chronic myeloid leukemia (Cancer)

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Information
Disease name
chronic myeloid leukemia
Disease ID
DOID:8552
Description
"A myeloid leukemia that is characterized by over production of white blood cells." [url:http\://www.cancer.gov/dictionary?CdrID=46755]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT00710892 Active, not recruiting Phase 1 CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene December 2008 July 2026
NCT04233346 Active, not recruiting Phase 2 The Study for CML Who Failed Prior TKIs or With T315I Mutation or Ph+ ALL Who Failed Prior TKIs or With T315I Mutation July 9, 2020 December 31, 2025
NCT04645706 Active, not recruiting Innate T Cells and TKI Discontinuation April 20, 2021 April 2028
NCT03193281 Active, not recruiting Phase 2 KISS Study: Kinase Inhibition With Sprycel Start up July 17, 2017 December 31, 2025
NCT04013685 Active, not recruiting Phase 1 Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies November 21, 2019 July 2026
NCT03906292 Active, not recruiting Phase 2 Frontline Asciminib Combination in Chronic Phase CML August 19, 2019 December 2027
NCT03709017 Active, not recruiting Iclusig PMS in CML or Ph+ALL Patients August 7, 2018 June 2023
NCT03874858 Active, not recruiting Phase 2 De-escalation and TFR Study in CML Patients Treated With Nilotinib Followed by a Second Attempt After Nilotinib and Asciminib Combination March 22, 2019 December 31, 2026
NCT03480360 Active, not recruiting Phase 3 Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression March 28, 2018 September 13, 2025
NCT02917720 Active, not recruiting Phase 2 2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patients September 2016 September 2027
NCT01698905 Active, not recruiting Phase 2 Treatment-free Remission After Achieving Sustained MR4.5 on Nilotinib (ENESTop) December 20, 2012 January 24, 2025
NCT06233890 Active, not recruiting The Analysis of Fatigue on Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukaemia May 12, 2023 May 12, 2026
NCT04578847 Active, not recruiting Phase 2 A Study of REduction And DIscontinuation Treatment of TKI (Imatinib, Nilotinib, Dasatinib and Bosutinib) January 15, 2020 January 15, 2025
NCT00905593 Approved for marketing Nilotinib in Adult Patients With Imatinib-resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase September 2008
NCT00854841 Available The Randomized Study of Dasatinib and High-Dose Imatinib (600mg) in Suboptimal Responder
NCT00219752 Completed Phase 2 Safety and Efficacy of Imatinib in Chronic Myelogenous Patients Older Than 70 Years May 2002 May 2007
NCT00257647 Completed Use of SV40 Vectors to Treat Chronic Myeloid Leukemia (CML) September 2005 November 2007
NCT00261846 Completed Phase 2 Study Evaluating SKI-606 (Bosutinib) In Philadelphia Chromosome Positive Leukemias January 18, 2006 August 6, 2015
NCT00267085 Completed Phase 2 Synthetic Vaccine in Patients With Chronic Myeloid Leukemia and Minimal Residual Disease December 2005 July 2008
NCT00303290 Completed Phase 1 PEG Interferon Alpha 2B and Low-Dose Ara-C in Early Chronic Phase CML January 2000 November 2014
NCT00352677 Completed Phase 1 Safety and Tolerability Study of INNO-406 to Treat Chronic Myeloid Leukemia or Acute Lymphocytic Leukemia July 2006 May 2008
NCT00354120 Completed Phase 2/Phase 3 Thymoglobuline Versus Alemtuzumab in Patients Undergoing Allogeneic Transplant March 2005 August 2011
NCT00375219 Completed Phase 2 Homoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene Mutation September 20, 2006 June 28, 2013
NCT00435864 Completed N/A Natural Killer Index From Hematopoietic Stem Cell Graft April 2007 November 2013
NCT00001144 Completed Phase 2 Modified Bone Marrow Stem Cell Transplantation for Chronic Myelogenous Leukemia October 1999 October 2002
NCT00460694 Completed Phase 1/Phase 2 Allogeneic Cytokine-induced Killer Immunotherapy for Relapse After Allogeneic Marrow Transplant for Haematological Malignancies August 2006 December 2012
NCT00462943 Completed Phase 2 Open Label Study of Subcutaneous Homoharringtonine (Omacetaxine Mepesuccinate) in Patients With Advanced CML March 7, 2007 June 27, 2013
NCT00469014 Completed Phase 2 Busulfan, Fludarabine, Clofarabine With Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia September 2006 March 2013
NCT00469729 Completed Phase 2/Phase 3 Efficacy and Safety Study of StemEx®, to Treat Subjects With High Risk Hematologic Malignancies, Following Myeloablative Therapy October 2007 June 2015
NCT00481052 Completed Phase 2 Nilotinib as First-line Treatment of Ph+ CML in Early Chronic Phase June 23, 2007 April 30, 2018
NCT00493181 Completed Phase 2 Interleukin 11, Thrombocytopenia, Imatinib in Chronic Myelogenous Leukemia (CML) Patients October 2005 January 2011
NCT00511303 Completed Phase 2 Protein-Tyrosine Kinase Inhibitor (STI571) for Treatment of Patients With Ph+ Chronic Myeloid Leukemia August 2000
NCT00513175 Completed Non-Myeloablative Allogeneic Stem Cell Transplantation With Matched Unrelated Donors for Treatment of Hematologic Malignancies, Renal Cell Carcinoma, and Aplastic Anemia October 2001 November 2007
NCT00514488 Completed Phase 3 Imatinib Standard Dose (400 mg/Day) Versus Imatinib High Dose (800 mg/Day) June 2004
NCT00514969 Completed Phase 2 Protein-Tyrosine Kinase Inhibitor (STI571) for Treatment of Patients With Ph+ Chronic Myeloid Leukemia in Accelerated and Blastic Phase August 2000
NCT00516152 Completed Phase 2 Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCT November 2002 November 2007
NCT00574873 Completed Phase 3 Compare Bosutinib To Imatinib In Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive CML February 5, 2008 May 27, 2015
NCT00460629 Completed Phase 1/Phase 2 Prophylactic Transfer of Leukemia-reactive T Cells After Allogeneic Transplantation March 2005
NCT00001432 Completed The Collection of Peripheral Blood Lymphocytes and Marrow Progenitor Cells From Normal Volunteers and Volunteers With Lymphoid or Hematologic Malignancies March 1995 November 2003
NCT00038675 Completed N/A Therapy of HES, PV, Atypical Chronic Myelocytic Leukemia (CML) or Chronic Myelomonocytic Leukemia (CMML), and Mastocytosis With Imatinib Mesylate June 2001 November 2013
NCT00061581 Completed Phase 2 Experimental Bone Marrow Transplant Protocol May 19, 2003 June 14, 2017
NCT00067028 Completed Phase 2 Clofarabine Combinations in Relapsed/Refractory Acute Myeloid Leukemia (AML), Myelodysplastic Syndromes (MDS) and Myeloid Blast Phase Chronic Myeloid Leukemia (CML) December 2003 June 2013
NCT00101595 Completed Phase 2 Dasatinib (BMS-354825) in Subjects With Lymphoid Blast Phase Chronic Myeloid Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia January 2005 December 2007
NCT00101660 Completed Phase 2 Study of BMS-354825 (Dasatinib) in Patients With Chronic Myeloid Leukemia Who Are Either Resistant or Intolerant to Imatinib February 2005 April 2008
NCT00101816 Completed Phase 2 Dasatinib (BMS-354825) in Subjects With Myeloid Blast Phase Chronic Myeloid Leukemia Resistant to or Intolerant of Imatinib Mesylate December 2004 March 2008
NCT00103844 Completed Phase 2 Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemia February 2005 March 2008
NCT00143559 Completed Phase 2 Stem Cell Transplantation as Immunotherapy for Hematologic Malignancies August 2005 January 2009
NCT00145613 Completed Phase 2 Haploidentical Stem Cell Transplant for Treatment Refractory Hematological Malignancies June 2003 February 2009
NCT00145626 Completed Phase 2 HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic Malignancies May 2004 July 2016
NCT00152139 Completed Phase 3 Stem Cell Transplantation for Patients With Hematologic Malignancies May 2002 January 2009
NCT00219726 Completed Phase 2 Safety and Efficacy of Imatinib in Chronic Myelogenous Patients in Relapse After Stem Cell Transplantation May 2002 July 2007
NCT00219739 Completed Phase 3 STI571 ProspectIve RandomIzed Trial: SPIRIT September 2003 December 2014
NCT00632255 Completed Long Term Therapy With Imatinib: Development of Late Side Effects and Compliance to Treatment January 2008 May 2009
NCT00750659 Completed Phase 2 Nilotinib Pre and Post Allogeneic Stem Cell Transplantation July 2009 April 2016
NCT00786812 Completed Phase 4 Study of Treatment With Nilotinib in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase August 2008 January 2012
NCT00815321 Completed Phase 2 Autologous Cytokine Induced Killer Cells (CIK) for Chronic Myeloid Leukemia (CML) Patients on Standard Drug Therapy December 2008 November 2011
NCT00827138 Completed Phase 1 Study Safety and Preliminary Efficacy of DCC-2036 in Patients With Leukemias (Ph+ CML With T315I Mutation) March 2009 January 2013
NCT00845221 Completed Phase 4 Glivec in Pediatric Chronic Myeloid Leukemia (CML) July 2004
NCT00852566 Completed Phase 2 Randomized Study Comparing the Effect of Dasatinib and Imatinib on Malignant Stem Cells in Chronic Myeloid Leukemia March 2009 December 2015
NCT00858806 Completed Phase 2 Intermittent Imatinib Treatment in Chronic Myeloid Leukemia and Philadelphia Chromosome (Ph+CML) Patients Who Achieved a Complete Cytogenetic Response (CCgR) on Standard Imatinib Therapy April 2008 December 2014
NCT00866736 Completed Phase 2 A Study of Dasatinib in Patients With Imatinib Resistant or Intolerant Chronic Myeloid Leukemia March 2009 June 2012
NCT00896129 Completed Mid-to Long-Term Outcomes in Chronic Myeloid Leukemia (CML) Patients With Complete Cytogenetic Response After Imatinib as First Line Therapy March 2010 December 2010
NCT00947830 Completed Investigating Intracellular and Plasma Imatinib Levels in Chronic Myeloid Leukemia July 2009 April 2012
NCT00988013 Completed N/A Intensity Modulated Total Marrow Irradiation (IM-TMI) for Advanced Hematologic Malignancies September 2009 February 2016
NCT01068301 Completed Phase 1 A Pediatric Study of a Plerixafor Containing Regimen In Second Allogeneic Stem Cell Transplantation May 2010 October 2013
NCT01077544 Completed Phase 1 A Pharmacokinetic (PK) Study of Nilotinib in Pediatric Patients With Philadelphia Chromosome-positive (Ph+) Chronic Myelogenous Leukemia (CML) or Acute Lymphoblastic Leukemia (ALL) April 14, 2011 July 1, 2015
NCT01114087 Completed N/A Impact of the Inhibitors of Tyrosine Kinase on the Male Fertility October 2008 May 2009
NCT01126892 Completed Phase 3 A Study of Nilotinib in Adult Patients With Imatinib Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase January 2009 April 2011
NCT01167166 Completed Phase 1/Phase 2 Safety and Efficacy of 72-hour and 120-hour Infusion of Rigosertib in Acute Myeloid Leukemia (AML) and Acute Lymphoid Leukemia (ALL) July 2010 June 2014
NCT01207440 Completed Phase 2 Ponatinib for Chronic Myeloid Leukemia (CML) Evaluation and Ph+ Acute Lymphoblastic Leukemia (ALL) September 30, 2010 January 17, 2019
NCT01215487 Completed A Study Investigating the Predictive Value of Philadelphia Positive Stem Cell Properties in Newly Diagnosed Patients With Chronic Myeloid Leukemia in Chronic Phase Receiving Treatment With Imatinib October 2010 May 31, 2020
NCT01220648 Completed Phase 1 Determining the Maximum Tolerated Dose of Low Dose Interferon-alpha in Conjunction With Nilotinib in Pretreated Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP) April 2012 January 2014
NCT01223898 Completed Phase 1 To Evaluate the Effects of Multiple Doses of Nilotinib on the Pharmacokinetics and Metabolism of Midazolam in CML Patients With Additional Extension Phase to Evaluate the Safety of Nilotinib June 2010 December 2013
NCT01244750 Completed Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting December 2, 2010 January 8, 2020
NCT01252589 Completed Patient Reported Outcomes in Chronic Myeloid Leukemia November 2010 September 2013
NCT01254188 Completed Phase 3 Safety and Efficacy of Nilotinib in Newly Diagnosed Chronic Myeloid Leukemia Patients April 2011 November 2014
NCT01270984 Completed Phase 1 Study to Evaluate the Pharmacokinetic Characteristics of Luckyvec 400mg Tablet, in Healthy Subjects November 2010 December 2010
NCT01275196 Completed Phase 3 Safety and Efficacy of Nilotinib vs. Imatinib in the Treatment of Newly Diagnosed Chinese Ph+ CML-CP Patients April 2011 October 2014
NCT01290302 Completed Phase 1 Bioequivalence Trial of Luitpold Azacitidine Versus Vidaza® in Patients With Myelodysplastic Syndrome, Myelofibrosis, Chronic Myeloid Leukemia or Chronic Lymphocytic Leukemia October 2010
NCT01297543 Completed Phase 1/Phase 2 Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Chemotherapy for Leukemia March 2011 January 2015
NCT01342679 Completed Phase 2 A Study of Complete Molecular Response for Chronic Myeloid Leukemia in Chronic Phase Patients, Treated With Dasatinib April 2011 September 2014
NCT01344876 Completed Phase 1 Phase I Study of OPB-51602 in Patients With Hematologic Malignancies April 2011 April 2014
NCT01350245 Completed Phase 2 Bone Marrow Transplantation of Patients in Remission Using Partially Matched Relative Donor July 2010 May 2014
NCT01394666 Completed Non-interventional Treatment Patterns Study in Chronic Phase Chronic Myelogenous Leukemia (CP-CML) May 2011 December 2012
NCT01490853 Completed Follow-up of Ph+ Chronic Myleoid Leukemia Patients in Complete Cytogenetic Response With Interferon Based Therapy October 2009 December 2014
NCT01535391 Completed Phase 3 Nilotinib in PH+, BCR-, ABL+ CML Patients January 2012 April 27, 2018
NCT01572662 Completed Phase 2 Allogeneic Transplantation Using Timed Sequential Busulfan and Fludarabine Conditioning April 11, 2012 August 11, 2022
NCT01578213 Completed Phase 4 Validation of Digital-PCR Analysis Through Programmed Imatinib Interruption in PCR Negative CML Patients November 9, 2011 November 28, 2018
NCT01596114 Completed Phase 3 European Stop Tyrosine Kinase Inhibitor Study May 30, 2012 December 31, 2019
NCT01606579 Completed Phase 1/Phase 2 Safety and Efficacy Study of PRI-724 in Subjects With Advanced Myeloid Malignancies July 2012 December 30, 2016
NCT01657604 Completed Phase 3 TKI and Interferon Alpha Evaluation Initiated by the German Chronic Myeloid Leukemia Study Group - the TIGER Study August 24, 2012 May 31, 2022
NCT01683123 Completed Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical Sibling Donor HSCT July 2007 October 2012
NCT01751919 Completed Phase 1 A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I) May 2012 August 2012
NCT01795716 Completed Phase 1 Bioequivalence Study of Mesylate Imatinib Capsule in Chronic Myeloid Leukemia Body September 2012 June 2013
NCT01805843 Completed Pulmonary Vasculopathy Under Second-line Therapy of Chronic Myeloid Leukemia July 2012 June 2015
NCT01819558 Completed Phase 1/Phase 2 Phase I/II Study of Immune Therapy After Allograft in Patients With Myeloid Hemopathy March 2013 March 2015
NCT01903733 Completed N/A Bosutinib Treatment Extension Study Only For Subjects With Chronic Myeloid Leukemia (CML) Who Have Previously Participated In Bosutinib Studies B1871006 Or B1871008 August 28, 2013 June 5, 2020
NCT02011945 Completed Phase 1 A Phase 1B Study to Investigate the Safety and Preliminary Efficacy for the Combination of Dasatinib Plus Nivolumab in Patients With Chronic Myeloid Leukemia February 7, 2014 December 26, 2018
NCT02016833 Completed Development of Immunological Assays for the Evaluation of Tumor Antigen Specific Immunity October 2013 December 2014
NCT02057185 Completed Occupational Status and Hematological Disease September 8, 2014 November 11, 2015
NCT02103322 Completed Phase 2/Phase 3 Comparative Bioequivalence Study in Adult Patients Suffering From Chronic Myeloid Leukemia & Gastrointestinal Stromal Tumor Under Fed Conditions February 2014 June 2014
NCT02129582 Completed Phase 1 Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies November 5, 2014 March 5, 2020
NCT02253277 Completed Phase 1 Safety and Tolerability of Combined Treatment With Nilotinib and Ruxolitinib in CML and Ph+ ALL Patients February 18, 2015 April 3, 2018
NCT02353728 Completed Phase 2 Stem Cell Monitoring for CML Patients Undergoing Nilotinib Therapy January 2015 February 2021
NCT02487069 Completed N/A Allo-HSCT With Alternative Donor in Treatment of Hematologic Malignancy June 2015 February 29, 2020
NCT02546674 Completed Phase 4 Study Assessing Deep Molecular Response in Adult Patients With CML in Chronic Phase Treated With Nilotinib Firstline. February 18, 2016 March 25, 2021
NCT02556931 Completed Phase 2 Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies December 2015 April 2021
NCT02707393 Completed Phase 2/Phase 3 Allogeneic Stem Cell Transplantation for Children With CML April 30, 2009 December 1, 2020
NCT02767388 Completed Electrophysiological Biomarkers of Chemotherapy-related Cognitive Impairment and Recovery September 1, 2016 March 15, 2018
NCT02810990 Completed Phase 2 Bosutinib in Elderly Chronic Myeloid Leukemia November 17, 2016 June 22, 2022
NCT02842320 Completed N/A Targeting Leukemic Stem Cell Expressing the IL-1RAP Protein in Chronic Myelogenous Leukemia (CML) October 14, 2015 July 15, 2020
NCT02890758 Completed Phase 1 Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803 May 22, 2018 February 17, 2023
NCT02895542 Completed Preparatory Work to Assess Adherence to Oral Chemotherapy December 20, 2016 April 28, 2017
NCT02896829 Completed Follow-up of the Persistence of the Complete Molecular Remission After Stopping Imatinib Chronic Myeloid Leukemia April 3, 2013 April 2019
NCT03018223 Completed Phase 1 Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT January 31, 2017 March 18, 2021
NCT03262974 Completed Effect of Pharmacogenetics on Imatinib Plasma Level and Response October 29, 2017 October 1, 2023
NCT03455517 Completed Phase 2 Activity and Safety of Front-line Venetoclax and Rituximab in Young and Fit Patients With Chronic Lymphocytic Leukemia October 31, 2018 May 11, 2023
NCT03509896 Completed Study of Chinese Newly Diagnosed Participants With Philadelphia Chromosome-Positive (Ph+) Chronic Myeloid Leukemia in Chronic Phase (CML-CP) November 30, 2017 September 28, 2019
NCT03540654 Completed Budget Impact Analysis of Discontinuing Tyrosin Kinase Inhibitors in Patients With Chronic Myeloid Leukemia Achieving a Complete Molecular Response by Using Probabilistic Markov Approach December 7, 2016 April 2019
NCT03678454 Completed Iclusig® (Ponatinib) in Clinical Practice for the Treatment of Chronic Myeloid Leukemia or Ph+ Acute Lymphoblastic Leukemia in Belgium February 3, 2017 March 31, 2022
NCT03885830 Completed Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients June 20, 2019 June 15, 2022
NCT03996096 Completed Tyrosine Kinase Inhibitor Withdrawal Syndrome in CML Patients: Observatory Trial Studying the Biological Factors. April 23, 2019 March 16, 2023
NCT04048564 Completed Observational Study on CML Patients in Any Phase of the Disease Treated With Ponatinib (Iclusig®) February 23, 2018 July 3, 2023
NCT04089839 Completed A Study of Dasatinib Management Among CP-CML (Chronic Phase, Chronic Myeloid Leukemia) Participants Initiating Dasatinib in a Real Life Setting April 21, 2016 January 16, 2020
NCT04595955 Completed N/A Effects of a Digital Patient Platform (CMyLife) for Patients With Chronic Myeloid Leukemia (CML) on Information Provision, Patient Empowerment, Medication Compliance, Guideline Adherence and Quality of Life July 1, 2019 August 31, 2020
NCT04605211 Completed N/A A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors September 18, 2020 September 30, 2022
NCT05260203 Completed N/A MargheRITA (Remote Intelligence for Therapeutic Adherence) June 4, 2022 January 16, 2023
NCT05387330 Completed Dynamic Changes in the Levels of sCD62L and SPARC in Chronic Myeloid Leukemia Patients During Imatinib Treatment April 1, 2018 December 28, 2021
NCT05421091 Completed Special Drug Use-results Surveillance of Scemblix Tablets July 4, 2022 February 29, 2024
NCT05433532 Completed Phase 2 Study of Azacitidine,Venetoclax,and Flumatinib in Newly Diagnosed Ph-positive Acute Leukemia and CML-AP/BP Patients May 1, 2022 April 13, 2024
NCT05476562 Completed Study Conducted Among Patients With CML March 8, 2021 October 15, 2021
NCT05611216 Completed Clinical Outcomes of 3L+ Therapies Among Patients With Chronic Myeloid Leukemia and Those With T315I Mutation December 1, 2020 December 23, 2021
NCT05619978 Completed French Study to Highlight the Unmet Treatment Needs of 3L+ CP-CML and With T315I-mutated CML Patients May 3, 2021 October 29, 2021
NCT05734053 Completed Nilotinib for Patients With Chronic Myeloid Leukemia in First Line and Any Subsequent Line June 28, 2016 September 8, 2022
NCT06042660 Completed Comorbidity Burden and Use of Concomitant Medications at CML Diagnosis February 2016 August 2016
NCT06148493 Completed Real-World Usage of Asciminib Among Patients With Chronic Myeloid Leukemia in Chronic Phase in the United States Using a Large Claims Database September 20, 2022 December 15, 2022
NCT01200017 No longer available Expanded Access Protocol (EAP) Using the CliniMACS® Device for Pediatric Haplocompatible Donor Stem Cell Transplant
NCT01549548 No longer available Compassionate Use Ponatinib
NCT00302016 No longer available Expanded Access Program of AMN107 in Imatinib-resistant or Intolerant Adult Patients With Chronic Myeloid Leukemia January 2006
NCT02258490 No longer available Expanded Use of G-CSF Mobilized Donor CD34+ Selected Cells for Allogeneic Transplantation
NCT06398457 Not yet recruiting Early Phase 1 Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies June 2024 December 2026
NCT06423911 Not yet recruiting Phase 3 A Phase 3 Registrational Study of Olverembatinib (HQP1351) in Patients With CML May 2024 February 2026
NCT06390306 Not yet recruiting The Efficacy and Safety of Third-generation TKIs Combined With Azacitidine and Bcl-2 Inhibitor in Patients With CML-MBP May 1, 2024 December 1, 2026
NCT06355583 Not yet recruiting Phase 2 Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) Trial April 15, 2024 May 1, 2027
NCT05440747 Not yet recruiting Treatment Free Remission (TFR) in CML Patients (CML-CP)Study July 31, 2022 October 31, 2031
NCT06163430 Not yet recruiting Phase 1 CARDINAL- A Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia December 13, 2023 May 31, 2026
NCT06409936 Not yet recruiting Phase 2 PEARL Study: PotEntial of Asciminib in the eaRly Treatment of CML September 2024 September 2031
NCT06453902 Not yet recruiting Phase 2 TGRX-678 Chinese Phase II in Chronic Myelogenous Leukemia (CML) Patients June 15, 2024 December 15, 2027
NCT04626024 Recruiting Phase 2 Safety And Efficacy Of TKI Cessation For CML Patients With Stable Molecular Response In A Real World Population December 22, 2020 November 15, 2025
NCT05282108 Recruiting Efficacy and Safety of Generic Imatinib (Carcemia®) Compared to Glivec® in Real-Life Management of Chronic Phase of Chronic Myeloid Leukemia July 20, 2022 August 2024
NCT05304377 Recruiting Phase 1 A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia May 22, 2022 December 2026
NCT05334069 Recruiting Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection August 1, 2022 February 2025
NCT05362773 Recruiting Phase 1 A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies July 13, 2022 March 2025
NCT06229860 Recruiting Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Pts w/Chronic Myeloid Leukemia January 25, 2024 January 2026
NCT05400122 Recruiting Phase 1 Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer September 9, 2022 June 1, 2026
NCT05413915 Recruiting Phase 3 Asciminib Used in Consolidation With Imatinib vs. Imatinib to Achieve TFR in CP-CML June 19, 2023 December 2025
NCT06236724 Recruiting Phase 2 Phase II Study Assessing Efficacy and Safety of Asciminib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase. January 31, 2024 July 1, 2035
NCT05605379 Recruiting CML Pediatric ITK Response According to Molecular Identification at Diagnosis February 27, 2023 March 2024
NCT03326310 Recruiting Phase 1 Selumetinib and Azacitidine in High Risk Chronic Blood Cancers September 4, 2018 September 4, 2025
NCT05701215 Recruiting Phase 2 Venetoclax After TKI to Target Persisting Stem Cells in CML August 31, 2023 December 1, 2025
NCT03533816 Recruiting Phase 1 Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide January 31, 2020 January 2025
NCT05753384 Recruiting Phase 3 Discontinuation of TyrosIne Kinase Inhibitors (TKI) in Chronic Myeloid Leukemia (CML) and Impact on the Immune System December 1, 2023 December 1, 2029
NCT05768711 Recruiting Phase 2 Azacitidine Combined With Venetoclax in Patients With Higher-risk Chronic Myelomonocytic Leukemia (AVENHIR) October 4, 2023 October 2028
NCT03802695 Recruiting Phase 1 A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies April 8, 2019 April 2028
NCT03831776 Recruiting Phase 2 Long-acting Low Dose Ropeginterferon for Chronic Myeloid Leukemia Treated With Bosutinib From Diagnosis March 25, 2019 March 2028
NCT05800210 Recruiting Phase 2 Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases May 3, 2024 May 2027
NCT05943522 Recruiting Asciminib RMP Study July 19, 2023 July 31, 2025
NCT04028479 Recruiting The Registry of Oncology Outcomes Associated With Testing and Treatment May 5, 2021 October 1, 2031
NCT06001385 Recruiting Phase 2 HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis December 8, 2023 June 30, 2026
NCT01281735 Recruiting International Chronic Myeloid Leukemia Pediatric Study January 2011 December 2028
NCT04167683 Recruiting Muscle Dysfunction in Patients With Hematological Diseases Referred to Stem Cell Transplant October 1, 2023 December 31, 2026
NCT04260022 Recruiting Phase 1 Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL January 9, 2020 January 31, 2024
NCT06092879 Recruiting Asciminib Prospective Non Interventional Study as 3rd Line Therapy or More to Treat Adult Patients With CML- CP in Real World Setting in France March 6, 2024 December 15, 2026
NCT04621851 Recruiting Retro-prospective Observational Study on Risk of Progression in CP-CML Patients Eligible for TKI Discontinuation September 30, 2020 September 30, 2023
NCT04663100 Recruiting N/A Oral Adherence in Hematological Oncology Agents and Impact on Comorbid Therapy Adherence February 8, 2021 December 31, 2023
NCT04769947 Recruiting Italian Treatment Free Remission Registry August 9, 2021 February 8, 2030
NCT04835584 Recruiting Phase 1/Phase 2 KRT-232 and TKI Study in Chronic Myeloid Leukemia May 7, 2021 June 30, 2026
NCT04943757 Recruiting Phase 2 Post-transplantation Benadamustine and Cyclophosphamide in Patients With Refractory Myeloid Malignancies January 21, 2021 December 31, 2024
NCT01860456 Recruiting TyrosIne Kinase Inhibitors in Chronic Myeloid Leukemia: Efficacy and Tolerability. The TIKlet Study May 2013 December 31, 2024
NCT05115630 Recruiting Phase 1/Phase 2 Off-the-shelf NK Cells + SCT for Myeloid Malignancies April 8, 2022 June 1, 2024
NCT05130138 Recruiting N/A Interest of PHARMaceutical Conciliation to Understand Drug Interactions, Phytotherapy, and Targeted Therapies in Chronic Myeloid Leukemia January 27, 2022 November 1, 2025
NCT05236764 Recruiting N/A Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion December 6, 2023 August 1, 2030
NCT03326921 Suspended Phase 1 HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant February 23, 2018 July 16, 2028
NCT04151706 Suspended Phase 2 CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML February 27, 2020 February 2026
NCT04595851 Terminated N/A Pharmacists Coordinated Care Oncology Model (PCOM) for Patients Taking Oral Anti-cancer Medications March 26, 2021 July 14, 2022
NCT00895297 Terminated Phase 2 Efficacy and Safety Study of Dasatinib in Patients With Chronic Myeloid Leukemia February 2010 November 2011
NCT00968864 Terminated Phase 2 T-cell Depleted Alternative Donor Transplantation August 2009 November 2016
NCT01866553 Terminated Phase 2 Nilotinib Plus Pegylated Interferon-α2b in CML April 2013 May 1, 2016
NCT02174445 Terminated Phase 3 An Open-label, Randomised Multicenter Phase 3b Study to Determine the Confirmed Rate of Molecular Response ≥ 4 Log (MR4) at Two Years March 2014 October 2019
NCT02448095 Terminated Retrospective Evaluation of CML Patients in the National Compassionate Program December 22, 2015 July 17, 2018
NCT00593554 Terminated Phase 2 Phase 2 Haplotype Mismatched HSCT in Patients With Hematological Malignancies August 7, 2007 July 28, 2017
NCT02204722 Terminated Phase 4 A Study to Evaluate Efficacy and Safety of Glinib in Newly Diagnosed CML Patients October 13, 2014 January 9, 2018
NCT00573378 Terminated Phase 2 Imatinib or Nilotinib With Pegylated Interferon-α2b in Chronic Myeloid Leukemia September 2007 December 2015
NCT01650805 Terminated Phase 3 Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC) June 2012 October 2013
NCT02709083 Terminated Phase 2 Dasatinib or Nilotinib Followed by Imatinib in Patients With Newly Diagnosed, Chronic Phase Chronic Myeloid Leukemia October 2016 July 2018
NCT02078960 Terminated Phase 1/Phase 2 A Study to Evaluate the Pharmacokinetics, Safety,and Efficacy of Omacetaxine Given Subcutaneously as a Fixed Dose in Patients With Chronic Phase (CP) or Accelerated Phase (AP) Chronic Myeloid Leukemia (CML) (Referred to as the SYNSINCT Study) October 9, 2014 November 27, 2017
NCT00522990 Terminated Phase 1/Phase 2 Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemias September 2006 April 2009
NCT01169753 Terminated N/A Nuvigil in Treatment of Cancer-Related Fatigue in Chronic Myeloid Leukemia Patients May 2011 February 2013
NCT00464113 Terminated Phase 1 Study of XL228 in Subjects With Chronic Myeloid Leukemia or Philadelphia-Chromosome-Positive Acute Lymphocytic Leukemia May 2007 April 2011
NCT01749111 Terminated Phase 3 Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin Inhibitor for GVHD Prophylaxis December 2012 August 2016
NCT00511121 Terminated Phase 2 Study of the Combination of a Tyrosine Kinase Inhibitor (STI571) and a Pegylated Human Recombinant Interferon alfa2b (PEGINTRON) April 2001
NCT00461929 Terminated Phase 4 Chromosome Abnormalities in Chronic Myeloid Leukemia (CML) on Imatinib. GIST Patients on Imatinib February 2005 December 2008
NCT03696537 Terminated Phase 1 IMRT-TMI With Fludarabine as Myeloablative Conditioning for Allogeneic HSCT August 29, 2018 April 13, 2021
NCT00790855 Terminated Phase 1/Phase 2 Bendamustine in Acute Leukemia and MDS November 2008 March 2012
NCT00531310 Terminated Phase 2 Reduced Intensity AlloSCT in(CML) With Persistent Disease January 2003 June 2010
NCT00219765 Terminated Phase 1/Phase 2 Safety and Efficacy of Imatinib in Combination With High Dose Chemotherapy for Acute Phase Chronic Myelogenous Patients May 2001 January 2006
NCT01073436 Terminated Discontinuation of Imatinib Mesylate in Patients With Chronic-Phase Chronic Myeloid Leukemia Previously Treated With Interferon-Alpha May 2009 November 2011
NCT01490983 Terminated N/A Telemonitoring Study - for Chronic Myeloid Leukemia (CML) April 2009 December 2014
NCT02869256 Unknown status Regional Central Database Recording of Chronic Myeloid Leukemia January 2014 January 2024
NCT03062436 Unknown status N/A To Study the Impact of Stopping Therapy in Patients of CML With Molecular Remission August 1, 2017 December 2020
NCT03075969 Unknown status Phase IV EORTC Quality of Life Module for Patients With Chronic Myeloid Leukemia August 3, 2017 December 2019
NCT03228303 Unknown status Early Phase 1 Nilotinib Versus Imatinib in Treatment of Patients With Newly Diagnosed Chronic Myeloid Leukemia December 1, 2017 August 1, 2020
NCT03241199 Unknown status Phase 2 The Efficacy and Safety of Induction-Maintenance Protocol for Patients With Chronic Myelogenous Leukaemia August 1, 2017 January 1, 2021
NCT00146913 Unknown status Phase 2 AFR10 - Combination Therapy of Imatinib Mesylate (IM) + Alpha-2A Interferon for Chronic Phase CML Patients Resistant or Refractory to IM Used as Single Therapy for at Least One Year March 2004
NCT00598624 Unknown status Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Treosulfan Based Conditioning Prior to Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) September 2005 December 2010
NCT03625583 Unknown status The Hong Kong CML Registry April 1, 2018 September 30, 2023
NCT01761890 Unknown status Front-line Treatment of BCR-ABL+ Chronic Myeloid Leukemia (CML) With Dasatinib January 28, 2014 December 2022
NCT00965224 Unknown status Phase 2 Efficacy of Dendritic Cell Therapy for Myeloid Leukemia and Myeloma January 2010
NCT03795779 Unknown status Early Phase 1 CLL1-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignancies March 1, 2018 September 30, 2022
NCT04818619 Unknown status TIGIT in Patients With Chronic Myeloid Leukemia April 2021 December 2022
NCT01802450 Unknown status Phase 2 Dasatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase March 2013 December 2016
NCT00328237 Unknown status Phase 2 Treatment of Hematologic Malignancies With Single-Unit or Double-Unit Cord Blood Transplantation November 2005
NCT02268370 Unknown status Phase 2 Treatment-free Remission Accomplished With Dasatinib in Patients With CML October 2014 October 2021
NCT00327262 Unknown status Phase 3 Comparing Imatinib Standard Dose With Imatinib High Dose Induction in Pretreated Chronic Myeloid Leukemia (CML) Patients in Chronic Phase January 2004 December 2008
NCT02164903 Unknown status LEONIDAS: Quality of Life Study in Chronic Myeloid Leukemia Patients September 11, 2014 October 2018
NCT04043676 Unknown status Phase 2 Consolidation Treatment With Ponatinib 15 mg on Treatment Free-Remission Rate in Patients With Chronic Myeloid Leukemia April 30, 2019 April 30, 2023
NCT04104035 Unknown status Leukemic Stem Cell Detection for Chronic Myeloid Leukemia Patients With Major Molecular Response August 13, 2019 January 2021
NCT04991532 Unknown status Dasatinib Down-regulates the Expression of PD-1 and Enhances Killing pH + Leukemia Stem Cells June 20, 2021 December 2022
NCT04155411 Unknown status Phase 4 Dose Reduced Dasatinib (70 mg Daily) as First-line Treatment for Newly Diagnosed CML-CP December 1, 2019 December 1, 2023
NCT04156256 Unknown status Early Phase 1 CD123-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignancies March 1, 2018 September 30, 2020
NCT02007811 Unknown status Phase 1/Phase 2 Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination November 2013 December 2015
NCT02422719 Unknown status Phase 2 Radotinib as 3rd or Later Line Therapy in CP-CML April 2015 March 2019
NCT02172365 Unknown status Allogeneic SCT for CML, TKI Failure After TKI Failure March 1, 2014 December 30, 2020
NCT01400074 Unknown status Phase 3 Efficacy of Nilotinib Versus Imatinib in Ph+ CML in Early CP Who Have a Suboptimal Molecular Response to Imatinib January 2009 June 2014
NCT02398825 Unknown status Phase 2 Activity and Risk Profile of Ponatinib in Chronic Phase Patients With Chronic Myeloid Leukemia Resistant to Imatinib June 23, 2016 February 2023
NCT01562847 Unknown status Prospective Investigation of Dynamics of ABL Mutations in Imatinib Failed CML Patients Treated With Nilotinib July 2011 June 2015
NCT01564836 Unknown status N/A Discontinuation Study of Imatinib in Adult CP CML Patients Who Have a Complete Molecular Response to Imatinib June 2010
NCT02317159 Unknown status Phase 4 Efficacy and Safety of Imatinib Mesylate as First-line Treatment for the Patients With Chronic Phase of Chronic Myeloid Leukemia February 2015 July 2017
NCT01627132 Unknown status Phase 2 Discontinuation of Dasatinib in Patients With Chronic Myeloid Leukemia-CP Who Have Maintained Complete Molecular Remission for Two Years; Dasatinib Stop Trial February 2012 January 2019
NCT02885766 Unknown status Phase 1/Phase 2 Study to Evaluate Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy of PF-114 for Oral Administration in Adults With Ph+ Chronic Myeloid Leukemia, Which is Resistant to the 2-nd Generation Bcr-Abl Inhibitors or Has T315I Mutation in the BCR-ABL Gene July 2016 May 2020
NCT02883036 Unknown status Vitro Study of Tigecycline to Treat Chronic Myeloid Leukemia September 2016
NCT03348033 Unknown status Phase 1/Phase 2 Safety and Feasibility of the Use of Natural Killer Cells in Patients With Chronic Myeloid Leukemia March 2019 March 2023
NCT03353558 Unknown status Sleep Assessment in CML December 2017 December 2018
NCT02201459 Unknown status Phase 3 Nilotinib ± Peg-IFN for First Line Chronic Phase CML Patients August 2014 August 2019
NCT01752062 Unknown status Observational Study of Conception/Pregnancy in Adult Patients With CML Treated With Tyrosine Kinase Inhibitors May 2, 2013 December 2022
NCT04464889 Withdrawn Phase 1 HA-1H TCR T Cell for Relapsed/Persistent Hematologic Malignancies After Allogeneic Stem Cell Transplantation July 2, 2020 July 2025
NCT02663648 Withdrawn Cell Cycle Regulatory Gene Study in Patients With Myeloproliferative Disorders June 2016 June 2020
NCT01188889 Withdrawn Phase 1/Phase 2 RAD001 in Patients With Chronic Phase Chronic Myeloid Leukemia w/ Molecular Disease. September 2013 December 2017
NCT02115672 Withdrawn Phase 1/Phase 2 Imatinib and BL-8040 (Novel Anti CXCR4 Antagonist) for Improving Molecular Response in Chronic Myelogenous Leukemia November 2014 November 2018
NCT00162513 Withdrawn Phase 1/Phase 2 Allogeneic Tumor Cell Vaccination in Patients With Chronic Myeloid Leukemia December 2006
NCT05201183 Withdrawn Phase 1/Phase 2 A Dose Escalation Study of Intensity Modulated Total Marrow Irradiation (IMRT-TMI) Followed by Fludarabine as a Myeloablative Conditioning Regimen for Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Relapsed and Refractory Hematologic Malignancies October 2023 April 2029
NCT00570999 Withdrawn Phase 2 Palifermin After Haploidentical PBSCT February 2008 January 2013
NCT00349518 Withdrawn Phase 2/Phase 3 Study of Dasatinib in Imatinib Resistant or Intolerant Subjects With Chronic or Advanced Phase CML or Philadelphia Chromosome Positive ALL December 2006
Disase is a (Disease Ontology)
DOID:8692
Cross Reference ID (Disease Ontology)
EFO:0000339
Cross Reference ID (Disease Ontology)
GARD:6105
Cross Reference ID (Disease Ontology)
ICD9CM:205.1
Cross Reference ID (Disease Ontology)
ICDO:9863/3
Cross Reference ID (Disease Ontology)
KEGG:05220
Cross Reference ID (Disease Ontology)
MIM:608232
Cross Reference ID (Disease Ontology)
ORDO:521
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:154592009
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0023473
Exact Synonym (Disease Ontology)
chronic granulocytic leukaemia
Exact Synonym (Disease Ontology)
chronic granulocytic leukemia
Exact Synonym (Disease Ontology)
chronic myelogenous leukaemia
Exact Synonym (Disease Ontology)
chronic myelogenous leukemia
Exact Synonym (Disease Ontology)
chronic myeloid leukaemia
Exact Synonym (Disease Ontology)
CML
Exact Synonym (Disease Ontology)
CML - chronic Myelogenous Leukemia
Exact Synonym (Disease Ontology)
Myeloid Leukemia, chronic
OrphaNumber from OrphaNet (Orphanet)
521