Dinaciclib

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Information
Drug Name
Dinaciclib
Description
Entry(CIViC)
1
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
ovarian serous cystadenocarcinoma CCNE1 AMPLIFICATION
( ENST00000262643.8 ) CCNE1 AMPLIFICATION
( ENST00000262643.8 ) 		D Predictive Supports Sensitivity/Response Somatic 4 27663592 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
A high throughput compound screen identified syner... CCNE1 CCNE1 AMPLIFICATION
( ENST00000262643.8 ) CCNE1 AMPLIFICATION
( ENST00000262643.8 ) 		Sensitivity true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT00937937 Active, not recruiting Phase 2 Dinaciclib in Treating Patients With Stage IV Melanoma July 1, 2009 March 8, 2025
NCT01434316 Active, not recruiting Phase 1 Veliparib and Dinaciclib in Treating Patients With Advanced Solid Tumors November 1, 2011 July 1, 2024
NCT01515176 Completed Phase 1/Phase 2 Ofatumumab and Dinaciclib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or B-Cell Prolymphocytic Leukemia January 2012 July 19, 2016
NCT01580228 Completed Phase 3 A Phase 3 Study Comparing Dinaciclib Versus Ofatumumab in Patients With Refractory Chronic Lymphocytic Leukemia (P07714) August 2012 December 2014
NCT01624441 Completed Phase 1 Dinaciclib and Epirubicin Hydrochloride in Treating Patients With Metastatic Triple-Negative Breast Cancer August 21, 2012 September 10, 2013
NCT01096342 Completed Phase 2 Dinaciclib in Treating Patients With Relapsed or Refractory Multiple Myeloma July 2009 December 2012
NCT01676753 Completed Phase 1 Phase 1b Trial of Dinaciclib With Pembrolizumab for Advanced Breast Cancer December 28, 2016 February 28, 2022
NCT01711528 Completed Phase 1 Dinaciclib, Bortezomib, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma December 19, 2012 November 22, 2016
NCT01783171 Completed Phase 1 Dinaciclib and Akt Inhibitor MK2206 in Treating Patients With Pancreatic Cancer That Cannot Be Removed by Surgery January 15, 2013 July 12, 2016
NCT01650727 Completed Phase 1 A Study of Dinaciclib in Combination With Rituximab in Participants With Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (P07974) October 2012 October 2013
NCT01026324 Terminated Phase 1/Phase 2 Dinaciclib in Treating Patients With Stage III-IV Melanoma September 2009 October 2014
NCT02684617 Terminated Phase 1 Study of Pembrolizumab (MK-3475) in Combination With Dinaciclib (MK-7965) in Hematologic Malignancies (MK-3475-155/KEYNOTE-155) March 29, 2016 April 6, 2020
NCT03484520 Terminated Phase 1 A Study of Venetoclax and Dinaciclib (MK7965) in Patients With Relapsed/Refractory Acute Myeloid Leukemia July 23, 2018 December 1, 2022