cystic fibrosis

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Information
Disease name
cystic fibrosis
Disease ID
DOID:1485
Description
"A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs." [url:http\://en.wikipedia.org/wiki/Cystic_fibrosis, url:http\://ghr.nlm.nih.gov/condition/cystic-fibrosis, url:http\://www.nhlbi.nih.gov/health/health-topics/topics/cf/, url:https\://www.genome.gov/Genetic-Disorders/Cystic-Fibrosis]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT03357562 Active, not recruiting N/A MR Imaging of Lung in the Follow-up Assessment of Cystic Fibrosis May 5, 2018 October 31, 2024
NCT03771313 Active, not recruiting Phase 4 Pharmacokinetic and Pharmacodynamic Analysis of Ceftaroline in Children and Adolescents With Cystic Fibrosis September 1, 2017 July 31, 2025
NCT05140967 Active, not recruiting N/A Effects of Training Intensity on Physical Fitness and Body Composition in Cystic Fibrosis October 15, 2021 December 2024
NCT04760548 Active, not recruiting Segmentation of Structural Abnormalities in Chronic Lung Diseases January 1, 2008 February 17, 2024
NCT06084468 Active, not recruiting Cardiac Structure and Function in Patients With Cystic Fibrosis January 1, 2023 March 1, 2032
NCT05699148 Active, not recruiting Gut Imaging for Function and Transit in Cystic Fibrosis 3 Junior April 1, 2022 April 1, 2023
NCT05010577 Active, not recruiting Phase 1/Phase 2 Nebulized Bacteriophage Therapy in Cystic Fibrosis Patients With Chronic Pseudomonas Aeruginosa Pulmonary Infection June 21, 2022 March 2024
NCT04395820 Active, not recruiting Prospective Surveillance of Lung Development During Childhood, Adolescence and Adulthood in Healthy and Patients With Cystic Fibrosis July 1, 2020 December 1, 2100
NCT03522831 Active, not recruiting N/A CF Bronchodilation May 1, 2018 December 31, 2024
NCT05420844 Active, not recruiting N/A Pilot Study to Evaluate a Voice Journaling Application in Adolescents With Cystic Fibrosis July 29, 2022 December 2024
NCT05599230 Active, not recruiting Daily Monitoring of Respiratory Symptoms and Spirometry During ETI Treatment in Persons With Cystic Fibrosis. September 1, 2022 November 30, 2022
NCT04206436 Active, not recruiting CFTR Modulator Effects on Bone and Muscle in Adults With Cystic Fibrosis December 18, 2019 July 13, 2024
NCT02690064 Active, not recruiting N/A Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF April 2015 January 2025
NCT05422222 Active, not recruiting Phase 3 Evaluation of VX-121/Tezacaftor/Deutivacaftor in Cystic Fibrosis (CF) Participants 1 Through 11 Years of Age June 21, 2022 June 2030
NCT04923880 Active, not recruiting N/A Pragmatic Implementation Trial of a CF Primary Palliative Care Intervention June 25, 2021 June 30, 2024
NCT02694393 Active, not recruiting Phase 1/Phase 2 Inhaled Sodium Nitrite as an Antimicrobial for Cystic Fibrosis February 2016 April 2023
NCT05581056 Active, not recruiting Evaluation of the Evolution of Quality of Life in Relation to Naso-sinus Symptomatology Under Treatment With CFTE Modulators in Children Aged 6 to 11 Years With Cystic Fibrosis With Compatible Mutation March 3, 2023 September 3, 2024
NCT06106789 Active, not recruiting A Study of the Clinical Benefit of Tobramycin Inhalation Solution January 1, 2021 April 30, 2024
NCT04613128 Active, not recruiting The PROMISE Pediatric Study 6 to 11 Years Old June 11, 2021 December 19, 2025
NCT04602468 Active, not recruiting Phase 4 Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER) September 3, 2020 July 1, 2029
NCT04259970 Active, not recruiting Phase 4 Hyperpolarized Imaging for New Treatments January 13, 2020 December 31, 2025
NCT05752019 Active, not recruiting TAAI Erasmus Research Initiative to Fight CF: Monitoring Inflammation in CF Lung Disease Into a New Era March 21, 2022 December 31, 2023
NCT00037765 Active, not recruiting Gene Modifiers of Cystic Fibrosis Lung Disease September 2001 July 2024
NCT03947957 Active, not recruiting N/A Microbial Biomarkers of EArly Pseudomonas Aeruginosa Colonization in CHildren With Cystic Fibrosis October 2, 2020 July 2026
NCT04392544 Active, not recruiting Intestinal Inflammation in CF Patients September 11, 2018 March 31, 2024
NCT05153317 Active, not recruiting Phase 3 Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis (CF) Participants 2 Years and Older January 17, 2022 April 2026
NCT05482048 Active, not recruiting N/A Pilot Trial of ExACT (Exercise as Airway Clearance Therapy) for People With Cystic Fibrosis February 2, 2023 May 1, 2024
NCT04354038 Active, not recruiting Host and Bacterial Mechanisms During Cystic Fibrosis Pulmonary Exacerbations January 7, 2020 December 2026
NCT04353752 Active, not recruiting Observational Trial of the Longitudinal Effects of CFTR Modulator Drugs September 16, 2019 December 2025
NCT05012306 Active, not recruiting Covid-19 Antibody Responses in Cystic Fibrosis May 28, 2021 May 2024
NCT06057558 Active, not recruiting N/A Airway Microbiome of Cystic Fibrosis Patients January 1, 2022 November 1, 2025
NCT03938324 Active, not recruiting N/A Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions October 29, 2019 May 2024
NCT04992234 Active, not recruiting COVID-19 Antibody Responses in Cystic Fibrosis August 31, 2021 August 2024
NCT06184763 Active, not recruiting Evolution of the 6-minute Walk Test in Patients Treated With ELEXACAFTOR / TEZACAFTOR / IVACAFTOR August 1, 2023 November 1, 2024
NCT04467957 Active, not recruiting Phase 4 Non-contrast Lung Perfusion Mapping Applied for New Insights in Cystic Fibrosis November 15, 2020 December 31, 2024
NCT05054582 Active, not recruiting COVID-19 Antibody Responses In Cystic Fibrosis: CAR-CF September 1, 2021 November 30, 2024
NCT05253859 Active, not recruiting CFTR Modulators and Gastrointestinal Complications October 1, 2021 September 30, 2023
NCT05561868 Active, not recruiting COVID-19 Antibody Responses in Cystic Fibrosis August 22, 2022 September 1, 2025
NCT00804583 Active, not recruiting Genetic Modifiers of Cystic Fibrosis (CF) Liver Disease March 2004 July 2024
NCT05444257 Active, not recruiting Phase 3 A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy November 8, 2022 October 2025
NCT05271643 Active, not recruiting N/A Pilot Study of a CF-specific CBT Intervention for Adolescents March 2, 2022 April 30, 2024
NCT06299709 Active, not recruiting Phase 1 A Study To Evaluate the Relative Bioavailability, Food Effect, and Dose Proportionality of a Granule Formulation of Vanzacaftor/Tezacaftor/Deutivacaftor(VNZ/TEZ/D-IVA) March 13, 2024 June 2024
NCT02848560 Active, not recruiting Monitoring Response to Orkambi in Cystic Fibrosis Lung Disease by Inhaled Xenon MRI March 2016 October 31, 2025
NCT04038047 Active, not recruiting A Prospective Study to Evaluate Biological and Clinical Effects of Significantly Corrected CFTR Function October 22, 2019 October 27, 2024
NCT05331183 Active, not recruiting Phase 3 Study to Evaluate Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) Long-term Safety and Efficacy in Subjects Without F508del November 23, 2022 April 2027
NCT04904445 Active, not recruiting COVID-19 Antibody Responses In Cystic Fibrosis May 21, 2021 May 1, 2024
NCT01381289 Approved for marketing VX-770 Expanded Access Program
NCT00499720 Approved for marketing Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Airway Infection
NCT00989807 Approved for marketing Expanded Access Program for Aztreonam Lysine for Inhalation in Canadian Patients With Cystic Fibrosis
NCT04702360 Approved for marketing ELX/TEZ/IVA Expanded Access Program for Cystic Fibrosis (CF) Patients With at Least One F508del Mutation
NCT03278314 Approved for marketing Tezacaftor/Ivacaftor Combination Therapy Expanded Access Program for Patients 12 Years of Age and Older With Cystic Fibrosis
NCT04058210 Approved for marketing VX-445/TEZ/IVA Expanded Access Program for Cystic Fibrosis (CF) Patients Heterozygous for F508del Mutation and a Minimal Function Mutation (F/MF Genotypes)
NCT05437120 Completed Phase 1 Pharmacokinetics and Safety Assessment of VX-121/Tezacaftor/Deutivacaftor in Participants With Moderate Hepatic Impairment July 22, 2022 March 16, 2023
NCT02003079 Completed Evaluating the Impact of Chronic Rhinosinusitis on the Health-Related Quality of Life Among Adults With Cystic Fibrosis September 2013 June 2014
NCT04161313 Completed Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children December 20, 2019 March 12, 2020
NCT02750722 Completed N/A Exercise and Oscillatory Positive Expiratory Pressure Therapy in Cystic Fibrosis May 2016 January 19, 2017
NCT00863694 Completed Fecal Calprotectin in Cystic Fibrosis February 2009 August 2013
NCT04135495 Completed Phase 2 A Phase 2 Study to Evaluate the Safety, Tolerability, PK and PD of ELX-02 in Cystic Fibrosis Patients With G542X Allele November 25, 2019 October 3, 2022
NCT01859390 Completed Phase 2 Effects of an Antioxidant-Enriched Multivitamin Supplement on Inflammation and Oxidative Stress in Cystic Fibrosis June 2013 July 2016
NCT04402801 Completed Patient Outcomes of Clinic Transition From Face to Face Encounter to Telemedicine in Cystic Fibrosis June 1, 2020 May 31, 2022
NCT02286050 Completed N/A Effect of a Nursing Program for Patients With Cystic Fibrosis on Disease Management November 2014 April 2017
NCT04249466 Completed Diet, Physical Activity and Glucose Tolerance in Cystic Fibrosis. Exploratory Study. June 5, 2020 November 8, 2021
NCT04809207 Completed N/A Acceptability, Feasibility and Preliminary Efficacy of CFWP to Treat Clinically Elevated Fatigue in Adults With CF May 1, 2021 July 25, 2023
NCT03091062 Completed N/A Evaluation of an Airway Clearance System March 30, 2017 February 2, 2018
NCT04798014 Completed HERO-2: Home-Reported Outcomes With CFTR Modulator Therapy May 26, 2021 August 15, 2023
NCT05948488 Completed Psychological Study in Children With Mucoviscidosis February 28, 2019 August 28, 2022
NCT00015756 Completed Tissue Collection From People With Cystic Fibrosis May 2, 2001 April 21, 2008
NCT04618185 Completed Gut Imaging for Function & Transit in CF - GIFT-CF 3 October 21, 2020 June 28, 2023
NCT02677701 Completed Phase 4 Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With Cystic Fibrosis (CF) October 21, 2016 February 13, 2020
NCT03637504 Completed N/A Feasibility of a Mobile Medication Plan Application in CF Patient Care September 5, 2018 June 30, 2021
NCT03390985 Completed Canadian Observation Trial in CF Patients Undergoing Treatment With Ivacaftor April 23, 2013 July 26, 2017
NCT00450073 Completed N/A Improving Vitamin D Status In Cystic Fibrosis November 2006 May 2011
NCT02947126 Completed Phase 1 Multilevel Models of Therapeutic Response in the Lungs January 2017 December 2022
NCT06312787 Completed Phase 1 A Study to Evaluate the Relative Bioavailability and Food Effect of a VX-118 Tablet Formulation April 2, 2024 May 4, 2024
NCT03420209 Completed N/A The Effect of Proprioceptive Neuromuscular Facilitation (PNF) Technique for Children With Chronic Pulmonary Diseases. December 1, 2016 August 1, 2022
NCT02894684 Completed Phase 4 Aztreonam for Inhalation Solution (AZLI) for the Treatment of Exacerbations of Cystic Fibrosis January 2017 September 2019
NCT00388505 Completed Phase 3 Safety of Tobramycin Inhalation Powder (TIP) vs Tobramycin Solution for Inhalation in Patients With Cystic Fibrosis February 2006 March 2009
NCT05033080 Completed Phase 3 A Phase 3 Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Heterozygous for F508del and a Minimal Function Mutation (F/MF) September 14, 2021 November 21, 2023
NCT04742049 Completed N/A The Effects of Telerehabilitation on Muscle Function, Physical Activity and Sleep in Cystic Fibrosis During Pandemic December 28, 2020 March 29, 2021
NCT04297709 Completed Study of Urinary Predictors of Exacerbations by Biomarkers in Cystic Fibrosis February 1, 2018 July 31, 2019
NCT04105972 Completed Phase 3 A Study Evaluating the Efficacy and Safety of VX-445/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects, Homozygous for F508del October 3, 2019 July 24, 2020
NCT03482960 Completed Early Phase 1 Comparison of 129Xe MRI With 19F MRI in CF Lung Disease May 29, 2018 April 10, 2019
NCT01712334 Completed Phase 4 A Study of the Comparable Efficacy and Safety of Pulmozyme (Dornase Alfa) Delivered by the eRapid Nebulizer System in Patients With Cystic Fibrosis December 2012 June 2013
NCT02015507 Completed Phase 1 An Open-Label, Phase 1 Study in Healthy Adult Subjects to Examine the Effects of Multiple-Dose Ciprofloxacin on Ivacaftor and VX-661 in Combination With Ivacaftor January 2014 February 2014
NCT05285410 Completed Observational Study Comparing Home to Office Spirometry November 30, 2022 December 19, 2023
NCT00809094 Completed Phase 2 NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients November 2008 February 2011
NCT06020547 Completed Cystic Fibrosis and Frailtyh What's in Common? May 1, 2022 August 1, 2023
NCT02524704 Completed Electrical Impedance Imaging of Patients With Cystic Fibrosis March 2015 December 2016
NCT01784419 Completed N/A Short Term Effects of Ivacaftor in Non-G551D Cystic Fibrosis Patients October 2013 December 2015
NCT00231686 Completed Phase 2/Phase 3 Effects of a 6-Months Physical Conditioning Program in Patients With Cystic Fibrosis November 2000 May 2003
NCT04684823 Completed N/A The Impact of Patch Rx Technologies on Adherence to Vitamin and Trikafta Therapies in Patients With Cystic Fibrosis January 15, 2021 December 27, 2021
NCT02847208 Completed Contraceptive Practices and Cervical Screening in Women With Cystic Fibrosis January 2014 December 2014
NCT02477319 Completed A Two-Part Multicenter Prospective Longitudinal Study of CFTR-dependent Disease Profiling in Cystic Fibrosis (PROSPECT) March 2015 July 27, 2018
NCT00244270 Completed Phase 4 Cystic Fibrosis and Totally Implantable Vascular Access Devices December 2005 March 2009
NCT00590330 Completed Microbial Community Composition and Dynamics in Lungs of Cystic Fibrosis Sibling Pairs October 2007 March 2009
NCT03525444 Completed Phase 3 A Phase 3 Study of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF) June 15, 2018 April 24, 2019
NCT00558844 Completed Phase 1/Phase 2 Safety/Tolerability Study of Arikayce™ in Cystic Fibrosis Patients With Chronic Infection Due to Pseudomonas Aeruginosa January 2008 June 2009
NCT01161537 Completed Phase 2 Study of the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects With Cystic Fibrosis and the G551D Mutation October 2010 February 2013
NCT03125395 Completed Phase 3 A Rollover Safety Study of Lumacaftor/Ivacaftor in Subjects Aged 2 Years and Older With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation May 12, 2017 July 17, 2019
NCT01822197 Completed N/A Pilot Trial of Phototherapy for Acute Depression in Hospitalized Cystic Fibrosis Patients March 2013 June 2015
NCT00274313 Completed Phase 1/Phase 2 Safety Study of Inhaled 552-02 in Cystic Fibrosis Patients January 2006 August 2006
NCT00865904 Completed Phase 2 Study of VX-809 in Cystic Fibrosis Subjects With the ∆F508-CFTR Gene Mutation March 2009 December 2009
NCT03000348 Completed Phase 2 A Study of the Dosing, Efficacy, and Safety of Oral Cysteamine in Adult Patients With Cystic Fibrosis Exacerbations December 2016 April 2018
NCT01465529 Completed Phase 1/Phase 2 A Cross-over Study of OligoG in Subjects With Cystic Fibrosis. Fibrosis May 2011 November 2013
NCT00585364 Completed Mechanisms of Immune Tolerance and Inflammation in Patients With Cystic Fibrosis With ABPA March 2005 December 2010
NCT00546663 Completed N/A Tolerability of Inhaled Hypertonic Saline in Infants With Cystic Fibrosis September 2007 July 2008
NCT04017559 Completed N/A Clinical Impact of MI on Inhaled Antibiotic Adherence in Cystic Fibrosis October 22, 2014 May 17, 2017
NCT02342964 Completed N/A Comparison of Non-invasive Measurement Methods of Hepatic Fibrosis in Cystic Fibrosis January 8, 2015 January 24, 2019
NCT03625466 Completed Phase 2 A Study to Explore the Impact of Lumacaftor/Ivacaftor on Disease Progression in Subjects Aged 2 Through 5 Years With Cystic Fibrosis, Homozygous for F508del August 10, 2018 October 7, 2021
NCT05001841 Completed Renal Failure Following Lung Transplantation in Cystic Fibrosis Patients January 1, 2013 May 31, 2021
NCT01223183 Completed Phase 1 Absorptive Clearance After Inhaled Osmotics in Cystic Fibrosis September 2010 December 2012
NCT02807415 Completed ICM to Evaluate the Activation of p.Phe508del-CFTR by Lumacaftor in Combination With Ivacaftor June 1, 2016 February 10, 2020
NCT03534986 Completed N/A Effect of High Frequency Chest Wall Oscillation Vests on Spirometry Measurements February 20, 2018 March 16, 2018
NCT02875366 Completed Phase 4 A Study of the Effects of Lumacaftor/Ivacaftor (LUM/IVA) on Exercise Tolerance in Subjects With Cystic Fibrosis (CF), Homozygous for the F508del-CFTR Mutation September 2016 October 2017
NCT03256968 Completed Phase 4 PTC Study to Evaluate Ataluren in Combination With Ivacaftor January 27, 2017 December 31, 2018
NCT00982930 Completed Phase 3 Open Label Extension to Bridging Study CTBM100C2303 August 12, 2009 October 6, 2011
NCT00297167 Completed Phase 3 Study to Evaluate the Safety and Efficacy of EUR-1008 (APT-1008) Pancreatic Enzyme Product in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency May 2006 November 2006
NCT01400750 Completed Phase 4 Comparison of 2 Treatment Regimens for Eradication of P Aeruginosa Infection in Children With Cystic Fibrosis August 2001 May 2011
NCT01880723 Completed N/A Utilizing Exhaled Breathe Condensate Collection to Study Ion Regulation in Cystic Fibrosis May 2009 January 2013
NCT03377686 Completed Breath Analysis in Children by New Point-of-care Instruments March 2016 December 2017
NCT04451213 Completed N/A Magnetic Resonance Imaging and Neuro-Psychological Testing In Cystic Fibrosis August 23, 2021 December 23, 2022
NCT00177645 Completed Phase 1 Inhaled Bicarbonate Therapy in Cystic Fibrosis March 2002 December 2006
NCT03150719 Completed Phase 3 A Study to Evaluate Safety, Efficacy, and Tolerability of TEZ/IVA in Orkambi® (Lumacaftor/Ivacaftor) -Experienced Subjects With Cystic Fibrosis (CF) May 24, 2017 August 9, 2018
NCT03524859 Completed Evaluation of Sit-to-stand Test in Patients With Cystic Fibrosis and Matched Controls. May 3, 2018 April 25, 2019
NCT00671736 Completed Phase 2 Lancovutide (Moli1901) Inhalation Solution Study in Adolescents and Adults With Cystic Fibrosis October 2007 July 2009
NCT00432861 Completed Phase 3 Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis January 2007 September 2007
NCT02950883 Completed Phase 2/Phase 3 Saline Hypertonic in Preschoolers + CT March 24, 2015 June 25, 2021
NCT03965832 Completed N/A HFNT During Exercise in CF May 24, 2019 December 1, 2020
NCT00368446 Completed Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease October 17, 2006
NCT04926701 Completed Phase 1 A First in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled ETD001 in Healthy Subjects June 11, 2021 March 22, 2022
NCT01112059 Completed N/A Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients November 2008 November 2012
NCT02363764 Completed The Challenge of Obtaining Qualitative Bacterial Cultures in Non-expectorating Cystic Fibrosis Patients January 2015 October 2016
NCT00712166 Completed Phase 3 Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis, Mild Lung Disease, and P. Aeruginosa May 2008 August 2009
NCT03298685 Completed SAFETIM-needs : Exploring Adolescent's and Parent's Needs During Transition in French CF Centers June 12, 2017 December 31, 2018
NCT01880346 Completed Phase 4 Comparison of Absorption of Vitamin D in Cystic Fibrosis October 2013 October 2015
NCT00934362 Completed Phase 2 Effect of Lucinactant on Mucus Clearance in Cystic Fibrosis Lung Disease October 2008 August 2010
NCT00945347 Completed Phase 2 Does a Nasal Instillation of Miglustat Normalize the Nasal Potential Difference in Cystic Fibrosis Patients ? July 2009 June 2011
NCT00685971 Completed N/A Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients December 2008 July 2013
NCT01889927 Completed N/A INSPIRE-CF: an Alternative Physiotherapy Model for Children With Cystic Fibrosis May 1, 2012 December 31, 2017
NCT00970346 Completed Phase 1 Safety and Efficacy of Inhaled OligoG CF-5/20 for the Treatment Cystic Fibrosis September 2009 November 2009
NCT04847882 Completed Case-control Study of Sleep Disorders in Children With Cystic Fibrosis May 20, 2021 December 20, 2021
NCT02343445 Completed Phase 2 Clearing Lungs With Epithelial Sodium Channel (ENaC) Inhibition in Cystic Fibrosis (CF) April 2015 February 2016
NCT03516331 Completed Phase 1 A Drug-Drug Interaction Study of FDL169 and FDL176 in Healthy Subjects March 7, 2018 August 22, 2018
NCT01327703 Completed Phase 4 Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency April 2011 May 2012
NCT02359357 Completed Phase 1 FTIH - Single and Repeat Oral Doses of FDL169 in Healthy Volunteers January 2015 March 2016
NCT04217889 Completed Cystic Fibrosis Adherence Study November 1, 2019 June 2, 2020
NCT03748199 Completed Phase 1/Phase 2 Clinical Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of POL6014 in Patients With CF November 8, 2018 December 30, 2020
NCT00006280 Completed Phase 2 A Study of the Safety and Efficacy of Tobramycin for Inhalation in Young Children With Cystic Fibrosis February 2000 February 2002
NCT01686672 Completed N/A Web-based Delivery of Effective Treatment for Growth in Cystic Fibrosis October 2012 October 2014
NCT00506792 Completed Phase 2 Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QAU145 in Patients With Cystic Fibrosis July 2007 November 2009
NCT01572870 Completed Duplication in CHIT1 Gene and the Risk for Aspergillus Lung Disease in CF Patients December 2010 September 2011
NCT03782909 Completed N/A Evaluation of a Behavioural Intervention Using App Technology in CF May 8, 2019 March 1, 2020
NCT03647228 Completed Phase 1 A Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Doses of IONIS-ENaCRx in Healthy Volunteers and Patients With Cystic Fibrosis December 13, 2018 October 13, 2020
NCT00157183 Completed Phase 1/Phase 2 Non-invasive Ventilation and Oxygen Therapy in Cystic Fibrosis Patients With Nocturnal Oxygen Desaturation March 2003 March 2006
NCT00510484 Completed Phase 3 Study Investigating a Delayed-Release Pancrelipase in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis November 2007 March 2008
NCT06122025 Completed N/A Evaluation of Patient Access to People With Cystic Fibrosis (CF) and Healthcare Professionals December 11, 2017 October 7, 2019
NCT00758771 Completed Using Rheological Methods to Characterize Cystic Fibrosis (CF) Sputum and the Effects of Mucoactive Agents October 2007 December 2012
NCT02325362 Completed Phase 2/Phase 3 Effect of Miglustat on the Nasal Potential Difference in Patients With Cystic Fibrosis Homozygous for the F508del Mutation March 17, 2015 April 3, 2017
NCT03381157 Completed Fidgety Movements in Cystic Fibrosis October 2, 2017 February 2, 2019
NCT03601637 Completed Phase 3 Safety and Pharmacokinetic Study of Lumacaftor/Ivacaftor in Participants 1 to Less Than 2 Years of Age With Cystic Fibrosis, Homozygous for F508del September 7, 2018 October 29, 2021
NCT01956916 Completed Phase 3 Probiotics in Cystic Fibrosis October 2010 December 2014
NCT00130182 Completed Phase 2 A Study in Pediatric Patients With Cystic Fibrosis Lung Disease August 2005
NCT00918957 Completed Phase 3 A Study of Tobramycin Inhalation Powder From a Modified Manufacturing Process Versus Placebo June 2009 May 2011
NCT02707562 Completed Phase 2 Study of GLPG1837 in Subjects With Cystic Fibrosis (G551D Mutation) February 2016 November 2016
NCT00688051 Completed N/A Changes in Adherence After Playing "My Life With CF" Game May 2008 May 2009
NCT00095732 Completed Phase 2 Oral TheraCLEC™ - Total in Cystic Fibrosis Subjects With Exocrine Pancreatic Insufficiency June 2004 March 2005
NCT00449878 Completed Phase 3 Liprotamase Efficacy Trial in Patients With Cystic Fibrosis-Related Exocrine Pancreatic Insufficiency May 2007 June 2008
NCT01684410 Completed Phase 2 Safety and Tolerability Trial of Inhaled Alpha1-Proteinase Inhibitor (Human), Hydrophobic Chromatography Process (Alpha-1 HC) in Subjects With Cystic Fibrosis August 2012 October 2013
NCT00446680 Completed Phase 3 Long Term Administration of Inhaled Dry Powder Mannitol In Cystic Fibrosis - A Safety and Efficacy Study March 2007 May 2010
NCT00782288 Completed Phase 2 Phase II Study of Digitoxin to Treat Cystic Fibrosis August 2010 August 2016
NCT00265434 Completed Phase 3 Nasal Inhalation of Dornase Alfa (Pulmozyme) in Patients With Cystic Fibrosis and Chronic Rhinosinusitis December 2005 May 2006
NCT00817947 Completed Phase 3 Airway Clearance Using High Frequency Chest Wall Oscillation January 2007 September 2007
NCT01116414 Completed Molecular Phenotypes for Cystic Fibrosis Lung Disease July 2009 October 25, 2023
NCT00004806 Completed Phase 1 Phase I Study of Liposome-Mediated Gene Transfer in Patients With Cystic Fibrosis June 1995 November 2002
NCT00308243 Completed Phase 1 Inhaled Sodium Pyruvate for the Treatment of Cystic Fibrosis. March 2006 March 2007
NCT04857814 Completed N/A Integrating Electronic Patient Reported Biometric Measures (ePReBMs) From Wearable Devices in Respiratory Diseases July 1, 2021 March 1, 2023
NCT02767297 Completed Phase 1/Phase 2 Bioavailability and Pharmacokinetics Study of FDL169 in Healthy Subjects and Subjects With Cystic Fibrosis April 2016 October 2016
NCT01958944 Completed Phase 1/Phase 2 Evaluation of the Safety and Tolerability of Inhaled Nitric Oxide to Subjects With Cystic Fibrosis December 2013 November 2015
NCT03494894 Completed Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia June 1, 2017 February 19, 2019
NCT00753987 Completed Phase 1 Tolerability of Hypertonic Saline in Infants With Cystic Fibrosis March 2006 January 2007
NCT00686361 Completed N/A Choline Nutrition in Children With Cystic Fibrosis (CF) October 2007 August 2010
NCT03961516 Completed Glycemic Characterization and Pancreatic Imaging Correlates in Cystic Fibrosis May 1, 2019 August 30, 2021
NCT01658449 Completed N/A Comparison of the Tolerability of Two Formulations of Hypertonic Saline in Cystic Fibrosis Patients December 2009 September 2011
NCT01241890 Completed Prevention of CF Exacerbation in Childhood: PREVEC Study October 2011 July 2014
NCT00589745 Completed N/A Nasal Potential Difference (NPD) for the Diagnosis of Cystic Fibrosis September 2003 December 18, 2019
NCT03181932 Completed Phase 3 AeroVanc in the Treatment of Methicillin-resistant Staphylococcus Aureus Infection in Patients With Cystic Fibrosis September 20, 2017 January 15, 2021
NCT04018495 Completed N/A STeP IT UP CF: STimulating ImProved Health And Well-being In CysTic Fibrosis September 10, 2019 August 24, 2022
NCT01100892 Completed Phase 3 Cystic Fibrosis - Insulin Deficiency, Early Action December 2010 February 2023
NCT00792714 Completed Phase 1 Pharmacokinetics of Inhaled Mannitol in Cystic Fibrosis Patients December 2008 September 2009
NCT01424696 Completed Baby Observational and Nutritional Study December 2011 April 2015
NCT00411736 Completed Phase 4 Scandinavian Cystic Fibrosis Azithromycin Study May 2008 March 2014
NCT02295566 Completed Phase 2 RATNO, Reducing Antibiotic Tolerance Using Nitric Oxide in CF - a Phase 2 Pilot Study May 2011 July 2013
NCT00721071 Completed Phase 2 Utility of Induced Sputum Using Hypertonic Saline to Evaluate Infection and Inflammation in Cystic Fibrosis December 2006 May 2008
NCT01343524 Completed Changes in Lung Function Based on Differences in Spirometry Equipment Used in Children With Cystic Fibrosis March 2010 January 2012
NCT03632525 Completed Phase 4 Intravenous Iron in Adults With Cystic Fibrosis February 22, 2019 October 26, 2021
NCT02262871 Completed N/A HFN Versus NIV in Cystic Fibrosis. The HIFEN Study December 2014 July 30, 2017
NCT01347190 Completed Phase 1 Safety and Tolerability Study of Liquid Alpha1 Proteinase Inhibitor (API) in Subjects With Cystic Fibrosis April 2011 August 2011
NCT03593434 Completed Airway Clearance Therapy on Hyperpolarized 129Xenon and MRI July 30, 2018 December 30, 2021
NCT04400955 Completed A Study of Web and Tablet-based Interactive Audiometry in Adults With CF March 1, 2018 June 1, 2019
NCT02378454 Completed Multiple Breath Nitrogen Washout in Healthy and Cystic Fibrosis Children August 2014 April 2015
NCT01509235 Completed N/A Self Drainage in Pediatric Cystic Fibrosis Patients March 2006 March 2008
NCT00103714 Completed Phase 2 Study of Denufosol Tetrasodium in Patients With Cystic Fibrosis Lung Disease January 2005 August 2005
NCT03795363 Completed Orkambi Treatment in 2 to 5 Year Old Children With CF April 10, 2019 June 16, 2021
NCT02831348 Completed Association of Transcutaneous Pulse CO-oximetry With Inflammatory Lung Diseases October 2015 December 2021
NCT03652090 Completed Primary Nasal Cell Culture as a Tool for Personalized Therapy in Cystic Fibrosis September 1, 2010 March 3, 2016
NCT01576315 Completed Phase 2 ATCF (Azole Therapy in Cystic Fibrosis) June 2014 November 2015
NCT00455130 Completed Phase 2 A Phase 2 Study to Determine the Safety and Efficacy of Inhaled Dry Powder Mannitol in Cystic Fibrosis March 2004 August 2005
NCT02399241 Completed N/A Using Remote Telemonitoring to Detect Early Decline in Lung Function & Streamline Clinics in Adults With Cystic Fibrosis May 2015 March 1, 2017
NCT00908830 Completed Effects of Mycophenolate Mofetil in Cystic Fibrosis Lung Transplant Patients June 2009 May 2011
NCT00027183 Completed Role of Toxins in Lung Infections Caused by Pseudomonas Aeruginosa March 17, 1998 December 28, 2018
NCT01060566 Completed Phase 1 Study of VX-770 on Midazolam and Rosiglitazone and the Effect of Fluconazole on VX-770 February 2010 April 2010
NCT00157690 Completed Phase 4 Study of Alendronate to Prevent and Treat Osteoporosis in Cystic Fibrosis Patients December 2003 August 2006
NCT02884622 Completed N/A DNA Methylation and Lung Disease in Cystic Fibrosis June 2013 August 2016
NCT00669760 Completed Dissection of Staphylococcus Aureus Infection From Colonization in Cystic Fibrosis Patients July 2008 January 2015
NCT00909727 Completed Phase 3 Study of Ivacaftor in Cystic Fibrosis Subjects Aged 6 to 11 Years With the G551D Mutation August 2009 April 2011
NCT02014181 Completed Phase 1 Flaxseed Modulates Inflammation and Oxidative Stress in CF July 2012 January 2013
NCT03525548 Completed Phase 3 A Study of VX-445 Combination Therapy in CF Subjects Homozygous for F508del (F/F) August 3, 2018 December 28, 2018
NCT01594827 Completed Phase 2 Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP) October 2012 December 30, 2017
NCT00458341 Completed Phase 2 A Study of Ataluren in Pediatric Participants With Cystic Fibrosis March 23, 2007 February 29, 2008
NCT03424486 Completed Prevalence and Impact of Depression and Anxiety in Cystic Fibrosis November 23, 2017 July 11, 2019
NCT02141958 Completed Phase 1 Safety Study of Fenretinide in Adult Patients With Cystic Fibrosis April 2014 February 2015
NCT02468908 Completed Phase 1 Inhaled Molgramostim (rhGM-CSF) in Healthy Adult Subjects May 2015 October 2015
NCT01991028 Completed Phase 2 A Study to Investigate Lung Deposition of Radiolabelled OligoG April 2014 September 2014
NCT01180634 Completed Phase 3 MP-376 (Aeroquin™, Levofloxacin for Inhalation) in Patients With Cystic Fibrosis November 4, 2010 May 7, 2012
NCT01285882 Completed Representations of Transplantation in Patients and in Health Care Professionals June 2009 December 2012
NCT00274391 Completed Phase 2 Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis July 2001 April 2004
NCT02449785 Completed N/A Assessment of Cystic Fibrosis Lung Involvement With UTE Pulse Sequences September 30, 2015 September 6, 2017
NCT01731015 Completed Phase 1 Imaging Lung Function Using Oxygen Enhanced MRI January 2012 September 2012
NCT04892485 Completed Relationship of Skeletal Muscle Thickness, Strength, and Diaphragm Function in Adults With CF September 1, 2017 April 30, 2018
NCT04888767 Completed N/A Safety and Feasibility of High-intensity Interval Training Program in CF Patients September 1, 2021 September 13, 2023
NCT00890370 Completed Phase 4 Should Any One Airway Clearance Technique be Recommended for People With Cystic Fibrosis? July 1999 September 2003
NCT02721498 Completed N/A Improving Outcome Measures For Adult CF ACT Trials September 2016 December 2021
NCT04114227 Completed N/A Acceptance and Commitment Therapy vs. Supportive Psychotherapy With Cystic Fibrosis Patients July 1, 2019 October 31, 2023
NCT04620096 Completed MENstrual Symptom Tracking to Understand and Assess (Women) Living With Cystic Fibrosis June 1, 2021 April 22, 2022
NCT00670579 Completed Study About Complications of Totally Implanted Venous Access Devices (TIVADs) in People With Cystic Fibrosis (CF) May 2008 September 2010
NCT03591094 Completed Phase 2 Study Assessing PTI-428 Safety, Tolerability, Pharmacokinetics and Effect in Subjects With Cystic Fibrosis August 21, 2018 February 18, 2019
NCT03674216 Completed Study of Peripherally Inserted Venous Catheters in Cystic Fibrosis Patients November 12, 2018 June 30, 2021
NCT00792194 Completed N/A Improvement of Aerobic Capacity in Cystic Fibrosis Patients With a One-year Home Training Period December 2008 December 2014
NCT00016744 Completed Phase 1/Phase 2 Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis) September 2001 October 2005
NCT00221546 Completed Phase 2 Influence of DHA-rich Supplement on DHA-status and Health Evolution of Patients With Cystic Fibrosis September 2007 September 2008
NCT00951522 Completed Phase 1 A Trial to Assess the Safety, Tolerability, and Pharmacokinetics of GS-9411 in Healthy Male Volunteers September 2009 September 2009
NCT01531673 Completed Phase 2 Study of VX-661 Alone and in Combination With Ivacaftor in Subjects Homozygous or Heterozygous to the F508del-Cystic Fibrosis Transmembrane Conductance Regulator(CFTR) Mutation February 2012 March 2014
NCT02894619 Completed Urinary and Anorectal Functional Disorders and Their Impact on CF Adults (PerineoMucoRMO) January 2017 June 2018
NCT05111145 Completed Phase 3 A Study Evaluating the Safety of Elexacaftor/Tezacaftor/Ivacaftor in Participants With Cystic Fibrosis (CF) January 14, 2022 December 20, 2022
NCT05090904 Completed Phase 2 A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Brensocatib Tablets in Adults With Cystic Fibrosis November 30, 2021 November 1, 2022
NCT02934139 Completed Phase 1 MAD Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Cavosonstat (N91115) in Healthy Subjects (SNO-9) October 2016 January 2017
NCT00362739 Completed Blood Collection From Individuals With Lung Disease for Genetic Studies September 2005 August 2015
NCT01018303 Completed Phase 1/Phase 2 Safety and Efficacy of an Antioxidant-rich Multivitamin Supplement in Cystic Fibrosis August 2007 November 2009
NCT00528190 Completed Phase 4 Treatment of Aspergillus Fumigatus (a Fungal Infection) in Patients With Cystic Fibrosis October 2007 May 2011
NCT00237380 Completed Phase 2 Safety and Efficacy of Ataluren (PTC124) for Cystic Fibrosis November 30, 2005 May 31, 2006
NCT01788267 Completed N/A Bone Microarchitecture in Young Cystic Fibrosis Patients January 2013 May 2015
NCT01379040 Completed Volatile Organic Compounds in Cystic Fibrosis August 2009 December 2010
NCT01661491 Completed Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis August 2012 December 2020
NCT00311883 Completed Phase 1 Hydroxychloroquine in Cystic Fibrosis March 2006 December 2007
NCT01181622 Completed Phase 2 A Safety and Tolerability Study of Denufosol in 2-4 Year Olds August 2010 October 2010
NCT02056132 Completed Breath Condensate Study in Patients With Cystic Fibrosis. February 2014 August 22, 2023
NCT02564354 Completed Phase 1 Exploratory Study to Evaluate QR-010 in Subjects With Cystic Fibrosis ΔF508 CFTR Mutation September 2015 September 2016
NCT01832519 Completed Using MRI to Observe Lung Changes in Infants With CF Compared to Infants Without CF February 2013 January 9, 2017
NCT02953314 Completed Phase 3 A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of VX-661/Ivacaftor in Pediatric Subjects With Cystic Fibrosis (CF) November 2016 September 2018
NCT05069597 Completed Phase 4 Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon October 14, 2021 August 28, 2023
NCT01746784 Completed Phase 1 Safety and Pharmacokinetic Study of N6022 in Subjects With Cystic Fibrosis Homozygous for the F508del-CFTR Mutation February 2014 May 2014
NCT00004779 Completed Phase 1 Phase I Pilot Study of Ad5-CB-CFTR, an Adenovirus Vector Containing the Cystic Fibrosis Transmembrane Conductance Regulator Gene, in Patients With Cystic Fibrosis January 1993
NCT02029521 Completed N/A Supplementation of Oral Reduced Glutathione in Pediatric Cystic Fibrosis Patients March 2011 July 2012
NCT03800459 Completed N/A Effect of a Family Empowerment Program on Coping, Problem Solving in Parents, and Quality of Life in Children With Cystic Fibrosis December 14, 2016 June 2, 2017
NCT01179347 Completed Phase 3 Tiotropium Bromide in Cystic Fibrosis September 2010
NCT04589897 Completed N/A Manuka Honey Sinus Rinse Study January 7, 2019 October 31, 2021
NCT06299566 Completed Perceptions of the CF Screening Protocol Incorporating NGS January 19, 2022 February 28, 2023
NCT06350474 Completed N/A Impact of Discontinuing Dornase Alfa in People With CF on Highly Effective CFTR Modulator Therapy-A SIMPLIFY Sub-Study August 25, 2020 July 11, 2022
NCT00625612 Completed Phase 3 Study of Denufosol Tetrasodium Inhalation Solution in Patients With Cystic Fibrosis (CF) Lung Disease February 2008 October 2010
NCT00737100 Completed Phase 2 Safety and Efficacy of 12-wk Treatment With Two Doses of Tiotropium Respimat in Cystic Fibrosis September 2008
NCT02514473 Completed Phase 3 A Study to Evaluate the Efficacy and Safety of Lumacaftor in Combination With Ivacaftor in Subjects With CF, Homozygous for the F508del-CFTR Mutation July 2015 September 2016
NCT01953367 Completed Phase 1 Bioequivalence and Safety of Vantobra and TOBI in Healthy Subjects September 2013 November 2013
NCT03768089 Completed Phase 1/Phase 2 Study of VX-121 in Healthy Subjects and in Subjects With Cystic Fibrosis March 20, 2018 May 3, 2019
NCT03684759 Completed Sputum Validation for the Molecular Diagnosis of Respiratory Viral Infections in Cystic Fibrosis February 24, 2016 February 6, 2017
NCT00779077 Completed Cystic Fibrosis (CF) Flow Rates Study January 2009 February 2009
NCT03628456 Completed N/A Effect of HFCWO Vests on Spirometry Measurements September 13, 2018 July 2, 2019
NCT04468100 Completed Phase 3 Efficacy and Safety of Tigerase® vs. Pulmozyme® in Patients With Cystic Fibrosis August 30, 2017 May 16, 2018
NCT02866721 Completed Phase 1 Safety and Tolerability Study of Allogeneic Mesenchymal Stem Cell Infusion in Adults With Cystic Fibrosis August 2016 August 2020
NCT00609050 Completed N/A Exercise Training Study for Patients With Cystic Fibrosis March 2007 December 2010
NCT01078740 Completed Detection of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity in Rectal Tissues From Human Subjects October 2009 August 2010
NCT01355796 Completed Phase 1/Phase 2 Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis May 2011 February 2015
NCT02722057 Completed A Study to Confirm the Long-term Safety and Effectiveness of Kalydeco in Patients With Cystic Fibrosis Who Have an R117H-CFTR Mutation, Including Pediatric Patients December 2015 December 2019
NCT03754088 Completed In Vitro Model of the Cystic Fibrosis Bronchial Epithelium Via iPS Technology November 5, 2018 April 25, 2019
NCT02508207 Completed Phase 2 A Phase 2 Study to Evaluate Effects of VX-661/Ivacaftor on Lung and Extrapulmonary Systems in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation February 2016 June 2017
NCT05599958 Completed Clinical and Genetic Profile of Pediatric Patients With Cystic Fibrosis in Sohag. October 10, 2022 October 2, 2023
NCT01946412 Completed Phase 3 Roll-Over Study of Ivacaftor in Cystic Fibrosis Pediatric Subjects With a CF Transmembrane Conductance Regulator Gene (CFTR) Gating Mutation December 2013 December 2015
NCT04966897 Completed N/A Assessment of a PERT-free Nutritional Therapeutic Delivery System for Cystic Fibrosis August 31, 2018 September 30, 2019
NCT02276898 Completed Phase 2 A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance Index November 2011 September 2014
NCT02039986 Completed Ivacaftor (Kalydeco) and Insulin in Cystic Fibrosis (CF) January 6, 2014 October 11, 2016
NCT03797677 Completed N/A MN4000 for Treatment of CF and MND Patients in the Home Setting March 9, 2017 November 30, 2017
NCT02480270 Completed Outpatient Antibiotic Treatment for a Cystic Fibrosis Pulmonary Exacerbation August 2014 January 4, 2017
NCT01626157 Completed A Novel Assay to Quantify Treatment Response in Cystic Fibrosis (CF) May 2011 January 2018
NCT00333957 Completed Capsule Endoscopy in Cystic Fibrosis July 2006 August 2008
NCT01815866 Completed Cough-Generated Aerosols of NTM in Cystic Fibrosis April 2013 July 2015
NCT03052556 Completed N/A Human Papillomavirus and Cervical Dysplasia in Women With Cystic Fibrosis March 8, 2017 September 18, 2019
NCT01641822 Completed Phase 3 Phase 3 Study of Aztreonam for Inhalation Solution (AZLI) in a Continuous Alternating Therapy Regimen for the Treatment of Chronic Pseudomonas Aeruginosa Infection in Patients With CF December 2012 January 2015
NCT03277196 Completed Phase 3 A Study to Evaluate the Safety of Long-term Ivacaftor Treatment in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age at Treatment Initiation and Have an Approved Ivacaftor-Responsive Mutation August 16, 2017 October 2, 2023
NCT04537793 Completed Phase 3 Evaluation of ELX/TEZ/IVA in Cystic Fibrosis (CF) Subjects 2 Through 5 Years November 19, 2020 June 3, 2022
NCT01916577 Completed Phase 1 Autologous CD117+ Progenitor Cell Mobilization for Lung Transplantation August 2013 December 2017
NCT01858519 Completed Prevalence of Antibodies to Selected Porcine Viruses in Patients With Cystic Fibrosis Receiving Porcine-derived Pancreatic Enzyme Replacement Therapy August 2013 September 2016
NCT03921229 Completed N/A Tele-Coaching Intervention to Improve Treatment Adherence in Cystic Fibrosis January 13, 2020 February 1, 2023
NCT03068312 Completed Phase 3 A Study to Evaluate Efficacy of Ivacaftor in Subjects With Cystic Fibrosis Who Have a 3849 + 10KB C→T or D1152H CFTR Mutation July 18, 2017 December 18, 2018
NCT00391976 Completed Phase 3 Efficacy and Safety of 28 or 56 Day Treatment for Pseudomonas Aeruginosa in Children With Cystic Fibrosis November 2003 January 2008
NCT03560726 Completed N/A Telehealth Cognitive Behavioral Stress Management for Adults With Cystic Fibrosis June 4, 2018 June 1, 2020
NCT00924547 Completed Phase 2 Oral Docosahexanoic Acid Supplementation in Cystic Fibrosis November 2013 July 2015
NCT01883037 Completed Comparing Laboratory Blood Glucose Results With HemoCue Glucose 201 RT June 2013 May 2014
NCT03474042 Completed Phase 2 GLPG2737 on Top of Orkambi in Subjects With Cystic Fibrosis November 29, 2017 April 10, 2018
NCT00577252 Completed Coping Compliance and Adjustment in Adolescents With Cystic Fibrosis October 2007 April 2008
NCT00004705 Completed N/A Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis September 1996 January 1999
NCT02994017 Completed N/A Prognostic Value of Functional Exercise Test (EFX) in Cystic Fibrosis March 5, 2012 June 16, 2019
NCT02188758 Completed Biomarkers of Iron Homeostasis and Responses to Cystic Fibrosis Pulmonary Exacerbation (CFPE) Treatment July 2014 January 2018
NCT03820349 Completed Cystic Fibrosis and Cognitive Function May 7, 2018 December 10, 2019
NCT00449904 Completed Phase 3 Open-Label Phase III Long-Term Safety Trial of Liprotamase June 2007 April 2009
NCT00999531 Completed Phase 1 A Randomized, Double-Blind, Placebo-Controlled Multiple Dose Trial of GS-9411 in Healthy Volunteers October 2009 March 2010
NCT01429259 Completed Phase 4 Population Pharmacokinetics of Prolonged Infusion Meropenem in Cystic Fibrosis (CF) Children February 2012 January 2014
NCT01031706 Completed N/A Effect of Hypertonic Saline on Mucus Clearance in Children Ages 5-12 With Cystic Fibrosis September 2009 July 2012
NCT01759342 Completed N/A Comprehensive Exercise Training Program During Hospitalization for an Acute CF Exacerbation April 2008 October 2008
NCT00628134 Completed N/A Self-dispersing Liquids as Aerosol Drug Carriers March 2008 August 2009
NCT03913507 Completed N/A Efficacy of a New Sweat Collection Support: Impact on Neonatal Screening and Early Treatment of Cystic Fibrosis July 14, 2018 March 22, 2021
NCT03323983 Completed Exploratory Study on Link Between Dynamic Hyperinflation and Lung Clearance Index in Cystic Fibrosis May 1, 2016 November 30, 2016
NCT00909532 Completed Phase 3 Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older With the G551D Mutation June 2009 November 2012
NCT03424252 Completed Phase 1 An Phase 1 Study to Evaluate the Pharmacokinetic (PK) Profile of FDL169 New Formulations in Healthy Subjects December 18, 2017 January 15, 2018
NCT06238856 Completed Phase 1 Single Dose Escalation Study of TR02 (Sustained Lipid Inhalation Technology [SLIT™] Amikacin) in Participants With Cystic Fibrosis (CF) Having Chronic Infections of Pseudomonas Aeruginosa May 12, 2004 February 8, 2005
NCT00928135 Completed Phase 1/Phase 2 Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects January 22, 2013 April 9, 2018
NCT00716664 Completed N/A Do Musculoskeletal Techniques Improve Forced Expiratory Volume in One Second in Adults With Cystic Fibrosis? March 2007 August 2008
NCT00458614 Completed Phase 1 Pharmacokinetic Study of Lansoprazole in Cystic Fibrosis June 2006 April 2007
NCT01537614 Completed Phase 1 Pharmacokinetic Study of Aerosolized Colimycin in Cystic Fibrosis October 2011
NCT03853629 Completed Air Pollution and Children With Cystic Fibrosis February 15, 2017 January 30, 2020
NCT01293084 Completed Phase 2 Hypertonic Saline and Mucociliary Clearance in Children July 2007 June 2009
NCT02730208 Completed Phase 2 A Study to Evaluate the Effect of VX-661 in Combination With Ivacaftor on Chest Imaging Endpoints in Subjects With Cystic Fibrosis, Homozygous for the F508del CFTR Mutation September 2016 July 2018
NCT04545515 Completed Phase 3 A Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis (CF) Particpants 6 Years and Older and F/MF Genotypes January 11, 2021 March 24, 2023
NCT01614470 Completed Phase 3 Study of Ivacaftor in Subjects With Cystic Fibrosis (CF) Who Have a Non-G551D CF Transmembrane Conductance Regulator (CFTR) Gating Mutation July 2012 October 2013
NCT01844778 Completed Phase 4 Ease of Use and Microbial Contamination of Tobramycin Inhalation Powder (TIP) Versus Nebulised Tobramycin Inhalation Solution (TIS) and Nebulised Colistimethate (COLI) August 2013 October 2015
NCT02544451 Completed Phase 3 Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment With Lumacaftor in Combination With Ivacaftor August 2015 April 2020
NCT04043806 Completed Phase 3 A Study Evaluating the Long-term Safety of VX-445 Combination Therapy August 9, 2019 December 14, 2022
NCT04608019 Completed N/A Streamlined Treatment of Pulmonary Exacerbations in Pediatrics November 10, 2020 August 18, 2022
NCT02179710 Completed Cystic Fibrosis Treatment Adherence Cayston Proof-of-Concept Pilot Study March 2015 September 2016
NCT03736096 Completed Molecular Diagnosis of Respiratory Viral Infections on Sputum From Cystic Fibrosis Patients October 3, 2018 June 24, 2021
NCT01783613 Completed N/A Eficacy of Long-term Suplementation With Docosahexaenoic Acid in Patients With Cystic Fibrosis October 2011 January 2015
NCT02178540 Completed Phase 4 Study to Validate the Instructions for Use of TOBI® Podhaler™ in Cystic Fibrosis Patients August 2014 February 2015
NCT00572975 Completed Phase 4 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea August 2006 March 2008
NCT01479166 Completed Bronchial Inflammation of Small Airways in Patients With Cystic Fibrosis June 2011 May 2012
NCT00570349 Completed Phase 1/Phase 2 Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis July 2004 December 2008
NCT01025258 Completed N/A Improving Adherence and Clinical Outcome in Cystic Fibrosis (CF) Patients December 2009 June 2011
NCT02157922 Completed Phase 2 A Phase IIb Study of OligoG in Subjects With Cystic Fibrosis October 2014 September 2017
NCT00219895 Completed N/A Assessment of Inflammatory Mediators (AIM) August 2004 March 2006
NCT00743483 Completed Phase 2 Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency August 2008 June 2009
NCT03911713 Completed Phase 2 A Phase 2 Study to Evaluate Efficacy and Safety of VX-561 in Subjects Aged 18 Years and Older With Cystic Fibrosis April 17, 2019 August 20, 2020
NCT04596319 Completed Phase 1/Phase 2 Ph 1/2 Study Evaluating Safety and Tolerability of Inhaled AP-PA02 in Subjects With Chronic Pseudomonas Aeruginosa Lung Infections and Cystic Fibrosis December 22, 2020 December 14, 2022
NCT01707290 Completed Phase 3 Rollover Study of Ivacaftor in Subjects With Cystic Fibrosis and a Non G551D CFTR Mutation February 2013 April 2016
NCT00850551 Completed N/A Early Intervention in Pulmonary Exacerbation in Cystic Fibrosis January 2009 December 2011
NCT02083263 Completed N/A Non Invasive Ventilation as Airway Clearance in Patients With Cystic Fibrosis October 2012 September 2013
NCT03801993 Completed Multicenter Study of Patient-reported Gastrointestinal Symptoms in People With Cystic Fibrosis May 1, 2019 September 17, 2019
NCT04599465 Completed Phase 3 A Study to Assess the Effect of ELX/TEZ/IVA on Glucose Tolerance in Participants With Cystic Fibrosis (CF) January 15, 2021 July 14, 2022
NCT00476281 Completed N/A Nutritional, Metabolic and Respiratory Status in Cystic Fibrosis April 2008 January 2020
NCT00004287 Completed Phase 1 Phase I Study of the Third Generation Adenovirus H5.001CBCFTR in Patients With Cystic Fibrosis November 1995
NCT01035853 Completed Phase 2 Sino-nasal Inhalation of Colistin in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Colonization December 2009 April 2012
NCT02951195 Completed Phase 2 A Study Evaluating the Safety of VX-152 Combination Therapy in Adults With Cystic Fibrosis November 2016 January 2018
NCT00104494 Completed N/A Zinc Homeostasis and Kinetics in Children With Cystic Fibrosis (CF) May 2004 September 2007
NCT02305784 Completed Kinetics of YKL-40 Protein in Serum of Cystic Fibrosis Patients May 2015 June 20, 2018
NCT03734822 Completed N/A Comparative Analysis of CO2 Monitoring Methods in Patients With CF Undergoing General Anesthesia March 10, 2016 December 20, 2017
NCT02368080 Completed Multiple Breath Nitrogen Washout in Healthy and Cystic Fibrosis Adults April 2013 January 2014
NCT00004829 Completed Phase 3 Phase III Randomized Study of the Inhalation of Tobramycin in Patients With Cystic Fibrosis June 1995 May 1998
NCT02646995 Completed N/A Lipid Formulation to Increase the Bioavailability of Fatty Acids in Cystic Fibrosis (CF) Patients January 2016 May 4, 2017
NCT00633191 Completed Phase 1/Phase 2 Anti-pseudomonas IgY to Prevent Infections in Cystic Fibrosis November 2003 December 2012
NCT00659529 Completed Phase 1/Phase 2 Safety and Efficacy of Sildenafil in Cystic Fibrosis (CF) Lung Disease August 2008 December 2012
NCT03045523 Completed Phase 2 A Study to Evaluate GLPG2222 in Ivacaftor-treated Subjects With Cystic Fibrosis January 2017 August 11, 2017
NCT05292690 Completed An Assistive Powered Wheelchair: Stage 2 Trial March 29, 2021 August 31, 2021
NCT03052231 Completed N/A Interactive Mobile Health Information to Enhance Patient Care at a Cystic Fibrosis Center March 2016 February 2017
NCT00388466 Completed N/A Whole Body Vibration - a New Therapeutic Approach to Improve Muscle Function in CF June 2005 August 2006
NCT01599052 Completed Social Cognition in Children Treated for a Brain Tumour March 2011 March 2017
NCT01708655 Completed N/A Sweat Evaporimeter Measurement December 2011 December 2014
NCT01569880 Completed Pre-flight Evaluation of Adult Patients With Cystic Fibrosis January 2006 December 2008
NCT02832479 Completed Costs of Care and Adherence to Treatment for Cystic Fibrosis October 2014 February 2016
NCT02043717 Completed Increased Vitamin D Reduces Pulmonary Exacerbations in CF January 2014 June 2015
NCT00515229 Completed Phase 2 Anti-Inflammatory Pulmonal Therapy of CF-Patients With Amitriptyline and Placebo October 2006 July 2007
NCT03710538 Completed N/A The Effect of a Pre-meal Snack and/or Exercise on Post-prandial Glycemic Excursions in Adults With Cystic Fibrosis April 1, 2019 December 31, 2022
NCT03525574 Completed Phase 3 A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy October 9, 2018 January 9, 2023
NCT02141464 Completed Energy Balance and Weight Gain With Ivacaftor Treatment March 2014 November 2016
NCT04302662 Completed Phase 2 Phase 2 Combination Study With Escalating Doses of MS1819-SD on Top of a Stable Dose of PPEs June 27, 2019 June 3, 2021
NCT00241969 Completed N/A Behavioral & Nutritional Treatment to Help CF Preschoolers Grow January 2006 June 2015
NCT01285895 Completed Needs in Education for Pulmonary or Cardiopulmonary Transplanted Cystic Fibrosis Patients September 2009 October 2013
NCT01111383 Completed Phase 3 A Single Arm 48-Week Follow-on Safety Study to a Core Study Comparing the Efficacy and Tolerability of Tobrineb®/Actitob®/Bramitob® Versus TOBI® September 2009 May 2011
NCT00221572 Completed Can Quantitative Ultrasound be Used for the Evaluation of Bone Health in Adolescents and Adults With Cystic Fibrosis June 2006 June 16, 2011
NCT01094704 Completed Phase 1 Durability of Hypertonic Saline for Enhancing Mucociliary Clearance in Cystic Fibrosis November 2009 May 2010
NCT03391414 Completed Phase 1 Effects of Inhaled Bicarbonate on Airway pH in Cystic Fibrosis August 2014 July 2016
NCT05026918 Completed N/A Manual Chest Physiotherapy and Active Cycle of Breathing Techniques (ACBT) in Patients of Cystic Fibrosis October 13, 2020 July 20, 2021
NCT01150136 Completed Choline Nutritional Status Of Children With Cystic Fibrosis X-Sectional Study October 2007 March 2009
NCT03357913 Completed Non-respiratory Comorbidities Observed in Pulmonary French Transplant Patients With Cystic Fibrosis June 1, 2017 October 30, 2017
NCT02212431 Completed Phase 1/Phase 2 First Study of Oral Cysteamine in Cystic Fibrosis August 2014 April 2015
NCT01897233 Completed Phase 3 Study of Lumacaftor in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation July 2013 October 2015
NCT01216046 Completed Phase 1 Drug-Drug Interaction Study of VX-770 and VX-809 in Healthy Subjects October 2010 May 2011
NCT01055847 Completed Phase 2 Aztreonam for Inhalation (AI) in Patients With Cystic Fibrosis & P. Aeruginosa Infection June 2003 September 2004
NCT01944735 Completed Phase 1 Phase 1 Study Assessing the Safety and Tolerability of CTX-4430 in Cystic Fibrosis Patients September 2013 November 2014
NCT01799642 Completed Evaluating Sensations of Breathlessness in Patients With Cystic Fibrosis June 2013 December 2014
NCT01140451 Completed Phase 3 Extension Study of Ataluren (PTC124) in Cystic Fibrosis August 12, 2010 December 2, 2013
NCT04696198 Completed N/A Thoracic Mobility in Cystic Fibrosis Care September 9, 2019 October 31, 2023
NCT01806025 Completed Correlation Between Haptoglobin Phenotypes and Infectious and Other Complications in Cystic Fibrosis Patients April 2013 January 2015
NCT02269189 Completed Phase 1 Safety, Tolerability and Pharmacokinetics of BIIL 284 BS in Adult and Pediatric Cystic Fibrosis (CF) Patients April 2002
NCT02750501 Completed N/A Absorption and Safety With Sustained Use of RELiZORB Evaluation (ASSURE) Study July 20, 2016 March 30, 2017
NCT01057524 Completed Phase 3 High Frequency Chest Wall Oscillation and Cystic Fibrosis February 2010 December 2012
NCT00004428 Completed Phase 1 Phase I Randomized Study of CPX for the Treatment of Adult Patients With Mild Cystic Fibrosis September 1997 October 1999
NCT00625703 Completed Phase 2 Pharmacokinetics of Linezolid in Children With Cystic Fibrosis December 2010 May 2011
NCT04961008 Completed N/A Bottle PEP in Cystic Fibrosis April 1, 2019 October 31, 2020
NCT01207245 Completed Phase 4 Circadian Rhythm In Tobramycin Elimination In Cystic Fibrosis May 2011 June 2012
NCT02734810 Completed Phase 3 SIMPLICITY: Studying Impacts on Malabsorption With Liprotamase in Cystic Fibrosis June 2016 March 2017
NCT01232478 Completed Phase 3 I Change Adherence & Raise Expectations October 2009 March 2015
NCT00531882 Completed N/A Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers September 2007 February 2009
NCT02277626 Completed Phase 4 Electro Flo 5000 and Vest Therapy April 2012 April 2013
NCT00486837 Completed Phase 2 Deposition of Inhaled Prolastin in Cystic Fibrosis Patients December 2003 June 2004
NCT04170114 Completed N/A Comparison of the Efficacy of Comprehensive Respiratory Physiotherapy in Children With Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis January 1, 2020 November 1, 2020
NCT00534079 Completed Phase 3 Nasal Inhalation of Pulmozyme in Patients With Cystic Fibrosis and Chronic Rhinosinusitis September 2007 February 2009
NCT03256799 Completed Phase 4 Evaluation of Ivacaftor in Patients Using Ataluren for Nonsense Mutations March 17, 2017 February 16, 2018
NCT01837589 Completed N/A Quantitative Computed Tomodensitometry in Patients With Cystic Fibrosis January 2012 September 2016
NCT00788138 Completed N/A Effects of Vitamin D Supplementation on Lung Function in an Acute Pulmonary Exacerbation of Cystic Fibrosis October 2008 September 2010
NCT00742092 Completed Phase 2 Miglustat in Cystic Fibrosis August 2008 December 2008
NCT02303808 Completed N/A Positive Expiratory Pressure During Inhalation of Hypertonic Saline in Patients With Cystic Fibrosis December 2014 November 2015
NCT00503490 Completed Phase 1 Safety, Pharmacokinetic and Pharmacodynamic Study of MP-376 in Patients With Cystic Fibrosis June 2007 December 2007
NCT01144507 Completed Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis January 12, 2010 June 14, 2023
NCT02564393 Completed Induction of Neutrophilic Traps ( NETs ) by the Environment and Infectious Inflammatory Lung Cystic Fibrosis May 2011
NCT02994706 Completed N/A A Study of Home Monitoring in Adults With Cystic Fibrosis (HOMECF) January 2006 September 2018
NCT01818206 Completed N/A Bacteriophage Effects on Pseudomonas Aeruginosa February 2012 April 2012
NCT04519853 Completed N/A A Pilot Study of a Low Glycemic Load Diet in Adults With Cystic Fibrosis October 25, 2021 July 1, 2023
NCT01863238 Completed An Ocular Safety Study of Ivacaftor-Treated Pediatric Patients 11 Years of Age or Younger With Cystic Fibrosis May 2013 May 2016
NCT00959010 Completed Phase 3 Omega 3 Supplementation in Cystic Fibrosis Patients October 2008
NCT02412111 Completed Phase 3 A Phase 3 Study of Tezacaftor (VX-661) in Combination With Ivacaftor (VX-770) in Subjects Aged 12 Years and Older With Cystic Fibrosis (CF), Who Have One F508del-CFTR Mutation and a Second Mutation That Has Been Demonstrated to be Clinically Responsive to Ivacaftor June 2015 September 2017
NCT01117012 Completed Phase 3 Rollover Study of VX-770 in Cystic Fibrosis Subjects July 2010 May 2014
NCT01222273 Completed N/A Open-label Vitamin D Trial for Patients With Cystic Fibrosis and Allergic Bronchopulmonary Aspergillosis September 2010 September 2013
NCT04016571 Completed Parameters to Assess Response to Intra-Venous Antibiotic Treatment for Pulmonary Exacerbations in Cystic Fibrosis December 1, 2016 March 1, 2019
NCT01615484 Completed N/A Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability September 2013 January 2017
NCT02172534 Completed Phase 1 Safety, Tolerability and Pharmacokinetics of Tiotropium in Cystic Fibrosis Patients September 2006
NCT04038710 Completed Clinical Outcomes of Triple Combination Therapy in Severe Cystic Fibrosis Disease. September 5, 2019 February 26, 2021
NCT03069625 Completed N/A Sit-to-stand Test in Cystic Fibrosis Children and Adolescents August 31, 2017 July 24, 2019
NCT01755455 Completed N/A Does a Daily Iron Tablet Improve Anemia in Cystic Fibrosis June 2011 November 2012
NCT02109822 Completed Pilot Observational Study to Determine Feasibility of a Standardized Treatment of Pulmonary Exacerb. in Patients With CF January 2014 June 2015
NCT00531531 Completed Evaluation of the Emission Distance of P. Aeruginosa From the Respiratory Tract of People With Cystic Fibrosis September 2007 August 2008
NCT02803944 Completed Continuous Azithromycin in Cystic Fibrosis Patients Beyond Two Years September 2014 September 2015
NCT00485082 Completed Disclosing a Cystic Fibrosis Diagnosis to a Dating Partner June 5, 2007
NCT00676169 Completed The EPIC Observational Study October 2004 December 2018
NCT00789867 Completed Phase 1/Phase 2 Single Dose of pGM169/GL67A in CF Patients November 2008 December 2010
NCT01375036 Completed Registry to Monitor the Susceptibility to Aztreonam of Pseudomonas Aeruginosa Isolates From Cystic Fibrosis Patients August 2011 December 2016
NCT00981214 Completed Phase 3 Study of Pancreatic Enzyme Product in Pediatric Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency May 2006 September 2006
NCT03020719 Completed Phase 2 The Role of Oral Glutathione on Growth Parameters in Children With Cystic Fibrosis June 14, 2017 December 12, 2018
NCT00786513 Completed Phase 2 Use of a Biofilm Antimicrobial Susceptibility Assay to Guide Antibiotic Therapy November 2008 March 2014
NCT05225805 Completed Phase 1 Study to Assess the Safety and PK of Oral and IV Xenleta in Adults With Cystic Fibrosis March 1, 2022 January 13, 2023
NCT00266474 Completed Prevalence of Chronic Rhinosinusitis in Cystic Fibrosis December 2005 September 2007
NCT01543191 Completed Phase 1 A Safety and Tolerability Study OF PUR118 In Subjects With Cystic Fibrosis February 2012 December 2012
NCT06112717 Completed N/A The Application of the Self Care Deficit Nursing Theory in Adolescents With Cystic Fibrosis February 14, 2019 September 30, 2019
NCT00416182 Completed Phase 2 Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis December 2006 June 2012
NCT03783286 Completed Ivacaftor Treatment in 4 Month to 2 Year Old CF Subjects February 6, 2019 December 30, 2021
NCT01306279 Completed The Infective Pulmonary Exacerbations in Cystic Fibrosis - an Ecological Perspective February 2011
NCT01072721 Completed N/A Non Invasive Study of the Hepatic Fibrosis in Paediatrics by the Method of Study of Pediatric Hepatic Fibrosis January 19, 2010 April 30, 2018
NCT00004533 Completed Phase 1 Phase I Randomized Study of Adeno-Associated Virus-CFTR Vector in Patients With Cystic Fibrosis August 1999 August 2002
NCT02464267 Completed Developing and Validating a Patient-reported Outcome Instrument to Monitor Symptom Management in Pulmonary Exacerbation in CF April 2015 September 2017
NCT02668575 Completed N/A Integrating Supportive Care in Cystic Fibrosis March 2, 2016 October 7, 2019
NCT02134353 Completed Phase 3 A Safety and Efficacy Trial of Inhaled Mannitol in Adult Cystic Fibrosis Subjects September 2014 February 2017
NCT01348204 Completed Phase 2 Nasal Potential Studies Utilizing Cystic Fibrosis Transmembrane Regulator (CFTR) Modulators March 2010 November 2011
NCT01375049 Completed Phase 2 Aztreonam Lysine for Pseudomonas Infection Eradication Study August 2011 May 2013
NCT01860872 Completed Comparing Chest Images From MRI to CT in Patients With Cystic Fibrosis (CF) April 2013 April 2019
NCT01018368 Completed Phase 1 Study of VX-770 and Rifampin in Healthy Male Subjects November 2009 March 2010
NCT02342951 Completed N/A Evaluation of the Lung Clearance Index April 2014 July 2019
NCT01131507 Completed Phase 4 PR-018: An Open-Label, Safety Extension of Study PR-011 July 2010 December 2011
NCT02279498 Completed Phase 3 SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic Fibrosis June 2015 January 20, 2017
NCT00596232 Completed Investigating Mucinase Activity in Airway Disease April 2003 April 2016
NCT00804661 Completed Sleep in Patients With Cystic Fibrosis July 2007 June 2009
NCT04353817 Completed Phase 3 A Study Evaluating Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis and F/MF Genotypes June 19, 2020 May 17, 2021
NCT04279769 Completed Phase 1 Study to Evaluate the Safety of CB-280 in Patients With Cystic Fibrosis July 3, 2020 November 23, 2021
NCT00217204 Completed Phase 2 An Effectiveness, Safety, and Palatability Study of Pancrelipase Microtablets in Infants and Toddlers With Cystic Fibrosis and Fat Malabsorption July 2005 February 2006
NCT05584982 Completed N/A Clinical Performance of the AtbFinder® Test System for Selection of Antibiotic Therapy in Persons With Cystic Fibrosis January 2016 October 12, 2022
NCT01710449 Completed Phase 1 Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen September 2009 October 2012
NCT02084043 Completed N/A In Vitro Assessment of a Breath-synchronized Vibrating Mesh Nebulizer During Non Invasive Ventilation March 2014 June 2015
NCT00097773 Completed Phase 2 Comparison of Two Treatment Regimens to Reduce PA Infection in Children With Cystic Fibrosis September 2004 August 2009
NCT00408317 Completed Phase 3 Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI) November 2006 April 2007
NCT03537651 Completed Phase 3 A Study to Evaluate the Safety and Efficacy of Long-term Treatment With TEZ/IVA in CF Participants With an F508del CFTR Mutation April 25, 2018 September 29, 2023
NCT01983774 Completed Phase 2 Effect of Proton Pump Inhibitors on CF Pulmonary Exacerbations February 2008 August 2011
NCT02453789 Completed Phase 2 A Study of OligoG in Cystic Fibrosis Subjects With Burkholderia Spp. Infection February 2015 December 2017
NCT03518697 Completed N/A Effects of an Individualized Exercise Program on Health-related and Skill/Performance-related fitness in CF. September 10, 2014 August 10, 2018
NCT02261987 Completed N/A Resistive Inspiratory Manoeuvre as Airway Clearance Technique in Cystic Fibrosis November 2014 June 2016
NCT00557089 Completed Phase 4 The Effect of rhDNase on Ventilation Inhomogeneity in Patients With Cystic Fibrosis January 2008 June 2009
NCT02416375 Completed Home Monitoring to Predict Exacerbation in Cystic Fibrosis May 2015 January 2019
NCT01705145 Completed Phase 3 Study of Ivacaftor in Cystic Fibrosis Subjects 2 Through 5 Years of Age With a CFTR Gating Mutation January 2013 March 2014
NCT01685801 Completed Phase 2 Pilot Study Testing the Effect of Ivacaftor on Lung Function in Subjects With Cystic Fibrosis and Residual CFTR Function September 2012 April 2014
NCT01931644 Completed At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions July 2013 April 2024
NCT04460586 Completed Phase 4 Pharmacokinetics of Omadacycline in Cystic Fibrosis July 1, 2021 December 31, 2023
NCT02532764 Completed Phase 1/Phase 2 Dose Escalation Study of QR-010 in Homozygous ΔF508 Cystic Fibrosis Patients June 2015 September 14, 2017
NCT04010799 Completed Phase 1 A Clinical Study to Investigate Safety, Tolerability and Distribution of CHF 6333 After One or After Repeated Inhalation in Patients With Cystic Fibrosis (CF) and in Patients With Non Cystic Fibrosis (NCFB) Bronchiectasis May 27, 2019 March 8, 2021
NCT04884308 Completed Phase 2 Bacille Calmette-Guerin (BCG) Vaccine for Immune Protection Against Infections April 28, 2021 December 30, 2023
NCT02139306 Completed Phase 3 Study of Ataluren in Nonsense Mutation Cystic Fibrosis (ACT CF) August 2014 November 2016
NCT03078088 Completed Phase 1 Airway Alkalinization and Nasal Colonization June 15, 2017 February 27, 2019
NCT04623879 Completed Real Life Evaluation of the Multi-organ Effects of Lumacaftor/Ivacaftor on F508del Homozygous Cystic Fibrosis Patients. December 29, 2016 February 26, 2020
NCT02423447 Completed N/A Comparison of the Airway Clearance Efficacy of Electro Flo 5000 and the G5 Flimm-Fighter in Patients With CF November 2013 June 2014
NCT05535959 Completed Phase 1 A Study to Evaluate the Relative Bioavailability of a Fixed-dose Combination Tablet of VX-121/Tezacaftor/Deutivacaftor September 15, 2022 November 9, 2022
NCT00750932 Completed Biodistribution of Neutrophile Proteases in the Sputum of Patients Affected by Cystic Fibrosis January 2008 January 2012
NCT03029455 Completed Phase 1 A Study to Evaluate Safety and Pharmacokinetics of VX-659 in Healthy Subjects and in Adults With Cystic Fibrosis November 2016 August 2017
NCT03850145 Completed Educational Program Through Video Conference for Inhaled Therapies in Cystic Fibrosis Patients February 1, 2019 December 30, 2019
NCT00104520 Completed Phase 3 Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis Patients With P. Aeruginosa February 2005 September 2006
NCT00719381 Completed Phase 1 Effect of Pioglitazone on Inflammation in Cystic Fibrosis January 2008 June 2009
NCT02070744 Completed Phase 2 Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion March 2014 May 27, 2016
NCT04879381 Completed Epidemiology of Anaerobic Bacteria in Cystic Fibrosis Patients: Descriptive and Non-interventional Study March 29, 2018 October 5, 2018
NCT00954018 Completed Microbial Community Composition and Metabolism in Cystic Fibrosis August 2009 November 10, 2017
NCT02718495 Completed Phase 1/Phase 2 Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis July 19, 2016 November 28, 2017
NCT03551691 Completed Phase 2 Proton Pump Inhibitors (PPI) and Fat Absorption in Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI) August 7, 2018 November 2, 2022
NCT03969888 Completed Phase 2 A Phase 2 Study of ABBV-3067 Alone and in Combination With ABBV-2222 December 11, 2019 June 9, 2022
NCT03475381 Completed Real-life Follow-up of Cystic Fibrosis Patients Treated With Ivacaftor+Lumacaftor (Orkambi*) January 22, 2016 December 31, 2018
NCT02227888 Completed Phase 1 PK Study of N91115 in Cystic Fibrosis Patients October 2014 January 2015
NCT02392234 Completed Phase 3 A Phase 3 Study to Evaluate the Efficacy and Safety of Ivacaftor and VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Heterozygous for the F508del-cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutation March 2015 February 2017
NCT02797912 Completed LBM & Lung Function in Adolescents With CF June 2016 August 1, 2017
NCT00016445 Completed Phase 2 Phase II Study of Growth Hormone in Children With Cystic Fibrosis February 2001
NCT04561973 Completed Pain in Patients With Cystic Fibrosis in Rouen University Hospital November 4, 2019 November 1, 2020
NCT04320381 Completed Qualitative Understanding of Experiences With the SIMPLIFY Trial December 23, 2020 September 16, 2022
NCT02445053 Completed Observational Study of Outcomes in Cystic Fibrosis Patients With Selected Gating Mutations on a CFTR Allele (The VOCAL Study) April 2015 October 2020
NCT02378467 Completed N/A Saline Hypertonic in Preschoolers March 1, 2015 August 31, 2018
NCT00351078 Completed Phase 2 PTC124 for the Treatment of Cystic Fibrosis December 2006 July 2007
NCT01848392 Completed Extrapulmonary Effects of Cystic Fibrosis on Physical Activity of Adult Patients. February 21, 2013 March 30, 2016
NCT01879228 Completed N/A Effect of Chronic Incretin-based Therapy in Cystic Fibrosis June 2013 March 2020
NCT04335370 Completed Pharmacokinetics of Polymyxin B in Adult Patients With Cystic Fibrosis January 9, 2019 July 1, 2021
NCT00308958 Completed N/A Comparison of Airway Clearance Efficacy of Two High Frequency Chest Wall Oscillation (HFCWO) Devices in Cystic Fibrosis February 2006 August 2006
NCT02203084 Completed Social Determinants in Chronic Disease in British Columbia September 1, 2014 August 1, 2017
NCT04259983 Completed Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF April 11, 2022 May 2, 2023
NCT00251056 Completed Phase 2 Mannitol Dose Response Study in Cystic Fibrosis October 2005 August 2008
NCT03589313 Completed Phase 1 Pharmacokinetics of GLPG3067 in Male Subjects With Cystic Fibrosis. February 12, 2018 March 26, 2018
NCT00889434 Completed N/A Efficacy and Safety Study of EGCG/Tocotrienol in 18 Patients With Splicing-mutation-mediated Cystic Fibrosis (CF) November 1, 2011 April 16, 2015
NCT01155115 Completed N/A Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary Dyskinesia January 2010 December 2014
NCT03486236 Completed Phase 1 A Study Evaluating Safety and Pharmacokinetics of VX-440 in Combination With Tezacaftor/Ivacaftor in Healthy Adult Subjects July 20, 2016 September 14, 2016
NCT02054377 Completed N/A Cystic Fibrosis- Children and Adults Tai Chi Study June 2014 November 2016
NCT00777296 Completed Phase 1/Phase 2 Multidose Safety and Tolerability Study of Dose Escalation of Liposomal Amikacin for Inhalation (ARIKACE™) February 22, 2007 February 27, 2008
NCT04058548 Completed N/A Clinical Utility of the 1-minute Sit to Stand Test as a Measure of Submaximal Exercise Tolerance in Patients With Cystic Fibrosis During Acute Pulmonary Exacerbation September 5, 2019 May 12, 2021
NCT00605761 Completed Phase 1 SD Cystic Fibrosis Study February 2008 December 2008
NCT04923464 Completed A Decentralized Study to Evaluate Physical Activity and Cough Frequency Using Wearable Technology in Cystic Fibrosis June 30, 2021 December 20, 2021
NCT00823238 Completed Phase 1 Comparison of Antibiotics for Pseudomonas in Early CF July 2004 May 2008
NCT02700282 Completed Phase 4 Backpack Carrying in Children With Cystic Fibrosis March 2016 November 2016
NCT01225211 Completed Phase 2 Study of VX-809 Alone and in Combination With VX-770 in Cystic Fibrosis (CF) Patients Homozygous or Heterozygous for the F508del-CFTR Mutation October 2010 April 2014
NCT02589236 Completed Phase 2 Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation November 2015 December 2016
NCT04176328 Completed Phase 1 Open-label, Dose-escalation Study to Evaluate the Pharmacokinetics of Inhaled Teicoplanin in Cystic Fibrosis Patients October 25, 2019 September 30, 2020
NCT04685720 Completed N/A A Pilot Study to Assess the Effect of Intermittent iNO on the Treatment of NTM Lung Infection in CF and Non-CF Patients December 7, 2020 October 10, 2022
NCT01744561 Completed N/A Effects of a Partially Supervised Conditioning Program in CF July 1, 2014 October 15, 2018
NCT05173194 Completed N/A Remotely Supervised Exercise for Adults With Cystic Fibrosis October 26, 2021 December 30, 2021
NCT01293019 Completed Phase 3 Osteopathic Treatment in Adult Patients With Cystic Fibrosis November 2009 December 2011
NCT03460990 Completed Phase 3 A Study of VX-659 Combination Therapy in CF Subjects Homozygous for F508del (F/F) May 1, 2018 October 8, 2018
NCT01426256 Completed Phase 3 Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC Study) October 2011 July 2017
NCT01093521 Completed Phase 1 A Pharmacokinetic and Safety Study of IV Gallium Nitrate (Ganite) in Cystic Fibrosis Patients April 2010 August 31, 2013
NCT02496780 Completed Phase 2/Phase 3 The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic Cystic Fibrosis Patients August 2015 July 2022
NCT03820752 Completed Vaccination Coverage and Level of Protection in Patients at Risk October 2014 August 30, 2020
NCT02122289 Completed Early Phase 1 Muco Smartphone Exacerbation April 2014 January 2016
NCT02038803 Completed Efficacy of TOBI Podhaler vs. Tobramycin Inhalation Solution October 2013 May 2014
NCT03190031 Completed N/A Respiratory Muscle Training in CF Patients February 1, 2017 December 30, 2019
NCT00004489 Completed N/A Randomized Study of Alendronate in Adult Patients With Cystic Fibrosis Related Osteoporosis October 1998 September 2002
NCT02700243 Completed N/A Increase Tolerance for Exercise and Raise Activity Through Connectedness Trial March 14, 2016 April 2019
NCT02310789 Completed N/A (Study: Vertex IIS) Does Ivacaftor Alter Wild Type CFTR-Open Probability In The Sweat Gland Secretory Coil? July 31, 2015 August 23, 2017
NCT03924947 Completed Phase 4 A Study to Compare US Marketed Creon Manufactured With a Modernized Process at an Alternate Manufacturing Site and Manufactured With the Approved Manufacturing Process at an Alternate Active Pharmaceutical Ingredient Site, in Participants With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis October 23, 2019 July 11, 2022
NCT04094441 Completed N/A Modeling of Chest Physiotherapy Using Impedance Measurements (PHYSIOMOD) January 10, 2019 January 10, 2021
NCT01899105 Completed Phase 1 A Phase 1 Study to Investigate the Food Effect of Lumacaftor in Combination With Ivacaftor July 2013 August 2013
NCT01345617 Completed A Study of Sweat Testing Using a Quantitative Patch January 2012 October 2013
NCT02682290 Completed N/A Assessment of Rheological Parameters of Human Sputum. March 3, 2016 July 4, 2017
NCT03375684 Completed N/A Effects of Inspiratory Muscle Training on Postural Stability, Balance, Pulmonary Function and Functional Capacity in Children With Cystic Fibrosis January 2, 2018 May 21, 2018
NCT00179998 Completed Phase 2 Effectiveness of Pulmozyme in Infants With Cystic Fibrosis January 2005 July 2016
NCT01546779 Completed N/A The Use of Visual Feedback in Airway Clearance December 2008 July 2009
NCT01915875 Completed N/A Impact of Global Care of the Pain at Chronic Painful Patients Affected by Cystic Fibrosis February 15, 2012 November 19, 2014
NCT02347657 Completed Phase 3 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor January 2015 January 20, 2017
NCT02225899 Completed BioEnergetics and Metabolomics in Cystic Fibrosis September 2014 November 7, 2018
NCT00153634 Completed N/A Standard vs. Biofilm Susceptibility Testing in Cystic Fibrosis (CF) March 2004 November 2007
NCT03100214 Completed N/A Effects of an Early Rehabilitation Program During Hospitalization in Patients With Cystic Fibrosis August 2016 May 1, 2019
NCT01877707 Completed N/A Near Patient Microbial Testing in Cystic Fibrosis January 2013 June 2014
NCT03500263 Completed Phase 1/Phase 2 Safety, Tolerability, and Pharmacokinetics of PTI-808, PTI-801, and PTI-428 Combination Therapy in Subjects With Cystic Fibrosis January 30, 2018 March 13, 2019
NCT03227471 Completed Phase 1/Phase 2 A Study of VX-445 in Healthy Subjects and Subjects With Cystic Fibrosis January 23, 2017 March 27, 2018
NCT04556162 Completed Evaluation of Salt Status in Patients With Cystic Fibrosis January 1, 2018 November 21, 2021
NCT03078127 Completed N/A Researching the Effects of Airway Clearance Therapies in Cystic Fibrosis February 1, 2017 January 10, 2018
NCT01100606 Completed Phase 4 A Study to Evaluate the Mode of Administration and Safety of EUR-1008 (APT-1008) in Infants 1 to 12 Months of Age June 2010 December 2010
NCT04702386 Completed Concerns of Children Whose Parents Have Cystic Fibrosis February 18, 2021 February 18, 2022
NCT00541190 Completed N/A Absorptive Clearance in the Cystic Fibrosis Airway October 2007 April 2008
NCT04397861 Completed T Cell Memory Fuels the Innate Response in Chronic CF Lung Disease May 6, 2015 November 1, 2021
NCT01059565 Completed Phase 3 Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Patients With Cystic Fibrosis and Chronic Burkholderia Species Infection February 2010 January 2012
NCT03659214 Completed Impact of the Introduction of ORKAMBI on Anxiety, Depression, Quality of Life and Adherence of Adolescents and Young Adults December 1, 2017 January 19, 2022
NCT00360503 Completed Antimicrobial Resistance in Cystic Fibrosis (CF) March 2006 June 2008
NCT03760120 Completed N/A Short-term Effects of Physiotherapy on LCI November 21, 2016 December 2022
NCT02951182 Completed Phase 2 A Study Evaluating the Safety and Efficacy of VX-440 Combination Therapy in Subjects With Cystic Fibrosis October 2016 August 2017
NCT01840735 Completed Phase 1 Phase 1b Safety, Tolerability, and PK Study to Assess GS-5737 in Subjects With CF May 2013 August 2013
NCT00255242 Completed Phase 1 Effect of Simvastatin on CF Airway Inflammation July 2004 May 2009
NCT03886350 Completed Implication of UNconventionaL T Lymphocytes in Cystic Fibrosis (UNLOCk) April 3, 2019 July 20, 2020
NCT02211235 Completed Glycemic Monitoring in Cystic Fibrosis August 2014 May 16, 2018
NCT02057458 Completed Phase 2 Blood Flow and Vascular Function in Cystic Fibrosis April 2014 July 2018
NCT02372383 Completed N/A Improving Treatment of Nontuberculous Mycobacterial Infection in Cystic Fibrosis October 2014 June 2016
NCT02679729 Completed Phase 1 To Assess the Safety, Tolerability and Pharmacokinetics of AZD5634 Following Inhaled and Intravenous (IV)Dose Administration February 11, 2016 October 24, 2016
NCT01882400 Completed Phase 4 Assessment of Response to Treatment of Osteoporosis With Oral Bisphosphonates in Patients With Muscular Dystrophy May 2001 September 2007
NCT02562911 Completed Puberty in Girls Followed for Cystic Fibrosis January 2013 December 2015
NCT03295201 Completed N/A Clinical Effects of Exercise Program Added to Pulmonary Rehabilitation in Patients With Cystic Fibrosis March 5, 2017 November 24, 2017
NCT02110914 Completed N/A A Coaching Intervention to Young Adults With Cystic Fibrosis May 2014 December 21, 2016
NCT00774072 Completed Phase 2 Nasal Inhalation of Tobramycin in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Colonization October 2008 November 2010
NCT02209571 Completed N/A Breath Analysis in in Adults With Cystic Fibrosis (CF) October 2014 December 2015
NCT03894657 Completed N/A Validation of Respiratory Epithelial Functional Assessment to Predict Clinical Efficacy of Orkambi®. December 18, 2019 May 12, 2022
NCT00903201 Completed Phase 2 28 Day Repeat Dose in Cystic Fibrosis Patients September 28, 2009 December 29, 2010
NCT06072365 Completed Treatment With Elexacaftor/Tezacaftor/Ivacaftor, in Patients With Cystic Fibrosis and Caloric Intake October 21, 2021 January 15, 2023
NCT00757848 Completed Phase 2 A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Cystic Fibrosis October 2008 August 2009
NCT05076149 Completed Phase 3 A Study of VX-121 Combination Therapy in Participants With Cystic Fibrosis (CF) Who Are Homozygous for F508del, Heterozygous for F508del and a Gating (F/G) or Residual Function (F/RF) Mutation, or Have At Least 1 Other Triple Combination Responsive (TCR) CFTR Mutation and No F508del Mutation October 27, 2021 November 30, 2023
NCT02869932 Completed N/A Prospective Study of the Phenotypic Expression of Cystic Fibrosis (CF) Screened Positive Newborns With an Atypical Form of CF (DPAM) March 2012 March 2015
NCT01270074 Completed Phase 3 Prevention of Bronchiectasis in Infants With Cystic Fibrosis April 2012 March 2021
NCT03056989 Completed Phase 1 A Safety Study of SPX-101 Inhalation Solution in Subjects With Cystic Fibrosis May 31, 2017 August 2, 2017
NCT01548729 Completed Phase 1/Phase 2 Metabolic Efficiency of Combined Pancreatic Islet and Lung Transplant for the Treatment of End-Stage Cystic Fibrosis February 25, 2012 December 20, 2019
NCT00043225 Completed The Role of Bacteria and Genetic Variations in Cystic Fibrosis June 20, 2001 July 10, 2018
NCT02776098 Completed Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance May 2016 March 4, 2024
NCT01319253 Completed A Comparator Study Evaluating Microbiological Resistance and Effects of Alternating Inhaled Antibiotic Therapies March 2011 October 2015
NCT00684346 Completed Phase 3 18FDG-PET Imaging to Detect Changes in Airways Inflammation in Cystic Fibrosis Patients April 2008 April 2010
NCT03728595 Completed Validation of a Predictive Score for HAST October 29, 2018 March 31, 2021
NCT04743206 Completed N/A Airway Clearance for Pediatric and Adult Cystic Fibrosis Patients Using a Portable Intra-Pulmonary Percussion Device May 18, 2021 August 1, 2021
NCT03919604 Completed ECMO for Lung Transplantation in Cystic Fibrosis Patients January 1, 2013 December 31, 2018
NCT00014950 Completed N/A Benefits and Risks of Newborn Screening for Cystic Fibrosis
NCT01316276 Completed Phase 3 Extension Study of Liposomal Amikacin for Inhalation in Cystic Fibrosis (CF) Patients With Chronic Pseudomonas Aeruginosa (Pa) Infection October 5, 2012 July 16, 2015
NCT02684422 Completed Initial and Chronic Methicillin Resistant Staphylococcus Aureus (MRSA) Infection in Cystic Fibrosis (CF) July 2015 December 2021
NCT02690519 Completed Phase 2 Study of GLPG1837 in Subjects With Cystic Fibrosis (S1251N Mutation) January 2016 September 2016
NCT00880100 Completed Phase 3 Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) April 2009 November 2009
NCT00630812 Completed Phase 3 Long Term Administration of Inhaled Mannitol in Cystic Fibrosis September 2008 November 2010
NCT00457821 Completed Phase 2 Safety Study of Ivacaftor in Subjects With Cystic Fibrosis May 2007 August 2008
NCT01086839 Completed N/A Sino-nasal Inhalation of Sodium Chloride 6,0% in Patients With Cystic Fibrosis and Chronic Rhinosinusitis March 2010 June 2013
NCT01427712 Completed Special Investigation (All Cases) of LipaCreon in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis August 2011 March 2018
NCT05135156 Completed N/A Lung Transplant READY Pilot Study December 6, 2021 November 1, 2022
NCT00004440 Completed N/A Study of Ibuprofen to Preserve Lung Function in Patients With Cystic Fibrosis August 1996 June 1999
NCT04016194 Completed Prediction of Survival in Children With Cystic Fibrosis Using the Multiple-breath Washout January 1, 1990 December 2005
NCT04732195 Completed N/A Pilocarpine Microneedles for Sweat Induction (PMN-SI) January 20, 2022 March 17, 2022
NCT04734743 Completed N/A Muscle Strength, Functional Capacity, Respiratory Function and Quality Of Life In Cystic Fibrosis Patients May 1, 2016 November 15, 2016
NCT06299696 Completed Phase 1 A Study of Vanzacaftor/Tezacaftor/Deutivacaftor (VNZ/TEZ/D-IVA) in Healthy Adult Panelists March 26, 2024 April 16, 2024
NCT02907788 Completed Inflammatory Markers in Broncho-alveolar Lavage Fluid as Risk Factors for Lung Disease in Infants With Cystic Fibrosis: the I-BALL Study September 2014 January 2021
NCT02390219 Completed Phase 3 Study to Evaluate Lumacaftor and Ivacaftor Combination Therapy in Subjects 12 Years and Older With Advanced Lung Disease March 2015 October 2016
NCT00817180 Completed Phase 2 Long-term Study, Comparing Vest Therapy to Positive Expiratory Pressure (PEP) Therapy in the Treatment of Cystic Fibrosis October 2008 July 2012
NCT00079742 Completed Phase 2 A Study to Evaluate Nutropin AQ for the Treatment of Growth Restriction in Children With Cystic Fibrosis September 2003 May 2007
NCT04673331 Completed Physical Activity, Exercise Capacity and Coronavirus Phobia of Adult Cystic Fibrosis Patients During COVID-19 Pandemic November 4, 2020 August 5, 2021
NCT00037778 Completed Genetic Modifiers of Cystic Fibrosis: Sibling Study September 2001 February 2013
NCT01768663 Completed Phase 1 A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects January 2013
NCT00005112 Completed Phase 3 Growth Hormone Use in Cystic Fibrosis - a Multicenter Study
NCT00794586 Completed Phase 2 Study Evaluating Fosfomycin/Tobramycin for Inhalation in Cystic Fibrosis Patients With Pseudomonas Aeruginosa Lung Infection November 2008 March 2010
NCT04476433 Completed N/A Intervention in Chronic Pediatric Patients and Their Families. February 4, 2019 December 30, 2023
NCT00112359 Completed Phase 3 International Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis Patients With P. Aeruginosa May 2005 April 2007
NCT03423576 Completed N/A Effects of a Comprehensive Patient-centered Health Service in Cystic Fibrosis (VEMSE-CF) August 1, 2011 December 31, 2016
NCT00219882 Completed Phase 1 Safety Study of Orally Administered Curcuminoids in Adult Subjects With Cystic Fibrosis April 2005 January 2006
NCT01651455 Completed Retrospective Observational Study to Compare Cystic Fibrosis Patients in Two Decades Before and After 2000 September 2012 June 2013
NCT01943890 Completed N/A High Volumes of Hypertonic Saline and Chest Physiotherapy in CF Patients February 2010 December 2011
NCT01910415 Completed Phase 1 Phase 1, QT/QTC Interval Study in Healthy Subjects June 2013 March 2014
NCT02444234 Completed Phase 4 Pharmacokinetics of Tedizolid Phosphate in Cystic Fibrosis July 2015 December 31, 2017
NCT00843817 Completed Phase 4 RhDNase and Biodistribution of PMN Serine Proteases in Cystic Fibrosis Sputum April 2009 April 2013
NCT01070446 Completed N/A Choline Nutrition in Children With Cystic Fibrosis October 2007 February 2010
NCT00381628 Completed Nasal Epithelial Cells/Blood Lymphocyte Markers for Cystic Fibrosis (CF)/CF Pulmonary Exacerbations September 2006 September 2011
NCT01488721 Completed Clinical Evaluation of NeoPlex4 Assay and NeoPlex System December 2011 April 2012
NCT03577756 Completed Neurodevelopmental Assessment of Infants With Cystic Fibrosis June 11, 2018 March 1, 2021
NCT01957072 Completed N/A Pilot Study of Behavioural Intervention for Nutrition in Cystic Fibrosis February 2014 December 2014
NCT04938726 Completed N/A Ketone Supplementation in Cystic Fibrosis November 1, 2021 April 30, 2023
NCT02992080 Completed N/A Small Circulating RNA as Molecular Markers of Lung Disease in Cystic Fibrosis July 12, 2016 June 2020
NCT00413140 Completed Non-Invasive Biomarkers in Cystic Fibrosis June 2004 May 2005
NCT02810691 Completed N/A The Effect of Soluble Fiber to Reduce Post-prandial Glycemic Excursion in Adults With Cystic Fibrosis July 2016 April 2018
NCT01883284 Completed N/A Action of Epigenetic Modifiers in Cystic Fibrosis Treatment January 2012 November 2014
NCT01614457 Completed Phase 3 Study of Ivacaftor in Subjects With Cystic Fibrosis (CF) Who Have the R117H-CF Transmembrane Conductance Regulator (CFTR) Mutation (KONDUCT) July 2012 October 2013
NCT00431964 Completed Phase 4 Effect of Azithromycin on Lung Function in 6-18 Year-olds With Cystic Fibrosis (CF) Not Infected With P. Aeruginosa February 2007 November 2009
NCT01353950 Completed Costimulatory Molecules as Biomarkers in Cystic Fibrosis July 2011 June 2013
NCT03227094 Completed N/A Simplification of CF-related Diabetes Screening at Home November 13, 2017 April 1, 2020
NCT00004296 Completed Multicenter Study of Nontuberculous Mycobacteria in Cystic Fibrosis Patients September 1995
NCT01805713 Completed Biomarkers of Injury and Destruction in the Cystic Fibrosis Lung December 2012 December 2017
NCT01812551 Completed Phase 3 Treatment of Low Bone Density in Cystic Fibrosis. October 2002 July 2007
NCT03265288 Completed Phase 2 Study of LAU-7b in the Treatment of Cystic Fibrosis in Adults October 10, 2018 September 15, 2021
NCT02358798 Completed N/A Respiratory Function at Preschool Age of Children Detected of Cystic Fibrosis in Neonatal Period August 19, 2014 January 17, 2020
NCT00043316 Completed Phase 1/Phase 2 Interferon Gamma-1b by Inhalation for the Treatment of Patients With Cystic Fibrosis February 2001 October 2002
NCT01710644 Completed Phase 1/Phase 2 Efficacy and Tolerability of NM-BL in Patients With Exocrine Pancreatic Insufficiency Due to Cystic Fibrosis May 2013 August 2014
NCT00322868 Completed N/A Safety and Efficacy of Pioglitazone as an Anti-inflammatory for the Treatment of Cystic Fibrosis (CF) Lung Disease April 2006 April 2007
NCT01315665 Completed N/A Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation April 2011 February 2013
NCT04277819 Completed The Use of Novel Diagnostic Tools to Increase Detection of Early Fibrosis in Cystic Fibrosis Related Liver Disease to Improve Clinical Management February 15, 2019 June 21, 2023
NCT00800579 Completed Phase 1 Trial to Assess the Safety, Tolerability and Pharmacokinetics of GS-9411 in Healthy Male Volunteers November 2008 February 2009
NCT02526004 Completed N/A Cystic Fibrosis Microbiome-determined Antibiotic Therapy Trial in Exacerbations: Results Stratified October 1, 2013 June 30, 2018
NCT02309229 Completed Sputum Purulence as a Predictor of Cystic Fibrosis Exacerbations: a Prospective Cohort Trial. December 2012 January 2014
NCT00404859 Completed FLAME: Airway Inflammation Monitoring in Asthma and Cystic Fibrosis January 2006 June 2007
NCT01521338 Completed G551D Observational Study- Expanded to Additional Genotypes and Extended for Long Therm Follow up (GOAL-e2) January 2014 June 2021
NCT00220259 Completed N/A Cystic Fibrosis Withdrawal of Inhaled Steroids Evaluation Study (CF WISE Study) May 2001 February 2005
NCT02958683 Completed Chest Wall Motion Analysis in Disease July 2011 July 31, 2015
NCT00760071 Completed Magnetic Resonance Imaging (MRI) for Early Diagnosis of Cystic Fibrosis (CF) July 2006 September 2009
NCT00638365 Completed Phase 1/Phase 2 Dose Escalation Study of KB001 in Cystic Fibrosis Patients Infected With Pseudomonas Aeruginosa March 2008 April 2009
NCT00271310 Completed Phase 3 The Effects of Long Term Inhalation of Hypertonic Saline in Subjects With Cystic Fibrosis September 2000 November 2003
NCT02127957 Completed N/A Effects of an Exercise Program Among CF Patients With Dysglycemia July 2013 July 2015
NCT05700604 Completed Hypoglycemia and Glucagon Response in CF January 1, 2020 December 31, 2020
NCT00635141 Completed Phase 3 The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic Fibrosis March 2008 December 2008
NCT02934698 Completed Phase 3 An Efficacy and Safety Study of Ivacaftor in Patients With Cystic Fibrosis and Two Splicing Mutations November 1, 2016 May 2018
NCT00056147 Completed Phase 2 Study of INS37217 Inhalation Solution in Mild to Moderate Cystic Fibrosis Lung Disease April 2003 February 2004
NCT04118010 Completed Phase 4 Vitamin D and Prebiotics for Intestinal Health in Cystic Fibrosis March 13, 2020 December 31, 2022
NCT00483769 Completed Phase 4 One Year Glargine Treatment in CFRD Children and Adolescents February 2006 January 2007
NCT00014781 Completed Study of Hepatic Glucose Production and De Novo Lipogenesis in Patients With Cystic Fibrosis February 2001
NCT02725567 Completed Phase 3 A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis Who Are Less Than 24 Months of Age and Have an Ivacaftor-Responsive CFTR Mutation June 2, 2016 June 28, 2022
NCT02589444 Completed N/A Vitamin D and Microbiota in Cystic Fibrosis December 2015 April 2017
NCT04825236 Completed N/A MyVoice:CF Decision Aid for Women With Cystic Fibrosis July 1, 2021 February 3, 2023
NCT05719311 Completed Phase 2 Study to Assess an Enteric Microgranule Formulation of Adrulipase in Patients With Cystic Fibrosis February 1, 2023 July 28, 2023
NCT00082238 Completed N/A Increased Gluconeogenesis is One Cause of Cystic Fibrosis Related Diabetes (CFRD) March 2003 March 2005
NCT03462056 Completed Phase 1/Phase 2 Ready to Use Therapeutic Food (RUTF) to Promote Growth in Cystic Fibrosis May 17, 2018 June 14, 2019
NCT04969224 Completed Phase 3 A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF) October 12, 2021 July 26, 2022
NCT04684641 Completed Phase 1/Phase 2 CYstic Fibrosis bacterioPHage Study at Yale (CYPHY) March 29, 2021 June 22, 2023
NCT03843723 Completed Cystic Fibrosis and Fit-to-Fly March 1, 2019 January 31, 2023
NCT03691779 Completed Phase 3 Evaluation of VX 445/TEZ/IVA in Cystic Fibrosis Subjects 6 Through 11 Years of Age October 2, 2018 August 7, 2020
NCT02552043 Completed N/A Video Game Exercise Effectiveness of a Domiciliary Pulmonary Rehabilitation Program in Cystic Fibrosis Patients July 2015 July 2016
NCT01303068 Completed N/A Detection of Pseudomonas Aeruginosa in the Airways of Patients With CF August 15, 2012 August 2015
NCT02976519 Completed Phase 1 BI 443651 Multiple Rising Dose in Healthy Volunteers Followed by a Cross-over in CF Subjects February 15, 2017 August 29, 2018
NCT01238081 Completed The Role of Respiratory Viruses in Exacerbations of Cystic Fibrosis in Adults December 2010 April 2012
NCT04803643 Completed Upper Extremity Exercise Capacity, Muscle Oxygenation, Balance in Patients With Cystic Fibrosis March 16, 2021 March 15, 2022
NCT01983787 Completed Pharmacokinetics of Piperacillin, Given as Continuous Infusion to Patients With Cystic Fibrosis July 2013 June 2015
NCT02277860 Completed N/A Gaming Console Home-Based Exercise for Adults With Cystic Fibrosis May 2015 December 2017
NCT01608555 Completed Phase 4 Tobramycin 300 mg Once-a-day (o.d.) Aerosol in Adults With Cystic Fibrosis January 2012 July 2012
NCT05147285 Completed N/A The Effect of Telerehabilitation on Functional Capacity, Oxidative Stress and Respiratory Parameters in Cystic Fibrosis October 22, 2020 May 20, 2022
NCT00405665 Completed Phase 2 The Short Term Safety and Efficacy of Inhaled L-arginine in Patients With Cystic Fibrosis November 2006 June 2009
NCT03056326 Completed Phase 1 A Study to Investigate Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of CHF6333 in Healthy Subjects November 2016 July 2017
NCT03450720 Completed Phase 1 Pharmacokinetics of GLPG2737 in Male Subjects With Cystic Fibrosis June 28, 2017 August 16, 2017
NCT02918409 Completed Phase 4 IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy August 26, 2016 November 22, 2021
NCT02538575 Completed N/A 6 Minute Walk Test in Cystic Fibrosis May 12, 2016 September 18, 2020
NCT00706004 Completed N/A Short Term Safety and Efficacy of Lubiprostone in Adults With Cystic Fibrosis July 2008 December 2009
NCT02201082 Completed N/A Evaluation of the Timing of the Nebulization Related to the Physiotherapy Session September 2012 July 2015
NCT04579939 Completed N/A Oral Glucose Tolerance Testing Using Candy for Cystic Fibrosis February 25, 2021 December 30, 2021
NCT06350461 Completed N/A Impact of Discontinuing Hypertonic Saline in People With CF on Highly Effective CFTR Modulators- A SIMPLIFY Sub-Study August 25, 2020 July 11, 2022
NCT03566550 Completed Gut Imaging for Function & Transit in Cystic Fibrosis Study 1 September 4, 2018 February 20, 2019
NCT02823964 Completed Phase 4 EASY: Extended Access to Sollpura Over Years September 2016 March 2018
NCT03447249 Completed Phase 3 A Phase 3 Study of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF) March 7, 2018 February 5, 2019
NCT01192360 Completed Phase 3 Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung Disease September 2010 December 2012
NCT02684552 Completed N/A Non Invasive Ventilation During Physical Training in Cystic Fibrosis February 2016 August 2016
NCT02443688 Completed Phase 2 EMPIRE CF: A Phase 2 Study to Evaluate the Efficacy, Safety, and Tolerability of CTX-4430 in Adult Cystic Fibrosis (CF) Patients October 30, 2015 May 16, 2018
NCT00966602 Completed Phase 1 Drug-Drug Interaction Study of VX-809 and VX-770 in Healthy Subjects September 2009 December 2009
NCT04613063 Completed Proximal Intestinal Obstruction Syndrome (PIOS) in a Patient With Cystic Fibrosis: A New Syndrome October 19, 2020 October 21, 2020
NCT00751647 Completed Phase 2 Cystic Fibrosis Core Strengthening and Respiratory Exercise Program December 2008 December 2013
NCT00043342 Completed Phase 1/Phase 2 Study of Interferon Gamma-1b by Injection for the Treatment of Patients With Cystic Fibrosis April 2002 March 2003
NCT01323101 Completed Phase 4 Doxycycline Effects on Inflammation in Cystic Fibrosis April 2008 December 2010
NCT02128984 Completed N/A Clinical Study With an Enteral Formula With Symbiotic and DHA for Malnourished Children January 2012 May 2015
NCT01401439 Completed Assessment of Fat Free Mass Index and Its Impact on Health in Children With Cystic Fibrosis June 2012 July 2016
NCT00004441 Completed N/A Study of Tauroursodeoxycholic Acid for Hepatobiliary Disease in Cystic Fibrosis September 1997 September 2001
NCT01721382 Completed Phase 1 Treatment of Dysglycemia Using Sitagliptin in Adolescents With Cystic Fibrosis November 2012 June 2016
NCT03892304 Completed Gynecological Health Improvement of Adult Women With Cystic Fibrosis January 2017 December 2017
NCT00645788 Completed Phase 2 Study to Evaluate the Safety and Efficacy of Ciprofloxacin (Inhaled) in Patients With Cystic Fibrosis May 2008 January 2011
NCT02565914 Completed Phase 3 A Study to Evaluate the Safety and Efficacy of Long Term Treatment With VX-661 in Combination With Ivacaftor in Participants With Cystic Fibrosis Who Have an F508del-CFTR Mutation August 2015 December 5, 2022
NCT01455675 Completed Phase 3 Efficacy Study of IgY (Antibody Against Pseudomonas) in Cystic Fibrosis Patients October 2011 June 27, 2017
NCT03140527 Completed Phase 1 Study Assessing the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interactions of PTI-801 in Healthy Volunteers, and Safety, Tolerability, and Pharmacokinetics of PTI-801 in Subjects With Cystic Fibrosis April 10, 2017 February 27, 2020
NCT02821130 Completed Orkambi Exercise Study July 2016 June 1, 2020
NCT03492567 Completed N/A Study of Circulating Blood Cell Monocytes as Predictive Biomarker of Bone Cystic Fibrosis Disease. Impact of CFTR Correctors. April 25, 2018 July 4, 2018
NCT02194881 Completed Ivacaftor in French Patients With Cystic Fibrosis and a G551D Mutation October 2014 May 2016
NCT04568980 Completed Assessment of Contraceptive Safety and Effectiveness in Cystic Fibrosis September 30, 2020 December 6, 2022
NCT00363402 Completed N/A 18FDG- PET/CT Contribution to the Assessment of Lesion Severity in Cystic Fibrosis (CF) August 2006 December 2007
NCT00164138 Completed N/A Prevalence and Treatment of Urinary Incontinence in Women With Cystic Fibrosis and Chronic Obstructive Pulmonary Disease December 2001 June 2004
NCT02398383 Completed Early Phase 1 Role of Glucagon In Glucose Control in Cystic Fibrosis Related Diabetes March 2015 June 22, 2017
NCT04378153 Completed N/A Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy August 25, 2020 July 11, 2022
NCT00840333 Completed Phase 1 "Safety, Tolerability and Pharmacokinetics of MP-376 Administered for 14 Days to Stable Pediatric (CF) Patients" April 2009 December 2009
NCT02606487 Completed Hyperpolarized Xenon MRI in Cystic Fibrosis Pulmonary Exacerbations November 2015 November 2017
NCT00406536 Completed Phase 2 Study of LYM-X-SORB™ to Improve Fatty Acid and Choline Status in Children With CF and PI January 2007 June 2012
NCT03540524 Completed Phase 1 A Study Looking at the Safety, Tolerability and Efficacy of the Combination of the Study Drugs GLPG2451 and GLPG2222 With or Without GLPG2737 in Patients With Cystic Fibrosis. May 31, 2018 March 11, 2019
NCT03318328 Completed Evaluation of Food Insecurity in Adults and Children With Cystic Fibrosis August 1, 2013 March 31, 2015
NCT02212587 Completed Phase 1 Tobramycin Inhalation Powder (TIP) in Cystic Fibrosis Patients Infected With Burkholderia Cepacia Complex September 2014 May 2016
NCT05944367 Completed The Use of Breath Volatile Organic Compounds in Early Detection of Acute Pulmonary Exacerbations in Cystic Fibrosis October 13, 2021 December 23, 2022
NCT01253733 Completed N/A MD2Me - Texting to Promote Chronic Disease Management October 2009 March 2012
NCT00662714 Completed Phase 3 Early Diagnosis of Diabetes Mellitus in Patients With Cystic Fibrosis September 2001 December 2011
NCT04187924 Completed N/A Effects of SIMEOX on Airway Clearance in Cystic Fibrosis November 27, 2019 November 30, 2021
NCT02265679 Completed Phase 1 Safety, Tolerability and Pharmacokinetics of Increasing Doses of BIIL 284 BS in Adult and Pediatric Cystic Fibrosis (CF) Patients October 2001
NCT01706445 Completed N/A Combined Inspiratory Muscle and 'Whole Muscle' Training in Children With Cystic Fibrosis September 2011
NCT02199340 Completed N/A The iStep Study: Development and Validation of an Incremental Exercise Step Test for Children With Cystic Fibrosis July 2011 October 2014
NCT03905642 Completed Phase 2 Study of Dose Escalation of Liposomal Amikacin for Inhalation (ARIKAYCE™) - Extension Phase January 8, 2009 November 2, 2010
NCT02690857 Completed Phase 2 Study of Docosahexanoic Acid in Patients With Cystic Fibrosis (CF) May 2010
NCT00004471 Completed Phase 1 Phase I Pilot Study of Gene Therapy for Cystic Fibrosis Using Cationic Liposome Mediated Gene Transfer August 1995
NCT01973192 Completed Viral Pathogenesis of Early Cystic Fibrosis Lung Disease May 2013 December 1, 2016
NCT00345449 Completed N/A Evaluation of a Decision Aid for Adult Cystic Fibrosis Patients Considering Bilateral Lung Transplantation September 2006 September 2008
NCT04503408 Completed A Comparison of Clinical Parameters in With and Without Abnormal Glucose Tolerance. September 13, 2019 March 11, 2020
NCT00788359 Completed Cystic Fibrosis Foundation (CFF) Biomarkers of Exacerbation December 2007 July 2014
NCT04489186 Completed N/A Continuous Cardiorespiratory Monitoring in Cystic Fibrosis December 1, 2018 December 31, 2019
NCT04397809 Completed Utility of CD64 and TLR2 Assays to Diagnose Acute Pulmonary Exacerbations in Cystic Fibrosis September 10, 2014 August 31, 2021
NCT04126473 Completed Phase 2 A Phase 2 Study to Evaluate the Safety, Tolerability, PK and PD in Cystic Fibrosis Patients With at Least 1 G542X Allele November 5, 2019 April 6, 2022
NCT03737630 Completed N/A Inspiratory Muscle Training in Individuals With Cystic Fibrosis August 5, 2019 January 31, 2020
NCT04777344 Completed N/A Clinical Effort Against Smoke Exposure in Cystic Fibrosis July 8, 2021 September 27, 2022
NCT02626182 Completed Phase 1/Phase 2 Evaluation and Treatment of Pulmonary Vascular Disease in Moderate to Severe CF December 2015 January 29, 2018
NCT04058366 Completed Phase 3 Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy December 5, 2019 December 16, 2022
NCT01961661 Completed Phase 3 Probiotics on Intestinal Inflammation in Cystic Fibrosis September 2009
NCT02465450 Completed Phase 2 Safety, Tolerability, Pharmacokinetics, and Efficacy of JBT-101 (Lenabasum) in Cystic Fibrosis September 29, 2015 December 28, 2016
NCT00803205 Completed Phase 3 Study of Ataluren (PTC124™) in Cystic Fibrosis September 8, 2009 November 12, 2011
NCT02129803 Completed N/A Evaluating High Flow Humidification Therapy in Patients With Cystic Fibrosis May 2015 May 29, 2019
NCT02275936 Completed Phase 1 Study of N91115 in Patients With Cystic Fibrosis Homozygous F508del-CFTR Mutation February 2015 July 2015
NCT02354859 Completed Phase 2 A Phase 2 IV Gallium Study for Patients With Cystic Fibrosis (IGNITE Study) March 2016 February 1, 2018
NCT04362761 Completed Phase 3 A Study Evaluating the Long-Term Safety of Elexacaftor Combination Therapy May 4, 2020 December 21, 2022
NCT00234663 Completed Phase 2 PTC124 for Cystic Fibrosis September 2005 August 2006
NCT05195216 Completed Psychosocial Factors and Quality of Life in the Effect of Fear of COVID-19 With Cystic Fibrosis November 20, 2021 December 25, 2021
NCT00248755 Completed N/A Assessing Mucociliary Clearance and Airway Liquid Volume in the CF Airway November 2005 August 2006
NCT01737801 Completed N/A Time to Perform Lung Function Test in Cystic Fibrosis February 2008 September 2012
NCT01486199 Completed N/A Imaging Airway Liquid Absorption in Cystic Fibrosis October 2011 October 2014
NCT00357279 Completed Phase 3 Study of Denufosol Inhalation Solution in Patients With Mild Cystic Fibrosis Lung Disease July 2006 September 2008
NCT04463628 Completed Impacts of the Covid-19 Epidemic and Associated Lockdown Measures on the Management, Health and Behaviors of Cystic Fibrosis Patients During the 2020 Epidemic May 15, 2020 March 1, 2022
NCT04006873 Completed Phase 2 Gut Imaging for Function & Transit in Cystic Fibrosis Study 2 September 3, 2019 October 29, 2020
NCT03451045 Completed Phase 2 Trial to Evaluate Efficacy and Safety of Lenabasum in Cystic Fibrosis December 22, 2017 June 17, 2020
NCT00690820 Completed Phase 3 Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency (PEI) Due to Cystic Fibrosis (CF) June 2008 December 2008
NCT00420836 Completed Phase 1 Tobramycin Administered by eFlow Rapid Nebulizer: Pharmacokinetic Study April 2006
NCT01377792 Completed Phase 4 Study of Long-term Treatment With Hypertonic Saline in Patients With Cystic Fibrosis March 2009 September 2012
NCT01746095 Completed Phase 2 Efficacy and Safety Study of AeroVanc for the Treatment of Persistent MRSA Lung Infection in Cystic Fibrosis Patients March 2013 November 2014
NCT02603666 Completed N/A Elastography of the Liver in Cystic Fibrosis Patients. Diagnostic and Prognostic Aspects January 2012 June 2014
NCT01104402 Completed N/A Early Intervention in Cystic Fibrosis Exacerbation October 2011 September 2015
NCT02202876 Completed N/A Redox Imbalance and the Development of Cystic Fibrosis Diabetes November 2014 September 9, 2018
NCT00128492 Completed Phase 3 Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis (CF) Patients With Pseudomonas Aeruginosa (PA) August 2005 January 2009
NCT04235140 Completed Phase 3 Long-term Safety of Lumacaftor/Ivacaftor in Subjects With Cystic Fibrosis Who Are Homozygous for F508del and 12 to <24 Months of Age at Treatment Initiation February 24, 2020 August 22, 2023
NCT01772758 Completed Phase 2 Cystic Fibrosis and Endothelial Function: At Rest and During Exercise August 2011 June 21, 2016
NCT01636219 Completed Cough Efficiency in Cystic Fibrosis September 2012 August 2013
NCT03434886 Completed N/A Outcomes in CF Patients Accessing Their Registry Health Records March 2016 September 2017
NCT01975259 Completed Investigating the Incretin Effect in Cystic Fibrosis December 2013 July 2015
NCT00399945 Completed Phase 1 Tobramycin Inhalation Solution Administered by eFlow Rapid Nebulizer: Scintigraphy Study May 2006
NCT00506688 Completed Phase 2 Efficacy and Safety Study of Inhaled Glutathione in Cystic Fibrosis Patients July 2007 May 2010
NCT04226118 Completed N/A Efficacy of an Infrared Visualization Technique for the Identification of the Peripheral Venous Access Site in Patients With Cystic Fibrosis Aged 12 Years and Older January 19, 2021 May 12, 2022
NCT01987271 Completed N/A Effects Of Noninvasive Ventilation On Functional Capacity Of Patients With Cystic Fibrosis August 2012 January 2013
NCT00221559 Completed Serum Zn Status of Patients With Cystic Fibrosis at Diagnosis and One Year Later, Compared to a Healthy Control Group September 2004
NCT04696484 Completed N/A Feasibility of a Goal-based Agenda Setting Intervention January 14, 2021 September 19, 2021
NCT02883816 Completed N/A Early Assessment of Respiratory Function, Inflammation and Bronchial Reshuffle Among Newborns Screened for Cystic Fibrosis August 2008 January 2014
NCT02516410 Completed Phase 3 A Study to Evaluate the Efficacy and Safety of VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Heterozygous for the F508del-CFTR Mutation August 2015 June 7, 2016
NCT00311506 Completed A Study to Determine the Variability of a 6-Minute Walk Test in Cystic Fibrosis Subjects With Advanced Lung Disease October 1999 June 2004
NCT04476758 Completed Immune Profiles in CF Fungal Infection February 10, 2021 October 30, 2023
NCT00499837 Completed Phase 2 Phase II Study of the Safety and Efficacy of Inhaled Alpha-1 Antitrypsin (AAT ) in Cystic Fibrosis Patients September 2007 July 2008
NCT01331980 Completed Bone Microarchitecture at the Radius: a Pilot Comparison Between Children With Cystic Fibrosis and Healthy Controls January 2011 July 2015
NCT02054156 Completed Phase 3 OPTIMIZing Treatment for Early Pseudomonas Aeruginosa Infection in Cystic Fibrosis June 2014 August 23, 2018
NCT00504361 Completed Blood Collection From Individuals With Lung Disease for Genetic Studies (Qatar) May 2006 May 2012
NCT00006169 Completed Phase 3 Behavioral Treatment of Weight Gain in CF June 1996 November 1999
NCT03093714 Completed Phase 1 A Study to Evaluate Safety, PK and PD of FDL169 in Cystic Fibrosis Subjects August 23, 2017 April 3, 2018
NCT02715921 Completed N/A Impact of Telerehabilitation Training on Pediatric Cystic Fibrosis Patients: An Exploratory Study November 2015 May 7, 2019
NCT03224351 Completed Phase 2 A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis August 8, 2017 February 28, 2018
NCT00730509 Completed N/A Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell Membrane in Children With Cystic Fibrosis April 2004 March 2006
NCT00185549 Completed N/A An Interactive Program to Improve Care for Children With CF March 2004 September 2005
NCT01051999 Completed Phase 2 Glutamine Supplementation in Cystic Fibrosis February 2010 February 2011
NCT01887197 Completed Phase 1 Repeatability and Response Study of Absorptive Clearance Scans June 2013 May 2018
NCT04058353 Completed Phase 3 A Phase 3 Study of VX-445 Combination Therapy in Cystic Fibrosis (CF) Subjects Heterozygous for F508del and a Gating or Residual Function Mutation (F/G and F/RF Genotypes) August 28, 2019 June 12, 2020
NCT03559062 Completed Phase 3 A Study to Evaluate Efficacy and Safety of TEZ/IVA in Subjects Aged 6 Through 11 Years With Cystic Fibrosis May 17, 2018 December 21, 2018
NCT02932657 Completed Perceived Impact of Art Therapy in Patients With Cystic Fibrosis and in Professional Interdisciplinary Teams Taking Care of Them. June 29, 2017 January 28, 2018
NCT01621867 Completed Phase 2 Repeated Application of Gene Therapy in CF Patients May 2012 May 2014
NCT03338595 Completed Longitudinal Assessment of Exercise Capacity and Vascular Function in Patients With CF May 2014 October 2020
NCT01404234 Completed Phase 3 Safety of AZLI in Children With Cystic Fibrosis (CF) and Chronic Pseudomonas Aeruginosa in the Lower Airways December 2011 April 2013
NCT03948958 Completed N/A PREMO Study: to Investigate Port REMoval Outcomes June 28, 2019 July 8, 2022
NCT00117208 Completed Phase 2 Comparison of Inhaled Mannitol and rhDNase in Children With Cystic Fibrosis November 2005 February 2008
NCT02504827 Completed Phase 4 Steady-state Pharmacokinetics of Ceftazidime/Avibactam in Cystic Fibrosis September 2015 October 2016
NCT02141191 Completed Phase 1 A Study of Lung Clearance After Hypertonic Saline Delivery Using the tPAD Device June 2014 October 2015
NCT00457301 Completed Using Health-related Quality of Life (HRQL) in Routine Clinical Care July 2005 May 2008
NCT00727285 Completed Cystic Fibrosis (CF) Leukocyte Genes as Biomarkers for Novel Therapies February 2008 October 2012
NCT01695343 Completed Phase 2 Study to Evaluate the Effect of KB001-A on Time-to-Need for Antibiotic Treatment December 2012 December 2014
NCT02198079 Completed A Prospective, Multicenter, Collaborative Study to Determine the Prevalence of Nontuberculous Mycobacteria (NTM) in Pediatric Patients With Cystic Fibrosis in Florida March 2010 March 2015
NCT01132482 Completed Phase 2 Effects of Sildenafil on CFTR-dependent Ion Transport Activity October 2015 May 2017
NCT01883531 Completed Phase 2 Crossover Trial Determining the Efficacy of Dry Powder Mannitol to Improve Lung Function in Subjects Aged 6-17 Years June 2013 October 2015
NCT00677560 Completed The Natural History of Small Airways Physiology in Diseased and Healthy States June 22, 2010 July 10, 2013
NCT00885365 Completed Phase 3 A Study Comparing the Efficacy and Tolerability of Tobrineb®/Actitob®/Bramitob® Versus TOBI® April 2009 May 2010
NCT02693431 Completed Impact of Art Therapy on Anxiety Identified During Hospitalizations Among Children With Cystic Fibrosis Aged 8 to 13 June 29, 2016 November 27, 2018
NCT03109912 Completed N/A Do More, B'More, Live Fit June 17, 2015 February 28, 2017
NCT04574050 Completed N/A SELF-BREATHE RCT for Chronic Breathlessness January 11, 2021 January 30, 2022
NCT04171583 Completed Mucoid Staphylococcus Aureus in Cystic Fibrosis Airways March 1, 2019 July 31, 2022
NCT01737983 Completed Phase 4 Effect of Lactobacillus Reuteri in Cystic Fibrosis May 2009 July 2011
NCT00757237 Completed Phase 3 Aztreonam for Inhalation Solution vs Tobramycin Inhalation Solution in Patients With Cystic Fibrosis & Pseudomonas Aeruginosa August 2008 November 2010
NCT03173573 Completed Phase 1 A Study to Assess the Safety, Tolerability and PK Profile of FDL176 in Healthy and CF Participants June 27, 2017 May 31, 2018
NCT01460836 Completed Indirect Comparison of Tobramycin Solution for Inhalation Versus Aztreonam Lysine for Inhalation in the Treatment of Cystic Fibrosis April 2010
NCT00105183 Completed Phase 3 EZ-2053 in the Prophylaxis of Acute Pulmonary Allograft Rejection January 2005 January 2011
NCT03061331 Completed Phase 2 Lumacaftor/Ivacaftor Combination Therapy in Subjects With CF Who Have an A455E CFTR Mutation January 31, 2017 October 4, 2017
NCT01172301 Completed N/A Leucine-enriched Essential Amino Acid Intake to Optimize Protein Anabolism in Children With Cystic Fibrosis July 2008 February 2013
NCT05867147 Completed Phase 1 An Electrocardiogram Study to Evaluate the Effect of Vanzacaftor on the QT/QTc Interval in Healthy Participants April 26, 2023 June 14, 2023
NCT01266473 Completed N/A Study of Individualized Physiotherapy for Airway Clearance in Cystic Fibrosis. August 2010 April 2011
NCT00004747 Completed Phase 2 Phase II Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Mucoid Exopolysaccharide Pseudomonas Aeruginosa Immune Globulin for Cystic Fibrosis July 1995
NCT03205904 Completed N/A Nutritional Intervention and Glycemic Improvement in Patients With Pre-diabetic Cystic Fibrosis. December 12, 2016 February 20, 2019
NCT06217952 Completed Phase 1 Safety, Tolerability, and Pharmacokinetics of SPL84 in Healthy Volunteers February 5, 2023 August 6, 2023
NCT00205634 Completed Phase 2 Macrolide Antibiotic Therapy for Patients With Cystic Fibrosis December 2000 October 2004
NCT05274269 Completed Phase 3 Evaluation of Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis Subjects Without an F508del Mutation May 9, 2022 July 5, 2023
NCT04024423 Completed Healthcare-associated Links in Transmission of Nontuberculous Mycobacteria in Cystic Fibrosis July 1, 2019 July 1, 2023
NCT03502070 Completed Phase 4 Human Factors Study to Validate the User Interface of TOBI Podhaler Using Placebo Capsules June 26, 2018 June 17, 2019
NCT03912233 Completed Phase 2 A Study to Evaluate the Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis April 30, 2019 December 10, 2019
NCT03489590 Completed Early Phase 1 19F MRI to Evaluate Regional Ventilation in Healthy Subjects and Subjects With Cystic Fibrosis July 1, 2015 December 31, 2018
NCT01616862 Completed The Carrier Rates of Pseudomonas Aeruginosa in Family Members of Children With Cystic Fibrosis February 2012 August 2013
NCT00806455 Completed Exercise-Induced Bronchospasm in Cystic Fibrosis July 2008 August 2013
NCT00709280 Completed N/A Infant Study of Inhaled Saline in Cystic Fibrosis April 2009 November 2011
NCT04183790 Completed Phase 3 Evaluation of Long-term Safety and Efficacy of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Who Are 6 Years of Age and Older February 17, 2020 February 24, 2024
NCT00685035 Completed Phase 4 Comparison of Airway Clearance Therapy in Cystic Fibrosis Using the Same VEST Therapy Device But With Different Settings May 2008 October 2008
NCT02709109 Completed Phase 2 A Study to Evaluate the Safety and Efficacy of VX-371 in Subjects With Cystic Fibrosis Who Are Homozygous for the F508del-CFTR Mutation February 2016 September 2017
NCT03258424 Completed Phase 1 Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis on KALYDECO® as Background Therapy July 28, 2017 October 3, 2018
NCT00806884 Completed N/A Do Physiotherapy Techniques Improve Posture During Admission for a Chest Infection in Adults With Cystic Fibrosis? June 2008 August 2009
NCT01537666 Completed Phase 1 Inhaled Vancomycin Tolerability, Safety and Pharmacokinetics November 2011 March 2012
NCT00775528 Completed Phase 3 Study Investigating a Delayed-Release Pancrelipase in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis April 2009 June 2009
NCT01270347 Completed Phase 3 Trial of Aeroquin Versus Tobramycin Inhalation Solution (TIS) in Cystic Fibrosis (CF) Patients January 2011 June 2013
NCT02421120 Completed Phase 4 Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients September 2015 October 2016
NCT03527095 Completed Phase 1 A Study to Compare the Pharmacokinetics of Different Oral Formulations of FDL169 in Healthy Subjects April 5, 2018 June 21, 2018
NCT03119649 Completed Phase 2 A Study to Evaluate Multiple Doses of GLPG2222 in Adult Subjects With Cystic Fibrosis March 18, 2017 October 19, 2017
NCT02919995 Completed Phase 2 A Study of RPL554 in Patients With Cystic Fibrosis February 8, 2017 November 3, 2017
NCT00547053 Completed Phase 1 Amiloride Solution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa in Patients With Cystic Fibrosis December 2006 January 2011
NCT03117764 Completed N/A 1STST and Muscle Weakness in CF Patients October 1, 2017 October 31, 2019
NCT03229213 Completed Interactive Video Game Responses in Cystic Fibrosis August 30, 2017 March 31, 2019
NCT00008762 Completed Bone Health of People With Cystic Fibrosis
NCT00072904 Completed Phase 3 Diabetes Therapy to Improve BMI and Lung Function in CF June 2001 December 2007
NCT01013896 Completed N/A Building Adherence to Live With And Navigate my Cystic Fibrosis (CF) Experience July 2009 May 2014
NCT03873688 Completed N/A Effects of Expiratory Muscle Training on Cough Efficacy in Children and Adolescents With Cystic Fibrosis January 2, 2019 October 31, 2019
NCT03104855 Completed Phase 1 Clearance of 25-hydroxyvitamin D in Cystic Fibrosis April 3, 2017 September 6, 2023
NCT04133246 Completed N/A Parenting Concerns in Patients With Cystic Fibrosis (MucoPar) September 25, 2019 December 21, 2020
NCT03229252 Completed Phase 2 An Efficacy and Safety Study of SPX-101 Inhalation Solution in Subjects With Cystic Fibrosis August 1, 2017 June 20, 2019
NCT05481190 Completed N/A The Impact Of A Tele-Exercise Program For Children With Cystic Fibrosis During The Covid-19 Pandemic On Quality Of Life April 1, 2021 February 15, 2022
NCT00846053 Completed N/A FDG-PET Imaging in Young Cystic Fibrosis Patients February 2009 February 2012
NCT00034515 Completed Phase 1/Phase 2 A Study in Adult and Pediatric Patients With Cystic Fibrosis June 2001 August 2002
NCT02025829 Completed IL-17 Neutrophils in CF Lung Inflammation February 2014 December 2014
NCT01729585 Completed N/A The Effects of Massage Therapy on QOL in Youth/Young Adults With Cystic Fibrosis July 2013 March 2015
NCT04922255 Completed N/A Cystic Fibrosis and Urinary Incontinence September 1, 2021 October 1, 2023
NCT03139266 Completed N/A Project UPLIFT to Reduce Anxiety and Depression in CF Patients April 7, 2015 August 2, 2022
NCT01262352 Completed Phase 2 Study of the Effect of Ivacaftor on Lung Clearance Index in Subjects With Cystic Fibrosis and the G551D Mutation January 2011 November 2011
NCT02301377 Completed N/A Exploring Novel Interventions to Improve Adherence in Children With Cystic Fibrosis November 2014 March 2015
NCT02569229 Completed Glucose Tolerance in Children With Cystic Fibrosis June 2015 November 18, 2016
NCT00323167 Completed Rare Genetic Disorders of the Breathing Airways May 2006 October 2012
NCT03172793 Completed Phase 4 Telavancin Pharmacokinetics in Cystic Fibrosis Patients August 8, 2017 April 17, 2019
NCT00006063 Completed N/A Randomized Study of Pancrelipase With Bicarbonate (PANCRECARB) Capsules in Reducing Steatorrhea in Patients With Cystic Fibrosis July 1999 August 1999
NCT00530244 Completed N/A Use of Formula Fortified With DHA in Infants With Cystic Fibrosis March 2003 October 2011
NCT02797132 Completed Phase 3 Safety and Pharmacokinetic Study of Lumacaftor/Ivacaftor in Subjects Aged 2 Through 5 Years With Cystic Fibrosis, Homozygous for F508del May 2016 September 2017
NCT01116089 Completed Phase 1 Pharmacokinetic Study of Bramitob® Administered for Inhalation by PARI eFlow® vs PARI LC® PLUS Nebulizer July 2010 October 2011
NCT02680418 Completed Phase 1 Pharmacokinetics of FDL169 in Healthy Female Subjects December 2015 February 2016
NCT02501369 Completed N/A Investigating the Use of a Positive Parenting Programme to Improve Treatment Adherence in Cystic Fibrosis July 2015 June 2016
NCT00513682 Completed Phase 3 Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI) July 2007 April 2008
NCT01180842 Completed Phase 2 Treatment of Anxiety/Depression and Pain Through Relaxation Yoga for Patient With Cystic Fibrosis (CF) March 2010 December 2013
NCT03910881 Completed N/A Technology-enabled Patient Support System for Self-management of CF February 18, 2020 January 31, 2021
NCT00662675 Completed Phase 3 A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency August 2008 February 2009
NCT02847156 Completed N/A Impact of Respiratory Viral Infections in Infants With Cystic Fibrosis. January 2015 January 2016
NCT04930289 Enrolling by invitation Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs October 15, 2021 December 30, 2025
NCT05844449 Enrolling by invitation Phase 3 Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older August 11, 2023 October 2030
NCT04579211 Enrolling by invitation Prospective Analysis of Urine LAM to Eliminate NTM Sputum Screening December 10, 2020 October 2025
NCT05686837 Enrolling by invitation Prospective Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria December 28, 2022 December 31, 2025
NCT03655223 Enrolling by invitation Early Check: Expanded Screening in Newborns October 15, 2018 December 31, 2025
NCT05822102 Enrolling by invitation Simultaneous quanTification of Elexacaftor/tezAcaftor/Ivacaftor Via Reverse Phase High Performance liquiD chromatographY February 9, 2023 September 2023
NCT02073409 Enrolling by invitation PREDICT Trial: PRospective Evaluation of NTM Disease In CysTic Fibrosis December 2013 March 2025
NCT06262282 Enrolling by invitation Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria February 5, 2024 December 2028
NCT02419989 Enrolling by invitation PATIENCE Trial: Prospective Algorithm for Treatment of NTM in Cystic Fibrosis January 2014 March 2025
NCT05727852 Enrolling by invitation Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases January 30, 2023 December 2026
NCT05654480 Not yet recruiting Combating Diagnostic Wandering and Impasse for Cystic Fibrosis January 2, 2023 December 31, 2024
NCT06356246 Not yet recruiting Oral Health Status of Cystic Fibrosis Patients. An Online Survey in Collaboration With the Vaincre la Mucoviscidose Patient Association. August 1, 2024 November 1, 2024
NCT06035055 Not yet recruiting Phase 4 Ceftolozane/Tazobactam Continuous Infusion for Infective Exacerbations of Cystic Fibrosis and Bronchiectasis October 2023 January 2024
NCT06280066 Not yet recruiting N/A An Intervention-Based Approach to Strengthen the Psychological Health of Children With Cystic Fibrosis and Their Mothers April 2024 September 2024
NCT06399094 Not yet recruiting Frequency-time Analysis of Pathological Lung Sounds: Detection and Quantification of Pathological Sounds in Patients With Cystic Fibrosis, Pulmonary Fibrosis or COPD (Chronic Obstructive Pulmonary Disease) June 1, 2024 January 1, 2025
NCT06460506 Not yet recruiting Phase 3 Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Participants 12 Months of Age and Older October 2024 September 2027
NCT06313827 Not yet recruiting N/A e-Health Program to Prevent Exacerbations in the Cystic Fibrosis Population March 2024 June 2025
NCT06413368 Not yet recruiting Phase 2/Phase 3 Maralixibat in Patients With Cystic Fibrosis and Constipation, A Within-Subjects Pilot Study July 1, 2024 June 30, 2027
NCT06147414 Not yet recruiting Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders April 2024 December 2026
NCT05526027 Not yet recruiting N/A Real-world Efficacy and Safety of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulator Therapy in Adult Patients With Cystic Fibrosis (CF) September 1, 2022 December 31, 2024
NCT06147778 Not yet recruiting N/A Performances and Safety of MuCopilot, a Digital Tool for the Unsupervised Objective Assessment of Cystic Fibrosis July 2024 March 2025
NCT06331000 Not yet recruiting Effect of One Year Elexacaftor-tezacaftor-ivacaftor Treatment March 2024 March 2025
NCT06122051 Not yet recruiting Dynamic Chest X-ray With Simultaneous Spirometry November 2023 August 2025
NCT05408910 Not yet recruiting Phase 2/Phase 3 Rifaximin for Treatment of Bloating in Children and Adults With Cystic Fibrosis July 2024 September 2024
NCT06120465 Not yet recruiting N/A YOGA-CF (Yoga Outcomes Get Assessed in Cystic Fibrosis) December 1, 2023 July 10, 2025
NCT05998629 Not yet recruiting N/A Skin-interfaced Colorimetric Bifluidic Sweat Sensor Device for the Diagnosis of Cystic Fibrosis (CF) July 1, 2024 December 1, 2025
NCT06045702 Not yet recruiting Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation September 2023 September 2025
NCT05795673 Not yet recruiting N/A Peer-supporting for Teenagers With Cystic Fibrosis in the Transition of Care From Paediatric to Adult Services September 1, 2023 September 1, 2026
NCT06128499 Not yet recruiting Development a Core Set for Adults With Cystic Fibrosis Based on the ICF March 10, 2024 March 30, 2024
NCT04940533 Not yet recruiting Pharmacokinetics of CFTR Modulators in Pregnant Individuals and in Postpartum Breastfeeding Mothers December 1, 2024 January 2025
NCT05986045 Not yet recruiting ENHANCE- Establishing Natural History in an Advanced New CF Care Era October 2023 September 30, 2028
NCT06457451 Not yet recruiting N/A Impact of a Coordinated Dietetic-adapted Physical Activity Program on the Percentage of Lean Body Mass in Adults With Cystic Fibrosis Treated With Elexacaftor-Tezacaftor-Ivacaftor: Multicentre Randomised Controlled Trial September 2024 September 2027
NCT02753374 Not yet recruiting Registry Study on Cystic Fibrosis in Chinese Children May 2016 July 2030
NCT05663255 Not yet recruiting Effectiveness of CFTR Modulators According to Co-therapy March 1, 2023 December 31, 2024
NCT06132048 Not yet recruiting N/A A Usability Validation of the MuCopilot Mobile Application, a Digital Tool for the Unsupervised Objective Assessment of Cystic Fibrosis April 2024 October 2024
NCT05932316 Recruiting N/A Evaluating Bronchodilator Response in Patients With Bronchiectasis May 20, 2023 December 2024
NCT04039087 Recruiting Phase 2/Phase 3 Sildenafil Exercise: Role of PDE5 Inhibition September 5, 2019 June 2024
NCT05668741 Recruiting Phase 1/Phase 2 A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF) February 27, 2023 March 2025
NCT05200429 Recruiting Canadian Observational Study Evaluating the Long-term IMPACT of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Modulators on People With CF November 1, 2021 December 31, 2027
NCT05809492 Recruiting N/A Use of A-STEP Test in Cystic Fibrosis Patients January 1, 2023 February 1, 2024
NCT05504837 Recruiting Phase 1 A Study Assessing KB407 for the Treatment of Cystic Fibrosis June 30, 2023 July 2024
NCT05829694 Recruiting Health Outcomes of Parents With Cystic Fibrosis July 12, 2023 July 2024
NCT03617718 Recruiting Phase 1/Phase 2 Project 2 Airway Potential Hydrogen (pH) in Asthma November 1, 2018 June 30, 2027
NCT05590169 Recruiting N/A Effects of Telerehabilitation-based Exercises in Cystic Fibrosis June 20, 2023 June 1, 2024
NCT05726994 Recruiting Volatilomic Approaches for the Study of CFTR Modulators (VOLATIL-CF) February 6, 2023 August 2024
NCT05882357 Recruiting Phase 3 Evaluation of Elexacaftor/Tezacaftor/Ivacaftor (ELX/TEZ/IVA) in Cystic Fibrosis (CF) Participants 12 to Less Than 24 Months of Age June 27, 2023 October 2025
NCT05099939 Recruiting Identification of Dysglycemia With Continuous Glucose Monitoring to Assess Clinical Evolution in Cystic Fibrosis November 25, 2021 July 2026
NCT02740868 Recruiting Phase 2 Xenon-129 Lung Magnetic Resonance Imaging: Study of Healthy Volunteers and Participants With Pulmonary Disease August 2015 December 2023
NCT06154447 Recruiting Phase 1 A Phase 1, First-in-human Study of VX-828 December 12, 2023 April 2025
NCT05362344 Recruiting Colorectal Cancer Screening in Cystic Fibrosis September 1, 2022 June 30, 2025
NCT06216704 Recruiting Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis April 1, 2024 June 30, 2029
NCT06251622 Recruiting Muscle Function and Physical Activity in the Modern Era of Cystic Fibrosis February 19, 2024 October 1, 2025
NCT06429176 Recruiting Phase 2 Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients With Cystic Fibrosis July 1, 2024 December 31, 2025
NCT05074680 Recruiting COVID-19 Antibody Responses In Cystic Fibrosis February 14, 2022 May 2024
NCT03840928 Recruiting PatientSpot Formerly Known as ArthritisPower April 1, 2015 March 1, 2025
NCT06057714 Recruiting Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis January 20, 2021 December 2025
NCT02417740 Recruiting Natural History of Noncirrhotic Portal Hypertension July 27, 2015 September 4, 2029
NCT06133335 Recruiting N/A Cystic Fibrosis and Periodontal Diseases July 20, 2023 January 20, 2025
NCT05937815 Recruiting N/A Intestine-lung Axis of Cystic Fibrosis Patients Treated With the Combination Elexacaftor/Tezacaftor/Ivacaftor September 13, 2021 September 13, 2024
NCT05561764 Recruiting Phase 4 Imipenem/Cilastatin/Relebactam Pharmacokinetics, Safety, and Outcomes in Adults and Adolescents With Cystic Fibrosis January 3, 2023 December 2023
NCT05802264 Recruiting Phase 1 Study to Assess Amphotericin B Cystetic for Inhalation (ABCI) Doses in Healthy Volunteers & People With Cystic Fibrosis March 21, 2023 December 2024
NCT05675592 Recruiting Trikafta/Kaftrio and Pseudomonas Aeruginosa February 22, 2022 May 16, 2025
NCT05249322 Recruiting N/A Study of Satisfaction of Patients and Care Providers for an Alternate Follow-up With In-hospital Consults and Tele-consult for Patients With Cystic Fibrosis March 31, 2022 March 31, 2024
NCT06088485 Recruiting The Effect of Bone Mineral Density in Patients With Adult Cystic Fibrosis September 5, 2023 February 16, 2024
NCT06175182 Recruiting Assessment of Cognitive Function and Exercise Capacity in Cystic Fibrosis December 14, 2022 December 2023
NCT06306508 Recruiting Effect of Parental Attitude on Functional and Physical Level of Children With Cystic Fibrosis February 16, 2024 February 16, 2025
NCT05314764 Recruiting Phase 4 Cefiderocol Pharmacokinetics in Adult Patients With Cystic Fibrosis June 1, 2022 June 2023
NCT01852448 Recruiting Genetics of Insulin and Incretins in Cystic Fibrosis May 2013 July 2025
NCT04732910 Recruiting Cystic Fibrosis Transmembrane Regulator (CFTR) Biomarker Study to Evaluate the Rescue of Mutant CFTR in Patients With Cystic Fibrosis Treated With CFTR-modulators July 1, 2018 December 31, 2027
NCT00001532 Recruiting Role of Genetic Factors in the Development of Lung Disease September 13, 1996
NCT04644471 Recruiting N/A Comparison Between Ultra-low-dose Computed Tomography and Lung MRI in Cystic Fibrosis August 5, 2021 August 2024
NCT06296394 Recruiting Health Outcomes of Parents With Cystic Fibrosis-Aim 2 June 1, 2024 February 1, 2031
NCT05548283 Recruiting Phase 4 Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study April 23, 2023 November 15, 2026
NCT06012084 Recruiting N/A The Development and Evaluation of iCF-PWR for Healthy Siblings of Individuals With Cystic Fibrosis September 6, 2023 April 2024
NCT05896488 Recruiting Sweat Response, Sweat Composition and Thermoregulatory Response to Exercise in Heat in Adults With Cystic Fibrosis on Modulator Therapy. March 18, 2023 March 18, 2024
NCT04002882 Recruiting Role of Body Fat Distribution in Metabolic and Pulmonary Decline in Cystic Fibrosis (ORBIT-CF) July 8, 2019 May 2025
NCT05745948 Recruiting COVID-19 ANtibody Responses in Cystic Fibrosis: CAR-CF January 24, 2023 May 2025
NCT06350149 Recruiting N/A A Pilot and Feasibility Study to Evaluate High vs Low Glycemic Index Mixed Meal Tolerance Test in Adolescents and Young Adults With Cystic Fibrosis March 22, 2024 September 2025
NCT06237335 Recruiting Phase 1 A Phase 1 Study Evaluating Safety and Tolerability of RCT2100 in Healthy Participants February 1, 2024 August 17, 2024
NCT05052294 Recruiting COVID-19 Antibody Responses in Cystic Fibrosis September 13, 2021 September 13, 2024
NCT04624490 Recruiting Phase 1 Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease November 2, 2020 October 26, 2026
NCT03624101 Recruiting Phase 4 Novel Therapeutic Approaches for Treatment of CF Patients With W1282X Premature Termination Codon Mutations December 1, 2018 January 31, 2025
NCT04391322 Recruiting Assessment of CFTR-Modulator Treatment in Cystic Fibrosis Lung Disease Using Novel Structural and Functional MRI October 20, 2020 January 2024
NCT03921060 Recruiting Phase 4 Markers of Osteoporosis in Cystic Fibrosis September 2, 2021 July 2027
NCT06197490 Recruiting Renal Impact of KAFTRIO in Mucoviscidose Population January 1, 2022 December 31, 2023
NCT05639556 Recruiting Strength and Muscle Related Outcomes for Nutrition and Lung Function in CF April 20, 2023 December 2028
NCT05100823 Recruiting N/A Validation of Therapeutic Efficacy Targeting the Splicing Variants in Cystic Fibrosis and CFTR Pathologies March 30, 2022 September 30, 2027
NCT04530383 Recruiting Phase 2 Effects of Metformin on Airway Ion Channel Dysfunction in Cystic Fibrosis-related Diabetes February 14, 2022 October 1, 2025
NCT05982795 Recruiting Impact of Highly Effective Modulator Therapy on the Cystic Fibrosis Microbiome November 8, 2023 December 1, 2026
NCT01533636 Recruiting CF And Effects of Drugs Mixed Ex Vivo With Sputum for Mucolytic Treatment July 2012 April 2024
NCT06163482 Recruiting Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis March 28, 2023 December 31, 2025
NCT04994301 Recruiting Evaluation of Lung T1-MRI in Pediatric Cystic Fibrosis Patients December 15, 2020 December 31, 2024
NCT06159725 Recruiting Phase 1/Phase 2 A Study To Evaluate The Safety Of CMTX-101 In People With Cystic Fibrosis January 17, 2024 February 2025
NCT06302270 Recruiting CFTR Modulators in Pregnancy and Postpartum March 15, 2024 January 31, 2039
NCT00943514 Recruiting Natural History of Bronchiectasis August 1, 2009
NCT05279040 Recruiting Trikafta Exercise Study in Cystic Fibrosis November 10, 2021 December 2025
NCT04509050 Recruiting Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children November 18, 2020 October 1, 2025
NCT06191640 Recruiting Sinus Disease in Young Children With Cystic Fibrosis April 12, 2023 April 2026
NCT04580368 Recruiting N/A Testing Drug Efficacy in Cystic Fibrosis Through N-of-1 Trials May 1, 2021 January 31, 2027
NCT05941832 Recruiting ANNE Sensor Monitoring in Cystic Fibrosis July 3, 2023 December 31, 2023
NCT03016689 Recruiting The Sinonasal Cavity as a Reservoir for Upper Airway Bacterial Development May 31, 2017 January 1, 2026
NCT04825067 Recruiting N/A Remote Monitoring of High-Risk Patients With Chronic Cardiopulmonary Diseases April 1, 2022 December 31, 2022
NCT04828382 Recruiting Prospective Study of Pregnancy in Women With Cystic Fibrosis September 30, 2021 December 30, 2026
NCT02657837 Recruiting Measures of Respiratory Health (MRH) January 2016 December 1, 2024
NCT04166396 Recruiting Early Phase 1 Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis February 17, 2020 January 2025
NCT05687474 Recruiting Baby Detect : Genomic Newborn Screening September 1, 2022 August 31, 2025
NCT04469439 Recruiting Impact of Sinus Surgery on Individuals With Cystic Fibrosis July 1, 2020 January 31, 2025
NCT03489629 Recruiting Phase 2 STaph Aureus Resistance-Treat Early and Repeat (STAR-TER) April 3, 2018 December 30, 2025
NCT02717650 Recruiting N/A The Alfred Step Test Exercise Protocol (A-STEP), for Adults With Cystic Fibrosis. August 25, 2016 October 2024
NCT05865886 Recruiting Phase 2 A Study to Test How Well BI 1291583 is Tolerated by People With Cystic Fibrosis Bronchiectasis (Clairafly™) January 31, 2024 October 24, 2024
NCT03669614 Recruiting Phase 1/Phase 2 SAD and MAD of Inhaled AR-501 in Health Adults and P. Aeruginosa Infected Cystic Fibrosis Subjects December 7, 2018 July 2023
NCT03350828 Recruiting CHaractErizing CFTR Modulated Changes in Sweat Chloride and Their Association With Clinical Outcomes January 15, 2018 December 31, 2024
NCT05748444 Recruiting The Relationship Between Diet and Glycemic Response and Inflammatory Markers in Children With Cystic Fibrosis January 1, 2023 August 1, 2024
NCT04341532 Recruiting Bacterial Gene Profiling to Predict Antibiotic Resistance During Cystic Fibrosis Pulmonary Exacerbations February 20, 2020 December 2025
NCT05635266 Recruiting Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives October 26, 2021 October 2025
NCT05453578 Recruiting Phase 1/Phase 2 A Phase 1b/2 Trial of the Safety and Microbiological Activity of Bacteriophage Therapy in Cystic Fibrosis Subjects Colonized With Pseudomonas Aeruginosa October 3, 2022 June 28, 2024
NCT03161808 Recruiting Rare CFTR Mutation Cell Collection Protocol (RARE) October 5, 2017 December 1, 2024
NCT04553419 Recruiting Phase 3 Antibiotic Treatment Of Staphylococcus Aureus In Stable People With CF July 27, 2020 June 30, 2025
NCT04735952 Recruiting Improving P. Aeruginosa Detection With Breath-based Diagnostics (IMPACT-Breath) May 3, 2019 December 31, 2024
NCT06149793 Recruiting Phase 2/Phase 3 SGLT2 Inhibitor Therapy in Cystic Fibrosis-related Diabetes December 30, 2023 December 31, 2025
NCT06364176 Recruiting Phase 2 Targeting Inflammation With Losartan to Improve Response to Modulator Therapy in Cystic Fibrosis. June 3, 2024 October 2027
NCT05801952 Recruiting N/A PEP and OPEP Devices in Cystic Fibrosis January 1, 2020 February 28, 2025
NCT06311292 Recruiting N/A Intrapulmonary Percussive Ventilation for Sputum Induction in Adults With Cystic Fibrosis May 29, 2024 June 2025
NCT04970225 Recruiting N/A Cystic Fibrosis Blood Neutrophils July 8, 2021 October 2024
NCT05788965 Recruiting Phase 2/Phase 3 Semaglutide in CFRD April 30, 2023 December 31, 2025
NCT00001223 Recruiting Diagnosis and Treatment of Patients With Cystic Fibrosis January 1, 1988
NCT06222905 Recruiting Analysis of Remote Monitoring/Virtual Clinic Data in Adult Patients With Cystic Fibrosis (Project Breathe) February 20, 2019 December 31, 2030
NCT06370962 Recruiting Circadian Rhythm Disorders in Children With Cystic Fibrosis Under CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Modulators April 29, 2024 January 29, 2026
NCT06273566 Recruiting French Validation of the AdT-Physio Scale April 1, 2024 July 31, 2025
NCT05568134 Recruiting Alternate Measures of Glucose During OGTT Testing for CFRD July 17, 2023 February 1, 2026
NCT04242420 Recruiting N/A Connexin Genotypes in Cystic Fibrosis April 2002 December 31, 2024
NCT06274840 Recruiting COVID-19 Antibody Responses In Cystic Fibrosis August 8, 2022 May 2024
NCT05295524 Recruiting N/A Description of the Short-term Effects of KAFTRIO® by Continuous Monitoring With the PHEAL-CR-K Application in Real Life in Patients With Cystic Fibrosis Eligible for KAFTRIO® Treatment March 14, 2022 March 2023
NCT06327802 Recruiting Improving the Well-being of Caregivers of Cystic Fibrosis Patients During Physiotherapy Treatment April 1, 2024 July 31, 2025
NCT05740618 Recruiting Phase 4 Inhaled Mannitol on Mucociliary Clearance in Moderate to Severe Cystic Fibrosis March 28, 2023 March 31, 2025
NCT04731272 Recruiting Phase 2 GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance April 20, 2021 June 30, 2027
NCT05455671 Recruiting Real-Time Assessment of Lung Structure and Function in Children and Young Adults With CF Using Electrical Impedance Tomography August 1, 2022 May 2025
NCT03587961 Recruiting Early Phase 1 Personalized Theratyping Trial August 1, 2019 January 1, 2025
NCT05501587 Recruiting Measures of Respiratory Health Registry October 11, 2018 May 2028
NCT06289972 Recruiting Development,Validity and Reliability of a Caregiver Version of the Breathlessness Beliefs Questionnaire February 20, 2024 February 20, 2025
NCT06339593 Recruiting Regional Monitoring of CF Lung Disease January 5, 2024 January 2028
NCT05519020 Recruiting Inhaled Therapy Adherence and Outcomes to Kaftrio in Cystic Fibrosis July 27, 2022 December 31, 2026
NCT04793867 Recruiting Regional Phenotyping of CF and Non-CF Bronchiectasis February 8, 2021 March 2027
NCT05392855 Recruiting N/A Symptom Based Performance of Airway Clearance After Starting Highly Effective Modulators for Cystic Fibrosis (SPACE-CF) September 5, 2023 January 1, 2026
NCT05963503 Recruiting Relationship Between Health Literacy and Physical Activity in Adult Patients With Cystic Fibrosis August 15, 2023 August 2024
NCT05857709 Recruiting Fitness, Body Composition, Physical Activity and Sleep Patterns in People With Cystic Fibrosis on Modulator Therapy. January 10, 2023 February 2024
NCT04798118 Recruiting N/A Role of Toilet Bronchoscopy in RICU April 1, 2022 December 2023
NCT04687475 Recruiting N/A Implementation of a Clinical Tool to Improve Waitlist Mortality in Patients With Cystic Fibrosis April 20, 2020 June 30, 2024
NCT06032273 Recruiting N/A Lung Transplant READY CF 2: CARING CF Ancillary RCT September 6, 2023 July 31, 2027
NCT05704036 Recruiting Phase 4 Estrogen Supplementation and Bone Health in Women With CF May 2, 2023 December 2025
NCT05934656 Recruiting Understanding Gut Symptoms in People With Cystic Fibrosis June 26, 2023 March 31, 2026
NCT05576324 Recruiting Effect of the CFTR-modulating Triple Therapy Elexacaftor - Tezacaftor - Ivacaftor December 30, 2020 October 18, 2023
NCT06030206 Recruiting N/A Lung Transplant READY CF 2: A Multi-site RCT September 6, 2023 July 31, 2027
NCT06072287 Recruiting The Living With a Long-Term Condition Study June 28, 2023 January 10, 2024
NCT04549077 Recruiting Pulmonary Vascular Disease in CF July 29, 2020 July 29, 2025
NCT03506061 Recruiting Phase 2 Trikafta in Cystic Fibrosis Patients September 4, 2019 August 2024
NCT05251467 Recruiting A Comprehensive Approach To Relief Of Digestive Symptoms In Cystic Fibrosis: CARDS-CF February 28, 2022 September 30, 2023
NCT03435939 Recruiting Early Phase 1 Effect of Losartan in Cystic Fibrosis (CF)-NIH Grant #133240 February 15, 2022 July 31, 2024
NCT06322446 Recruiting N/A Exercise in People With Cystic Fibrosis on CFTR Modulator Therapy February 27, 2024 December 23, 2025
NCT04010253 Recruiting N/A Impact of Bronchial Drainage Technique by the Medical Device Simeox® on Respiratory Function and Symptoms in Adult Patients With Cystic Fibrosis September 30, 2019 December 31, 2023
NCT06371261 Recruiting Pathogenicity of Species of the Achromobacter Genus in Patients From Reunion Island With Cystic Fibrosis February 29, 2024 March 2027
NCT02128711 Recruiting Mapping Chemical and Microbiological Heterogeneity Throughout Explanted Cystic Fibrosis Lung Specimens July 2014 July 2025
NCT04075864 Recruiting N/A Feasibility of a New Model for Exercise Prescription in Cystic Fibrosis December 1, 2020 December 1, 2024
NCT03226795 Recruiting N/A Improving Therapeutic Adherence With a Co-constructed Program Involving Both Patients and Health Care Professionals January 18, 2021 October 18, 2025
NCT04137133 Recruiting N/A Patienthèque of Finisterian (South of Brittany) Children With Cystic Fibrosis in the Time of Precision Medicine March 21, 2022 March 2030
NCT03256773 Recruiting High Resolution Micro OCT Imaging April 15, 2016 December 31, 2024
NCT05359991 Recruiting N/A Exercise in Child Health November 12, 2020 June 2024
NCT03670472 Recruiting Correction of Nonsense Mutations in Cystic Fibrosis February 3, 2016 January 2030
NCT02965326 Recruiting N/A Surrogate Markers of Response to New Therapies in Cystic Fibrosis Patients May 2016 October 2026
NCT04877223 Recruiting Monocytes as Predictors of Cystic Fibrosis-related Bone Disease June 1, 2021 November 1, 2025
NCT04680403 Recruiting N/A Video Telehealth Exercise Training in Cystic Fibrosis July 1, 2022 December 2025
NCT05712538 Recruiting Phase 1 Safety, Tolerability, and Pharmacokinetics of ARCT-032 in Healthy Adult Subjects and Adults With Cystic Fibrosis. February 15, 2023 May 30, 2024
NCT02748798 Recruiting Early Phase 1 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders November 10, 2020 December 22, 2023
NCT05614336 Recruiting N/A COVID-19 Antibody Responses in Cystic Fibrosis June 15, 2022 June 2025
NCT06063785 Recruiting Multispectral Optoacoustic Tomography in Patients With Cystic Fibrosis October 1, 2023 March 31, 2025
NCT05517655 Recruiting Phase 4 BEGIN Novel ImagiNG Biomarkers May 1, 2022 November 1, 2028
NCT05766774 Recruiting N/A FEED-Cystic Fibrosis (FEED-CF) June 28, 2023 June 2027
NCT05696912 Recruiting N/A Functional Tests to Resolve Unsolved Rare Diseases. Rares. January 30, 2023 February 2025
NCT01851694 Recruiting N/A Beta-cell Response to Incretin Hormones in Cystic Fibrosis May 2013 December 2025
NCT03052283 Recruiting Development and Validation of a Disease Specific PROM to Assess Abdominal Involvement in Patients With CF (CFAbd-Score) January 26, 2017 December 31, 2027
NCT05723445 Recruiting N/A The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes September 1, 2023 July 1, 2025
NCT02912637 Suspended Hyperpolarized Xenon Imaging in Patients With Cystic Fibrosis October 2016 October 2019
NCT00008775 Suspended N/A Pressure Support Ventilation During CF Exacerbations
NCT04306939 Suspended Genomic Resources for Enhancing Available Therapies (GREAT1.0) Study November 1, 2014 December 1, 2025
NCT03756922 Suspended Phase 1/Phase 2 A DDI Study of FDL169 and FDL176 in Healthy Subjects November 27, 2018 February 2020
NCT00005110 Suspended N/A A Multi-Centered Study of the Long-Term Effect of Salmeterol and Albuterol in Cystic Fibrosis
NCT01329172 Terminated N/A Nasal Mucin Oral Supplementation Treatment Respiratory Inflammation Using PUFA in Cystic Fibrosis (CF) Patients September 20, 2010 October 2017
NCT00125346 Terminated Phase 3 Tobramycin Inhalation Powder (TIP) in Cystic Fibrosis Subjects September 2005 February 2007
NCT02113397 Terminated Evaluation of Inhaled Antibiotics on Bacterial Diversity and Richness in the Cystic Fibrosis Lung April 2014 August 2016
NCT02649751 Terminated Phase 2 Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation February 22, 2016 July 26, 2018
NCT03367494 Terminated N/A A New Optical Sweat Test Method Based on a Citric Acid-derived Multi-halide Sensor March 1, 2018 December 1, 2020
NCT01923753 Terminated Phase 2 A Short-term Comparative Study of Aerosure for Airway Clearance in Patients With Cystic Fibrosis September 2013 November 2015
NCT00208078 Terminated Phase 4 Effect of Non-Invasive Ventilation in Cystic Fibrosis Patient With Chronic Respiratory Failure. May 2005 May 2011
NCT04060329 Terminated N/A Measuring and Improving Coproduction Using coopeRATE December 2, 2019 March 16, 2020
NCT01417481 Terminated Phase 2 Effect of Glycine in Cystic Fibrosis March 2012 September 2013
NCT01241942 Terminated N/A Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability December 2010 March 2013
NCT02015663 Terminated Phase 4 Tobramycin Inhalation Powder (TIP) Administered Once Daily Continuously Versus TIP Administered BID in 28 Day on / 28 Day Off Cycles January 2014 December 2014
NCT01694069 Terminated Phase 4 Continuous Infusion Piperacillin-tazobactam for the Treatment of Cystic Fibrosis September 2012 September 2013
NCT03447262 Terminated Phase 3 A Study Evaluating the Long Term Safety and Efficacy of VX-659 Combination Therapy July 13, 2018 September 9, 2020
NCT02971839 Terminated Phase 2 Study to Evaluate the Safety and Efficacy of CTP-656 in Patients With Cystic Fibrosis With CFTR Gating Mutations December 2016 August 2017
NCT01200888 Terminated Controlled Ventilation CT in CF Infants September 1, 2015 June 30, 2017
NCT04921332 Terminated N/A Bright Light Therapy for Depression Symptoms in Adults With Cystic Fibrosis (CF) and COPD September 7, 2021 March 22, 2022
NCT02323100 Terminated Phase 1/Phase 2 Glycerol Phenylbutyrate Corrector Therapy For CF (Cystic Fibrosis) December 2, 2018 March 1, 2022
NCT01002534 Terminated Phase 2 Does a Nasal Instillation of Vardenafil Normalize the Nasal Potential Difference in Cystic Fibrosis Patients? October 2011 March 2018
NCT04527796 Terminated Influence of a Residential Rehabilitation Program on Body Composition in Patients With Cystic Fibrosis September 1, 2018 July 1, 2020
NCT01349192 Terminated Phase 2 Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF) April 2011 May 2015
NCT05515250 Terminated N/A Neuromodulation for Children With Cystic Fibrosis Experiencing Chronic Abdominal Pain March 29, 2023 July 25, 2023
NCT02518672 Terminated Phase 2 Pro-resolving Effect of MAG-DHA in Cystic Fibrosis (PREMDIC) October 2015 November 2016
NCT02840136 Terminated N/A LC-MS/MS Based Method Development for the Monitoring of Antibiotic Concentrations in Sputum of Cystic Fibrosis Patients February 2016 September 1, 2017
NCT03956589 Terminated Phase 4 Functional Respiratory Imaging and Orkambi in CF October 1, 2018 April 1, 2020
NCT00953706 Terminated Phase 2 Study of Ivacaftor in Cystic Fibrosis Subjects Aged 12 Years and Older Homozygous for the F508del-CFTR Mutation September 2009 May 2013
NCT03237767 Terminated N/A A CFit Study - Acute Exercise May 1, 2018 December 1, 2020
NCT01586728 Terminated N/A Oxygen Therapy in Cystic Fibrosis October 2012 August 2014
NCT03304028 Terminated N/A MUCOviscidose EXacerbation Outils Connectés Education Thérapeutique October 20, 2017 June 18, 2020
NCT02858843 Terminated N/A The Effect of Combination Lumacaftor and Ivacaftor on Markers of Hyperglycemia August 1, 2016 May 1, 2018
NCT05267418 Terminated N/A Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance February 26, 2019 March 30, 2021
NCT03870841 Terminated Phase 2 The Effect of PC945 on Aspergillus Fumigatus Lung Infection in Patients With Cystic Fibrosis April 3, 2019 June 1, 2020
NCT02456103 Terminated Phase 3 Extension Study of Ataluren in Participants With Nonsense Mutation Cystic Fibrosis August 31, 2015 June 2, 2017
NCT00590538 Terminated Phase 1/Phase 2 Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis) February 2003 December 2008
NCT03633526 Terminated Phase 3 Evaluation of VX-659/TEZ/IVA in Cystic Fibrosis Subjects 6 Through 11 Years of Age August 3, 2018 January 18, 2019
NCT00434278 Terminated Phase 4 A Trial of Pulmozyme Withdrawal on Exercise Tolerance in Cystic Fibrosis Subjects With Severe Lung Disease (TOPIC) March 2007 November 2008
NCT00391703 Terminated N/A Assessment of Quadriceps Muscle Electrostimulation Used in Patients Suffering From Cystic Fibrosis October 2006 September 2010
NCT00060801 Terminated Phase 2 Efficacy and Safety of 24 Weeks of Oral Treatment With BIIL 284 BS in Adult and Pediatric Patients May 2003
NCT02888730 Terminated Phase 3 Tobramycin Delivered by Nebulized Sonic Aerosol for Chronic Rhinosinusitis Treatment of Cystic Fibrosis Patients February 16, 2017 July 8, 2019
NCT01793649 Terminated Phase 1 A Phase 1 Study to Characterize the Effect of GS-5737 Enhancement of Mucociliary Clearance (MCC) in Healthy Subjects October 2012 June 2013
NCT02324868 Terminated N/A Impact of Availability of Showerpatch for Patients With Intravenous Catheters January 2016 March 2016
NCT00839644 Terminated N/A Airway Secretion Clearance in Cystic Fibrosis December 1999 June 2003
NCT00787917 Terminated Phase 4 An Exploratory Study to Assess Multiple Doses of Omalizumab in Patients With Cystic Fibrosis Complicated by Acute Bronchopulmonary Aspergillosis (ABPA) November 2008 July 2010
NCT00680316 Terminated Phase 4 A Study of Pulmozyme® (Dornase Alpha) in 3- to 5-Year-Old Patients With Cystic Fibrosis June 2008 May 2009
NCT01201434 Terminated N/A Effect of Probiotics on Sputum Inflammation and Pulmonary Infections in Patients With Cystic Fibrosis October 2010 December 2013
NCT02498535 Terminated Phase 2 Efficacy and Safety of Inhaled Nitric Oxide (NO) in Cystic Fibrosis (CF) Patients February 22, 2017 June 1, 2020
NCT01753869 Terminated N/A Timing of Hypertonic Saline Inhalation Relative to Airways Clearance in Cystic Fibrosis December 2012 June 2016
NCT00967798 Terminated Phase 3 Prevention of Cystic Fibrosis Diabetes May 2010 December 31, 2017
NCT00566241 Terminated Phase 1 IGF-1 Therapy in Patients With Cystic Fibrosis June 2008 June 2012
NCT00333385 Terminated Phase 4 Continuous Versus Short Infusions of Ceftazidime in Cystic Fibrosis October 2001 April 2004
NCT00073463 Terminated Phase 2/Phase 3 Safety and Efficacy of Recombinant Adeno-Associated Virus Containing the CFTR Gene in the Treatment of Cystic Fibrosis June 2003 October 2005
NCT02107859 Terminated Phase 3 Study of Ataluren (PTC124) in Cystic Fibrosis May 23, 2014 June 5, 2017
NCT00332215 Terminated Phase 1 A Phase I Study of Inhaled Sodium Pyruvate for the Treatment of Cystic Fibrosis. February 2006
NCT03734744 Terminated N/A PK/PD of Vitamin D3 in Adults With CF June 17, 2019 May 16, 2022
NCT05088447 Terminated A Study to Investigate Cystic Fibrosis Pulmonary Exacerbations and the Lung Microbiome February 2015 March 2017
NCT02010411 Terminated Phase 2 Alpha1 Antitrypsin Aerosol Therapy in Cystic Fibrosis June 2004 October 2005
NCT00846573 Terminated N/A Hyperpolarized Noble Gas MR Imaging for Pulmonary Disorders November 2008 April 2011
NCT03066453 Terminated Phase 3 Evaluation of Short Antibiotic Combination Courses Followed by Aerosols in Cystic Fibrosis June 13, 2017 January 16, 2020
NCT02730793 Terminated Phase 2 Aztreonam Aerosol to Treat Cystic Fibrosis Nasal Disease January 2017 September 19, 2019
NCT03497117 Terminated Early Phase 1 19F MRI of Ventilation in Subjects With Cystic Fibrosis Undergoing Treatment for Pulmonary Exacerbation August 25, 2015 September 13, 2019
NCT02061852 Terminated N/A Evaluation of the Safety of the Medical Device Simeox® July 2014 September 2015
NCT00425165 Terminated Phase 2 Study of Denufosol Inhalation Solution in Patients With Mild to Moderate Cystic Fibrosis Lung Disease August 2007 May 2008
NCT00418470 Terminated Phase 4 Prolonging the Duration of Peripheral Venous Catheters in Cystic Fibrosis People March 2007 August 2011
NCT02170025 Terminated Phase 2 Early Signs of Efficacy Study With Riociguat in Adult Homozygous Delta F508 Cystic Fibrosis Patients September 30, 2014 September 22, 2017
NCT03219164 Terminated Phase 3 Study of Aztreonam for Inhalation in Children With Cystic Fibrosis and New Infection of the Airways by Pseudomonas Aeruginosa Bacteria November 28, 2017 September 23, 2021
NCT00996424 Terminated Phase 4 The Effect of Inhaled N-Acetylcysteine Compared to Normal Saline on Sputum Rheology and Lung Function January 2010 December 2010
NCT02759562 Terminated Phase 2 Effect of Andecaliximab on FEV1 in Adults With Cystic Fibrosis November 4, 2016 July 21, 2017
NCT02404714 Terminated A Multi-Center Study of the CF Quantum® Sweat Test System February 8, 2017 July 1, 2018
NCT00803179 Terminated Phase 1 Growth Hormone Therapy for Wasting in Cystic Fibrosis November 2008 March 2012
NCT00744250 Terminated Phase 4 Intraduodenal Aspiration Study to Assess the Bioavailability of Oral Pancrecarb® Compared to Placebo Control August 2008 May 2010
NCT02823470 Terminated Phase 4 A Pilot Study to Evaluate the Use of Smart Adherence Technology to Measure Lumacaftor/Ivacaftor Adherence in CF Subjects Homozygous for the F508del CFTR Mutation June 2016 August 2017
NCT02742519 Terminated Phase 3 A Study to Evaluate Efficacy and Safety of Ivacaftor in Subjects With Cystic Fibrosis Aged 3 Through 5 Years Who Have a Specified CFTR Gating Mutation May 2016 August 2017
NCT01257464 Terminated Phase 2 Sitagliptin in Cystic Fibrosis-Related Diabetes September 2010 June 2012
NCT00537602 Terminated Phase 2 Miglustat / OGT 918 in the Treatment of Cystic Fibrosis November 2007 March 2008
NCT04059094 Terminated Phase 2 A 4-week Study to Test Different Doses of BI 1265162 in Adolescents and Adults With Cystic Fibrosis Using the Respimat® Inhaler - BALANCE - CF™1 September 16, 2019 April 24, 2020
NCT00846781 Terminated Phase 3 Study 08-114 Open-label Extension of Study 08-110 - A Multi-Center Study of Denufosol Tetrasodium Inhalation Solution in Patients With Cystic Fibrosis Lung Disease (P08642) February 2009 February 2011
NCT03309358 Terminated Phase 1 A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis September 28, 2017 December 18, 2017
NCT02955888 Terminated Phase 2 Study of Safety, Tolerability & Efficacy in Cystic Fibrosis Patients With Abnormal Glucose Tolerance January 3, 2017 February 2018
NCT01572194 Terminated N/A Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC) April 2012 April 2018
NCT02190604 Terminated Phase 1/Phase 2 Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients July 31, 2012 November 30, 2015
NCT01885650 Terminated N/A The Addition of Non-Invasive Ventilation To Airway Clearance Techniques In Adults With Cystic Fibrosis July 2013 May 11, 2017
NCT00376428 Terminated Phase 2 Interest of Gentamicin-induced Readthrough in Cystic Fibrosis Patients January 2003 June 2005
NCT02598999 Terminated Phase 1 Dose Escalation Study of ALX-009 in Healthy Men and Cystic Fibrosis (CF) and Non-CF Bronchiectasis Patients November 2015 December 2021
NCT02769637 Terminated Effect of Acid Blockade on Microbiota and Inflammation in Cystic Fibrosis (CF) September 7, 2017 January 18, 2018
NCT05101915 Terminated Phase 2 Study of a Nebulised Nitric Oxide Generating Solution in Patients With Mycobacterium Abscessus November 1, 2021 April 23, 2024
NCT00577499 Terminated Effect of Lubiprostone on Nutritional Status and Pulmonary Function in Adults With Cystic Fibrosis October 2007 June 2009
NCT00014768 Terminated Study of Metabolic Effects of Pregnancy in Women With Cystic Fibrosis February 2001
NCT02950116 Terminated N/A Lung Clearance Index (LCI) in Pediatric Patients With Obstructive Lung Disease March 9, 2017 April 7, 2017
NCT01810536 Terminated N/A High Flow Nasal Oxygen for Children With Cystic Fibrosis Presenting With Respiratory Failure - a Randomized Controlled Study April 2013 May 2016
NCT03206788 Terminated Phase 2 Losartan and Inflammation in Cystic Fibrosis November 11, 2017 December 30, 2019
NCT00763477 Unknown status N/A Ghrelin in Cystic Fibrosis April 2010 April 2011
NCT02591524 Unknown status N/A Upper and Lower Airway Colonization in Cystic Fibrosis Patients After Lung Transplantation November 2015 April 2016
NCT05206097 Unknown status N/A Determinants of Daily Physical Activity Level in Patients With Cystic Fibrosis - Pilot Study Protocol May 23, 2022 June 2, 2023
NCT02703155 Unknown status N/A The Use of Home Oral Glucose Tolerance Test Kit in Screening Cystic Fibrosis Related Diabetes October 2015 October 2016
NCT01468428 Unknown status Small Intestinal Function in Patients With Cystic Fibrosis October 2010 December 2011
NCT03903913 Unknown status Phase 2 Safety, Tolerability and Efficacy of S-1226 in Cystic Fibrosis and Non CF Bronchiectasis August 8, 2019 August 2022
NCT01937325 Unknown status Phase 4 CPET in CF Patients With One G551D Mutation Taking VX770 February 2014 December 2016
NCT01149005 Unknown status N/A Cystic Fibrosis (CF) Exacerbation and Insulin Treatment June 2010 December 2015
NCT00546962 Unknown status Tissue Bank for Pulmonary Diseases April 1999
NCT03485456 Unknown status Phase 1/Phase 2 DPI-Tobra-Kind Cyclops® in Children With Cystic Fibrosis May 29, 2019 January 1, 2022
NCT02131857 Unknown status N/A The Effectiveness of a Systemic Mindfulness-based Intervention Program in a Cystic Fibrosis Clinic May 2014 December 2015
NCT03279965 Unknown status MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia May 5, 2017 May 5, 2018
NCT01885169 Unknown status LAIV (Flumist®) Administration in CF Patients August 2013 December 2015
NCT04814797 Unknown status Use of Capnography for the Follow-up of Cystic Fibrosis Children May 5, 2021 December 31, 2021
NCT02850692 Unknown status N/A Portal Hypertension and Systemic Endothelial Function April 18, 2016 December 2021
NCT00006273 Unknown status Study of Total Energy Expenditure in Infants and Children With Moderate to Severe Cystic Fibrosis June 1996
NCT03910920 Unknown status Cross Transmissions of Pseudomonas Aeruginosa Between Children From a Same Cystic Fibrosis Center. February 6, 2019 January 31, 2021
NCT04256772 Unknown status Anti-IL5 and Other Biotherapies in Cystic Fibrosis July 1, 2019 March 31, 2022
NCT04531410 Unknown status N/A NETwork of Linoleic Acid Supplementation in Cystic Fibrosis October 25, 2021 January 31, 2024
NCT05158829 Unknown status COVID-19 Antibody Responses In Cystic Fibrosis January 1, 2022 May 2024
NCT03645473 Unknown status N/A Evaluation of Device Settings for Airway Clearance Using The Monarch Airway Clearance System January 24, 2019 April 12, 2019
NCT03902236 Unknown status Reaction Time and Postural Control in Individuals With Cystic Fibrosis and Bronchiectasis March 1, 2019 November 4, 2019
NCT04071314 Unknown status Evaluating the Alimentary and Respiratory Tracts in Health and Disease (EARTH) Research Program. April 18, 2018 March 13, 2023
NCT02308267 Unknown status Impaired Secretory IgA and Mucosal Immunity in Cystic Fibrosis November 2015 December 2017
NCT00004315 Unknown status Phase 2 Phase II Pilot Study to Compare the Bioavailability of Buffered, Enteric-Coated Ursodiol With Unmodified Ursodiol for Chronic Cholestatic Liver Disease and Cystic Fibrosis-Associated Liver Disease November 1995
NCT02538588 Unknown status N/A Comparison of Amikacin Lung Delivery With Two Nebulizers August 2015 December 2015
NCT03993600 Unknown status N/A New Markers of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function in Sweat December 4, 2018 December 31, 2021
NCT00298922 Unknown status Phase 2 Azithromycin in Patients With CF, Infected With Burkholderia Cepacia Complex February 2006 October 2009
NCT00129350 Unknown status Phase 1 Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation September 2004 February 2008
NCT00164021 Unknown status The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation February 2001
NCT04056702 Unknown status Impact of Triple Combination CFTR Therapy on Sinus Disease. September 5, 2019 July 2022
NCT01309178 Unknown status Phase 2 Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo May 2009 May 2011
NCT03653949 Unknown status N/A Effects of Aerobic Interval Training on Glucose Tolerance in Children and Adolescents With Cystic Fibrosis February 4, 2019 December 2020
NCT04882267 Unknown status N/A General Health, Attitudes, and Activity in Self-directed Exercise in Patients With Cystic Fibrosis (GAINS-CF) May 31, 2021 May 31, 2023
NCT03312075 Unknown status Epidemiology and Clinical Characteristics of Non-Tuberculous Mycobacteria Infections in Cystic Fibrosis Patients. January 2018 January 2022
NCT05029817 Unknown status Ovarian Reserve in Women With Cystic Fibrosis and the Correlation With Demographic and Clinical Parameters July 15, 2021 December 2021
NCT04966234 Unknown status Phase 2/Phase 3 A New Posaconazole Dosing Regimen for Paediatric Patients With Cystic Fibrosis and Aspergillus Infection April 22, 2021 November 2023
NCT04249999 Unknown status N/A ActivOnline: Physical Activity in Cystic Fibrosis Trial UK May 7, 2020 July 2022
NCT02976714 Unknown status N/A Identification of Predictive Epigenetic Biomarkers of Lung Disease Severity in Cystic Fibrosis December 12, 2016 December 2021
NCT03809091 Unknown status WGS of Korean Idiopathic Bronchiectasis January 2019 December 2021
NCT03699982 Unknown status N/A Resting Energy Expenditure in Patients With Cystic Fibrosis: A Pilot Study October 10, 2018 January 22, 2021
NCT04891159 Unknown status Training in Shared Decision-making of Cystic Fibrosis Centers Competences in the Treatment of CF Related Diabetes in Adult Patients September 2021 April 2023
NCT05239611 Unknown status Phase 2 Feasibility of Home-based Exercise Program for Adults With Cystic Fibrosis February 14, 2022 April 30, 2023
NCT05377502 Unknown status Performance and Patient Acceptance of a Commercially Available Beverage as Compared to an Oral Glucose Solution for Oral Glucose Tolerance Tests in Cystic Fibrosis (CF) Patients Who Are Screened for CF-related Diabetes. December 15, 2021 December 31, 2022
NCT02048592 Unknown status Phase 4 Impact of Immunonutrition on the Patients With Cystic Fibrosis September 2013 December 2014
NCT03335202 Unknown status Longitudinal Analysis of Respiratory and Intestinal Microbiome in Cystic Fibrosis September 28, 2017 September 2020
NCT02906826 Unknown status N/A Adherence to Airway Clearance. Novel Approaches to Improving Adherence August 2016 September 2017
NCT03051490 Unknown status Phase 3 RESULT: Reliable, Emergent Solution Using Liprotamase Treatment April 28, 2017 June 2018
NCT02535130 Unknown status N/A Evaluation of Nebulization and Positive Expiratory Pressure Combination August 2015 June 2018
NCT00163696 Unknown status Multi Breath Nitrogen Washout (MBNW) as a Measure of Small Airway Function in Patients With Respiratory Disease September 2004
NCT04458129 Unknown status Phase 2 Polyethylene Glycol and Intestinal Inflammation in Cystic Fibrosis July 8, 2020 July 8, 2022
NCT02724527 Unknown status Phase 2 Study of Cavosonstat (N91115) in CF Patients Who Are Heterozygous for F508del-CFTR and a Gating Mutation and Being Treated With Ivacaftor April 2016 April 2017
NCT04453358 Unknown status N/A Cystic Fibrosis Remote Monitoring System September 1, 2020 August 31, 2021
NCT00202072 Unknown status Mucin in Sputum of CF During Pulmonary Exacerbation January 2004 September 2005
NCT00908505 Unknown status N/A Comparison Between RTX (Biphasic Cuirass Ventilator) and Physiotherapy in Cystic Fibrosis Patients July 2009 December 2011
NCT03911258 Unknown status N/A Epidemiology of the Nasal Flora at the Reference Center for Cystic Fibrosis of Queen Fabiola Children's University Hospital. February 6, 2019 April 30, 2020
NCT02489955 Unknown status N/A Antibiotic Nephrotoxicity in Adult Patients With Cystic Fibrosis February 2015
NCT03859531 Unknown status Gastrointestinal Study at Orkambi Therapy in CF Patients February 27, 2019 June 30, 2020
NCT03264950 Unknown status N/A Utility of Point Shear-wave Elastography to Assess for Hepatic & Pancreatic Fibrosis in Pediatric CF Patients October 1, 2017 January 31, 2018
NCT04735679 Unknown status Characterization of Pulmonary Microbiome in Cystic Fibrosis Patients January 1, 2021 December 31, 2023
NCT02600039 Unknown status N/A The Short-term Effect of ELTGOL on Pulmonary Ventilation Valued Through Electrical Impedance Tomography in Cystic Fibrosis Patients October 2015 April 2016
NCT04683809 Unknown status N/A Effects of a Telerehabilitation Approach in Children With Cystic Fibrosis January 2021 June 2021
NCT01667094 Unknown status Phase 4 A Study Comparing Continuous Infusion Antibiotics to Standard Treatment for Lung Infections in Cystic Fibrosis September 2012 July 2017
NCT04461561 Unknown status N/A Using NPT to Evaluate Providing PPC as ELNEC-PPC WBT for Nurses July 1, 2020 September 1, 2021
NCT03290144 Unknown status Pregnancies and Cystic Fibrosis February 2, 2015 September 2, 2018
NCT03145051 Unknown status N/A Efficacy of Nasal Irrigation With Respimer® Netiflow® vs Saline Among Patients With Cystic Fibrosis and Chronic Rhinosinusitis January 2015 December 2017
NCT00700050 Unknown status Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis Airways April 2008 December 2022
NCT01446861 Unknown status Exocrine Pancreatic Function Testing in Cystic Fibrosis January 2011 July 2018
NCT02790879 Unknown status Transition From Pediatric to Adult Cystic Fibrosis Care Center October 2015 October 2016
NCT02148978 Unknown status N/A Cystic Fibrosis Related Diabetes March 2014
NCT03285100 Unknown status The Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin Degradation October 31, 2017 October 1, 2018
NCT01837355 Unknown status N/A Modulation of Intestinal and Pulmonary Inflammation by Lactobacillus Diet Supplementation in Pediatric Cystic Fibrosis March 2013 December 2019
NCT00163852 Unknown status Phase 2/Phase 3 Treatment of Metabolic Alkalosis in Acute Exacerbations of Cystic Fibrosis February 2004 February 2006
NCT00916682 Unknown status Structure and Function of Salivary Proteins November 2007
NCT02722122 Unknown status Phase 2 Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Exploratory Efficacy Parameters of AIR DNase™in Patients With Cystic Fibrosis Previously Treated With Pulmozyme® May 2016
NCT00687466 Unknown status Phase 3 Study on the Efficacy of Slow Release Insulin in Cystic Fibrosis Patients With Glucide Intolerance and Clinical Decay August 2005 October 2009
NCT04863573 Unknown status COVID-19 Antibody Responses In Cystic Fibrosis November 19, 2021 May 2024
NCT01543620 Unknown status Prospective Observational Study to Evaluate Biomarkers of Aminoglycoside Nephrotoxicity in Patients With Cystic Fibrosis February 2012 June 2015
NCT04999865 Unknown status Cystic Fibrosis Reproductive and Sexual Health Collaborative: Building Online Research Partnerships April 19, 2019 December 31, 2021
NCT01450267 Unknown status Phase 3 Inhaled Glutathione (GSH) Versus Placebo in Cystic Fibrosis June 2010 December 2012
NCT02802839 Unknown status N/A Virtual Reality for the Reduction of Pain During Venipuncture in Children With CF June 2016 June 2017
NCT03622892 Unknown status Non-invasive Prenatal Diagnosis of Monogenic Disorders by Linked-reads Technology October 18, 2018 October 18, 2021
NCT03375047 Unknown status Phase 1/Phase 2 Study to Evaluate the Safety & Tolerability of MRT5005 Administered by Nebulization in Adults With Cystic Fibrosis May 10, 2018 December 2021
NCT00564304 Unknown status NPD Measurement in Infants March 2008 March 2010
NCT03672058 Unknown status N/A Steps Ahead: Optimising Physical Activity and Health in Adults With Cystic Fibrosis October 1, 2018 June 28, 2020
NCT01288170 Unknown status N/A Pharmacokinetic Bioequivalence Study of Nebcinal® 150mg/3ml Administered by Aeroneb® Idehaler® Versus Tobi® 300mg/5ml Administered by Pari LC Plus® February 2010
NCT00983671 Unknown status Standardisation of Measurements in Exhaled Breath and Exhaled Breath Condensate. February 2010 December 2013
NCT03655249 Unknown status N/A Effects of AD on VI in Patients With CF August 1, 2018 December 2021
NCT02234401 Unknown status N/A Non Invasive Ventilation for Acute Exacerbations in Adult CF August 2014 September 2017
NCT03565692 Unknown status Lum-Iva-biota: Exploring the Respiratory Mycobiota and Microbiota Profile in French CF Patients Taking Lumacaftor-Ivacaftor July 1, 2018 February 28, 2023
NCT03607396 Unknown status Study for Evaluating the Real Use of Inhaled Aztreonam Lysine in Patients With Cystic Fibrosis July 1, 2018 July 1, 2019
NCT01325766 Unknown status N/A Study of Yoga as a Therapy for Cystic Fibrosis (CF) Patients February 2011 October 2011
NCT03421366 Unknown status Modified Release Posaconazole in Patients With Cystic Fibrosis March 1, 2018 February 5, 2021
NCT04543929 Unknown status N/A Effects of Innovative Aerobic Exercise Training in Cystic Fibrosis February 11, 2020 December 31, 2020
NCT01321905 Unknown status Phase 2 Prospective Intervention Study on Vitamin D in Patients With Cystic Fibrosis April 2010
NCT01494909 Unknown status N/A Development Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and Function January 2011 February 2021
NCT00023465 Unknown status Quantification of Pulmonary Neutrophil Activity in Cystic Fibrosis Using Radiolabeled Fluorodeoxyglucose and PET Imaging
NCT02252601 Unknown status N/A Evaluation of the High Frequency Digit Triplet Test in Cystic Fibrosis January 2015
NCT02239458 Unknown status N/A DPP-IV Inhibition Prior to Development of Diabetes in Patients With Cystic Fibrosis June 2015 June 2016
NCT04058340 Unknown status N/A Taste Receptors Regulation in CF Patients July 30, 2019 December 30, 2019
NCT01044719 Unknown status Phase 4 Duration of Antibiotics in Infective Exacerbations of Cystic Fibrosis January 2010 April 2011
NCT03320382 Unknown status Multiple Breath Washout, a Clinimetric Dataset May 5, 2017 March 2024
NCT01183286 Unknown status Phase 2 CFfone: A Cell Phone Support Program for Adolescents With Cystic Fibrosis September 2010
NCT02433132 Unknown status N/A Cystic Fibrosis Diagnosis by Analyzing Nasal Brushing March 2015 September 2018
NCT05217784 Unknown status COVID-19 Antibody Responses in Cystic Fibrosis (CAR-CF) January 25, 2022 January 2024
NCT01337219 Unknown status Phase 1/Phase 2 Pharmacokinetic Bioequivalence Study of Nebcinal® 150mg/3ml Administered by Aeroneb® Idehaler® Versus Tobi® 300mg/5ml Administered by Pari LC Plus® /Pulmoaid® in Patients With Cystic Fibrosis April 2011
NCT05276960 Unknown status Phase 4 Efficacy of Intensive Cholecalciferol Monitoring and Supplementation on Serum vitD Levels in Pediatric Patients With CF February 22, 2022 September 30, 2023
NCT01605565 Unknown status N/A Functional Analysis by Dynamic Imaging of the Respiratory Epithelium in Infants With Cystic Fibrosis November 2011 November 2014
NCT03822455 Unknown status Phase 2 A Phase 2b Randomised, Placebo Controlled Study of OligoG in Patients With Cystic Fibrosis May 16, 2019 July 10, 2021
NCT03045198 Unknown status Phase 4 Effect of Azithromycin on Fatty Acids in CF March 2012 December 2018
NCT04215796 Unknown status N/A Evaluation of the ReX-C System, in Patients Receiving CFTR Modulators for the Treatment of Cystic Fibrosis (CF). May 12, 2020 July 31, 2022
NCT03069651 Unknown status N/A Virtual Care in CF (VIRTUAL-CF) Study March 29, 2016 December 31, 2020
NCT03273959 Unknown status N/A Program Of Exercises During The Hospitalization Of Children And Adolescents With Cystic Fibrosis August 28, 2017 March 28, 2019
NCT02605538 Withdrawn N/A Hepatitis B in Cystic Fibrosis and Latent Tuberculosis Respectively September 1, 2015 December 31, 2025
NCT04496921 Withdrawn N/A Vitamin K Supplementation to Reduce Deficiencies in Adults With Cystic Fibrosis August 10, 2020 August 16, 2021
NCT00765401 Withdrawn An Investigation of the Association Between Helicobacter Pylori Infection and Abdominal Pain in Cystic Fibrosis Patients November 2008 April 2011
NCT03931252 Withdrawn N/A Thermic Effect of Feeding in Cystic Fibrosis January 2022 December 2022
NCT02653027 Withdrawn N/A Effect of Lumacaftor-ivacaftor on Glucose Handling and Tolerance in Cystic Fibrosis Phe508del January 1, 2018 May 1, 2018
NCT04254705 Withdrawn N/A Organoid Study R334W March 1, 2020 March 1, 2021
NCT03058068 Withdrawn Phase 1 Human MesenchymAl Stem Cells Infusion in Patients With Cystic Fibrosis December 2020 September 2028
NCT00663975 Withdrawn N/A Open Label Safety Study of DCI-1020 in Pediatric Cystic Fibrosis (CF) Patients February 2009 November 2009
NCT01025713 Withdrawn Phase 1 A Phase 1 Trial to Assess the Safety, Tolerability, and Pharmacokinetics of GS 9411 in Subjects With Cystic Fibrosis (CF) December 2009 April 2010
NCT02547116 Withdrawn Phase 4 Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis December 2020 December 2021
NCT02048163 Withdrawn Intermittent Versus Continuous Infusion Meropenem in Cystic Fibrosis December 2013 August 2015
NCT01229553 Withdrawn N/A Effect of Topical and Systemic Decolonization of Staphylococcus Aureus (SA) in Pediatric Cystic Fibrosis (CF) Patients January 2011 January 2011
NCT01155752 Withdrawn Phase 3 Pulmozyme in Cystic Fibrosis With Sinusitis July 2013 June 2015
NCT00287430 Withdrawn N/A Growth Hormone Use in Adolescents and Adults With Cystic Fibrosis January 2006 January 2006
NCT05095246 Withdrawn Phase 1 A Study of Inhaled KB407 for the Treatment of Cystic Fibrosis March 8, 2022 October 30, 2024
NCT00762918 Withdrawn Phase 3 Vitamin D3 for the Treatment of Low Vitamin D in Cystic Fibrosis March 2008 September 2008
NCT00977158 Withdrawn Microbiota of the Respiratory Flora in Children With Cystic Fibrosis During the First Year of Life May 2011
NCT01090908 Withdrawn Evaluation of Ciprofloxacin for Inhalation to Cystic Fibrosis Patients With P. Aeruginosa September 2010 June 2011
NCT01702415 Withdrawn Phase 4 Zoledronic Acid in Cystic Fibrosis October 2013 December 2015
NCT00743158 Withdrawn Transfer Impedance in Cystic Fibrosis August 2008 March 3, 2011
NCT01509339 Withdrawn Phase 1 Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis January 2012 December 23, 2021
NCT04541875 Withdrawn Medication Adherence and Non-adherence in Adults With Rare Disease January 2021 September 2022
NCT01092572 Withdrawn Phase 1/Phase 2 Statins To Treat Adult Cystic Fibrosis May 2010 May 2010
NCT05641298 Withdrawn Phase 2 Study to Determine the Efficacy&Safety of ARV-1801(ACG-701) for the Treatment of Cystic Fibrosis Pulmonary Exacerbations February 10, 2023 September 2023
NCT01460849 Withdrawn Assess Increased Mortality Risk With Each Year of Delayed Tobramycin Solution (TIS) Initiation, and Effect of TIS on Mortality Across Study Centers March 2011 March 2011
NCT00256555 Withdrawn Phase 2/Phase 3 Growth Hormone Treatment Study in Children With Cystic Fibrosis February 2000 December 12, 2018
NCT03261219 Withdrawn N/A IPV vs CPT for Airway Clearance During CF Exacerbation July 2018 October 30, 2018
NCT01315691 Withdrawn Phase 3 Study to Evaluate Arikace™ in CF Patients With Chronic Infection Due to Pseudomonas Aeruginosa
NCT03644199 Withdrawn N/A Development of Diabetes in Adults With Cystic Fibrosis (CF) March 30, 2011 August 30, 2017
NCT04274413 Withdrawn N/A CFTR Related Pancreatitis Study February 1, 2021 February 1, 2021
NCT03698448 Withdrawn Phase 2/Phase 3 A Dose-finding Study of Inhaled OligoG vs Placebo in Patients With Cystic Fibrosis September 1, 2021 November 1, 2022
NCT03041571 Withdrawn Impact of Early Implementation of Narrative Medicine Techniques on Patient Centered Attitudes of Medical Students March 1, 2017 October 18, 2019
NCT05157646 Withdrawn N/A The Relationship Between CFTR Gene Mutations and Exercise Capacity August 2022 November 2022
NCT00812045 Withdrawn Phase 2 Study to Assess Efficacy of AZD1236 in Patients With Cystic Fibrosis December 2009 August 2010
NCT00287443 Withdrawn N/A Metabolic Abnormalities in Hispanic Children With Cystic Fibrosis February 2, 2006 February 2, 2006
Disase is a (Disease Ontology)
DOID:225
Cross Reference ID (Disease Ontology)
GARD:6233
Cross Reference ID (Disease Ontology)
ICD10CM:E84
Cross Reference ID (Disease Ontology)
ICD9CM:277.0
Cross Reference ID (Disease Ontology)
MESH:D003550
Cross Reference ID (Disease Ontology)
MIM:219700
Cross Reference ID (Disease Ontology)
NCI:C2975
Cross Reference ID (Disease Ontology)
ORDO:586
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:85809002
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0010674
Exact Synonym (Disease Ontology)
CF
Exact Synonym (Disease Ontology)
mucoviscidosis
OrphaNumber from OrphaNet (Orphanet)
586
ICD10 preferred id (Insert disease from ICD10)
D0003938
ICD10 class code (Insert disease from ICD10)
E84
MeSH unique ID (MeSH (Medical Subject Headings))
D003550