotherapy. June 14, 2019 June 2024
NCT04146701 Unknown status Metabolomics and Microbiomics in Cardiovascular Diseases February 1, 2019 December 31, 2022
NCT01139086 Unknown status Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF) May 2010 May 2011
NCT03061994 Unknown status Metabolomic Study of All-age Cardiomyopathy October 2016 October 2020
NCT03076580 Unknown status An Integrative-"Omics" Study of Cardiomyopathy Patients for Diagnosis and Prognosis in China July 1, 2015 December 31, 2021
NCT03082508 Unknown status N/A A Pivotal Trial to Establish the Efficacy and Safety of Algisyl in Patients With Moderate to Severe Heart Failure August 2017 January 2024
NCT01914081 Unknown status Phase 3 Resveratrol: A Potential Anti- Remodeling Agent in Heart Failure, From Bench to Bedside October 9, 2018 November 2020
NCT01873976 Unknown status Cardiac Biomarkers in Pediatric Cardiomyopathy (PCM Biomarkers) June 2013 June 2022
NCT02915718 Unknown status N/A A Clinical Study of Immunoadsorption Therapy for Dilated Cardiomyopathy October 2016 February 2018
NCT02989181 Unknown status Phase 3 Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea November 2014 December 2019
NCT00646243 Unknown status Echo Assessment of Intraventricular Dyssynchrony March 2008 March 2009
NCT00703443 Withdrawn The Genetics of Cardiomyopathy and Heart Failure April 2007 April 2007
NCT02001961 Withdrawn Pathophysiology of Dilated Cardiomyopathy January 2014 June 2015
NCT02216760 Withdrawn N/A Using Ripple Mapping to Guide Substrate Ablation of Scar Related Ventricular Tachycardia. August 2014 August 2018
NCT00483236 Withdrawn Prospective Study Looking at Quality of Life Measures in Non-ischaemic Cardiomyopathy After Mitral Valve Repair December 1, 2007 June 1, 2009
NCT03207230 Withdrawn N/A Multicenter Exploratory Study of Accelerometry in Dilated Cardiomyopathy August 2017 March 2018
Disase Synonym (Disease Ontology)
Congestive cardiomyopathy
Disase Synonym (Disease Ontology)
Familial dilated cardiomyopathy
Disase Synonym (Disease Ontology)
Idiopathic dilation cardiomyopathy
Exact Synonym (Disease Ontology)
primary dilated cardiomyopathy
Disase is a (Disease Ontology)
DOID:0060036
Cross Reference ID (Disease Ontology)
EFO:0000407
Cross Reference ID (Disease Ontology)
GARD:221
Cross Reference ID (Disease Ontology)
ICD10CM:I42.0
Cross Reference ID (Disease Ontology)
KEGG:05414
Cross Reference ID (Disease Ontology)
MESH:D002311
Cross Reference ID (Disease Ontology)
MIM:PS115200
Cross Reference ID (Disease Ontology)
NCI:C84673
Cross Reference ID (Disease Ontology)
ORDO:217604
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:74368002
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0007193
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0001644
HPO alt_id (Human Phenotype Ontology)
HP:0001725
HPO alt_id (Human Phenotype Ontology)
HP:0005159
HPO alt_id (Human Phenotype Ontology)
HP:0200130
OMIM Phenotype Series Number (OMIM)
PS115200
MedGen unique identifier (MedGen Concept name)
880309
MedGen concept unique identifier (MedGen Concept name)
CN235865
ICD10 class code (Insert disease from ICD10)
I42.0
ICD10 preferred id (Insert disease from ICD10)
D0007150