Metformin
Information
- Drug Name
- Metformin
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| cancer | NRAS MUTATION NRAS MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 25504439 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Preclinical study in 16 NRAS mutant cell lines (me... | NRAS | NRAS MUTATION NRAS MUTATION | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02879409 | Active, not recruiting | N/A | HbA1c Variability in Type II Diabetes | November 2016 | October 1, 2024 |
| NCT02780024 | Active, not recruiting | Phase 2 | Metformin, Neo-adjuvant Temozolomide and Hypo- Accelerated Radiotherapy Followed by Adjuvant TMZ in Patients With GBM | March 2015 | February 28, 2026 |
| NCT04947020 | Active, not recruiting | dataBase for Analysis of Rectal Cancer Oncological Results | August 1, 2021 | December 31, 2024 | |
| NCT00038727 | Active, not recruiting | Phase 3 | Diabetes Prevention Program Outcomes Study | September 2002 | January 2025 |
| NCT03617458 | Active, not recruiting | Phase 2 | Interventions Against Insulin Resistance in Pulmonary Arterial Hypertension | August 23, 2018 | July 2025 |
| NCT00268476 | Active, not recruiting | Phase 2/Phase 3 | Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy | July 8, 2005 | December 2030 |
| NCT01762046 | Active, not recruiting | Phase 1 | Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans | January 2008 | December 2025 |
| NCT02500147 | Active, not recruiting | Phase 4 | Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS) | September 8, 2011 | November 30, 2025 |
| NCT02365597 | Active, not recruiting | Phase 2 | An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer | April 22, 2015 | December 31, 2024 |
| NCT06227832 | Active, not recruiting | Phase 1 | A Study to Determine the Effect of KP-001 on Metformin and Midazolam Pharmacokinetics and the Effect of Clarithromycin on KP-001 Pharmacokinetics in Healthy Adult Participants | December 15, 2023 | July 31, 2024 |
| NCT03606694 | Active, not recruiting | Phase 2 | Effect of Dihydromirycetin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes Mellitus | October 30, 2019 | December 30, 2023 |
| NCT04885530 | Active, not recruiting | Phase 3 | ACTIV-6: COVID-19 Study of Repurposed Medications | June 8, 2021 | November 2024 |
| NCT06042855 | Active, not recruiting | Phase 3 | ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin) | September 5, 2023 | November 2024 |
| NCT03603912 | Active, not recruiting | Phase 4 | Targeting Risk Interventions and Metformin for Atrial Fibrillation (TRIM-AF) | August 24, 2018 | December 2025 |
| NCT01750567 | Active, not recruiting | Phase 2 | A Pilot Study of Metformin Therapy in Patients With Relapsed Chronic Lymphocytic Leukemia (CLL) and Untreated CLL | November 2012 | May 2024 |
| NCT02186847 | Active, not recruiting | Phase 2 | Chemotherapy and Radiation Therapy With or Without Metformin Hydrochloride in Treating Patients With Stage III Non-small Cell Lung Cancer | August 2014 | April 16, 2025 |
| NCT01697566 | Active, not recruiting | Phase 3 | An Endometrial Cancer Chemoprevention Study of Metformin | May 2, 2013 | May 30, 2025 |
| NCT04220021 | Active, not recruiting | Phase 2 | Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD | January 10, 2020 | August 26, 2024 |
| NCT04029480 | Active, not recruiting | Phase 3 | Ertugliflozin Type 2 Diabetes Mellitus (T2DM) Pediatric Study (MK-8835/PF-04971729) (MK-8835-059) | October 8, 2019 | April 23, 2025 |
| NCT01686126 | Active, not recruiting | Phase 2 | Improving the Treatment for Women With Early Stage Cancer of the Uterus | December 2012 | December 2023 |
| NCT01529593 | Active, not recruiting | Phase 1 | Temsirolimus in Combination With Metformin in Patients With Advanced Cancers | March 26, 2012 | June 1, 2024 |
| NCT02087826 | Active, not recruiting | N/A | Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS | April 2014 | December 2024 |
| NCT03499704 | Active, not recruiting | Phase 4 | A Study to Evaluate the Effect of add-on Pioglitazone or Dapagliflozin in Participants With Type 2 Diabetes Mellitus Inadequately Controlled by DPP-4 Inhibitor and Metformin Therapy | February 11, 2020 | June 30, 2024 |
| NCT04341571 | Active, not recruiting | Phase 2 | Effect of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes. | October 24, 2019 | December 2024 |
| NCT03982381 | Active, not recruiting | Phase 4 | SGLT2 Inhibitor or Metformin as Standard Treatment of Early Stage Type 2 Diabetes | September 5, 2019 | October 15, 2025 |
| NCT04300790 | Active, not recruiting | Phase 2 | Study to Evaluate the Effect of Metformin in the Prevention of HG in HR[+]/HER2[-] PIK3CA-mut Advanced BC Patients | October 23, 2020 | June 30, 2026 |
| NCT05708053 | Active, not recruiting | Phase 3 | Cardio-protective Effect of Metformin in Patients Undergoing PCI | December 9, 2019 | December 2024 |
| NCT05280496 | Active, not recruiting | Phase 3 | A Pragmatic Approach to Lower Diabetes Risk After Gestational Diabetes | June 1, 2022 | August 2024 |
| NCT06359015 | Active, not recruiting | Phase 4 | Metformin and Esomeprazole in Preterm Pre-eclampsia | February 11, 2021 | June 2025 |
| NCT01864096 | Active, not recruiting | Phase 3 | The Metformin Active Surveillance Trial (MAST) Study | October 2013 | August 2024 |
| NCT03006172 | Active, not recruiting | Phase 1 | To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer | December 13, 2016 | November 30, 2024 |
| NCT05680129 | Active, not recruiting | Phase 3 | A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Dulaglutide in Participants With T2DM | January 10, 2023 | October 3, 2024 |
| NCT05519813 | Active, not recruiting | Phase 4 | Effects of Pioglitazone Combined With Metformin on Gonadal and Metabolic Profiles in Chinese Nonobese PCOS Patients. | January 1, 2022 | March 20, 2023 |
| NCT02946996 | Active, not recruiting | Phase 2 | Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy | December 28, 2016 | May 31, 2024 |
| NCT03800602 | Active, not recruiting | Phase 2 | Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer | January 15, 2019 | January 31, 2025 |
| NCT03710343 | Active, not recruiting | Phase 2 | Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study | November 14, 2023 | March 31, 2025 |
| NCT04248998 | Active, not recruiting | Phase 2 | Calorie Restriction With or Without Metformin in Triple Negative Breast Cancer | May 5, 2020 | May 1, 2024 |
| NCT01797523 | Active, not recruiting | Phase 2 | A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma | October 7, 2013 | October 31, 2025 |
| NCT00263276 | Completed | Phase 2 | A Trial of BMS-512148 in Patients With Type 2 Diabetes Mellitus | December 2005 | February 2007 |
| NCT00266253 | Completed | Phase 2 | A Study of GK Activator (2) in Patients With Type 2 Diabetes Mellitus Treated With a Stable Dose of Metformin | November 2005 | March 2007 |
| NCT00272064 | Completed | Phase 3 | ELEONOR STUDY: Insulin Glulisine in Type 2 Diabetes Mellitus. | October 2005 | May 2008 |
| NCT00279045 | Completed | Phase 3 | Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide | January 3, 2000 | June 19, 2006 |
| NCT00279240 | Completed | Phase 1 | Life Style Modifications Prevents Type 2 Diabetes in Asian Indians | March 2001 | December 2004 |
| NCT00283816 | Completed | Phase 3 | Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy | January 2006 | January 2008 |
| NCT00286442 | Completed | Phase 3 | Efficacy and Safety of Alogliptin Combined With Metformin in Participants With Type 2 Diabetes Mellitus | March 2006 | June 2007 |
| NCT00295633 | Completed | Phase 3 | A Study Assessing Saxagliptin Treatment in Type 2 Diabetic Subjects Who Are Not Controlled With TZD Therapy Alone | March 2006 | October 2008 |
| NCT00313313 | Completed | Phase 3 | A Study of Saxagliptin in Subjects With Type 2 Diabetes Who Have Inadequate Blood Sugar Control With Sulfonylureas | April 2006 | September 2008 |
| NCT00316082 | Completed | Phase 3 | Study of BMS-477118 as Monotherapy With Titration in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise | June 2006 | November 2008 |
| NCT00316758 | Completed | Phase 2 | A Study to Evaluate the Long-Term Safety and Tolerability of GK Activator (2) in Patients With Type 2 Diabetes. | February 2006 | October 2007 |
| NCT00318461 | Completed | Phase 3 | To Compare the Effect of Liraglutide When Given Together With Metformin With the Effect of Metformin Given Alone and With the Effect of Glimepiride and Metformin Given Together | May 2006 | November 2008 |
| NCT00327015 | Completed | Phase 3 | A Phase 3 Study of BMS-477118 in Combination With Metformin in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise | May 2006 | December 2008 |
| NCT00328172 | Completed | Phase 2 | Efficacy and Safety of 3 Doses of BI1356 (Linagliptin) in Type 2 Diabetes Patients | May 2006 | |
| NCT00331851 | Completed | Phase 3 | Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes | May 2006 | April 2007 |
| NCT00333151 | Completed | Phase 3 | Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 Diabetes | May 2006 | August 2007 |
| NCT00347100 | Completed | Phase 4 | Insulin Glargine in Type 2 Diabetic Patients | June 2006 | |
| NCT00350779 | Completed | Phase 3 | Sitagliptin Metformin/PPARg Agonist Combination Therapy Add-on (0431-052) | June 12, 2006 | June 11, 2008 |
| NCT00353691 | Completed | Phase 3 | Glimepiride vs Metformin as Monotherapy in Pediatric Subjects With Type 2 Diabetes Mellitus | October 2002 | November 2004 |
| NCT00358124 | Completed | Phase 4 | Insulin Glargine v Rosiglitazone as add-on Therapy in Patients Failing Sulfonylurea and Metformin Combination Therapy | January 2001 | June 2002 |
| NCT00359112 | Completed | Phase 3 | AVANDAMET Versus Metformin And Sulphonylurea In People With Poorly Controlled Type 2 Diabetes | February 2004 | |
| NCT00360698 | Completed | Phase 4 | Insulin Glulisine in Type 2 Diabetic Patients | July 2006 | August 2008 |
| NCT00362323 | Completed | Phase 3 | Fenofibrate and Metformin Fixed Combination vs Metformin - FAME METFO | October 2006 | March 2009 |
| NCT00367055 | Completed | Phase 4 | Rosiglitazone-Metformin Combination Versus Metformin-Sulfonylurea Combination On Beta-Cell Function In Type 2 Diabetes | October 2004 | October 2008 |
| NCT00373178 | Completed | Phase 4 | Metabolic Effects of Treatment in Patients With Recently Diagnosed Type 2 Diabetes | January 2005 | June 2008 |
| NCT00379769 | Completed | Phase 3 | RECORD: Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes | April 2001 | December 2008 |
| NCT00382096 | Completed | Phase 3 | Efficacy of Fixed Combination Therapy of Vildagliptin and Metformin Compared to the Individual Monotherapy Components in Drug Naive Patients With Type 2 Diabetes | September 2006 | June 3, 2008 |
| NCT00390273 | Completed | Phase 1/Phase 2 | Effect of Metformin on Lactate Metabolism | December 2006 | October 2007 |
| NCT00391261 | Completed | Phase 4 | An Open-label Trial of Metformin for Weight Control of Pediatric Patients on Antipsychotic Medications. | July 2006 | October 2007 |
| NCT00396357 | Completed | Phase 3 | Efficacy/Safety of Vildagliptin and Metformin Combination Therapy in Patients With Type 2 Diabetes Not Well Controlled With Metformin Alone | October 2006 | |
| NCT00399360 | Completed | N/A | Lifestyle Modification and Metformin Use in the Treatment of HIV | December 2006 | June 2012 |
| NCT00401973 | Completed | Phase 3 | Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine | November 2006 | September 2008 |
| NCT00413179 | Completed | Phase 3 | The Effect of Metformin Added to Clomiphene Citrate on Pregnancy Rates in Hyperandrogenic, Chronic Oligoovulatory or Anovulatory Women | December 1997 | April 2003 |
| NCT00420511 | Completed | Phase 2 | Beta-Cell Function and Sitagliptin Trial (BEST) | January 2007 | September 2009 |
| NCT00425009 | Completed | Phase 1/Phase 2 | Therapeutic Effects of Berberine in Patients With Type 2 Diabetes | January 2004 | December 2004 |
| NCT00428311 | Completed | Phase 4 | Effects of Metformin vs Oral Contraceptives on CV Risk Markers in PCOS | April 2004 | October 2006 |
| NCT00432276 | Completed | Phase 3 | Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus | January 2007 | June 2009 |
| NCT00443755 | Completed | Phase 2 | Effect of Insulin Sensitizer Therapy on Atherothrombotic and Inflammatory Profiles Associated With Insulin Resistance | August 2005 | August 2010 |
| NCT00445627 | Completed | Effect of Short-Term Beta-Cell Rest in Adolescents and Young Adults With Type 2 Diabetes Mellitus | June 18, 2007 | ||
| NCT00451399 | Completed | Phase 4 | Efficacy of Lifestyle Interventions and Metformin for the Treatment of Antipsychotic-Induced Weight Gain | October 2004 | December 2006 |
| NCT00451568 | Completed | Phase 4 | Metformin and Oral Contraceptives in PCOS | March 2007 | April 2013 |
| NCT00454233 | Completed | Phase 2 | A Safety and Efficacy Study With YM543 in Type 2 Diabetes Mellitus Subjects | February 2007 | June 2008 |
| NCT00463502 | Completed | Phase 4 | The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus | ||
| NCT00466622 | Completed | Phase 3 | Uterine Artery Blood Flow in Pregnant Women With PCOS Treated With Metformin | April 2007 | February 2010 |
| NCT00469092 | Completed | Phase 4 | Comparison of Biphasic Insulin Aspart 30 Versus Insulin Glargine Both in Combination With Metformin and Glimepiride in Subjects With Type 2 Diabetes | May 2007 | April 2008 |
| NCT00471523 | Completed | Phase 4 | Treatment of Anovulatory Infertility in PCOS Patients | May 2006 | March 2007 |
| NCT00473876 | Completed | Phase 4 | Metformin in Insulin Resistant Left Ventricular (LV) Dysfunction (TAYSIDE Trial) | August 2007 | April 2009 |
| NCT00481663 | Completed | Phase 2 | A Study of Different Doses of Sitagliptin (MK-0431) in Participants With Type 2 Diabetes Mellitus (MK-0431-014) | August 19, 2003 | May 14, 2006 |
| NCT00482729 | Completed | Phase 3 | MK0431A Comparative Study in Patients With Type 2 Diabetes (0431A-079)(COMPLETED) | June 19, 2007 | April 27, 2009 |
| NCT00491725 | Completed | Phase 4 | Efficacy and Safety of Repaglinide and Metformin Combination Therapy in Type 2 Diabetes Failing on Oral Anti-diabetic Drugs | September 2005 | June 2006 |
| NCT00513630 | Completed | Phase 4 | Study on the Prognosis and Effect of Anti-diabetic Drugs on Type-2 Diabetes Mellitus With Coronary Artery Disease | June 2004 | July 2010 |
| NCT00519480 | Completed | Phase 1 | A Study To Assess The Safety And Tolerability Of GSK189075 When Given With A Total Daily Dose Of >/ 2000mg of Metformin | September 11, 2007 | April 1, 2008 |
| NCT00528372 | Completed | Phase 3 | A Phase III Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes Who Are Not Well Controlled With Diet and Exercise | September 2007 | July 2010 |
| NCT00528879 | Completed | Phase 3 | A Phase III Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes Who Are Not Well Controlled on Metformin Alone | September 2007 | May 2010 |
| NCT00546728 | Completed | Phase 4 | The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes | October 2007 | July 2011 |
| NCT00546741 | Completed | Phase 1 | Drug Interaction With Metformin | November 2007 | February 2008 |
| NCT00560690 | Completed | Phase 4 | The Effect of Adding Metformin to the Treatment of Hepatitis C | December 2007 | December 2010 |
| NCT00562172 | Completed | Phase 4 | Insulin Glargine (Lantus) vs Sulfonylurea (SU) for BETA Cell Function (BETA Study) | September 2007 | October 2010 |
| NCT00568984 | Completed | Phase 4 | Efficacy and Safety of Repaglinide and Metformin Combined in Type 2 Diabetes | November 21, 2002 | November 10, 2003 |
| NCT00575588 | Completed | Phase 3 | 52-week add-on to Metformin Comparison of Saxagliptin and Sulphonylurea, With a 52-week Extension Period | December 2007 | August 2010 |
| NCT00577590 | Completed | N/A | Effects of Fatty Acid Delivery on Heart Metabolism and Function in Type 2 Diabetes (T2DM | October 2003 | September 2012 |
| NCT00592969 | Completed | Phase 4 | Efficacy and Safety of Metformin Plus Biphasic Insulin Aspart 30 in Type 2 Diabetes | December 3, 2003 | November 2, 2004 |
| NCT00598793 | Completed | Phase 3 | Biphasic Insulin Aspart 30 in Type 2 Diabetes Failing OAD Therapy | November 2002 | March 2004 |
| NCT00605475 | Completed | Phase 2 | Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ACZ885 in Patients With Type 2 Diabetes | December 2007 | September 2010 |
| NCT00611884 | Completed | Phase 2 | Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes | January 2008 | August 2008 |
| NCT00613951 | Completed | Phase 2 | Comparison of Two NN5401 Formulations Versus Biphasic Insulin Aspart 30, All in Combination With Metformin in Subjects With Type 2 Diabetes | January 2008 | August 2008 |
| NCT00614055 | Completed | Phase 2 | Comparison of Two NN5401 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes | January 2008 | July 2008 |
| NCT00614120 | Completed | Phase 3 | Effect of Liraglutide or Glimepiride Added to Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes | January 2008 | February 2009 |
| NCT00617240 | Completed | Phase 2 | Strategies to Reduce Antipsychotic-Associated Weight Gain in Youth | January 2007 | October 2012 |
| NCT00619697 | Completed | Phase 4 | Efficacy and Safety of Biphasic Insulin Aspart 30 in Combination With Metformin in Type 2 Diabetes | December 2003 | March 2005 |
| NCT00620191 | Completed | Phase 2 | Metformin in Amnestic Mild Cognitive Impairment | June 1, 2008 | February 2012 |
| NCT00624364 | Completed | Phase 4 | Efficacy and Safety of Biphasic Insulin Aspart 30 With Metformin in Type 2 Diabetes | May 2004 | May 2005 |
| NCT00627445 | Completed | Phase 3 | Effect of Biphasic Insulin Aspart 50 on Blood Glucose Control in Subjects With Type 2 Diabetes | February 2008 | January 2009 |
| NCT00631488 | Completed | Phase 2 | A Study to Test the Effectiveness and Safety of MK0893 in Combination With Other Drugs Used to Treat Type 2 Diabetes (0893-015) | February 2008 | January 2009 |
| NCT00636766 | Completed | N/A | Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque | September 2005 | January 2009 |
| NCT00657943 | Completed | Phase 4 | The Copenhagen Insulin and Metformin Therapy Trial | April 2008 | December 2012 |
| NCT00661362 | Completed | Phase 3 | Evaluate Efficacy and Safety of Saxagliptin in Combination With Metformin in Adult Patients With Type 2 Diabetes | June 2008 | September 2009 |
| NCT00667498 | Completed | Phase 4 | Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance | March 2004 | December 2007 |
| NCT00669864 | Completed | Phase 4 | Effect of Biphasic Insulin Aspart 30 Combined With Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes Inadequately Controlled With Basal Insulin | November 2007 | April 2009 |
| NCT00670800 | Completed | N/A | Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome | January 2008 | August 2009 |
| NCT00672386 | Completed | Phase 2 | A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes | December 2007 | September 2008 |
| NCT00673465 | Completed | Phase 1 | Effect of SCH 497079 on Metabolic Parameters and Influence of Race/Ethnic Origin on Therapeutic Response (Study P05338)(COMPLETED) | April 17, 2008 | December 11, 2008 |
| NCT00676338 | Completed | Phase 3 | Safety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4) | November 2008 | January 2011 |
| NCT00678080 | Completed | N/A | Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes | September 2008 | August 2011 |
| NCT00679679 | Completed | Phase 4 | Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome | January 2003 | December 2005 |
| NCT00679939 | Completed | Phase 4 | Study In Postmenopausal Women With Type 2 Diabetes Looking At Approved Diabetes Drugs And How They Affect Bone Health | April 21, 2008 | September 16, 2010 |
| NCT00681460 | Completed | N/A | Metformin in Gestational Diabetes Mellitus | May 2008 | May 2013 |
| NCT00682448 | Completed | Phase 4 | Metformin for the Prevention of the Metabolic Side-effects of Zyprexa | August 2007 | August 2011 |
| NCT00683735 | Completed | Phase 2/Phase 3 | Quantification of the Dipeptidyl Peptidase (DPP)-4 Inhibition-mediated Enhancement of the Activity of the Entero-insular Axis | February 2009 | December 2013 |
| NCT00694759 | Completed | N/A | Cortisol Regulation in Polycystic Ovary Syndrome (PCOS) | October 2006 | July 2011 |
| NCT00698230 | Completed | Phase 2 | Safety and Efficacy of INCB013739 Plus Metformin Compared to Metformin Alone on Glycemic Control in Type 2 Diabetics | May 2008 | May 2009 |
| NCT00700817 | Completed | Phase 3 | The Effect of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin on Glycaemic Control in Subjects With Type 2 Diabetes Mellitus | June 2008 | June 2010 |
| NCT00707031 | Completed | Phase 3 | GLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | June 2008 | November 2010 |
| NCT00708578 | Completed | Phase 4 | Optimal Oral Hypoglycaemic Agents (OHA) for Combination With Insulin Glargine (Sulfonylurea vs. Metformin) | May 2008 | December 2009 |
| NCT00712673 | Completed | Phase 3 | GLP-1 Receptor Agonist Lixisenatide (Morning or Evening) in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | June 2008 | March 2011 |
| NCT00713830 | Completed | Phase 3 | GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Sulfonylurea | July 2008 | January 2011 |
| NCT00714233 | Completed | Phase 3 | Treatment of Adolescent Polycystic Ovary Syndrome (PCOS) | August 2002 | December 2007 |
| NCT00715624 | Completed | Phase 3 | GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Basal Insulin | July 2008 | February 2011 |
| NCT00720161 | Completed | N/A | Metformin in Children With Motor Deficit | November 2006 | July 2011 |
| NCT00722371 | Completed | Phase 3 | MK0431 and Pioglitazone Co-Administration Factorial Study in Patients With Type 2 Diabetes Mellitus (0431-102 AM2) | September 5, 2008 | March 25, 2011 |
| NCT00723307 | Completed | Phase 4 | Carotid Atherosclerosis: MEtformin for Insulin ResistAnce Study | February 2009 | December 2012 |
| NCT00727857 | Completed | Phase 3 | Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus. | June 2007 | August 2008 |
| NCT00728351 | Completed | Phase 3 | Efficacy and Safety of Fixed Combination Therapy of Vildagliptin and Metformin (25/1000 mg Bid) in Patients With Type 2 Diabetes Inadequately Controlled With Prior Metformin Monotherapy (HbA1c 7.0-9.5%) | June 2008 | |
| NCT00734474 | Completed | Phase 2/Phase 3 | A Study of LY2189265 Compared to Sitagliptin in Participants With Type 2 Diabetes Mellitus on Metformin | August 2008 | July 2012 |
| NCT00744367 | Completed | Phase 3 | A Study of Taspoglutide Versus Placebo for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Plus Pioglitazone. | October 2008 | November 2010 |
| NCT00745433 | Completed | Switch From Metformin Monotherapy to a Bitherapy With Metformin and Repaglinide | January 2008 | March 2009 | |
| NCT00751114 | Completed | Phase 4 | Evaluation of Insulin Glargine Versus Sitagliptin in Insulin-naive Patients | November 2008 | July 2011 |
| NCT00754403 | Completed | Phase 4 | Efficacy of Pioglitazone and Fortamet Combination Therapy in Subjects With Type 2 Diabetes | July 2005 | October 2006 |
| NCT01160042 | Completed | Phase 1 | Bioequivalence Study of Metformin Hydrochloride Tablets 1000 mg Tablets of Dr. Reddy's Laboratories Limited Under Fasting Condition | January 2005 | April 2005 |
| NCT00005104 | Completed | N/A | Randomized Study of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome | January 2000 | |
| NCT00005654 | Completed | N/A | Randomized Study of the Effect of Decreased Hyperinsulinemia on the Ovulatory Response to Clomiphene Citrate in Obese Women With Polycystic Ovary Syndrome | January 2000 | |
| NCT00015626 | Completed | Phase 2 | A Clinical Trial to Prevent the Complications of Insulin Resistance (Including Type-2 Diabetes) | ||
| NCT00032487 | Completed | Phase 3 | Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT) | December 1, 2000 | May 30, 2008 |
| NCT00046462 | Completed | Phase 3 | Determine Whether Glycemic Control is Different Between Lantus & a 3rd Oral Agent When Failure With Other Treatment | November 2001 | December 2004 |
| NCT00063232 | Completed | Phase 2 | Treating Nonalcoholic Steatohepatitis (NASH) With Metformin | June 2003 | March 2008 |
| NCT00063635 | Completed | Phase 3 | Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC) | September 2005 | February 2010 |
| NCT00081328 | Completed | Phase 3 | Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) | May 2004 | February 2014 |
| NCT00086502 | Completed | Phase 3 | Pioglitazone Add-on Study in Patients With Type 2 Diabetes Mellitus | June 2004 | November 2005 |
| NCT00086515 | Completed | Phase 3 | Metformin Add-on Study in Patients With Type 2 Diabetes Mellitus (0431-020)(COMPLETED) | June 30, 2004 | February 2, 2007 |
| NCT00097279 | Completed | Phase 3 | Comparison of Biphasic Insulin Aspart 70/30 With Anti-Diabetic Drugs in Subjects With Type 2 Diabetes | August 2004 | August 2005 |
| NCT00097500 | Completed | Phase 3 | Effects of Exenatide and Insulin Glargine in Subjects With Type 2 Diabetes | September 2004 | December 2009 |
| NCT00102466 | Completed | Phase 3 | Vildagliptin Compared to Gliclazide in Combination With Metformin in Patients With Type 2 Diabetes | January 2005 | January 2009 |
| NCT00105066 | Completed | Phase 2 | The Effects of Metformin on Blood Vessel Structure and Function | January 2004 | May 2008 |
| NCT00106340 | Completed | Phase 3 | Vildagliptin Compared to Glimepiride in Combination With Metformin in Patients With Type 2 Diabetes | March 2005 | May 20, 2008 |
| NCT00108615 | Completed | Phase 4 | Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance | January 2004 | December 2007 |
| NCT00110851 | Completed | Phase 2 | Safety and Efficacy Study of PN2034 in Type 2 Diabetes Patients on Concomitant Rosiglitazone and Metformin (or Avandamet) | April 2005 | August 2007 |
| NCT00111631 | Completed | Phase 2 | A Study of DPP-IV Inhibitor in Patients With Type 2 Diabetes | May 2005 | October 2006 |
| NCT00118937 | Completed | Phase 4 | Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet | December 2003 | August 2006 |
| NCT00118950 | Completed | Phase 4 | Effect of Metformin Versus Repaglinide Treatment in Non-Obese Type 2 Diabetic Patients Uncontrolled by Diet | March 2001 | March 2003 |
| NCT00118963 | Completed | Phase 4 | Effect of Repaglinide Versus Metformin Treatment in Non-Obese Patients With Type-2-Diabetes | January 2003 | February 2006 |
| NCT00121641 | Completed | Phase 3 | Saxagliptin Treatment in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise | July 2005 | February 2010 |
| NCT00121966 | Completed | Phase 4 | South Danish Diabetes Study: Evaluation of the Antidiabetic Treatment of Type 2 Diabetes Mellitus | January 2003 | July 2007 |
| NCT00123110 | Completed | Phase 2 | Insulin Resistance and Testosterone in Women | July 2005 | December 2011 |
| NCT00131664 | Completed | Phase 3 | Avandia™ + Amaryl™ or Avandamet™ Compared With Metformin (AVALANCHE™ Study) | September 2005 | January 2008 |
| NCT00134290 | Completed | Phase 4 | The Effects of Calorie Restriction With or Without Metformin on Weight and Insulin Resistance | January 2002 | May 2004 |
| NCT00134303 | Completed | Phase 4 | Trial Comparing Metformin Versus Placebo in Non Alcoholic Steatohepatitis (NASH) Patients Receiving Bariatric Surgery for Obesity | June 2005 | March 31, 2006 |
| NCT00139477 | Completed | N/A | Study of Serum Markers for Cardiovascular Risk in Obese Youth and Impact of Lifestyle and Medication Intervention | November 2003 | September 2011 |
| NCT00151411 | Completed | Phase 2 | Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS) | October 2004 | March 2008 |
| NCT00159536 | Completed | Phase 3 | Metformin in Pregnant PCOS Women | February 2005 | October 2009 |
| NCT00174642 | Completed | Phase 3 | Opposing Step-by-step Insulin Reinforcement to Intensified Strategy | December 2004 | |
| NCT00184574 | Completed | Phase 3 | Comparison of Biphasic Insulin Aspart 70/30, 50/50, and 30/70 in Subjects With Type 2 Diabetes | April 2005 | March 2006 |
| NCT00184626 | Completed | Phase 4 | Comparison of Insulin Glargine Versus Biphasic Insulin Aspart 30/70 or Biphasic Insulin Aspart 30/70 in Combination With Metformin in Subjects With Type 2 Diabetes. | September 10, 2004 | October 24, 2005 |
| NCT00187681 | Completed | Phase 4 | Organic Cation Transporter 1 (OCT1), on Response to Metformin in Healthy Subjects | July 2003 | March 2008 |
| NCT00187720 | Completed | Phase 4 | Genetic Basis for Variation in the Renal Elimination of Metformin | May 2002 | April 2008 |
| NCT00191464 | Completed | Phase 4 | Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes | December 2003 | September 2005 |
| NCT00232583 | Completed | N/A | Preservation of Beta-cell Function in Type 2 Diabetes Mellitus | November 2003 | December 2011 |
| NCT01555164 | Completed | Phase 3 | A Phase 3 Study of Ranolazine in Subjects With Type 2 Diabetes Who Are Inadequately Controlled on Metformin Alone | June 2012 | October 2013 |
| NCT01557504 | Completed | Phase 1 | A Study to Assess the Pharmacokinetics and the Ability for Pediatric Participants With Type 2 Diabetes to Swallow MK-0431A XR Tablets (MK-0431A-296) | July 18, 2012 | April 29, 2014 |
| NCT01563120 | Completed | Phase 4 | A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus | January 2012 | December 2014 |
| NCT01573377 | Completed | N/A | Efficacy of Metformin and Diane-35 on PCOS Patients,a Randomized, Controlled, Prospective Clinical Trial | February 2012 | February 2013 |
| NCT01573949 | Completed | N/A | A Pilot Study: Metformin Therapy in Heart Failure Patients With Early Diabetes or at High Risk of Developing Diabetes (Pre-Diabetes) | December 2011 | December 2012 |
| NCT01579812 | Completed | Phase 2 | Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in Gynecologic Patients | October 2011 | July 2017 |
| NCT01581814 | Completed | Phase 3 | Effects of Drospirenone-ethinylestradiol and/or Metformin on Cardiovascular Risk in Hyperinsulinemic Women With Polycystic Ovary Syndrome | October 2008 | March 2012 |
| NCT01581931 | Completed | Phase 1 | Bioequivalence of Metformin Under Fed Conditions After Administration of Linagliptin / Metformin Fixed Dose Combination Tablet and Single Tablets | April 2012 | June 2012 |
| NCT01587378 | Completed | N/A | Metformin to Prevent Late Miscarriage and Preterm Delivery in Women With Polycystic Ovary Syndrome | October 2012 | October 31, 2017 |
| NCT01589367 | Completed | Phase 2 | Neoadjuvant Letrozole Plus Metformin vs Letrozole Plus Placebo for ER-positive Postmenopausal Breast Cancer | May 2012 | August 2018 |
| NCT01590771 | Completed | Phase 3 | A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Sulfonylurea With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-253) | July 9, 2012 | June 24, 2014 |
| NCT01590797 | Completed | Phase 3 | A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Insulin With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-254) | July 10, 2012 | June 25, 2014 |
| NCT01593371 | Completed | N/A | Comparison of Metformin and Pioglitazone Effects on Adipokines Concentrations in Newly Diagnosed Type 2 Diabetes Patients | July 2011 | January 2012 |
| NCT01594697 | Completed | N/A | Metformin in Pregnancy in Women With Polycystic Ovary Syndrome | ||
| NCT01596504 | Completed | Phase 2 | Pharmacodynamic Effects of Lixisenatide Compared to Liraglutide in Patients With Type 2 Diabetes Not Adequately Controlled With Insulin Glargine With or Without Metformin | May 2012 | July 2013 |
| NCT01610401 | Completed | Phase 4 | The Metformin-FMD Trial | May 2012 | January 2013 |
| NCT01612858 | Completed | Phase 4 | Metabolic Abnormalities in HIV-infected Persons | June 2011 | November 2014 |
| NCT01613755 | Completed | Phase 4 | Metformin-Dipyridamole Interaction Trial | April 2012 | July 2012 |
| NCT01620593 | Completed | Phase 2 | Castration Compared to Castration Plus Metformin as First Line Treatment for Patients With Advanced Prostate Cancer | April 2011 | September 2016 |
| NCT01622257 | Completed | Phase 2 | Cavitation Ultrasound in Treatment of Patients With PCOS | June 2011 | June 2012 |
| NCT01624116 | Completed | N/A | Comparison of Hypoglycaemic Regimens During Ramadan Fasting in Type 2 Diabetes | August 2011 | September 2011 |
| NCT01624259 | Completed | Phase 3 | A Study Comparing the Effect of Dulaglutide With Liraglutide in Type 2 Diabetes | June 2012 | November 2013 |
| NCT01648582 | Completed | Phase 3 | A Study Comparing the Effects and Safety of Dulaglutide With Insulin Glargine in Type 2 Diabetes Mellitus | July 2012 | December 2014 |
| NCT01650181 | Completed | Phase 4 | Effects of Siliphos-Selenium-Methionine-Alpha Lipoic Acid in Patients With Fatty Liver and Non-alcoholic Steatohepatitis | November 2011 | June 2014 |
| NCT01650506 | Completed | Phase 1 | Study of Erlotinib and Metformin in Triple Negative Breast Cancer | July 2012 | June 2016 |
| NCT01656057 | Completed | N/A | The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion | July 2012 | April 2014 |
| NCT01658501 | Completed | Phase 2 | Phase 2b Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Assess the PD Response and Safety of Three Dose Levels of (PB1023) Injection Following 20 Weeks of Weekly SC Dosing in Adults With T2DM | July 2012 | July 2013 |
| NCT01672788 | Completed | Phase 1 | Demonstration of Bioequivalence of Empagliflozin and Metformin Given in One Tablet Compared to the Intake of Single Tablets | August 2012 | November 2012 |
| NCT01677897 | Completed | Phase 2 | Impact of the Addition of Metformin to Abiraterone in Metastatic Prostate Cancer Patients | August 2013 | June 2018 |
| NCT01677923 | Completed | Phase 3 | Obesity in Children and Adolescents: Associated Risks and Early Intervention | May 2013 | December 2015 |
| NCT01679574 | Completed | N/A | Letrozole or Combined Clomiphene Citrate Metformin as a First Line Treatment in Women With Polycystic Ovarian Syndrome | January 2009 | January 2012 |
| NCT01681680 | Completed | Phase 1 | Effect of Genetic Variation in the Transporter OCT2, MATE1 and MATE2-K on the PKPD of Metformin | October 2010 | October 2013 |
| NCT01681693 | Completed | Phase 1 | Effect of Genetic Variants in MATE1 and OCT3 on the Pharmacodynamics of Metformin in African Americans | February 2010 | July 2013 |
| NCT01682759 | Completed | Phase 3 | A Study of the Safety and Efficacy of Omarigliptin (MK-3102) Compared With Glimepiride in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-3102-016) | September 10, 2012 | January 26, 2015 |
| NCT01685762 | Completed | Early Phase 1 | Metformin for the Treatment of Endometrial Hyperplasia | January 10, 2013 | December 1, 2015 |
| NCT01702298 | Completed | Phase 3 | A Study to Assess the Safety and Tolerability of Sitagliptin/Simvastatin Fixed-dose Combination (FDC) in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-312) | December 7, 2012 | May 29, 2013 |
| NCT01704261 | Completed | Phase 3 | Addition of Omarigliptin (MK-3102) to Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Combination Therapy With Glimepiride and Metformin (MK-3102-022) | October 18, 2012 | December 23, 2014 |
| NCT01709305 | Completed | Phase 4 | A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313) | November 8, 2012 | April 17, 2015 |
| NCT01717313 | Completed | Phase 3 | A Study to Assess the Safety and Efficacy of Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus (T2DM) and Inadequate Glycemic Control (MK-3102-011) | December 5, 2012 | June 19, 2015 |
| NCT01718093 | Completed | Phase 4 | A Pilot Study to Assess the Glucose Lowering Effect of Metformin and Sitagliptin in Adolescents With Type 1 Diabetes | October 2012 | December 2015 |
| NCT01719614 | Completed | Phase 1 | A Study to Explore Pharmacokinetic Interaction Between Rilpivirine and Metformin in Healthy Participants | October 2012 | January 2013 |
| NCT01720290 | Completed | Phase 4 | Comparison of Repaglinide and Metformin Administered Alone or in Combination in Type 2 Diabetes | July 25, 2002 | February 25, 2003 |
| NCT01725126 | Completed | Phase 2 | To Investigate the Safety, Tolerability and Pharmacodynamics of GSK2890457 in Healthy Volunteers and Subjects With Type 2 Diabetes | February 10, 2013 | September 12, 2013 |
| NCT01725490 | Completed | Phase 2 | The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized Controlled Study | February 15, 2013 | August 30, 2020 |
| NCT01726764 | Completed | Phase 1 | Interaction Between St John's Wort and Metformin? | January 2013 | May 2014 |
| NCT01728740 | Completed | Phase 1 | Bioequivalence Study for Acarbose / Metformin FDC | September 2012 | December 2012 |
| NCT01729156 | Completed | Phase 4 | Effects of Metformin on Hepatic FFA Metabolism | January 2013 | May 5, 2017 |
| NCT01729403 | Completed | Phase 2 | A Study of The Effect of Aleglitazar on Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus Who Are Inadequately Controlled With Metformin | December 2012 | September 2013 |
| NCT01755156 | Completed | Phase 3 | A Study to Evaluate the Safety, Tolerability, and Efficacy of the Addition of Omarigliptin (MK-3102) to Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin Therapy (MK-3102-024) | January 11, 2013 | March 16, 2016 |
| NCT01756417 | Completed | Phase 1 | A Study to Investigate Whether Pharmacokinetic and Pharmacodynamic Interactions Exist Between Metformin and Canagliflozin (JNJ-28431754) in Healthy Volunteers | October 2007 | November 2007 |
| NCT01758380 | Completed | Phase 4 | Vildagliptin Compared to Gliclazide as Dual Therapy With Metformin in Muslim Patients With Type 2 Diabetes Fasting During Ramadan | January 2013 | September 2013 |
| NCT01760447 | Completed | Phase 3 | A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289) | December 7, 2011 | September 17, 2019 |
| NCT01763346 | Completed | N/A | Beta Cell Restoration Through Fat Mitigation | June 2013 | June 2018 |
| NCT01765946 | Completed | Phase 4 | Metformin and Longevity Genes in Prediabetes | June 2010 | March 2013 |
| NCT01766778 | Completed | Phase 4 | Early add-on Vildagliptin in Patients With Type 2 Diabetes Inadequately Controlled by Metformin | May 13, 2013 | October 22, 2015 |
| NCT01775813 | Completed | Phase 4 | The Health Influences of Puberty (HIP) Study | June 2011 | May 31, 2018 |
| NCT01778244 | Completed | Phase 4 | Metformin for Treatment of Antipsychotic-induced Dyslipidemia | November 2008 | June 2012 |
| NCT01779362 | Completed | Phase 3 | RISE Adult Medication Study | April 2013 | August 2019 |
| NCT01779375 | Completed | Phase 3 | RISE Pediatric Medication Study | June 16, 2013 | April 2018 |
| NCT01786707 | Completed | Phase 1/Phase 2 | Autologous Stem Cell and Hyperbaric Oxygen Therapy in Type 2 Diabetes Mellitus | July 2009 | March 2013 |
| NCT01787396 | Completed | Phase 3 | Phase III Trial to Evaluate the Efficacy and Safety of Initial Combination Therapy With Gemigliptin 50mg q.d and Metformin q.d | April 2013 | March 2015 |
| NCT01792830 | Completed | Phase 3 | Efficacy and Safety of a Glargine-based Hospital Discharge Algorithm in Coronary Artery Bypass Graft (CABG) Patients | October 2012 | February 2014 |
| NCT01796028 | Completed | Phase 2 | Metformin-Docetaxel Association in Metastatic Hormone-refractory Prostate Cancer | January 2013 | May 31, 2018 |
| NCT01804049 | Completed | Phase 1/Phase 2 | Metformin and Muscle in Insulin-resistant Older Veterans | April 8, 2014 | August 31, 2018 |
| NCT01808690 | Completed | Phase 3 | EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes | March 2013 | December 2, 2016 |
| NCT01811953 | Completed | Phase 1 | Equivalence of Resorption of Empagliflozin/Metformin Administered as Combination Tablet Compared With Empagliflozin/Metformin as Single Tablets Administered Together | March 2013 | May 2013 |
| NCT01813929 | Completed | Phase 4 | Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes | June 2011 | March 24, 2017 |
| NCT01814748 | Completed | Phase 3 | A Study of the Safety and Efficacy of Omarigliptin (MK-3102) in ≥18 and <45 Year-Old Participants With Type 2 Diabetes Mellitus and Inadequate Glycemic Control (MK-3102-028) | May 3, 2013 | September 14, 2015 |
| NCT01822548 | Completed | Phase 3 | Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes | October 2010 | January 2015 |
| NCT01825798 | Completed | Phase 3 | Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD) | April 2013 | October 2015 |
| NCT01842620 | Completed | Phase 4 | OXEMET™ 1000 mg Coated Tablets (Metformin Hydrochloride) Bioequivalence Study. OXEMET (TM) is a Trademark of the GlaxoSmithKline Group of Companies. GLAFORNIL(TM) is a Trademark of Merck. | March 13, 2013 | May 4, 2013 |
| NCT01856907 | Completed | Phase 4 | Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM | September 28, 2013 | September 28, 2017 |
| NCT01857609 | Completed | Phase 1 | Clinical Trial to Investigate the Effect of Proton Pump Inhibitor on the Pharmacokinetics and Pharmacodynamics of Metformin | August 2012 | December 2012 |
| NCT01869621 | Completed | Phase 1 | Study of Metformin Pharmacogenetics in Twins | April 2013 | October 2014 |
| NCT01871415 | Completed | Phase 3 | A Study of Aleglitazar in Combination With Metformin in Patients With Type 2 Diabetes Mellitus Who Are Inadequately Controlled With Metformin Monotherapy | May 2013 | August 2013 |
| NCT01871558 | Completed | Phase 3 | Vildagliptin/Metformin in T2DM Patients Starting Basal Insulin | June 2013 | February 2015 |
| NCT01873859 | Completed | N/A | Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media | May 2013 | February 2014 |
| NCT01877564 | Completed | Phase 2 | A Randomized Pilot Study to Evaluate the Effects of a Short Course of Metformin Versus No Therapy in the Period Prior to Hysterectomy for Grade 1-2 Adenocarcinoma of the Endometrium in Obese Non-Diabetic Women | August 29, 2013 | July 10, 2017 |
| NCT01879293 | Completed | Phase 4 | Metformin Reduces Left Ventricular Mass in Patients With Ischemic Heart Disease | July 2013 | August 2015 |
| NCT01884558 | Completed | Phase 1 | A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Metformin | February 2013 | February 2013 |
| NCT01892254 | Completed | Phase 4 | Incretin Effect in PCOS Women | June 2013 | November 23, 2017 |
| NCT01899430 | Completed | Phase 4 | Polycystic Ovary Syndrome and Liraglutide | November 2011 | April 2013 |
| NCT01911247 | Completed | Early Phase 1 | Preoperative Window Study of Metformin for the Treatment of Endometrial Cancer | May 2011 | February 2013 |
| NCT01911468 | Completed | Phase 4 | Polycystic Ovary Syndrome and Liraglutide as Add-on Therapy on Metformin | November 2011 | April 2013 |
| NCT01915550 | Completed | Phase 3 | Metformin as Adjuvant to Insulin Therapy in Insulin-resistant Diabetes Mellitus With Pregnancy | April 2012 | February 2013 |
| NCT01917656 | Completed | Phase 4 | Efficacy and Safety of Liraglutide Versus Sulphonylurea Both in Combination With Metformin During Ramadan in Subjects With Type 2 Diabetes | January 9, 2014 | September 4, 2014 |
| NCT01929863 | Completed | Phase 2 | Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2330672 in Type 2 Diabetes Patients Taking Metformin | August 1, 2013 | November 21, 2013 |
| NCT01935804 | Completed | Phase 2 | Effect of Pioglitazone Versus Metformin on Bone Health in Postmenopausal Women With Type 2 Diabetes | January 2009 | January 2014 |
| NCT01941199 | Completed | Phase 1 | Pharmacokinetic/Pharmacodynamic Drug-drug Interaction of DA-1229 and Metformin After Oral Administration in Healthy Male Subjects | July 2013 | |
| NCT01947153 | Completed | Phase 1 | Two-way Crossover Study in Healthy Male and Female Subjects to Evaluate the Bioequivalence of Jentadueto®. | November 2013 | January 2014 |
| NCT01956305 | Completed | Phase 1 | Randomized, Placebo-controlled, 2 Period, Single-blind, Sequential, Multiple Ascending Dose Study | September 2013 | June 2014 |
| NCT01956929 | Completed | Phase 1 | Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism. | October 2013 | March 2016 |
| NCT01958671 | Completed | Phase 3 | A Study of the Efficacy and Safety of Ertugliflozin Monotherapy in the Treatment of Participants With Type 2 Diabetes Mellitus and Inadequate Glycemic Control Despite Diet and Exercise (MK-8835-003, VERTIS MONO) | October 9, 2013 | July 28, 2016 |
| NCT01963663 | Completed | N/A | Metformin and Pioglitazone Effects on YKL-40 Concentrations in Type 2 Diabetes Patients | November 2012 | April 2013 |
| NCT01965756 | Completed | Phase 2 | Effect of Insulin Sensitizer Metformin on AD Biomarkers | January 2013 | April 2017 |
| NCT01966978 | Completed | Phase 4 | The Effect of Simple Basal Insulin Titration, Metformin Plus Liraglutide for Type 2 Diabetes With Very Elevated HbA1c - The SIMPLE Study | November 2014 | December 2017 |
| NCT01971034 | Completed | Phase 2 | Treatment of Patients With Advanced Pancreatic Cancer After Gemcitabine Failure. | June 2011 | |
| NCT01972724 | Completed | Phase 4 | Efficacy of Pioglitazone in Participants With Inadequately Controlled Type 2 Diabetes Mellitus Treated With Stable Triple Oral Therapy | December 16, 2013 | October 17, 2016 |
| NCT01980823 | Completed | Early Phase 1 | Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer | October 2013 | December 2022 |
| NCT01981525 | Completed | Phase 1 | A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome | January 27, 2014 | December 11, 2020 |
| NCT01992211 | Completed | Phase 1 | Evaluating of Pharmacokinetic Profile of BCWP_C003 and Co-administration of Rosuvastatin and Metformin | December 15, 2016 | July 10, 2017 |
| NCT01999218 | Completed | Phase 3 | Ertugliflozin vs. Glimepiride in Type 2 Diabetes Mellitus (T2DM) Participants on Metformin (MK-8835-002) | December 16, 2013 | April 18, 2017 |
| NCT02002221 | Completed | Phase 4 | Study of Efficacy and Safety of Vildagliptin as add-on Insulin Therapy in T2DM Patients | December 2013 | February 2015 |
| NCT02004886 | Completed | Phase 2 | A Study to Assess the Safety, Tolerability and Glucose-Lowering Efficacy of MK-0893 in Participants With Type 2 Diabetes Mellitus (MK-0893-005) | August 11, 2006 | February 7, 2007 |
| NCT02005419 | Completed | Phase 2 | Metformin Combined With Gemcitabine as Adjuvant Therapy for Pancreatic Cancer After Curative Resection | December 2013 | December 2017 |
| NCT02007278 | Completed | Phase 4 | Glycemic Excursions in Type 2 Diabetic Patients With Vildagliptin and Metformin Versus Vildagliptin and Glimepiride | January 3, 2014 | February 22, 2016 |
| NCT02014740 | Completed | Phase 4 | Effect of Liraglutide on Epicardial Fat in Subjects With Type 2 Diabetes | March 2014 | March 2017 |
| NCT02017561 | Completed | Phase 2 | Metformin in the Diastolic Dysfunction of Metabolic Syndrome | January 2014 | December 2019 |
| NCT02022254 | Completed | Phase 1 | Influence of Semaglutide on Pharmacokinetics and Pharmacodynamics of Warfarin and Pharmacokinetics of Metformin in Healthy Subjects | December 17, 2013 | August 28, 2014 |
| NCT02027103 | Completed | N/A | Metformin and Pioglitazone Effects on Fetuin-A and Osteoprotegrin Concentrations in Type 2 Diabetes Patients | January 2012 | April 2012 |
| NCT02027753 | Completed | Phase 4 | Efficacy and Safety of Insulin Glargine in Patients With Type 2 Diabetes With Inadequate Control on DPP-4 Inhibitor Therapy | December 2013 | April 2015 |
| NCT02028221 | Completed | Phase 2 | Phase II Study of Metformin for Reduction of Obesity-Associated Breast Cancer Risk | March 7, 2014 | June 14, 2022 |
| NCT02033889 | Completed | Phase 3 | A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monotherapy (MK-8835-007). | December 13, 2013 | August 3, 2017 |
| NCT02035787 | Completed | Phase 2 | Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients | February 27, 2014 | April 12, 2024 |
| NCT02036515 | Completed | Phase 3 | Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006; VERTIS SITA2) | March 12, 2014 | June 6, 2016 |
| NCT02037672 | Completed | Phase 4 | PDE-4 Inhibitor Roflumilast and Polycystic Ovary Syndrome | September 2013 | January 2014 |
| NCT02040246 | Completed | Phase 4 | Comparison of Metformin and Repaglinide Monotherapy in the Treatment of New Onset Type 2 Diabetes Mellitus in China | February 2009 | January 2014 |
| NCT02040376 | Completed | Phase 3 | Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma | June 13, 2014 | December 15, 2017 |
| NCT02045290 | Completed | Phase 3 | Insulin Clamp Ancillary Study for Assessment of Insulin Resistance | January 2014 | February 15, 2016 |
| NCT02049814 | Completed | Phase 4 | Efficacy and Safety of Voglibose Compared With Acarbose in Participants With Type 2 Diabetes | May 9, 2014 | June 28, 2016 |
| NCT02050074 | Completed | Phase 4 | The Role of Metformin and Colesevelam in Human GLP-1 Secretion | January 2014 | September 2014 |
| NCT02058147 | Completed | Phase 3 | Efficacy and Safety of Insulin Glargine/ Lixisenatide Fixed Ratio Combination Compared to Insulin Glargine Alone and Lixisenatide Alone on Top of Metformin in Patients With T2DM | February 2014 | June 2015 |
| NCT02060383 | Completed | Phase 4 | Study of Management of Pasireotide-induced Hyperglycemia in Adult Patients With Cushing's Disease or Acromegaly | May 23, 2014 | March 26, 2018 |
| NCT02069379 | Completed | Phase 4 | Endogenous Opioid Activity and Affective State in Insulin Resistant Women | July 2014 | September 2017 |
| NCT02083692 | Completed | Early Phase 1 | Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling | September 5, 2013 | April 6, 2017 |
| NCT02084056 | Completed | Phase 1 | Bioequivalence of a FDC Tablet of Linagliptin/Metformin (2.5mg/1000mg) Extended Release in Healthy Subjects. | April 2014 | July 2014 |
| NCT02086526 | Completed | Phase 1 | Targeting Pathways in Polycystic Ovary Syndrome (PCOS) Using Metformin (MET) | March 2014 | November 20, 2016 |
| NCT02088918 | Completed | Phase 1 | A Open-label, Single-dose, 2-Sequence, 2-Period, Crossover Study to Assess Safety and Pharmacokinetics of a Nateglinide/Metformin HCl Combined Tablet Compared With a Nateglinide 120 mg Tablet and Metformin HCl 500 mg Tablet Under Fasting Conditions in Healthy Male Subjects | October 2012 | |
| NCT02091362 | Completed | Phase 2 | A Study of LY2409021 on Blood Pressure and Pulse Rate in Participants With Type 2 Diabetes Mellitus | March 2014 | January 2015 |
| NCT02109679 | Completed | Phase 1 | Relative Bioavailability of Multiple Oral Doses of BI 187004 and Metformin After Co-administration Compared to Multiple Oral Doses of BI 187004 Alone and Metformin Alone in Healthy Male Subjects | May 2014 | July 2014 |
| NCT02119819 | Completed | Phase 2 | A Study to Compare a New Drug for Type 2 Diabetes to Placebo and to a Treatment Already Available for Type 2 Diabetes | April 2014 | October 2015 |
| NCT02125305 | Completed | Phase 1 | Clinical Study to Investigate the Pharmacokinetics and Pharmacodynamics of Metformin in the Elderly | August 2013 | |
| NCT02151461 | Completed | Phase 2 | Dose Comparisons of Leucine-Metformin Combinations on Blood Glucose Levels In Type 2 Diabetic Patients | July 2014 | January 2016 |
| NCT02152371 | Completed | Phase 3 | A Study of Dulaglutide (LY2189265) in Participants With Type II Diabetes | May 2014 | October 2015 |
| NCT02167620 | Completed | Phase 4 | Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness | June 2014 | March 2018 |
| NCT02172248 | Completed | Phase 1 | Relative Bioavailability BI 10773 and Metformin in Healthy Male Volunteers | January 2009 | |
| NCT02173639 | Completed | Phase 1 | Bioavailability of Combination Tablet BI 1356/Metformin Compared With Single BI 1356 and Metformin Administered Together to Healthy Male and Female Subjects | April 2009 | |
| NCT02179788 | Completed | Phase 1/Phase 2 | Metformin to Augment Low Milk Supply (MALMS) Study | June 2014 | July 2016 |
| NCT02183506 | Completed | Phase 1 | Bioavailability of BI 1356 BS and Metformin After Co-administration Compared to the Bioavailability of BI 1356 BS Alone and Metformin Alone in Healthy Male Volunteers | September 2005 | |
| NCT02184832 | Completed | Early Phase 1 | Dietary Intake of Tryptophan and Metformin Response | August 2014 | March 2016 |
| NCT02186483 | Completed | Phase 1 | Clinical Trial to Investigate the Pharmacokinetics Drug Interaction Between Metformin and Rosuvastatin | August 2014 | February 2015 |
| NCT02187250 | Completed | Phase 4 | PDE-4 Inhibitor Roflumilast and GLP-1 Agonist Liraglutide in Polycystic Ovary Syndrome | March 2014 | June 2014 |
| NCT02188654 | Completed | N/A | Metformin in Psoriatic Arthritis | September 2013 | April 2014 |
| NCT02202161 | Completed | Phase 2 | A Study Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK2330672 Administered With Metformin to Type 2 Diabetes Patients | August 27, 2014 | January 30, 2015 |
| NCT02205528 | Completed | Phase 2 | A Study of Once-Daily NNC0090-2746 in Participants With Type 2 Diabetes Inadequately Controlled With Metformin | August 18, 2014 | September 15, 2015 |
| NCT02220647 | Completed | Phase 1 | Bioequivalence of a 2.5 mg Linagliptin / 850 mg Metformin Fixed Dose Combination Tablet Compared With Single Linagliptin 2.5 mg and Metformin 850 mg Tablets in Healthy Volunteers | January 2010 | |
| NCT02221180 | Completed | Phase 1 | Bioequivalence Study of Metformin Component of Fixed Dose Combination (FDC) Immediate Release (IR) Tablet of Canagliflozin and Metformin Compared to Metformin IR Tablet Co-administered With Canagliflozin in Healthy Fed and Fasted Participants | August 2014 | November 2014 |
| NCT02221401 | Completed | Phase 1 | Bioequivalence of a Linagliptin / Metformin Fixed-dose Combination (FDC) Tablet Compared With Single Linagliptin and Metformin Tablets Administered Together in Healthy Volunteers | January 2010 | |
| NCT02221414 | Completed | Phase 1 | Bioequivalence of a 2.5 mg Linagliptin / 500 mg Metformin Fixed Dose Combination Tablet Compared With Single Linagliptin 2.5 mg and Metformin 500 mg Tablets Administered Together in Healthy Volunteers | January 2010 | |
| NCT02230995 | Completed | Phase 1 | Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Metformin Extended Release Compared With Mono Compound Tablets in Healthy Subjects | September 2014 | October 2014 |
| NCT02234440 | Completed | N/A | Effect of Metformin on Disease Progression in Patients With Cryptogenic Cirrhosis (NASH-related Cirrhosis) With Diabetes or Impaired Glucose Tolerance or Insulin Resistance | September 1, 2014 | December 31, 2015 |
| NCT02235298 | Completed | Phase 4 | Dapagliflozin Effects on Epicardial Fat | September 2015 | September 10, 2020 |
| NCT02249910 | Completed | Phase 1 | Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects | September 18, 2014 | March 6, 2015 |
| NCT02252081 | Completed | Phase 2 | Metformin in Kidney Disease | October 1, 2014 | December 31, 2019 |
| NCT02266472 | Completed | Phase 1 | Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Metformin Extended Release Compared With Mono Compound Tablets in Healthy Male and Female | November 2014 | December 2014 |
| NCT02274948 | Completed | Phase 4 | Use of Metformin in Treatment of Childhood Obesity | July 2014 | April 2016 |
| NCT02278965 | Completed | Phase 1 | Metformin and Omega-3 Fatty Acids in Woman With a History of Early Stage Breast Cancer | January 22, 2015 | April 19, 2017 |
| NCT02280057 | Completed | Phase 4 | Trial With Metformin in Women With Polycystic Ovary Syndrome | September 2001 | December 2002 |
| NCT02283554 | Completed | Phase 2 | Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects | November 2013 | |
| NCT02302326 | Completed | N/A | Involvement of Reticulum Endoplasmic Stress in the Physiopathology of Polycystic Ovary Syndrome | January 2013 | December 2019 |
| NCT02308228 | Completed | Early Phase 1 | Metformin to Augment Strength Training Effective Response in Seniors (MASTERS) | January 14, 2015 | June 28, 2018 |
| NCT02312661 | Completed | Phase 1 | Study of Metformin With Carboplatin/Paclitaxel Chemotherapy in Patients With Advanced Ovarian Cancer | October 5, 2015 | November 2017 |
| NCT02325401 | Completed | Phase 1 | Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma | May 11, 2015 | February 21, 2020 |
| NCT02338921 | Completed | Phase 4 | Triple Combination Therapy in Type 2 Diabetic Patients Who Had Inadequate Glycemic Control With Combination Therapy | January 2015 | December 31, 2021 |
| NCT02342925 | Completed | Phase 1 | A Study of the Effect of RG1662 on Metformin in Healthy Volunteers | February 2015 | May 2015 |
| NCT02343926 | Completed | Phase 3 | Phase 3 Study to Compare the Efficacy and Safety of Gemigliptin and Vildagliptin as Add-on Therapy to Metformin in People With Type 2 Diabetes Inadequately Controlled With Metformin | December 2014 | April 2016 |
| NCT02376166 | Completed | N/A | Metformin for Rising PSA Remote Trial | July 2014 | December 2016 |
| NCT02394652 | Completed | Phase 2 | The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomized Trial | May 21, 2015 | January 12, 2021 |
| NCT02407899 | Completed | Phase 4 | Protective Effects of Saxagliptin (And Vitamin D3) on β Cell Function in Adult-onset Latent Autoimmune Diabetes | March 2015 | December 31, 2020 |
| NCT02411825 | Completed | Phase 1 | Multiple Ascending Dose Study in Healthy Male Subjects and Overweight to Obese Male and Female Type 2 Diabetes Mellitus (T2DM) Patients | March 2015 | January 2016 |
| NCT02417090 | Completed | Late Metabolic Effects of Metformin Therapy in Gestational Diabetes | May 2015 | December 1, 2019 | |
| NCT02429258 | Completed | Phase 4 | Effect of Dapagliflozin on 24-hour Blood Glucose in T2DM Patients Inadequately Controlled With Either Metformin Or Insulin | May 2015 | October 2015 |
| NCT02431676 | Completed | Phase 2 | Survivorship Promotion In Reducing IGF-1 Trial | May 2015 | December 2018 |
| NCT02432287 | Completed | Phase 4 | Metformin in Longevity Study (MILES). | October 2014 | December 2017 |
| NCT02434744 | Completed | Phase 2 | Study of KD026 in Combination With Metformin in Subjects With Type 2 Diabetes Mellitus | April 2015 | March 2016 |
| NCT02435277 | Completed | Phase 2 | An Extension Protocol to Evaluate Dose Comparisons of Leucine-Metformin Combinations in Type 2 Diabetic Patients | October 2014 | January 2016 |
| NCT02437656 | Completed | Phase 2 | Combination of Metformin to Neoadjuvant Radiochemotherapy in the Treatment of Locally Advanced Rectal Cancer (METCAP). | May 2015 | March 2017 |
| NCT02438540 | Completed | N/A | Comparative the Effect of Metformin and Acupuncture on Weight Loss and Insulin Sensitivity | May 2014 | April 2015 |
| NCT02446834 | Completed | N/A | Research of Intensive Lifestyle Intervention for PCOS Patients With IGT | April 2015 | April 2018 |
| NCT02463357 | Completed | Phase 4 | Three New Ideas to Protect Special Forces From the Stress of High Altitude | August 2015 | September 2016 |
| NCT02483299 | Completed | Phase 4 | Liraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome | January 2014 | April 2015 |
| NCT02488564 | Completed | Phase 2 | A Study of Liposomal Doxorubicin + Docetaxel + Trastuzumab + Metformin in Operable and Locally Advanced HER2 Positive Breast Cancer | December 17, 2014 | April 2020 |
| NCT02491333 | Completed | Phase 3 | The RCT of Acupuncture on PCOS Combined With IR | August 2015 | October 2018 |
| NCT02497313 | Completed | N/A | Effect of Metformin and Cholecystokinin-mediated Gallbladder Emptying on GLP-1 Secretion in Type 2 Diabetes | July 2015 | July 2016 |
| NCT02498522 | Completed | Early Phase 1 | Effect of Metformin on Early Pregnancy Loss in Pregnant Women With Polycystic Ovarian Syndrome | August 2015 | March 2016 |
| NCT02500628 | Completed | Phase 2 | Heart Rate Variability in Response to Metformin Challenge | July 2015 | February 2016 |
| NCT02505516 | Completed | Early Phase 1 | BLADDER CANCER SCREENING AMONG DIABETIC PATIENTS | June 2013 | February 2014 |
| NCT02514629 | Completed | Phase 3 | Testosterone, Metformin, or Both, for Hypogonadism in Obese Males | July 4, 2013 | July 12, 2016 |
| NCT02515773 | Completed | Phase 4 | Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs | December 2015 | June 2023 |
| NCT02516085 | Completed | Phase 1 | Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin | January 2012 | October 2012 |
| NCT02519543 | Completed | Phase 3 | Treating Insulin Resistance as a Strategy to Improve Outcome in Refractory Bipolar Disorder | September 2015 | September 2020 |
| NCT02524821 | Completed | N/A | The Effect of Gelesis100 on the Pharmacokinetics of Metformin | September 2015 | December 2015 |
| NCT02526615 | Completed | Phase 4 | Effects of Rosiglitazone and Metformin on Metabolism in Type 2 Diabetes | October 2000 | December 2001 |
| NCT02532855 | Completed | Phase 3 | A Study to Assess the Addition of Sitagliptin to Metformin Compared With the Addition of Dapagliflozin to Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) and Mild Renal Impairment Who Have Inadequate Glycemic Control on Metformin With or Without a Sulfonylurea (MK-0431-838) | October 20, 2015 | October 10, 2017 |
| NCT02546050 | Completed | Phase 1 | The Effect of Metformin on Composition of Human Gut Bacteria | June 2015 | February 2016 |
| NCT02551874 | Completed | Phase 3 | A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin | October 20, 2015 | November 10, 2017 |
| NCT02552355 | Completed | Phase 2 | Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin | August 2015 | August 2017 |
| NCT02561130 | Completed | Phase 4 | Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Forxiga | December 2015 | December 31, 2018 |
| NCT02562664 | Completed | Phase 2 | Metformin Improves Clinical Pregnancy Rate in Polycystic Ovarian Syndrome Patients | January 2014 | July 2014 |
| NCT02565862 | Completed | Phase 1 | A Drug-drug Interaction Study Between Daclatasvir and Metformin | January 2016 | April 2016 |
| NCT02568488 | Completed | Phase 4 | The Effect of Metformin on Different Hormones in PCOS Patients | March 2014 | September 2015 |
| NCT02570672 | Completed | Phase 2 | Metformin for Preventing Frailty in High-risk Older Adults | April 2016 | February 7, 2024 |
| NCT02577315 | Completed | Phase 1 | Demonstrate Bioequivalence of Two 12.5 mg Empagliflozin/500 mg Metformin Fixed Dose Combination Tablets With Free Combination of Empagliflozin 25 mg and Metformin 1000 mg in Healthy Male and Female Volunteers Under Fed Conditions | September 2015 | October 2015 |
| NCT02586129 | Completed | Phase 3 | Clinical Trial of YH14755 in Subjects With Dyslipidemia and Type II Diabetes | November 4, 2015 | July 7, 2017 |
| NCT02586636 | Completed | Phase 4 | Impact of OCT1 on Metformin Tolerance | March 2016 | April 9, 2018 |
| NCT02593097 | Completed | Phase 3 | Metformin for the Prevention of Episodic Migraine (MPEM) | February 2016 | June 2019 |
| NCT02597049 | Completed | Phase 3 | A Study of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes Mellitus | November 2015 | February 2017 |
| NCT02597101 | Completed | Phase 2 | Anti-Inflammatory Small Drug Adjunctive Therapy for Type 2 Diabetes | November 2015 | June 15, 2019 |
| NCT02597400 | Completed | Phase 1 | Drug-Drug Interaction Study of Glucokinase Activator HMS5552 and Metformin in T2DM | October 2015 | October 2015 |
| NCT02611518 | Completed | Phase 1 | A Pharmacokinetic Interaction Study Between JNJ-54861911 and Transporter Substrates Rosuvastatin and Metformin in Healthy Participants | April 5, 2016 | June 14, 2016 |
| NCT02621489 | Completed | Phase 4 | Effects on Re-endothelialisation With Bydureon Treatment in Type 2 Diabetes Subjects | December 2015 | October 2022 |
| NCT02629627 | Completed | Phase 2 | Conjugated Linoleic Acid / Leucine Versus Metformin on Visceral Fat in Metabolic Syndrome | March 2016 | October 2017 |
| NCT02630706 | Completed | Phase 3 | A Study to Evaluate the Efficacy and Safety of Ertugliflozin in Asian Participants With Type 2 Diabetes and Inadequate Glycemic Control on Metformin Monotherapy (MK-8835-012) | December 16, 2015 | December 27, 2017 |
| NCT02633488 | Completed | N/A | Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic Syndrome | June 2014 | July 2016 |
| NCT02638805 | Completed | Phase 3 | Study of the Safety and Tolerability of Switching to ITCA 650 in Patients With Type 2 Diabetes Receiving Liraglutide | December 2015 | October 2017 |
| NCT02644577 | Completed | Phase 4 | Metformin for Treatment Antipsychotic-induced Metabolic Syndrome in Bipolar Disorder Patients | June 2012 | September 2015 |
| NCT02656017 | Completed | Phase 2 | Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease | June 27, 2016 | December 7, 2020 |
| NCT02659306 | Completed | Phase 1 | Metformin Immunotherapy in HIV Infection | September 2016 | February 2020 |
| NCT02682121 | Completed | Phase 1 | Mitochondrial-related Platelet Transcript Expression Levels in Pre-diabetic Subjects Randomized to Metformin or Placebo | April 2012 | January 2017 |
| NCT02684578 | Completed | Phase 2 | Metformin for the Minimization of Geographic Atrophy Progression in Patients With AMD | April 2016 | October 2022 |
| NCT02689843 | Completed | Early Phase 1 | Effects of Cyproterone Compound-spironolactone, Metformin and Pioglitazone on Inflammatory Markers in PCOS | February 1, 2018 | December 30, 2018 |
| NCT02695810 | Completed | Phase 2 | The PRE-D Trial: Effect of Dapagliflozin, Metformin and Physical Activity in Pre-diabetes | February 24, 2016 | January 13, 2019 |
| NCT02696941 | Completed | Phase 1 | SGLT2 Inhibitors and Metformin on Metabolism and Non-Alcoholic SteatoHepatitis | February 2016 | April 1, 2018 |
| NCT02710448 | Completed | Phase 2 | May Metformin be Used in Renal Failure? | June 2012 | October 2015 |
| NCT02712619 | Completed | Phase 1 | Pharmacokinetic-Pharmacodynamic Relationship of Metformin in Healthy Volunteers | May 2014 | |
| NCT02733679 | Completed | Phase 4 | Response of Individuals With Ataxia-Telangiectasia to Metformin and Pioglitazone | September 29, 2016 | August 30, 2017 |
| NCT02738879 | Completed | Phase 3 | Randomized Sitagliptin Withdrawal Study (MK-0431-845) | May 9, 2016 | January 30, 2018 |
| NCT02741960 | Completed | Phase 4 | The Effect of Metformin on Reducing Lupus Flares | May 24, 2016 | December 7, 2018 |
| NCT02743260 | Completed | Phase 4 | Drug Transporter Interaction Study PHENTRA_2015_KPUK | April 2016 | December 2017 |
| NCT02744976 | Completed | Phase 4 | Coronary Artery Disease Progression in Patients With Prediabetes | February 2016 | September 2021 |
| NCT02745912 | Completed | Phase 1 | Study to Evaluate the Effect of Naltrexone and Bupropion Combination on the Pharmacokinetics of Metformin in Healthy Participants | April 2016 | August 2016 |
| NCT02749032 | Completed | Phase 1 | Feed-Back Suppression of Meal-Induced Glucagon-like Peptide 1 (GLP-1) Secretion | November 2011 | |
| NCT02752412 | Completed | Phase 3 | Efficacy and Safety of LixiLan Versus Insulin Glargine Alone Both With Metformin in Japanese With Type 2 Diabetes Mellitus Inadequately Controlled on Basal Insulin and Oral Antidiabetic Drugs | May 17, 2016 | October 4, 2018 |
| NCT02755844 | Completed | Phase 1/Phase 2 | Safety and Efficacy of Metronomic Cyclophosphamide, Metformin and Olaparib in Endometrial Cancer Patients | September 23, 2016 | June 2020 |
| NCT02760342 | Completed | Phase 1 | A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Metformin | May 15, 2016 | June 26, 2016 |
| NCT02765347 | Completed | Phase 4 | The Effects of Metformin on Glycemic Control and Insulin Sensitivity in Adolescents With T1DM | June 2016 | January 2018 |
| NCT02773927 | Completed | Phase 3 | Combination of Metformin/Inulin vs Inulin on Adiponectin in Metabolic Syndrome | January 2013 | June 2015 |
| NCT02778776 | Completed | Phase 3 | Combination of Metformine/Inulin Versus Metformin on Prostate Benign Hyperplasia in Metabolic Syndrome | January 2013 | June 2015 |
| NCT02783053 | Completed | N/A | Metformin and Core Temperature in Obese and Lean Males | October 2015 | June 2016 |
| NCT02793505 | Completed | Safety of Metformin in Pregnancy | January 2014 | ||
| NCT02794792 | Completed | Phase 3 | A Study to Assess the Efficacy and Safety of Ipragliflozin in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin | May 11, 2016 | June 20, 2017 |
| NCT02803918 | Completed | Phase 1 | A Study on Safety, Pharmacokinetics and Pharmacodynamics of Lixisenatide in Pediatric Patients With Type 2 Diabetes Mellitus (T2DM) | May 17, 2017 | January 27, 2020 |
| NCT02810132 | Completed | Phase 2 | Effects of Metformin Treatment on Myocardial Efficiency in Patients With Heart Failure | January 20, 2017 | February 14, 2018 |
| NCT02813863 | Completed | Phase 1 | The Drug-drug Interaction of SP2086 and Metformin | December 2015 | |
| NCT02831361 | Completed | Phase 3 | Trial to Evaluate the Efficacy and Safety of Gemigliptin Compared With Placebo Added on Insulin Alone or on Insulin in Combination With Metformin in Type 2 DM (ZEUS II Study) | October 17, 2016 | February 8, 2018 |
| NCT02836704 | Completed | Phase 4 | Comparison of Standard vs Higher Starting Dose of Insulin Glargine in Chinese Patients With Type 2 Diabetes (Glargine Starting Dose) | September 9, 2016 | April 26, 2018 |
| NCT02846233 | Completed | N/A | Stepping-down Approach in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy? | August 2016 | December 2018 |
| NCT02853630 | Completed | Phase 4 | A Clinical Trial to Study the Effects of Two Drugs, Vildagliptin and Metformin in Patients With Type 2 Diabetes Mellitus | December 2013 | December 2018 |
| NCT02854527 | Completed | Phase 1 | Transporter Cocktail Mutual Interaction | August 22, 2016 | November 19, 2016 |
| NCT02866786 | Completed | Phase 4 | The Effects of OCP and Metformin on Clinical, Hormonal, Metabolic and Ultrasonographic Characteristics in PCOS | August 15, 2016 | August 1, 2017 |
| NCT02872818 | Completed | Phase 4 | Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia | October 2014 | March 2015 |
| NCT02884089 | Completed | Phase 1 | A Study of the Effect of Abemaciclib on Metformin and Iohexol in Healthy Participants | August 2016 | December 2016 |
| NCT02895750 | Completed | Phase 2 | Efficacity and Safety of Metformin XR in CKD Stage 1 to 3 | August 30, 2017 | October 10, 2022 |
| NCT02903511 | Completed | Phase 2 | Feasibility Study of Metformin Therapy in ADPKD | November 2016 | August 17, 2020 |
| NCT02910817 | Completed | N/A | Impact of Metformin on In Vitro Fertilization Outcomes in Overweight and Obese PCOS Women | January 2015 | December 2016 |
| NCT02911792 | Completed | Phase 4 | Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration | December 20, 2016 | July 11, 2023 |
| NCT02920801 | Completed | Phase 4 | Study About Effect of Saxagliptin on Circulating Endothelial Progenitor Cells and Endothelial Function in Newly Diagnosed Type 2 Diabetic Patients | December 2014 | July 2015 |
| NCT02926950 | Completed | Phase 3 | Efficacy and Safety of Sotagliflozin Versus Placebo in Patients With Type 2 Diabetes Mellitus on Background of Metformin | November 2016 | March 22, 2019 |
| NCT02941367 | Completed | Phase 4 | Safety Assessment of Lyxumia (Lixisenatide) and Sulfonylurea as Add-on Treatment to Basal Insulin in Uncontrolled Patients With Type 2 Diabetes Mellitus Who Elect to Fast During Ramadan | February 23, 2017 | August 4, 2017 |
| NCT02941445 | Completed | Phase 4 | Weight Maintenance With Dipeptidyl Peptidase 4 (DPP4) Inhibitor Sitagliptin in Combination With Metformin After Liragludite Induced Weight Loss | October 2015 | August 2016 |
| NCT02949700 | Completed | Phase 1/Phase 2 | Phase I/II Study OF Metformin in Combination With Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma | January 26, 2017 | July 7, 2022 |
| NCT02951260 | Completed | N/A | The Effects of Metformin on Self-selected Exercise Intensity, Physical Fitness and Exercise-induced AMPK-activation | October 2016 | July 2017 |
| NCT02954692 | Completed | Phase 4 | A Study to Evaluate the Effectiveness and Safety Initiation and Titration of Insulin Glargine (U300) in Insulin-naïve Patients With Type 2 Diabetes Mellitus (T2DM) Controlled on Oral Antidiabetic Drug Treatment in Turkey | November 30, 2016 | December 22, 2017 |
| NCT02956044 | Completed | Phase 1 | Interaction of Bexagliflozin With Metformin, Glimepiride and Sitagliptin | November 2016 | March 2017 |
| NCT02960659 | Completed | Phase 1/Phase 2 | Title: Therapeutic Targets in African-American Youth With Type 2 Diabetes | May 9, 2017 | May 20, 2022 |
| NCT02972723 | Completed | Phase 4 | Metformin Therapy in HCV Infection | March 2011 | December 2011 |
| NCT02973321 | Completed | Phase 2 | A Study to Assess the Safety and Efficacy of SAR425899 in Patients With Type 2 Diabetes Mellitus | December 2, 2016 | December 27, 2017 |
| NCT02981329 | Completed | Early Phase 1 | Fetal Hemoglobin Induction Treatment Metformin | March 2, 2017 | July 20, 2020 |
| NCT02986659 | Completed | Phase 4 | Genomic Outcomes of Metformin | August 3, 2016 | November 15, 2018 |
| NCT03004612 | Completed | Phase 4 | Effect of Linagliptin + Metformin vs Metformin Alone in Patients With Prediabetes | January 2016 | June 2019 |
| NCT03008551 | Completed | Phase 2/Phase 3 | Empagliflozin vs Metformin in PCOS | August 18, 2017 | April 2, 2018 |
| NCT03010683 | Completed | N/A | Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With Diabetes Mellitus | November 2015 | December 2017 |
| NCT03017833 | Completed | Phase 1 | Sapanisertib and Metformin in Treating Patients With Advanced or Metastatic Relapsed or Refractory Cancers | March 12, 2018 | December 21, 2022 |
| NCT03029702 | Completed | Phase 4 | Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus | February 28, 2018 | August 31, 2023 |
| NCT03034941 | Completed | Phase 4 | Short Term Weight Loss With Liraglutide and Metformin in Infertile Obese PCOS Patients | April 2014 | December 2016 |
| NCT03053544 | Completed | Phase 2 | Metformin With Neoadjuvant Chemoradiation to Improve Pathologic Responses in Rectal Cancer | December 8, 2016 | June 26, 2019 |
| NCT03061981 | Completed | Phase 1 | A Study To Evaluate The Safety,Tolerability, PK and PD Of DA-1241 In Healthy Male Subjects | March 29, 2017 | October 11, 2017 |
| NCT03066830 | Completed | Phase 3 | Efficacy and Safety of Sotagliflozin Versus Placebo in Participants With Type 2 Diabetes Mellitus on Background of Sulfonylurea Alone or With Metformin | February 24, 2017 | April 30, 2019 |
| NCT03068065 | Completed | Phase 4 | Antidiabetic Effects on Intrahepatic Fat | May 2014 | October 2015 |
| NCT03072485 | Completed | Phase 1 | Phase 1 Study of the Effects of Combining Topical FDA-approved Drugs on Age-related Pathways on the Skin of Healthy Volunteers | March 1, 2017 | February 22, 2019 |
| NCT03086005 | Completed | Phase 3 | Study to Assess the Effect of Metformin Supplementation on IVF Outcome in Patients With Polycystic Ovarian Syndrome. | October 12, 2011 | July 23, 2015 |
| NCT03086733 | Completed | Phase 2 | Phase II Lung Metcore - Preoperative Metformin for Lung Cancer | December 5, 2016 | August 2020 |
| NCT03088631 | Completed | Phase 2 | Metformin in Intracytoplasmic Sperm Injection Cycles | March 1, 2017 | April 1, 2019 |
| NCT03088670 | Completed | Phase 3 | Efficacy and Safety of Gosogliptin as Monotherapy and in Combination With Metformin vs. Vildagliptin as Monotherapy and in Combination With Metformin in Drug-naive Type 2 Diabetic Patients. | April 23, 2013 | October 3, 2014 |
| NCT03106870 | Completed | N/A | Adding Metformin to Insulin in Controlling Pregestational and Gestational Diabetes Mellitus | June 2016 | December 2016 |
| NCT03117517 | Completed | Early Phase 1 | Treatment With Metformin and Combination of Metformin and Pioglitazone in Polycystic Ovarian Syndrome | March 20, 2017 | March 7, 2018 |
| NCT03118128 | Completed | N/A | Metformin Reduce the Relapse Rate on Patients With B-cell Precursor (Ph+ Negative) Acute Lymphoblastic Leukemia | January 1, 2015 | April 30, 2017 |
| NCT03129113 | Completed | Phase 2/Phase 3 | Adding MAraViroc &/or METformin for Hepatic Steatosis in People Living With HIV | March 1, 2017 | November 6, 2020 |
| NCT03130426 | Completed | Phase 3 | Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IGlarLixi | June 27, 2017 | September 30, 2020 |
| NCT03155087 | Completed | PRKAA2 Genetic Polymorphisms and Its Susceptibility to Chinese Type 2 Diabetes Mellitus and Diabetic Nephropathy | June 2013 | December 2015 | |
| NCT03167918 | Completed | Phase 2/Phase 3 | Lung Function in Patients With Early Type 2 Diabetes Mellitus | July 21, 2014 | May 1, 2017 |
| NCT03183752 | Completed | N/A | Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules | August 13, 2015 | April 17, 2019 |
| NCT03200015 | Completed | Phase 2 | Rituximab, Cyclophosphamide, Vincristine and Prednisone (R-CHOP) Plus Metformin in Diffuse Large-B-cell Lymphoma | October 1, 2017 | January 27, 2019 |
| NCT03202563 | Completed | Phase 4 | Trial to Evaluate the Efficacy on Glycemic Variability and Safety of Gemigliptin Compared With Dapagliflozin Added on Metformin Alone or Diabetes Medication Naïve Patient in Type 2 Diabetes Mellitus (Stable II Study) | August 9, 2017 | December 7, 2018 |
| NCT03204058 | Completed | Phase 2/Phase 3 | Locally Delivered Metformin & Rosuvastatin for Treatment of Intrabony Defects in Chronic Periodontitis | February 10, 2016 | February 23, 2017 |
| NCT03204071 | Completed | Phase 2/Phase 3 | Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis | February 2016 | February 2017 |
| NCT03214380 | Completed | Phase 3 | A Study of LY900014 Compared to Insulin Lispro in Participants With Type 2 Diabetes | July 14, 2017 | March 13, 2019 |
| NCT03246451 | Completed | N/A | The Role of GLP-1 Receptor Signalling in the Glucose-lowering Effect of Metformin in Patients With T2D | July 1, 2017 | December 10, 2017 |
| NCT03259919 | Completed | Phase 2 | Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study | October 2000 | March 2003 |
| NCT03267576 | Completed | Phase 4 | An Efficacy Study of Canagliflozin or Sitagliptin to Determine Glucose Variability in Mexican Participants With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin | October 27, 2017 | October 1, 2018 |
| NCT03268005 | Completed | Phase 3 | Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetes | September 19, 2017 | January 29, 2019 |
| NCT03270553 | Completed | Phase 1 | A Study to Assess the Effect of Plazomicin on the Pharmacokinetics of Metformin | August 31, 2017 | October 7, 2017 |
| NCT03307252 | Completed | Phase 1 | This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men | October 25, 2017 | May 2, 2018 |
| NCT03309007 | Completed | Phase 3 | A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes | September 1, 2017 | August 20, 2020 |
| NCT03310749 | Completed | Phase 1 | An Assessment of Pharmacokinetic Gemigliptin and Metformin Interactions in Healthy Mexican Volunteers | January 15, 2016 | May 3, 2016 |
| NCT03320694 | Completed | Phase 3 | Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus | February 1, 2016 | June 30, 2017 |
| NCT03332771 | Completed | Phase 3 | Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Participants With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy | December 1, 2017 | September 6, 2019 |
| NCT03349684 | Completed | Phase 3 | Loose-dose Combination of Acarbose and Metformin for T2DM in Metformin-failure Patients | March 5, 2018 | August 21, 2019 |
| NCT03352869 | Completed | Phase 4 | Research of Exenatide for Overweight/Obese PCOS Patients With IGR | November 28, 2017 | July 31, 2018 |
| NCT03359837 | Completed | Phase 4 | Comparison of Two Treatment Regimens in Patients With Type 2 Diabetes After Short-term Intensive Insulin Therapy | January 20, 2018 | June 29, 2020 |
| NCT03363815 | Completed | Phase 1 | A Study to Evaluate the Effect of Multiple Doses of CC-90001 on the Pharmacokinetics of Omeprazole, Midazolam, Warfarin, Rosuvastatin, Metformin, Digoxin, and Nintedanib in Healthy Adult Subjects | December 4, 2017 | July 29, 2018 |
| NCT03378297 | Completed | Early Phase 1 | IMPACT: A Randomized WOO Study of Novel Therapeutic Agents in Women Triaged to Primary Surgery for EOC | May 4, 2018 | January 5, 2023 |
| NCT03398356 | Completed | Phase 4 | Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients. | October 20, 2017 | April 30, 2019 |
| NCT03416127 | Completed | Phase 2 | Effect of Propolis or Metformin Administration on Glycemic Control in Patients With Type 2 Diabetes Mellitus | January 30, 2018 | December 20, 2019 |
| NCT03429543 | Completed | Phase 3 | Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TM | March 20, 2018 | May 31, 2023 |
| NCT03441750 | Completed | Phase 4 | Efficacy of Metformin in Preventing Diabetes in China | April 25, 2017 | June 30, 2021 |
| NCT03444584 | Completed | Phase 2 | Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Participants With Type 2 Diabetes | May 8, 2018 | December 6, 2018 |
| NCT03445702 | Completed | Early Phase 1 | Metformin Gastrointestinal Intolerance: Measurement of Mitochondrial Complex I | October 15, 2018 | October 27, 2020 |
| NCT03452306 | Completed | Phase 1 | Bioequivalence Study of Metformin 750 mg Tablets XR Versus Glucophage® Long 750 mg Tablets XR In Normal Healthy Subjects Under Fasting and Fed Conditions | June 15, 2017 | July 22, 2017 |
| NCT03458208 | Completed | Phase 1 | Bioequivalence Study of Metformin 1000 mg Tablets Immediate Release (IR) Versus Glucophage® 1000 mg Tablets IR In Healthy Subjects | February 14, 2017 | March 2, 2017 |
| NCT03467945 | Completed | Phase 1 | Bioequivalence and Drug - Drug Interaction Study of Metformin/Gliclazide in Healthy Participants | February 16, 2018 | April 29, 2018 |
| NCT03479476 | Completed | Phase 2/Phase 3 | A Trial of Metformin in Individuals With Fragile X Syndrome | April 30, 2018 | May 1, 2024 |
| NCT03503942 | Completed | N/A | The Pre-Diabetes Interventions and Continued Tracking to Ease-out Diabetes (Pre-DICTED) Program | December 30, 2017 | April 15, 2024 |
| NCT03510390 | Completed | N/A | Metformin in Head and Neck Squamous Cell Carcinoma: Effect on Tissue Oxygenation | June 13, 2018 | November 15, 2021 |
| NCT03529123 | Completed | Phase 3 | Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes (LixiLan-India) | June 19, 2018 | November 25, 2019 |
| NCT03566225 | Completed | Early Phase 1 | Pioglitazone Versus Metformin as First Treatment in Infertile Women With Polycystic Ovary Syndrome | January 30, 2018 | March 30, 2021 |
| NCT03593538 | Completed | Phase 2 | Effects of Metformin During Nicotine Withdrawal | April 1, 2016 | March 13, 2020 |
| NCT03593707 | Completed | Phase 1 | Drug-Drug Interaction Study to Evaluate the Effect of PF-06865571 on Metformin Pharmacokinetics | August 17, 2018 | February 13, 2019 |
| NCT03618654 | Completed | Early Phase 1 | Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma | November 1, 2018 | December 7, 2022 |
| NCT03655301 | Completed | Phase 1 | Effect of Copanlisib on Metformin Pharmacokinetics and Pharmacodynamics | September 11, 2018 | February 12, 2019 |
| NCT03674385 | Completed | Phase 2 | Efficacy of Vit E in PCOS Resistant to Clomiphene Citrate | July 19, 2018 | March 30, 2019 |
| NCT03686722 | Completed | Phase 1 | Effect of Co-administration of Metformin and Daclatasvir on the Pharmacokinetis and Pharmacodynamics of Metformin | September 9, 2017 | December 6, 2017 |
| NCT03722290 | Completed | Phase 2 | Metformin in Children and Adults With Fragile X Syndrome | September 1, 2018 | November 1, 2020 |
| NCT03746106 | Completed | Phase 4 | The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine | January 28, 2019 | August 10, 2023 |
| NCT03751657 | Completed | Phase 2 | A Research Study to Compare Insulin 287 Once a Week to Insulin Glargine (100 Units/mL) Once a Day in People With Type 2 Diabetes. | November 29, 2018 | January 17, 2020 |
| NCT03772262 | Completed | Early Phase 1 | Assessing Goldenseal-drug Interactions Using a Probe Drug Cocktail Approach | April 5, 2018 | March 31, 2019 |
| NCT03792984 | Completed | Phase 3 | The Effect of Calcium and Vitamin D Supplements on Metabolic and Hormonal Disturbances in Polycystic Ovary Syndrome Patients | December 1, 2016 | December 30, 2017 |
| NCT03794336 | Completed | Phase 4 | Efficacy and Safety of Alogliptin vs. Acarbose in Chinese Type 2 Diabetes Mellitus (T2DM) Patients With High CV Risk or CHD Treated With Aspirin and Inadequately Controlled With Metformin Monotherapy or Drug Naive | June 29, 2019 | December 14, 2020 |
| NCT03796182 | Completed | Phase 1 | Study of PF 04965842 Effect on MATE1/2K Activity in Healthy Participants | January 10, 2019 | March 12, 2019 |
| NCT03798054 | Completed | Phase 3 | Evaluation of Insulin Glargine/Lixisenatide Fixed Ratio Combination in Patients With Type 2 Diabetes Insufficiently Controlled With Oral Antidiabetic Drug(s) | February 15, 2019 | March 1, 2021 |
| NCT03798080 | Completed | Phase 3 | Comparison of the Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Ratio Combination to Insulin Glargine in Patients With Type 2 Diabetes Insufficiently Controlled on Basal Insulin | February 19, 2019 | December 1, 2020 |
| NCT03819790 | Completed | Phase 4 | The Effect of Soliqua on Glucose Variability in Type 2 Patients Among South Asians | October 2, 2018 | November 19, 2019 |
| NCT03824002 | Completed | Phase 4 | Dulaglutide in Diabetic Patients, Relationship Between Arterial Stiffness, Endothelial Function, Clinical and Laboratory Variables | April 1, 2017 | April 20, 2018 |
| NCT03826602 | Completed | Phase 1 | A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib on Metformin | February 12, 2019 | March 15, 2019 |
| NCT03841591 | Completed | Phase 3 | Maternal Weight Gain in Gestational Diabetes Controlled by Metformin Versus Insulin | February 1, 2018 | January 15, 2019 |
| NCT03862716 | Completed | Phase 3 | Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IDegLira | April 23, 2019 | July 31, 2023 |
| NCT03916263 | Completed | Early Phase 1 | Low Starch Dietary Education Program vs. Traditional Treatment for PCOS | August 29, 2018 | December 31, 2022 |
| NCT03921242 | Completed | Comparative Effectiveness of Metformin for Type 2 Diabetes With Chronic Kidney Disease | August 1, 2019 | August 1, 2023 | |
| NCT03928340 | Completed | Phase 4 | Effect of Adding Metformin to Insulin Therapy on Pregnancy Outcomes in Women With Uncontrolled Type I Diabetes. | April 29, 2019 | March 29, 2020 |
| NCT03982238 | Completed | Phase 4 | Effects of Hypoglycemic Drugs on Testosterone Levels in Type 2 Diabetes Patients | June 15, 2019 | December 31, 2019 |
| NCT04009603 | Completed | N/A | Comparison of Probiotics, Metformin & Their Combination Therapy in the Treatment of PCOS | December 6, 2018 | January 28, 2020 |
| NCT04010942 | Completed | Phase 4 | Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women | April 1, 2018 | March 30, 2019 |
| NCT04055012 | Completed | Phase 2 | Effects of Metformin on Low Back Pain | January 7, 2020 | December 15, 2023 |
| NCT04068246 | Completed | Phase 1/Phase 2 | The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients | August 1, 2019 | February 28, 2021 |
| NCT04088448 | Completed | Phase 1/Phase 2 | The Antidiabetic Metformin as a Novel Adjunct to Antidepressants in Major Depressive Disorder Patients | January 1, 2017 | June 1, 2020 |
| NCT04088461 | Completed | Phase 4 | Effect of Linagliptin + Metformin on Patients Who do Not Achieve Normoglucemia With Metformine | September 2016 | September 2018 |
| NCT04156750 | Completed | Phase 1 | A Study of LY3556050 in Healthy Participants | November 20, 2019 | August 3, 2020 |
| NCT04209075 | Completed | Phase 2 | Prebiotics and Metformin Improve Gut and Hormones in Type 2 Diabetes in Youth (MIGHTY-fiber) | March 10, 2020 | July 15, 2021 |
| NCT04231435 | Completed | Phase 1 | Influence of Fedratinib on the Pharmacokinetics of the Transporter Probe Substrates Digoxin, Rosuvastatin, and Metformin | December 18, 2019 | February 21, 2020 |
| NCT04268394 | Completed | Phase 1 | A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677 | March 13, 2020 | June 2, 2021 |
| NCT04377451 | Completed | Phase 1/Phase 2 | Metformin in Dengue With Obesity | July 27, 2020 | August 1, 2023 |
| NCT04428086 | Completed | Phase 1 | A Pharmacokinetic Interaction Study Between Apatinib and Rosuvastatin or Metformin in Solid Tumor Subjects. | July 27, 2020 | August 22, 2021 |
| NCT04448821 | Completed | Phase 1 | A Clinical Trial to Evaluate the Effect of Nilotinib on the PK/PD of Meformin | July 23, 2020 | September 7, 2020 |
| NCT04489147 | Completed | N/A | Effect of Metformin on Non PCO Women Undergoing IVF/ICSI | July 28, 2020 | November 27, 2020 |
| NCT04510194 | Completed | Phase 3 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | January 1, 2021 | February 14, 2022 |
| NCT04566718 | Completed | A Treatment Legacy Effect of Metformin in Obese Women With PCOS | March 25, 2019 | February 1, 2020 | |
| NCT04649502 | Completed | Phase 3 | Metformin for the Treatment of Hidradenitis Suppurativa (HS) | January 25, 2021 | August 23, 2023 |
| NCT04671953 | Completed | Phase 1 | Effect of BMS-986165 on the Blood Levels of Metformin | December 18, 2020 | March 30, 2021 |
| NCT04700839 | Completed | Phase 4 | SGLT2 Inhibitors in Patients With PCOS | May 1, 2020 | April 30, 2021 |
| NCT04707508 | Completed | Phase 4 | Effect of Adding Renin-Angiotensin System Inhibitors to Standard Antidiabetic Therapy on Glycemic Control in Patients With Type 2 Diabetes Ellitus | December 1, 2017 | November 29, 2019 |
| NCT04865835 | Completed | Phase 1 | A Clinical Trial Study to Determine the Effect of an Investigational Drug (SEP-363856) Has on the Way That the Drug Metformin Travels Through the Body in People With Schizophrenia. | May 12, 2021 | May 3, 2022 |
| NCT04879511 | Completed | Phase 2/Phase 3 | Effect of Metformin in Children With Type 1 Diabetes | February 10, 2018 | January 29, 2021 |
| NCT04892186 | Completed | N/A | Effects of Myo-inositol in Women With Polycystic Ovary Syndrome | March 26, 2021 | October 20, 2023 |
| NCT04907708 | Completed | N/A | Comparative Effects of Metformin and Insulin on Stereological Studies and Immunohistochemistry of Placenta | January 1, 2018 | August 7, 2019 |
| NCT04969627 | Completed | Phase 4 | Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia. | January 4, 2021 | March 29, 2022 |
| NCT04972396 | Completed | Phase 1 | ALT-801 DDI Study in Healthy Volunteers | October 5, 2021 | May 15, 2022 |
| NCT04973891 | Completed | Phase 1/Phase 2 | CANA/Met in Non-diabetic Women With PCOS | April 7, 2021 | March 8, 2022 |
| NCT05053841 | Completed | Phase 2 | Implication of Metformin Plus Aromatase Inhibitor in Obese Postmenopausal Breast Cancer Women | February 2014 | June 2015 |
| NCT05064488 | Completed | Phase 1 | Drug-Drug Interaction Study of Evobrutinib and Transporter Substrates | October 4, 2021 | December 10, 2021 |
| NCT05076877 | Completed | Phase 1 | A Study of Lazertinib (JNJ-73841937) in Healthy Participants | September 17, 2021 | February 10, 2022 |
| NCT05236530 | Completed | Phase 1 | Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir | March 9, 2022 | October 17, 2022 |
| NCT05240274 | Completed | Phase 2 | The POWERED Study: Prophylaxis With Metformin to Prevent PTDM | January 25, 2019 | August 30, 2022 |
| NCT05288153 | Completed | Phase 4 | Metformin Efficacy and Safety for Gastric Intestinal Metaplasia | April 1, 2022 | October 31, 2023 |
| NCT05332795 | Completed | N/A | The Impact of Metformin on the Outcome of Gouty Arthritis in a Cohort of Egyptian Gouty Patients. | June 28, 2022 | February 20, 2024 |
| NCT05343767 | Completed | N/A | Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus | September 12, 2018 | May 30, 2021 |
| NCT05351021 | Completed | Phase 2 | Efficacy of Metformin as Preventive Treatment in Paclitaxel Induced Peripheral Neuropathy in Breast Cancer Patients | April 12, 2022 | October 30, 2022 |
| NCT05386706 | Completed | N/A | Treating PCOS With Digital Intervention vs. Metformin | June 21, 2022 | September 1, 2023 |
| NCT05413369 | Completed | Phase 3 | iGlarLixi vs IDegAsp in Chinese Participants After OAD(s) | July 7, 2022 | October 20, 2023 |
| NCT05479214 | Completed | Phase 4 | Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy | July 29, 2022 | February 10, 2023 |
| NCT05480007 | Completed | N/A | Non-alcoholic Fatty Liver Disease and Its Treatment | January 30, 2011 | December 1, 2018 |
| NCT05526690 | Completed | Phase 1 | Study to Evaluate the Effect of CIN-107 on the Pharmacokinetics of the MATE Substrate, Metformin, in Healthy Subjects | October 28, 2020 | December 12, 2020 |
| NCT05550129 | Completed | Phase 1 | Study to Evaluate the Drug-drug Interactions Between Metformin and AMG 510 in Healthy Participants | November 13, 2019 | November 25, 2019 |
| NCT05572749 | Completed | N/A | Clinical Trial of Crocus Kozanis Administration in Obese Children and Adolescents | May 1, 2021 | September 30, 2023 |
| NCT05615012 | Completed | Phase 1 | A Study Investigating Interactions Between BMS-986322 and Rosuvastatin, Metformin and Methotrexate in Healthy Participants | November 11, 2022 | December 13, 2023 |
| NCT05615467 | Completed | Phase 1 | A Study of Effect of LY3556050 on Metformin in Healthy Participants | November 15, 2022 | December 27, 2022 |
| NCT05653895 | Completed | N/A | Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS | December 7, 2022 | February 7, 2024 |
| NCT05663749 | Completed | Phase 4 | Topiramate vs Metformin on Cardio-Metabolic Profile in Schizophrenia on Atypical Antipsychotics | September 20, 2022 | August 20, 2023 |
| NCT05740345 | Completed | New Approaches to INOCA | January 15, 2016 | January 15, 2021 | |
| NCT05815680 | Completed | Phase 1 | A Study to Evaluate the Drug-drug Interactions (DDIs) of IBI362 With Metformin, Warfarin, Atorvastatin, Digoxin in Overweight or Obese Subjects | April 6, 2023 | October 30, 2023 |
| NCT05921942 | Completed | Phase 3 | The Impact of Metformin Administration on the Clinical Outcome of Stage IV Colon Cancer | April 15, 2020 | December 30, 2022 |
| NCT05939921 | Completed | N/A | Effects of Metformin Therapy on Pancreatic and Hepatic Fat Content in Patients of Type 2 Diabetes Mellitus | May 1, 2022 | June 30, 2023 |
| NCT05965219 | Completed | Phase 1 | A Trial to Evaluate the Effects of Itraconazole and Carbamazepine on the Pharmacokinetics of Emraclidine and of Emraclidine on the Pharmacokinetics of Metformin in Healthy Adult Participants | August 15, 2023 | November 10, 2023 |
| NCT05981365 | Completed | Phase 1 | Voxelotor CYP and Transporter Cocktail Interaction Study | April 17, 2023 | October 4, 2023 |
| NCT06015594 | Completed | N/A | Metformin Treatment in Adolescent Patients With PCOS: A Long-term, Winning Metabolic Choice. | January 1, 2015 | May 1, 2022 |
| NCT06066060 | Completed | Phase 1 | A DDI Study of JMKX000623 and Metformin Hydrochloride | September 17, 2023 | November 6, 2023 |
| NCT06071442 | Completed | Phase 1 | Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine | January 17, 2024 | April 12, 2024 |
| NCT06084156 | Completed | Phase 1 | A Study to Evaluate the DDI of HSK7653 With Metformin | August 10, 2019 | December 9, 2019 |
| NCT06160414 | Completed | Phase 1 | A Study to Investigate the Potential Drug Interactions Between ALXN2080 and Rosuvastatin and Metformin in Healthy Adult Participants | December 7, 2023 | February 5, 2024 |
| NCT06204185 | Completed | N/A | Clinical and Biochemical Evaluation of 1% Metformin in Non-surgical Treatment of Periodontitis | February 1, 2019 | November 30, 2022 |
| NCT06244550 | Completed | N/A | Clinical Trials Using HepatoKeeper Herbal Essentials to Treat Non-alcoholic Fatty Liver Disease and Metabolic Factors | September 22, 2021 | June 13, 2023 |
| NCT06266598 | Completed | Phase 4 | Effectiveness of Antidiabetic Treatment Applied in Childhood Obesity | November 17, 2019 | October 27, 2021 |
| NCT06326840 | Completed | N/A | Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment | May 31, 2010 | June 10, 2011 |
| NCT00754988 | Completed | Phase 3 | A Study of Taspoglutide Versus Sitagliptin for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin. | October 2008 | March 2011 |
| NCT00755287 | Completed | Phase 3 | A Study of the Safety, Tolerability and Effect on Glycemic Control of Taspoglutide Versus Insulin Glargine in Insulin Naive Type 2 Diabetic Patients Inadequately Controlled With Metformin Plus Sulphonylurea. | November 2008 | December 2010 |
| NCT00763451 | Completed | Phase 3 | GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | September 2008 | January 2011 |
| NCT00763815 | Completed | Phase 3 | GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Pioglitazone | September 2008 | June 2011 |
| NCT00772174 | Completed | Phase 3 | Efficacy and Safety Study of Pioglitazone Combined With Metformin on Metabolic Syndrome in Subjects With Type 2 Diabetes | January 2007 | February 2008 |
| NCT00780715 | Completed | Phase 4 | Response To Oral Agents in Diabetes (ROAD)- Pilot Study | December 2008 | October 2009 |
| NCT00783744 | Completed | Phase 3 | Insulin Glargine Combination Therapies in Type II Diabetics | December 2001 | |
| NCT00789035 | Completed | Phase 2 | 12 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic Patients | October 2008 | |
| NCT00789191 | Completed | Phase 3 | Effect of Detemir and Sitagliptin on Blood Glucose Control in Type 2 Diabetes | November 2008 | August 2009 |
| NCT00792935 | Completed | Phase 2 | A Study to Test MK-0941 in Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-0941-017) | January 2009 | February 2010 |
| NCT00795808 | Completed | Phase 4 | PCOSMIC Trial - PolyCystic Ovary Syndrome, Metformin for Infertility With Clomiphene | August 2003 | October 2008 |
| NCT00798161 | Completed | Phase 3 | Safety and Efficacy of Linagliptin (BI 1356) Plus Metformin in Type 2 Diabetes, Factorial Design | December 2008 | |
| NCT00802100 | Completed | Phase 4 | Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia | December 2008 | October 2009 |
| NCT00806234 | Completed | Phase 4 | Reducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics | January 2009 | March 2014 |
| NCT00807092 | Completed | Phase 4 | Comparing the Efficacy and Safety of Biphasic Insulin Aspart 30 and Biphasic Human Insulin 30 on Blood Sugar Control in Subjects With Type 2 Diabetes | December 2008 | October 2009 |
| NCT00815399 | Completed | Phase 4 | Pioglitazone Versus Metformin in Type 2 Diabetes | October 2007 | April 2015 |
| NCT00816907 | Completed | Phase 4 | The Use of Metformin in the Treatment of Antipsychotic-Induced Weight Gain in Schizophrenia (The METS Study) | January 2009 | March 2010 |
| NCT00819741 | Completed | Phase 4 | Comparison of the Blood Sugar Lowering Effect Between Repaglinide Plus Metformin and Repaglinide Alone in Type 2 Diabetics Not Previously Treated With Oral Sugar-lowering Drugs | February 2009 | November 2009 |
| NCT00820573 | Completed | Phase 4 | Mechanisms of Glucose Lowering Effects of Sitagliptin and Metformin Alone and in Combination in Patients With T2DM | October 2009 | October 2012 |
| NCT00834652 | Completed | Phase 4 | Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight | September 2007 | May 2013 |
| NCT00835861 | Completed | Phase 2 | Effectiveness of Metformin Compared to Insulin in Pregnant Women With Mild Preexisting or Early Gestational Diabetes | August 2008 | April 2010 |
| NCT00838903 | Completed | Phase 3 | Efficacy and Safety of Albiglutide in Treatment of Type 2 Diabetes | February 2009 | April 2013 |
| NCT00839527 | Completed | Phase 3 | A Study to Determine the Safety and Efficacy of Albiglutide in Subjects With Type 2 Diabetes | February 2009 | April 2013 |
| NCT00851903 | Completed | Phase 3 | Evaluation of Insulin Glargine in Combination With Sitagliptin in Type 2 Diabetes Patients: EASIE Extension Trial | June 2009 | September 2011 |
| NCT00855166 | Completed | Phase 3 | Evaluation of the Effect of Dapagliflozin in Combination With Metformin on Body Weight in Subjects With Type 2 Diabetes | February 2009 | December 2011 |
| NCT00856284 | Completed | Phase 3 | Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus | March 2009 | October 2012 |
| NCT00856986 | Completed | Phase 3 | The Effect of Insulin Detemir in Combination With Liraglutide and Metformin Compared to Liraglutide and Metformin in Subjects With Type 2 Diabetes | March 2009 | November 2010 |
| NCT00857870 | Completed | Phase 4 | Insulin Glargine First Line vs Metformin in Type 2 Diabetic Subjects | March 2009 | December 2011 |
| NCT00860288 | Completed | Phase 2/Phase 3 | Efficacy and Long-Term Safety of Vildagliptin as Add-on Therapy to Metformin in Patients With Type 2 Diabetes | February 2009 | March 2011 |
| NCT00871936 | Completed | Phase 2 | A Comparison of SLx-4090 in Combination With Metformin Versus Metformin Therapy Alone in Patients With Type 2 Diabetes | April 2009 | October 2009 |
| NCT00881530 | Completed | Phase 2 | Empagliflozin (BI 10773) in Type Two Diabetes (T2D) Patients, Open Label Extension | March 2009 | |
| NCT00885352 | Completed | Phase 3 | Sitagliptin (MK-0431) vs. Placebo in Patients With Inadequate Glycemic Control on Metformin With Pioglitazone (MK-0431-128) | April 15, 2009 | November 10, 2010 |
| NCT00892073 | Completed | Phase 2 | Hypothalamic Obesity Following Craniopharyngioma Surgery: A Pilot Trial of Combined Metformin and Diazoxide Therapy | May 2006 | January 2008 |
| NCT00897884 | Completed | N/A | Clinical and Biologic Effects of Metformin in Early Stage Breast Cancer | October 2008 | July 2011 |
| NCT00901979 | Completed | Phase 2 | A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM) | April 2009 | June 2010 |
| NCT00909506 | Completed | Phase 2 | Efficacy and Safety of Adjuvant Metformin for Operable Breast Cancer Patients | June 2009 | December 2011 |
| NCT00915772 | Completed | Phase 3 | Treatment of Type 2 Diabetes With Linagliptin 2.5 mg Bid + Metformin 500 or 1000 mg Bid and Metformin 1000 mg Bid | June 2009 | |
| NCT00924573 | Completed | Phase 3 | Comparative Study of HOE490 O (Glimepiride and Metformin) Compared With Placebo on Top of Glimepiride | May 2009 | March 2010 |
| NCT00930579 | Completed | Phase 2 | Pre-Surgical Study: Effect of Metformin on Breast Cancer Proliferation | October 16, 2009 | January 9, 2017 |
| NCT00941148 | Completed | Phase 4 | Beta-Cell Function of Insulin Glargine Compared to Neutral Protamine Hagedorn (NPH) Insuline and to Insulin Detemir in Combination With Metformin | April 2008 | March 2009 |
| NCT00941161 | Completed | Phase 4 | Effect of Oral Combination Therapy in a Single Dosage Form in Patients With Type 2 Diabetes Mellitus | February 2009 | |
| NCT00941239 | Completed | Phase 1 | Tolerability and Pharmacokinetics of Metformin and Metformin Extended Release (ER) | January 2007 | February 2007 |
| NCT00948402 | Completed | Phase 3 | PED/PEA-15 Protein, PCOS, Obesity, Insulin Sensitivity Indexes, Metformin, Oral Contraceptives | December 2006 | January 2009 |
| NCT00951899 | Completed | Phase 4 | The Effect of Welchol on Glucose Metabolism in Type 2 Diabetics | August 2009 | December 2012 |
| NCT00959101 | Completed | Phase 1 | Comparison of Repaglinide and Metformin Combination Tablet Versus Repaglinide and Metformin as Separate Tablets in Healthy Volunteers | August 2009 | October 2009 |
| NCT00960661 | Completed | Phase 3 | A Trial Comparing Two Therapies: Basal Insulin/Glargine, Exenatide and Metformin Therapy (BET) or Basal Insulin/Glargine, Bolus Insulin Lispro and Metformin Therapy (BBT) in Subjects With Type 2 Diabetes | September 2009 | August 2012 |
| NCT00961909 | Completed | Phase 1 | A Study of RO5095932 in Patients With Type 2 Diabetes Mellitus | June 2009 | October 2010 |
| NCT00964184 | Completed | Phase 4 | Phenotypic and Genetic Correlates of Diabetes (Non-Type 1) in Young Non-Obese Asian Indians in North India and A Study to Evaluate the Efficacy of Sitagliptin (DPP-4 Inhibitor) in a Sub-group of the Study Population | September 2009 | July 2015 |
| NCT00965991 | Completed | N/A | Metformin Compared to Glyburide in Gestational Diabetes | July 2003 | August 2023 |
| NCT00968812 | Completed | Phase 3 | CANagliflozin Treatment And Trial Analysis-Sulfonylurea (CANTATA-SU) SGLT2 Add-on to Metformin Versus Glimepiride | September 2009 | January 2013 |
| NCT00971295 | Completed | Phase 1 | Effect of Eslicarbazepine Acetate on the Pharmacokinetics of Metformin in Healthy Volunteers | October 2007 | September 2008 |
| NCT00975286 | Completed | Phase 3 | 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine | October 2009 | August 2011 |
| NCT00976937 | Completed | Phase 3 | 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years | August 2009 | March 2011 |
| NCT00994812 | Completed | Phase 3 | The Effects of Metformin on Pregnancy and Miscarriage Rates in Polycystic Ovary Syndrome (PCOS) | August 2002 | December 2009 |
| NCT01005160 | Completed | Phase 1 | Drug Interaction Between CKD-501 and Metformin | October 2009 | February 2010 |
| NCT01006590 | Completed | Phase 4 | Efficacy and Tolerability of Saxagliptin add-on Compared to Uptitration of Metformin in Patients With Type 2 Diabetes | October 2009 | December 2010 |
| NCT01023581 | Completed | Phase 3 | Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes | November 2009 | June 2011 |
| NCT01028391 | Completed | Phase 3 | 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064) | September 1, 2007 | January 1, 2009 |
| NCT01034111 | Completed | Phase 3 | A Local Experiential Study With Sitagliptin (an Antihyperglycemic Drug) in 30 Patients With Type 2 Diabetes Mellitus (0431-178) | March 1, 2010 | October 4, 2010 |
| NCT01037660 | Completed | Early Phase 1 | Effects of Lipemia and Metformin on Endothelial Function | September 2005 | December 1, 2016 |
| NCT01043965 | Completed | Phase 1/Phase 2 | Myocardial Perfusion in Type 2 Diabetes | August 2005 | August 2009 |
| NCT01046032 | Completed | N/A | Metformin Treatment Before in Vitro Fertilization (IVF) in Women With Ultrasound Evidence of Polycystic Ovaries | December 2005 | May 2009 |
| NCT01046422 | Completed | Phase 2 | Safety Study of BMS-770767 in Subjects With Type 2 Diabetes | May 2010 | January 2011 |
| NCT01055691 | Completed | Phase 1 | A Study Comparing the Amount of Metformin and After Taking a Combination Tablet vs. Separate Tablets | January 2010 | April 2010 |
| NCT01059825 | Completed | Phase 2 | Study Of Safety And Efficacy Of Ertugliflozin (PF-04971729, MK-8835) In Participants With Type 2 Diabetes (MK-8835-016) | February 24, 2010 | January 20, 2011 |
| NCT01064687 | Completed | Phase 3 | A Study in Participants With Type 2 Diabetes Mellitus | February 2010 | May 2012 |
| NCT01068652 | Completed | Phase 4 | Effect of Different Insulin Administrations, All in Combination With Metformin, on Glycaemic Control in Subjects With Type 2 Diabetes Inadequately Controlled by Oral Anti-diabetic Drugs | March 2010 | May 2012 |
| NCT01068743 | Completed | Phase 1 | Bioequivalence Study of Fixed Dose Combination of 2.5 mg Saxagliptin/850 mg Metformin Tablet Relative to 2.5 mg Onglyza and 850 mg Glucophage Tablets Co-Administered | February 2010 | March 2010 |
| NCT01070160 | Completed | Endometrial Effects of Metformin Action in Women With Polycystic Ovarian Syndrome (PCOS) | June 2009 | July 2013 | |
| NCT01071850 | Completed | Phase 2 | A Study to Evaluate the Effect of ASP1941 in Adult Patients With Type 2 Diabetes Mellitus | March 3, 2010 | April 11, 2011 |
| NCT01075282 | Completed | Phase 3 | A Study in Participants With Type 2 Diabetes Mellitus (AWARD-2) | February 2010 | November 2012 |
| NCT01076075 | Completed | Phase 3 | A Study to Evaluate the Safety and Efficacy of Sitagliptin 100 mg in Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control (MK-0431-229) | June 3, 2010 | January 19, 2012 |
| NCT01077479 | Completed | Phase 2 | Metformin in Preventing Androgen Deprivation Therapy Induced Insulin Resistance and Metabolic Syndrome | February 2010 | June 2013 |
| NCT01084486 | Completed | Phase 1/Phase 2 | Effect of Treatment With Insulin Sensitizer on Arterial Properties, Metabolic Parameters and Liver Function in Patients With Nonalcoholic Fatty Liver Disease | ||
| NCT01087866 | Completed | Phase 2/Phase 3 | Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus | June 2005 | October 2009 |
| NCT01087983 | Completed | Phase 1 | Lapatinib With Sirolimus or Metformin | March 2010 | September 2015 |
| NCT01089166 | Completed | Phase 1 | Study to Compare the Bioavailability of Extended Release Metformin HCl Tablet Versus Glucophage XR® Tablets in Healthy Human Volunteers Under Fasting Condition | ||
| NCT01089179 | Completed | Phase 1 | Bioequivalence Study of Metformin Hydrochloride Extended Release 500 mg Tablet Versus Glucophage XR® 500 mg Tablet in Healthy Volunteers Under Fed Conditions | ||
| NCT01089192 | Completed | Phase 1 | Bioequivalence Study of Metformin Hydrochloride Extended Release 750 mg Tablets Versus Glucophage XR® 750 mg Tablet in Healthy Volunteers Under Fasting Conditions. | ||
| NCT01089205 | Completed | Phase 1 | Bioequivalence Study of Metformin Hydrochloride Extended Release 750 mg Tablets Versus Glucophage XR® 750 mg Tablet in Healthy Volunteers Under Fed Conditions. | ||
| NCT01090752 | Completed | Phase 4 | Renal and Hormonal Effects of Pioglitazone | October 2005 | October 2007 |
| NCT01095653 | Completed | Phase 3 | A Phase III Study of BMS-512148 (Dapagliflozin) in Asian Patients With Type 2 Diabetes Who Are Not Well Controlled With Diet and Exercise | June 2010 | March 2012 |
| NCT01095666 | Completed | Phase 3 | A Phase III Study of BMS-512148 (Dapagliflozin) in Asian Patients With Type 2 Diabetes Who Are Not Well Controlled on Metformin Alone | June 2010 | March 2013 |
| NCT01099618 | Completed | Phase 4 | Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment | March 2010 | August 2014 |
| NCT01106625 | Completed | Phase 3 | The CANTATA-MSU Trial (CANagliflozin Treatment And Trial Analysis - Metformin and SUlphonylurea) | May 2010 | April 2012 |
| NCT01106690 | Completed | Phase 3 | The CANTATA-MP Trial (CANagliflozin Treatment and Trial Analysis - Metformin and Pioglitazone) | June 2010 | July 2012 |
| NCT01111955 | Completed | Phase 2 | Safety Study of BMS-823778 in Subjects With Type 2 Diabetes | July 2010 | January 2011 |
| NCT01117350 | Completed | Phase 4 | Efficacy Assessment of Insulin Glargine Versus LiraglutidE After Oral Agents Failure | July 2010 | March 2013 |
| NCT01117584 | Completed | Phase 2 | A Study to Evaluate the Effect of ASP1941 in Combination With Metformin in Adult Patients With Type 2 Diabetes Mellitus | April 6, 2010 | April 1, 2011 |
| NCT01122316 | Completed | N/A | Management of Diabetes With Metformin In Patients With Chronic Heart Failure | September 2009 | January 2012 |
| NCT01123980 | Completed | Phase 4 | Comparison of the Blood Sugar Lowering Effect of Biphasic Insulin Aspart 30 and Insulin Glargine Both Combined With Metformin and Glimepiride in Chinese and Japanese Subjects With Type 2 Diabetes New to Insulin Treatment | May 2010 | June 2011 |
| NCT01125150 | Completed | Spectroscopic and Colorimetric Analysis of Acanthosis Nigricans in Patients With Hyperinsulinemia | February 2009 | June 2012 | |
| NCT01126580 | Completed | Phase 3 | A Study in Participants With Type 2 Diabetes Mellitus (AWARD-3) | May 2010 | June 2012 |
| NCT01131182 | Completed | Phase 4 | Study of Sitagliptin Treatment in Patients With Type 2 Diabetes During Ramadan (0431-263) | June 13, 2010 | November 4, 2010 |
| NCT01135433 | Completed | Phase 3 | A Study to Assess the Efficacy and Safety of ASP1941 in Combination With Metformin in Type 2 Diabetic Patients | May 15, 2010 | November 28, 2011 |
| NCT01137812 | Completed | Phase 3 | The CANTATA-D2 Trial (CANagliflozin Treatment And Trial Analysis - DPP-4 Inhibitor Second Comparator Trial) | July 2010 | March 2012 |
| NCT00004992 | Completed | Phase 3 | Diabetes Prevention Program | July 1996 | April 2001 |
| NCT01160068 | Completed | Phase 1 | Bioequivalence Study of Metformin Hydrochloride Tablets 1000 mg Tablets of Dr. Reddy's Laboratories Limited Under Fed Condition | February 2005 | May 2005 |
| NCT01169779 | Completed | Phase 3 | Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Mellitus Insufficiently Controlled by Metformin | July 2010 | December 2011 |
| NCT01175473 | Completed | Phase 2 | Effects of Lixisenatide Compared to Liraglutide on the Postprandial Plasma Glucose in Patients With Type 2 Diabetes | August 2010 | November 2010 |
| NCT01181674 | Completed | Phase 4 | Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial) | January 2011 | September 2015 |
| NCT01187849 | Completed | Phase 4 | Metformin to Prevent Metabolic Complications in Glucocorticoid Excess | August 2010 | December 2015 |
| NCT01204294 | Completed | Phase 3 | Comprehensive Add on Study in Japan | September 2010 | January 2012 |
| NCT01205672 | Completed | Early Phase 1 | Evaluation of the Molecular Effects of Metformin on the Endometrium in Patients With Endometrial Cancer | September 16, 2010 | May 28, 2017 |
| NCT01206153 | Completed | Phase 4 | Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients | June 2008 | March 2010 |
| NCT01210911 | Completed | Phase 2 | Metformin Combined With Chemotherapy for Pancreatic Cancer | August 2010 | April 2014 |
| NCT01217073 | Completed | Phase 2 | A Dose-Range Finding Study in Participants With Type 2 Diabetes (MK-3102-006) | October 8, 2010 | April 1, 2013 |
| NCT01217307 | Completed | Phase 2/Phase 3 | Metformin to Reduce Heart Failure After Myocardial Infarction | January 2011 | October 2015 |
| NCT01217892 | Completed | Phase 3 | Evaluation of Dapagliflozin Taken Twice-daily | November 2010 | August 2011 |
| NCT01228240 | Completed | Phase 4 | The Efficacy of Metformin Produced by Pars Mino Co in Comparison With Canadian Apotex Co. | December 2008 | September 2009 |
| NCT01231074 | Completed | Phase 1 | Reducing Antipsychotic-Induced Weight Gain in Children With Metformin | February 2010 | May 2013 |
| NCT01233206 | Completed | Phase 4 | Metformin in High Responder Polycystic Ovary Syndrome (PCOS) Patients Undergoing IVF Cycles | May 2009 | January 2011 |
| NCT01237522 | Completed | Phase 4 | A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers | August 2010 | December 2010 |
| NCT01240759 | Completed | Phase 2 | Safety and Efficacy of S-707106 in Subjects With Type 2 Diabetes Mellitus and Inadequate Glycemic Control With Metformin Therapy | October 2010 | January 2012 |
| NCT01240785 | Completed | Phase 4 | Metformin Versus Insulin in Gestational Diabetes | June 2006 | December 2012 |
| NCT01243385 | Completed | Phase 2 | Metformin Hydrochloride as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Prostate Cancer | December 23, 2010 | August 9, 2019 |
| NCT01247870 | Completed | Phase 4 | Metformin in Chronic Obstructive Pulmonary Disease | January 2011 | May 2014 |
| NCT01266486 | Completed | Phase 2 | Effect of Metformin on Breast Cancer Metabolism | May 2011 | May 2014 |
| NCT01273584 | Completed | Phase 2/Phase 3 | Metformin in Obese Non-diabetic Pregnant Women | October 2010 | September 2015 |
| NCT01274130 | Completed | N/A | Investigatory Study of Metformin's Pharmacokinetics, Pharmacodynamics and Drug Drug Interactions Classifying the Group by MATE1 Genotype in Healthy Volunteers | December 2010 | September 2011 |
| NCT01278160 | Completed | Phase 4 | Comparison of Biphasic Insulin Aspart 30 Twice Daily With Two Different Initial Dosage Split Regimens in Subjects With Type 2 Diabetes: An Extension to Trial BIASP-3756 | January 2011 | September 2011 |
| NCT01279512 | Completed | Phase 4 | Metformin Versus Acarbose Treatment in Infertile Overweight Women With Polycystic Ovary Syndrome (PCOS) | December 2006 | December 2008 |
| NCT01280409 | Completed | Phase 4 | Metformin Postpartum for GDM RCT for Reduced Weight Retention | January 2011 | August 2014 |
| NCT01289119 | Completed | Phase 3 | Efficacy and Safety of Alogliptin in Participants With Type 2 Diabetes | December 2010 | December 2011 |
| NCT01296412 | Completed | Phase 3 | Comparison of Two Treatment Regimens (Sitagliptin Versus Liraglutide) on Participants Who Failed to Achieve Good Glucose Control on Metformin Alone (MK-0431-403) | March 11, 2011 | February 29, 2012 |
| NCT01302145 | Completed | Phase 1 | Drug to Drug Interaction Study With ASP1941 and Metformin | February 25, 2009 | December 9, 2009 |
| NCT01302379 | Completed | N/A | Reach for Health Study: Obesity-related Mechanisms and Mortality in Breast Cancer Survivors | August 2011 | December 2016 |
| NCT01307306 | Completed | N/A | Glucose Control in Severely Burned Patients | March 2011 | March 2018 |
| NCT01310231 | Completed | Phase 2 | A Trial of Standard Chemotherapy With Metformin (vs Placebo) in Women With Metastatic Breast Cancer | August 22, 2011 | March 26, 2018 |
| NCT01318109 | Completed | Phase 2/Phase 3 | Efficacy and Safety of Alogliptin Used Combination With Metformin in Participants With Type 2 Diabetes in Japan | August 2008 | April 2009 |
| NCT01318564 | Completed | Diabetic Treatment Adherence | March 2011 | August 2016 | |
| NCT01319994 | Completed | Phase 2/Phase 3 | Prevention of Metabolic Complications of Glucocorticoid Excess | July 2012 | January 2015 |
| NCT01324180 | Completed | Phase 1 | Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) | July 18, 2011 | July 27, 2017 |
| NCT01334125 | Completed | Phase 3 | Adjunctive Metformin Therapy in Double Diabetes | February 2011 | December 2014 |
| NCT01336322 | Completed | Phase 2 | Metformin and Sitagliptin in Women With Previous Gestational Diabetes | May 2011 | December 2018 |
| NCT01340300 | Completed | Phase 2 | Exercise and Metformin in Colorectal and Breast Cancer Survivors | May 2011 | December 2017 |
| NCT01340664 | Completed | Phase 2 | An Efficacy, Safety, and Tolerability Study of Canagliflozin in the Treatment of Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Monotherapy | July 2011 | April 2012 |
| NCT01340768 | Completed | Phase 3 | Study to Compare Sitagliptin Versus Sulfonylurea Treatment During Ramadan Fasting in Patients With Type 2 Diabetes (MK-0431-262) | June 22, 2010 | September 21, 2011 |
| NCT01341717 | Completed | Phase 4 | Effects of Sitagliptin on Type 2 Diabetes Mellitus Patients on Treatment With Metformin and Insulin | February 2012 | May 2014 |
| NCT01341886 | Completed | N/A | Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer | April 2010 | April 2011 |
| NCT01342614 | Completed | N/A | The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension | May 2006 | August 2009 |
| NCT01349387 | Completed | N/A | Effect of Treatment With Metformin in Type 2 Diabetes Patients on Alternative Genes Splicing | May 2011 | January 2012 |
| NCT01353391 | Completed | Phase 3 | Metformin in Women With Type 2 Diabetes in Pregnancy Trial | May 25, 2011 | June 5, 2019 |
| NCT01357135 | Completed | An Observational Study of Type II Diabetics Treated With Dual Therapy With or Without Sitagliptin (Januvia®/Xelevia®, MK-0431-201) | July 15, 2009 | August 31, 2013 | |
| NCT01357876 | Completed | Phase 1 | Effect of Metformin on Gut Peptides , Bile Acids and Lipid Profiles in Type 2 Diabetics | October 1, 2010 | July 7, 2011 |
| NCT01365091 | Completed | Phase 1 | Bioequivalence Study of Fixed-dose Combinations and Coadministered Individual Tablets of Saxagliptin/Metformin-Brazil | June 2011 | November 2011 |
| NCT01368081 | Completed | Phase 3 | Empagliflozin (BI 10773) Comprehensive add-on Study in Japanese Subjects With Type 2 Diabetes Mellitus | May 2011 | April 2013 |
| NCT01370707 | Completed | Phase 3 | A Study to Evaluate the Efficacy and Safety of CJ-30001 and CJ-30002 in Type 2 Diabetes Mellitus Patients | April 2011 | July 2012 |
| NCT01381900 | Completed | Phase 3 | A Efficacy, Safety, and Tolerability Study of Canagliflozin in Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Alone or in Combination With a Sulphonylurea | August 2011 | November 2012 |
| NCT01394887 | Completed | Phase 2/Phase 3 | Metformin & Inflammation in Pre-diabetic Children | July 2002 | July 2011 |
| NCT01396564 | Completed | Phase 1/Phase 2 | Pioglitazone and Metformin in Diabetic Children | October 2005 | July 2011 |
| NCT01400191 | Completed | Phase 4 | The Inhibitory Effect of Metformin on Gluconeogenesis in Relation to Polymorphisms in Organic Cation Transporter 1 | January 2012 | December 2012 |
| NCT01404715 | Completed | Phase 1 | Drug-drug Interaction Study With Metformin and Imatinib | October 2011 | March 2013 |
| NCT01409395 | Completed | Phase 1 | Drug-Drug Interaction Study With Metformin and Nizatidine | September 2011 | March 2013 |
| NCT01410604 | Completed | Phase 4 | Adipokines in Obese Adolescents With Insulin Resistance | January 2007 | March 2010 |
| NCT01425580 | Completed | Phase 2 | Liraglutide and Heart Failure in Type 2 Diabetes | January 2012 | August 2016 |
| NCT01426399 | Completed | Phase 1 | Pharmacokinetic/Pharmacodynamic Drug-drug Interaction of LC15-0444 and Metformin After Oral Administration in Healthy Male Subjects | August 2011 | December 2011 |
| NCT01427595 | Completed | N/A | Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone | February 18, 2009 | January 17, 2015 |
| NCT01429818 | Completed | Phase 4 | Endothelial Disfunction Treatment With Glimepiride/Metformin Combination (Glimetal) in Type 2 Diabetes Patients | July 2007 | January 2008 |
| NCT01438723 | Completed | Phase 4 | The Metformin in Coronary Artery Bypass Graft (CABG) (MetCAB) Trial | November 2011 | July 2014 |
| NCT01438814 | Completed | Phase 4 | Linagliptin in Combination With Metformin in Treatment Naive Patients With Type 2 Diabetes Mellitus and Insufficient Glycaemic Control | November 2011 | March 2013 |
| NCT01442870 | Completed | Phase 1 | Evaluation of Clinical Safety of Combining Metformin With Anticancer Chemotherapy | September 2011 | November 2014 |
| NCT01459809 | Completed | Phase 3 | Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients | February 2012 | January 2014 |
| NCT01462266 | Completed | Phase 3 | Study of Sitagliptin for the Treatment of Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Insulin (MK-0431-260) | January 13, 2012 | June 7, 2013 |
| NCT01464437 | Completed | Phase 2 | AMG 151 Amgen Protocol Number 20100761 | September 2011 | December 2012 |
| NCT01465113 | Completed | Early Phase 1 | Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus | May 2010 | February 2016 |
| NCT01465152 | Completed | Phase 4 | Comparison of Metformin, Repaglinide or the Combination of Both in Subjects With Type 2 Diabetes | March 6, 2002 | October 21, 2004 |
| NCT01474967 | Completed | N/A | Effect of Dosage of Metformin on Menstruation and Lipid Profile in Women With Polycystic Ovary Syndrome | February 2010 | February 2011 |
| NCT01483560 | Completed | Phase 3 | REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL) | December 2011 | April 18, 2017 |
| NCT01485614 | Completed | Phase 3 | Study to Assess Safety & Efficacy of Sitagliptin as Initial Oral Therapy for Treatment of Type 2 Diabetes Mellitus in Pediatric Participants. (MK-0431-083) | February 10, 2012 | October 9, 2019 |
| NCT01487993 | Completed | Phase 3 | Metformin in Obese Children and Adolescents | August 2011 | February 28, 2017 |
| NCT01488552 | Completed | Phase 1/Phase 2 | Gemcitabine+Nab-paclitaxel and FOLFIRINOX and Molecular Profiling for Patients With Advanced Pancreatic Cancer | November 2011 | August 2016 |
| NCT01489644 | Completed | Phase 1 | Single Dose Pharmacokinetics of Repaglinide, Metformin and Combination Tablet in Healthy Volunteers | June 2006 | July 2006 |
| NCT01490658 | Completed | Phase 1 | Single Dose Pharmacokinetics of Repaglinide, Metformin and Combination Tablet in Fed Healthy Volunteers | June 2006 | August 2006 |
| NCT01505426 | Completed | Phase 3 | A Study to Assess the Efficacy and Safety of ASP1941 in Combination With Metformin in Asian Diabetes Patients | November 28, 2011 | January 14, 2013 |
| NCT01509001 | Completed | Phase 4 | Study of Metabolic and Haemodynamic Effects of Metformin and Glimepiride in Patients With Type 2 Diabetes Mellitus | January 2011 | January 2012 |
| NCT01511172 | Completed | Phase 2 | Effect of Liraglutide as add-on to Metformin Compared to Either Liraglutide or Metformin Alone, or to a Combination of Metformin and a SU (Sulphonylurea) Agent in Subjects With Type 2 Diabetes | August 2002 | December 2002 |
| NCT01511198 | Completed | Phase 2 | Efficacy and Safety of Metformin and Liraglutide in Obese Subjects With Type 2 Diabetes Previously Treated With an Oral Hypoglycemic Agent | February 2001 | October 2001 |
| NCT01512979 | Completed | Phase 4 | Linagliptin and Metformin Versus Linagliptin in Newly Diagnosed, Untreated Type 2 Diabetes | January 2012 | April 2013 |
| NCT01517412 | Completed | Phase 3 | Comparison of Lixisenatide Injected Prior to the Main Meal of the Day Versus Prior to Breakfast in Type 2 Diabetic Patients on Metformin | February 2012 | May 2013 |
| NCT01518101 | Completed | Phase 4 | Vildagliptin Versus Liraglutide - Patient Preference After Receiving Both Medications | January 2012 | October 2012 |
| NCT01519674 | Completed | Phase 4 | Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin | June 2012 | October 2013 |
| NCT01521624 | Completed | N/A | Metformin Effects on Oxidative Stress Parameters in Newly Diagnosed Type 2 Diabetes Patients | October 2010 | September 2011 |
| NCT01524705 | Completed | Phase 4 | FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR) | August 2012 | July 2014 |
| NCT01525823 | Completed | Phase 1 | Assessment of Blood Glucose Changes in Healthy Volunteers After BMS-754807 Alone or BMS-754807 With Metformin | February 2012 | April 2012 |
| NCT01526616 | Completed | N/A | Spironolactone Plus Metformin in Polycystic Ovary Syndrome | May 2010 | July 2011 |
| NCT01528046 | Completed | Phase 1 | Metformin in Children With Relapsed or Refractory Solid Tumors | September 24, 2012 | February 3, 2020 |
| NCT01528254 | Completed | Phase 4 | VERIFY:A Study to Compare Combination Regimen With Vildagliptin & Metformin Versus Metformin in Treatment-naïve Patients With Type 2 Diabetes Mellitus | March 30, 2012 | April 4, 2019 |
| NCT01541215 | Completed | Phase 3 | Efficacy and Safety of Liraglutide in Combination With Metformin Compared to Metformin Alone, in Children and Adolescents With Type 2 Diabetes | November 13, 2012 | May 20, 2020 |
| NCT01541956 | Completed | Phase 4 | Efficacy of VIldagliptin aS an Add-on Therapy to Metformin Compared to Metformin Up-TitratION in Chinese Patients With Type 2 Diabetes.(VISION) | February 2012 | December 2013 |
| NCT01545388 | Completed | Phase 3 | Metformin Add-on Regimen Comparison Study in Japanese Participants With Type 2 Diabetes Mellitus (MK-0431A-136) | February 23, 2012 | March 12, 2013 |
| NCT01546558 | Completed | Phase 1 | Single Cohort, 2-Period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine 500 mg | February 2012 | March 2012 |
| NCT01546597 | Completed | Phase 1 | Single Cohort 4-period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine | February 2012 | March 2012 |
| NCT06125873 | Enrolling by invitation | Phase 2 | Effect of Moringa Leaf Capsules on Glycemic Control of Type 2 Diabetic Patients | March 15, 2023 | August 1, 2024 |
| NCT06125587 | Enrolling by invitation | Phase 2/Phase 3 | Chiglitazar/Metformin in Non-obese Women With PCOS | November 2023 | May 2026 |
| NCT04224051 | Enrolling by invitation | Phase 2 | Metformin for Abdominal Aortic Aneurysm Growth Inhibition | February 12, 2020 | January 2026 |
| NCT05929495 | Not yet recruiting | Phase 2 | Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma | December 1, 2023 | January 1, 2026 |
| NCT05833958 | Not yet recruiting | Phase 2 | Polypill Versus Metformin in New Onset Type 2 Diabetes | September 2024 | September 2025 |
| NCT06353061 | Not yet recruiting | Phase 2 | Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer | April 15, 2024 | February 1, 2026 |
| NCT06257966 | Not yet recruiting | Phase 3 | A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin | March 1, 2024 | December 31, 2025 |
| NCT06140485 | Not yet recruiting | Phase 3 | A Trial to Investigate the Efficacy and Safety of NW Low-Glu® in Patients With Type II Diabetes Mellitus | March 2024 | October 2025 |
| NCT06147050 | Not yet recruiting | Phase 3 | Effect of Metformin in Reducing Fatigue in Long COVID in Adolescents | April 2024 | December 2024 |
| NCT06424860 | Not yet recruiting | Phase 1 | Fish Oil, Metformin and Heart Health in PCOS | August 1, 2024 | December 30, 2027 |
| NCT05468554 | Not yet recruiting | Phase 3 | Evaluation of Metformin Effect on the Fertility of Women Treated With 131I for Thyroid Cancer | November 1, 2022 | April 30, 2026 |
| NCT05426044 | Not yet recruiting | Phase 3 | Metformin as a Neuroprotective Therapy for Glaucoma - A Randomized Controlled Trial | July 1, 2022 | December 31, 2025 |
| NCT06087796 | Not yet recruiting | Phase 1 | Topical Pentoxifylline; Metformin Versus Betamethasone in the Treatment of Alopecia Areata. | October 2023 | October 2024 |
| NCT06083935 | Not yet recruiting | Phase 4 | Evaluation of the Effects of Diosmin/Hespiridin Combination on the Clinical Outcomes in Patients With Polycystic Ovary Syndrome | November 1, 2023 | December 1, 2024 |
| NCT05965908 | Not yet recruiting | Phase 3 | Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome | July 30, 2023 | October 30, 2023 |
| NCT04530058 | Not yet recruiting | Phase 2 | The Effects of Metformin on Morbidity and Mortality in Elderly Patients | March 2024 | March 2029 |
| NCT04523363 | Not yet recruiting | Phase 4 | Metformin Versus Standard of Care Treatment in Pregnant Women With Prediabetes | June 1, 2025 | June 30, 2026 |
| NCT06059287 | Not yet recruiting | N/A | The Effect of Henagliflozin and Metformin on Myocardial Tissue-level Characteristics | October 1, 2023 | December 31, 2025 |
| NCT06096454 | Not yet recruiting | Phase 4 | Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin Resistance | November 20, 2023 | October 30, 2024 |
| NCT06280274 | Not yet recruiting | Phase 4 | Metformin Use in Patients Undergoing Total Joint Replacement Surgery | February 26, 2024 | May 30, 2025 |
| NCT05412056 | Not yet recruiting | Phase 2/Phase 3 | Metformin to Prevent Preterm Birth in Twin Pregnancy | June 2022 | June 2025 |
| NCT06429007 | Not yet recruiting | Phase 2 | A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury | October 1, 2024 | October 1, 2027 |
| NCT04925063 | Not yet recruiting | Phase 2 | The Effect of Metformin in Patients With Newly Diagnosed mHSPC | June 16, 2021 | August 31, 2027 |
| NCT06445946 | Not yet recruiting | Phase 4 | DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes | July 2024 | December 2030 |
| NCT06185179 | Not yet recruiting | Early Phase 1 | Metformin and Muscle Recovery | September 1, 2024 | July 31, 2030 |
| NCT06147518 | Not yet recruiting | N/A | To Compare the Safety and Efficacy of Dapagliflozin Plus Metformin Versus Sitagliptin Plus Metformin for Treatment of Diabetes in Patients With Compensated and Stable Decompensated Cirrhosis | December 20, 2023 | December 31, 2024 |
| NCT06452511 | Not yet recruiting | Early Phase 1 | Comparing the Effect of Metformin vs. Pep2dia as an Adjunct to Letrozole on Ovulation Induction and Pregnancy Outcomes in Overweight Women With PCOS | July 1, 2024 | July 1, 2025 |
| NCT06439758 | Not yet recruiting | Phase 4 | Effects of First-Line Oral Hypoglycemics in Bone Markers of Treatment Naïve Saudi Adults With Type 2 Diabetes | August 1, 2024 | December 1, 2025 |
| NCT04926155 | Not yet recruiting | Phase 2 | The Effect of Metformin in Patients With Metastatic Castration-resistant Prostate Cancer | June 23, 2021 | August 31, 2024 |
| NCT06339086 | Not yet recruiting | Phase 3 | Efficacy and Safety of Semaglutide Injection in Subjects With Type 2 Diabetes | April 2024 | December 30, 2025 |
| NCT06296836 | Not yet recruiting | Phase 4 | Effect of Continuing Versus Holding Metformin During Hospitalizations. | April 1, 2024 | June 30, 2026 |
| NCT04945148 | Not yet recruiting | Phase 2 | Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide | May 2023 | October 2026 |
| NCT05655728 | Not yet recruiting | Phase 4 | Treatment With Metformin in Chinese Children With Alport Syndrome | January 3, 2023 | April 20, 2025 |
| NCT05910554 | Not yet recruiting | Phase 2 | Investigation of the Efficacy of Metformin Therapy on Pulmonary Sarcoidosis | May 1, 2024 | March 1, 2025 |
| NCT05572060 | Not yet recruiting | N/A | Effect of Metformin Use on Mortality in Diabetic and Non Diabetic Patients With Sepsis and Septic Shock. | December 1, 2022 | January 31, 2025 |
| NCT04298684 | Not yet recruiting | Phase 4 | Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules in Type 2 Diabetes | January 1, 2021 | July 1, 2024 |
| NCT03686657 | Not yet recruiting | Phase 1/Phase 2 | Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients | October 10, 2023 | January 31, 2026 |
| NCT04670666 | Not yet recruiting | Phase 3 | Efficacy and Safety of Madalena Association in the Treatment of Type II Diabetes Mellitus | May 2024 | June 2025 |
| NCT06405971 | Not yet recruiting | N/A | Metformin in Patients With Unruptured Vertebrobasilar Dissecting Aneurysms (METTLE) | June 1, 2024 | June 1, 2025 |
| NCT06080802 | Not yet recruiting | Phase 2/Phase 3 | The Effect of Addition of Metformin to SGLT2 In Diabetic Patients With Heart Failure With Preserved Ejection Fraction | November 1, 2023 | December 1, 2024 |
| NCT05646199 | Not yet recruiting | Phase 2/Phase 3 | Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS) | March 1, 2025 | December 30, 2025 |
| NCT05878535 | Not yet recruiting | Phase 2 | METFORMIN FOR ATRIAL FIBRILLATION | June 1, 2024 | April 2025 |
| NCT05942963 | Not yet recruiting | Phase 4 | Efficacy of Empagliflozin and Pioglitazone in Diabetic Patients With NAFLD | October 2023 | April 2024 |
| NCT05952882 | Not yet recruiting | Phase 3 | Liraglutide and Metformin Combination on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With PCOS, Obesity and Infertility | November 1, 2023 | December 31, 2025 |
| NCT05854966 | Not yet recruiting | Phase 2 | CPI-613 Given With Metformin in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) | July 2024 | September 2025 |
| NCT05694221 | Not yet recruiting | Phase 1 | Drug Drug Interaction (DDI) Between Supaglutide and Digoxin or Metformin | February 1, 2023 | December 31, 2023 |
| NCT05591235 | Not yet recruiting | Phase 3 | Effect of Metformin, Dapagliflozin, Combination of Metformin and Pioglitazone in Patients With Type 2 Diabetes | November 2022 | February 2023 |
| NCT06328426 | Not yet recruiting | N/A | Vitamin D With Omega-3 or Metformin in Osteoarthritis | August 2024 | December 2026 |
| NCT06405178 | Not yet recruiting | Phase 3 | Adjuvant Therapy With Letrozole in Induction of Ovulation With Polycystic Ovarian Syndrome | September 30, 2024 | December 30, 2024 |
| NCT05760456 | Not yet recruiting | Phase 3 | Safety and Efficacy of DIDALA Monotherapy in Patients With Type 2 Diabetes Compared With Metformin. | March 15, 2023 | August 31, 2024 |
| NCT06463743 | Not yet recruiting | Phase 2 | Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS) | August 2024 | May 2026 |
| NCT04742751 | Recruiting | Phase 2 | An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer | March 2, 2022 | March 2026 |
| NCT03629340 | Recruiting | Phase 2 | Metformin for Pulmonary Hypertension HFpEF | February 26, 2019 | September 2024 |
| NCT05722951 | Recruiting | Phase 3 | Metformin Efficacy and Safety in Epileptic Patients | October 18, 2022 | October 2023 |
| NCT04767841 | Recruiting | Phase 1/Phase 2 | The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Patients With Knee Osteoarthritis | February 16, 2021 | December 31, 2024 |
| NCT06367283 | Recruiting | Phase 3 | Metformin Treatment of Patients With Hand Osteoarthritis | June 2024 | April 2026 |
| NCT04792749 | Recruiting | Phase 3 | Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer | June 1, 2021 | March 31, 2024 |
| NCT04826692 | Recruiting | Phase 3 | TEsting METformin Against Cognitive Decline in HD | December 10, 2021 | August 2024 |
| NCT04836910 | Recruiting | Microbiome and Polycystic Ovaries | September 1, 2024 | March 30, 2026 | |
| NCT04841668 | Recruiting | Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly | April 10, 2021 | February 28, 2026 | |
| NCT05744479 | Recruiting | Phase 4 | Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability | February 28, 2023 | December 1, 2026 |
| NCT03570632 | Recruiting | Phase 4 | Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus | July 8, 2019 | December 2024 |
| NCT06096259 | Recruiting | Phase 2 | Preventing Injured Knees From osteoArthritis: Severity Outcomes | May 6, 2024 | December 2029 |
| NCT06100822 | Recruiting | Phase 1 | Managing Chronic Tendon Pain by Metformin | May 24, 2024 | April 2025 |
| NCT02969798 | Recruiting | N/A | Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT) | January 1, 2014 | July 2025 |
| NCT06335134 | Recruiting | Phase 1 | A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin | July 14, 2023 | March 31, 2024 |
| NCT02246257 | Recruiting | N/A | Early Rheumatoid Arthritis COR Intervention | September 2014 | September 2024 |
| NCT01638676 | Recruiting | Phase 1/Phase 2 | A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients | July 2012 | June 2027 |
| NCT06120881 | Recruiting | Early Phase 1 | Precision Dosing of Metformin in Youth With T2D | April 1, 2024 | December 31, 2025 |
| NCT06127433 | Recruiting | Phase 4 | The Effect of Short-term Insulin Intensive Therapy Based on the Application of Insulin Pump and Real-time Dynamic Glucose Monitoring Technology on Reversing the Newly Diagnosed Type 2 Diabetes | March 7, 2023 | December 30, 2024 |
| NCT03054519 | Recruiting | Phase 3 | Improve PAD PERformance With METformin | May 1, 2017 | December 31, 2024 |
| NCT03511118 | Recruiting | Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants | October 4, 2018 | September 23, 2024 | |
| NCT05093959 | Recruiting | Phase 2 | Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction | January 4, 2022 | September 2025 |
| NCT05098470 | Recruiting | Phase 3 | Effects of Modulators of Gluconeogenesis, Glycogenolysis and Glucokinase Activity | March 7, 2022 | March 31, 2025 |
| NCT05553704 | Recruiting | Phase 2 | Metformin in Patients With Ulcerative Colitis Treated With Mesalamine | November 1, 2022 | December 20, 2025 |
| NCT04033107 | Recruiting | Phase 2 | High Dose Vitamin C Combined With Metformin in the Treatment of Malignant Tumors | July 1, 2020 | December 2024 |
| NCT05120505 | Recruiting | Phase 4 | Metformin in Children With Fragile X Syndrome | December 29, 2021 | December 30, 2024 |
| NCT05182970 | Recruiting | Phase 3 | Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET) | December 2, 2021 | May 2026 |
| NCT05183204 | Recruiting | Phase 2 | Paxalisib With a High Fat, Low Carb Diet and Metformin for Glioblastoma | February 14, 2022 | December 2025 |
| NCT05243654 | Recruiting | Phase 2 | Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy | October 1, 2022 | February 28, 2026 |
| NCT05767515 | Recruiting | N/A | The Effects of Acetyl-L-Carnitine and Myo/Chiro-Inositol in Patients With PCOS | July 15, 2023 | March 10, 2024 |
| NCT06181422 | Recruiting | Phase 2/Phase 3 | Metformin and Lactoferrin in Sepsis in Icu | April 2024 | June 9, 2024 |
| NCT05292573 | Recruiting | Phase 3 | Longitudinal Follow-up in Women With Endometrial Hyperplasia Without Atypia | August 1, 2018 | January 29, 2026 |
| NCT05305898 | Recruiting | Phase 3 | "MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary Syndrome | February 8, 2022 | December 2025 |
| NCT06325956 | Recruiting | N/A | PCOS Immune Function Predicts Metformin Efficacy | March 16, 2024 | July 1, 2026 |
| NCT05779644 | Recruiting | N/A | Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus | February 23, 2023 | February 23, 2025 |
| NCT06199544 | Recruiting | Phase 1 | Effect of Unani Medicine for the Management of Anomalies Associated With Polycystic Ovarian Syndrome | October 1, 2022 | December 1, 2024 |
| NCT05345327 | Recruiting | Phase 3 | SGLT2 Inhibitors As First Line Therapy to Prevent Renal Decline in Type 2 Diabetes | January 1, 2023 | June 30, 2026 |
| NCT05366868 | Recruiting | Phase 4 | Durable Effect of Imeglimin on the Glycemic Control in Patients With Type 2 Diabetes Mellitus | May 26, 2022 | March 31, 2027 |
| NCT05373680 | Recruiting | Phase 2/Phase 3 | Efficacy and Safety of Metformin Versus Empagliflozin on Chronic Kidney Disease Progression | January 1, 2022 | June 2024 |
| NCT05781711 | Recruiting | Phase 2 | Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease | January 6, 2023 | November 20, 2025 |
| NCT03651895 | Recruiting | Phase 2 | Metformin to Reduce Airway Glucose in COPD Patients | May 17, 2022 | June 1, 2023 |
| NCT05394142 | Recruiting | Phase 2 | A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS) | May 24, 2022 | April 2025 |
| NCT06231758 | Recruiting | Phase 3 | Metformin Safety and Efficacy in Osteoarthritis. | January 30, 2024 | September 20, 2027 |
| NCT03271866 | Recruiting | N/A | Metformin Treatment on Cognitive Impairment of Schizophrenia Co-morbid Metabolic Syndrome | August 28, 2017 | December 31, 2023 |
| NCT05414409 | Recruiting | Phase 2 | The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action | September 28, 2022 | August 1, 2026 |
| NCT06377696 | Recruiting | Phase 2 | Remote Cognitive Assessment Battery and Wearable Device Monitoring Platform While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy | May 31, 2024 | May 2027 |
| NCT03311308 | Recruiting | Phase 1 | A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma | February 7, 2018 | December 2028 |
| NCT05966792 | Recruiting | Phase 4 | SGLT2 Inhibitors in Treating Patients With PCOS | November 10, 2023 | March 15, 2025 |
| NCT05469659 | Recruiting | Phase 2 | Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD) | September 22, 2021 | October 30, 2026 |
| NCT06446531 | Recruiting | Phase 1 | Prevention of Progression of Prediabetes, Obesity and CV Risk | July 1, 2024 | July 1, 2027 |
| NCT05979038 | Recruiting | Phase 3 | Clinical Evaluation of the Effect of Metformin in Sepsis | September 10, 2023 | July 10, 2024 |
| NCT05515978 | Recruiting | Early Phase 1 | Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients | October 17, 2022 | November 6, 2036 |
| NCT03379909 | Recruiting | Phase 2 | Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer | September 1, 2019 | October 1, 2029 |
| NCT04114136 | Recruiting | Phase 2 | Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies | September 14, 2020 | April 30, 2032 |
| NCT05847244 | Recruiting | Phase 2 | The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction | October 1, 2023 | December 1, 2024 |
| NCT05900466 | Recruiting | Phase 2 | Metformin for Fibromyalgia Symptoms (INFORM Trial) | April 1, 2023 | March 31, 2026 |
| NCT02587741 | Recruiting | Early Phase 1 | Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different Regimens | July 2015 | July 2025 |
| NCT05986838 | Recruiting | N/A | Effect of Laser Puncture Versus Ultraviolet Radiation on Women With Polycystic Ovarian Syndrome | August 30, 2023 | April 2024 |
| NCT03675893 | Recruiting | Phase 2 | RESOLVE: Abemaciclib + Letrozole +/- Metformin or Zotatifin in Endometrial or Low-Grade Serous Ovarian Cancer | December 24, 2018 | August 1, 2029 |
| NCT05988684 | Recruiting | Phase 4 | Effect of Metformin on Carotid Atherosclerosis for Non-diabetic Patients With PsA (CAMPA Study) | August 30, 2023 | October 2025 |
| NCT04264897 | Recruiting | Phase 3 | Antecedent Metabolic Health and Metformin Aging Study | July 29, 2020 | April 30, 2024 |
| NCT04275713 | Recruiting | Phase 2 | Altered Tumor Oxygenation by Metformin, a Potential Step in Overcoming Radiotherapy Resistance in LACC | May 22, 2020 | September 2025 |
| NCT02647827 | Recruiting | Phase 2 | Acupuncture or Metformin for Insulin Resistance in Women With PCOS | December 2015 | December 2025 |
| NCT04332393 | Recruiting | Phase 4 | Metformin to Treat Corticosteroids-induced Hyperglycemia | May 15, 2020 | December 2024 |
| NCT03862950 | Recruiting | Phase 2 | A Trial of Metformin in Individuals With Fragile X Syndrome (Met) | May 24, 2019 | June 2026 |
| NCT06044025 | Recruiting | Phase 1 | A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy | April 11, 2024 | October 2026 |
| NCT06049186 | Recruiting | N/A | CRD vs. Met in Patients With Obese PCOS Infertility | September 15, 2023 | March 31, 2026 |
| NCT01422746 | Recruiting | Early Phase 1 | Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess | March 20, 2017 | December 2024 |
| NCT04500756 | Recruiting | Phase 2 | Limiting AAA With Metformin (LIMIT) Trial | February 28, 2022 | March 31, 2027 |
| NCT06416800 | Recruiting | Phase 1 | A Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics When Administered Orally to Healthy Adult Participants | June 19, 2024 | August 10, 2024 |
| NCT04536805 | Recruiting | Phase 1/Phase 2 | Relapse in Previously Irradiated Prostate Bed : Stereotactic Ablative Reirradiation Potentiated by Metformin | November 17, 2020 | November 2030 |
| NCT03889795 | Recruiting | Phase 1 | Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors | June 5, 2019 | December 30, 2026 |
| NCT04581447 | Recruiting | Phase 3 | Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard Care | January 7, 2021 | November 2026 |
| NCT03905941 | Recruiting | Early Phase 1 | Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age | August 23, 2021 | May 1, 2027 |
| NCT04583462 | Recruiting | Phase 3 | Impact of Metformin on Peripheral Arterial Calcification in Type 1 Diabetes | June 2, 2021 | February 2, 2025 |
| NCT05574387 | Recruiting | Phase 2 | Metformin as Added on Therapy in Patients With Ulcerative Colitis | January 20, 2023 | April 2027 |
| NCT04623567 | Recruiting | Phase 1/Phase 2 | Efficacy Assessment of Chinese Herbal Medicine Jiangtang Tiaozhi Recipe Treating Participants With Glucose and Lipid Metabolism Disturbances | December 22, 2021 | June 30, 2024 |
| NCT04625946 | Recruiting | Phase 4 | Metformin as an Adjunctive Therapy to Catheter Ablation in Atrial Fibrillation | January 19, 2021 | February 2025 |
| NCT03925714 | Recruiting | Phase 3 | Impact of P53 and SIRT1 in Type 2 Diabetes | April 1, 2019 | December 2028 |
| NCT05932251 | Recruiting | Towards Precision Medicine for Diabetes in Pregnancy | June 19, 2023 | December 31, 2025 | |
| NCT04691960 | Recruiting | Phase 2 | A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging | August 2016 | December 2024 |
| NCT04741945 | Recruiting | Phase 2 | Repurposing Metformin as a Leukemia-preventive Drug in CCUS and LR-MDS | December 13, 2021 | June 2026 |
| NCT02521753 | Suspended | N/A | Omega 3 Polyunsaturated Fatty Acids (PUFA) or Magnesium in Obese Polycystic Ovary Syndrome Patients | August 2015 | July 2024 |
| NCT03713801 | Suspended | Phase 1 | Impact of Metformin on Immunity | January 14, 2019 | July 2026 |
| NCT04116203 | Suspended | Phase 1 | Dietary Fish Oil Intervention in Polycystic Ovary Syndrome (PCOS) | June 30, 2016 | December 30, 2024 |
| NCT00698789 | Terminated | Phase 2 | Evaluate the Safety and Tolerability of INCB019602 When Administered With Metformin in Patients With Type 2 Diabetes | May 2008 | June 2009 |
| NCT03031821 | Terminated | Phase 3 | Metformin in Patients Initiating ADT as Prevention and Intervention of Metabolic Syndrome | July 12, 2018 | November 24, 2023 |
| NCT00809536 | Terminated | Phase 1 | Investigation Of How PD 0332334 And Metformin Are Eliminated From The Body When They Are Administered At The Same Time | January 2009 | February 2009 |
| NCT02285855 | Terminated | Phase 2 | Metformin in Non Small Cell Lung Cancer (NSCLC) | February 20, 2015 | January 5, 2019 |
| NCT00814372 | Terminated | Phase 2 | Evaluate Safety and Effectiveness of MBX-102 in Type 2 Diabetes Patients With Poor Glycemic Control on Metformin | December 2008 | February 2010 |
| NCT02072096 | Terminated | Phase 4 | A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM) | February 2014 | October 2015 |
| NCT02495103 | Terminated | Phase 1/Phase 2 | Vandetanib in Combination With Metformin in People With HLRCC or SDH-Associated Kidney Cancer or Sporadic Papillary Renal Cell Carcinoma | August 26, 2015 | February 6, 2020 |
| NCT00868790 | Terminated | Phase 2 | A Study of the Safety and Efficacy of MK-3577 in Participants With Type 2 Diabetes Mellitus (MK-3577-009) | March 24, 2009 | July 13, 2010 |
| NCT02319200 | Terminated | Phase 3 | Primary Prevention Hepatocellular Carcinoma by Metformin | June 2015 | April 2016 |
| NCT01678820 | Terminated | Phase 3 | A Study of the Efficacy and Safety of MK-0431D (a Fixed-dose Combination of Sitagliptin and Simvastatin) for the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-266) | October 10, 2012 | November 1, 2013 |
| NCT02492763 | Terminated | Phase 2 | A Preliminary Study of the Efficacy and Safety of MK-8521 for Type 2 Diabetes (MK-8521-004) | July 27, 2015 | April 18, 2017 |
| NCT00469586 | Terminated | Phase 3 | Efficacy and Safety of Inhaled Insulin Compared to Metformin and Glimepiride in Type 2 Diabetes | April 26, 2007 | April 24, 2008 |
| NCT04170959 | Terminated | Phase 2 | The Addition of Metformin to Definitive Radiotherapy in Patients With Stage III NSCLC | July 30, 2018 | January 8, 2021 |
| NCT01666665 | Terminated | Phase 2/Phase 3 | Mechanisms of Improved Wound Healing and Protein Synthesis of Insulin and Metformin | November 2012 | April 23, 2019 |
| NCT01654640 | Terminated | Phase 4 | The Effect of Metformin on Obesity and Metabolic Disturbance in Patients Taking Clozapine | September 2012 | April 2015 |
| NCT01997775 | Terminated | Phase 2 | Metformin in Stage IV Lung Adenocarcinoma | August 2013 | June 2016 |
| NCT02932475 | Terminated | Phase 3 | Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) | May 25, 2017 | June 15, 2022 |
| NCT01578551 | Terminated | Phase 2 | Study of Metformin Plus Paclitaxel/Carboplatin/Bevacizumab in Patients With Adenocarcinoma. | May 2012 | January 2017 |
| NCT00362765 | Terminated | Phase 2/Phase 3 | Fenofibrate and Metformin Insulin Sensitivity in Type 2 Diabetics Study | October 2006 | July 2007 |
| NCT02931253 | Terminated | Phase 2 | Metformin as an Upstream Therapy in Atrial Fibrillation | April 11, 2017 | July 10, 2018 |
| NCT00767000 | Terminated | Phase 2 | Dose Range Finding Study of MK-0941 in Patients With Type 2 Diabetes Mellitus on Insulin (MK-0941-007 AM3 EXT1 AM1)(TERMINATED) | October 2008 | June 2010 |
| NCT03608358 | Terminated | Phase 3 | Safety and Efficacy of Dapagliflozin in Asian T2DM Subjects With Inadequate Glycemic Control on Metformin/Saxagliptin | February 27, 2019 | August 4, 2020 |
| NCT03761134 | Terminated | Phase 3 | Efficacy and Safety of Sotagliflozin Versus Placebo in Chinese Patients With Type 2 Diabetes Mellitus Not Adequately Controlled by Metformin With or Without Sulfonylurea | November 30, 2018 | April 29, 2020 |
| NCT02360059 | Terminated | Phase 2 | Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer | October 2015 | September 2016 |
| NCT00571519 | Terminated | Phase 3 | Randomized, Double-blind, Active-controlled, Study of Rivoglitazone in Type 2 Diabetes Mellitus | November 14, 2007 | May 23, 2008 |
| NCT00427154 | Terminated | Phase 3 | Effect of Inhaled Pre-prandial Human Insulin on Blood Glucose Control in Type 2 Diabetes | January 10, 2007 | March 11, 2008 |
| NCT00348712 | Terminated | Phase 3 | Efficacy and Safety of Inhaled Pre-prandial Human Insulin in Type 2 Diabetes | October 30, 2006 | March 5, 2008 |
| NCT01477060 | Terminated | Phase 2 | Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients With Metastatic Breast Cancer | November 2011 | December 2013 |
| NCT03451006 | Terminated | Phase 2 | Effect of Metformin on Frailty in 12 Subjects | May 24, 2018 | December 16, 2021 |
| NCT01632020 | Terminated | Phase 2 | Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth | August 2012 | January 2015 |
| NCT01482286 | Terminated | Phase 3 | Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS | May 2012 | December 2016 |
| NCT02640534 | Terminated | Phase 2 | Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in Combination With Enzalutamide vs. Enzalutamide Alone | June 10, 2016 | March 16, 2023 |
| NCT01627067 | Terminated | Phase 2 | Exemestane-RAD001-Metformin | September 2012 | February 1, 2019 |
| NCT00261352 | Terminated | Phase 3 | GALLANT 14 Tesaglitazar vs. Metformin and Fenofibrate | March 2005 | December 2006 |
| NCT02190838 | Terminated | Phase 2 | Comparison of Melatonin or Metformin and Dacarbazine Combination Versus Dacarbazine Alone in Disseminated Melanoma | April 2014 | December 31, 2018 |
| NCT01351753 | Terminated | Phase 2 | Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity | March 2011 | January 9, 2014 |
| NCT00449605 | Terminated | Phase 3 | A Glycemic Control Evaluation of Glimepiride Versus Rimonabant on Top of Metformin in Type 2 Diabetes | March 2007 | March 2009 |
| NCT02815397 | Terminated | Phase 2 | DA-EPOCH-Rituximab/Metformin (RM) for Double Hit Lymphoma | February 2016 | July 2016 |
| NCT00325910 | Terminated | Phase 3 | Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study | May 2006 | May 2007 |
| NCT00169624 | Terminated | Phase 3 | Peripheral and Coronary Endothelial Dysfunction In Type 2diabetic Patients- Role of Metformin | October 2005 | |
| NCT01756105 | Terminated | Phase 2 | Efficacy of Metformin in Achieving Glycaemia Goals as Recommended for the Treatment of Gestational Diabetes in Non Obese Women | June 2012 | June 2018 |
| NCT03118713 | Terminated | Phase 4 | A Study to Evaluate the Renal Protective Effect (Urine Albumin-to-Creatinine Ratio (UACR)), Efficacy and Safety of Ipragliflozin in Type 2 Diabetes Mellitus Patients With Albuminuria | April 25, 2017 | December 12, 2018 |
| NCT00282945 | Terminated | N/A | Beta Cell Function Tests Over Time In Patients With T2dm Randomized To Metformin Or Rosiglitazone | January 2006 | October 2007 |
| NCT02473094 | Terminated | Phase 2 | Neoadjuvant Metformin in Association to Chemoradiotherapy for Locally Advanced Rectal Cancer | July 2015 | February 2016 |
| NCT01167738 | Terminated | Phase 2 | Combination Chemotherapy With or Without Metformin Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer | July 2010 | April 2015 |
| NCT03151772 | Terminated | Early Phase 1 | Bioavailability of Disulfiram and Metformin in Glioblastomas | January 29, 2018 | September 24, 2020 |
| NCT02393573 | Terminated | N/A | Attenuating The Post-Operative Insulin Resistance And Promoting Protein Anabolism | November 2015 | March 2018 |
| NCT00762957 | Terminated | Phase 3 | Safety and Efficacy of TAK-559 in Combination With Metformin in Patients With Type 2 Diabetes Mellitus. | November 2004 | December 2004 |
| NCT02274740 | Terminated | Phase 2 | Effect of Lixisenatide on Postprandial Lipid Profile in Obese Type 2 Diabetic Patients | April 2015 | August 2015 |
| NCT02140788 | Terminated | Phase 4 | Effects of Metformin and Fish Oil on Treatment With Clozapine | May 2011 | February 2013 |
| NCT00251953 | Terminated | Phase 3 | GALLANT 8 Tesaglitazar Add-on to Metformin | July 2004 | March 2006 |
| NCT00682890 | Terminated | Phase 4 | Combination Metformin and Oral Contraception for Polycystic Ovary Syndrome (PCOS) | November 2005 | January 2010 |
| NCT00647023 | Terminated | N/A | Incretin Secretion in Women With Polycystic Ovary Syndrome (PCOS) | February 2004 | May 2006 |
| NCT01799057 | Terminated | Phase 4 | The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication | July 2013 | December 2014 |
| NCT01486043 | Terminated | N/A | Metformin and Transient Hyperglycemia | December 2011 | May 2013 |
| NCT02402348 | Terminated | Early Phase 1 | Pilot Study of Metformin in HNSCC to Investigate the Effects of MF, Tumor Genotype and MF-genotype Interactions, on Tumor Metabolism and Anoikis | December 2014 | August 2016 |
| NCT05536037 | Terminated | Phase 1 | Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions | May 4, 2022 | March 16, 2024 |
| NCT01177709 | Terminated | N/A | Metformin for Weight Loss in Schizophrenia | May 2008 | April 2011 |
| NCT02020616 | Terminated | Phase 1/Phase 2 | A Study of the Safety and Effectiveness of LY3053102 in Participants With Type 2 Diabetes | December 2013 | February 2015 |
| NCT03651531 | Terminated | Phase 3 | Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes Mellitus | January 3, 2018 | July 30, 2019 |
| NCT02472353 | Terminated | Phase 2 | Use of Metformin to Reduce Cardiac Toxicity in Breast Cancer | July 2014 | May 23, 2018 |
| NCT01834274 | Terminated | Phase 3 | Comparison of Fasiglifam (TAK-875) With Sitagliptin When Used in Combination With Metformin in Patients With Type 2 Diabetes | June 2013 | March 2014 |
| NCT03258723 | Terminated | Phase 4 | Diabetes Prevention With Lifestyle Intervention and Metformin Escalation | July 30, 2018 | December 1, 2021 |
| NCT01486966 | Terminated | Phase 4 | Comparing Efficacy and Safety of Insulin Detemir Plus Insulin Aspart and NPH Insulin Plus Human Soluble Insulin With or Without Metformin in Chinese Patients With Type 2 Diabetes | November 2011 | June 2012 |
| NCT02460354 | Terminated | Phase 1 | Metformin and Congenital Nephrogenic Diabetes Insipidus | September 2015 | June 2017 |
| NCT00617058 | Terminated | Phase 2 | Improving Metabolic Parameters of Antipsychotic Child Treatment With Ziprasidone, Aripiprazole, and Clozapine | March 2007 | September 2010 |
| NCT00900146 | Terminated | Phase 2/Phase 3 | Dose Finding, Safety and Efficacy of Monthly Subcutaneous Canakinumab Administration in Metformin Monotherapy Treated Type 2 Diabetic Patients | April 2009 | November 2010 |
| NCT02019979 | Terminated | Phase 2 | Metformin and Carbohydrate Restriction With Platinum Based Chemotherapy In Stage IIIB/IV Non-Squamous Non-Small Cell Lung Cancer (NS-NSCLC) | December 2013 | December 2016 |
| NCT02111096 | Terminated | Phase 2 | A Study of LY2409021 in Participants With Type 2 Diabetes Mellitus | April 2014 | September 2015 |
| NCT03477162 | Terminated | Early Phase 1 | Metformin Pharmacology in Human Cancers: A Proof of Principle Study | May 15, 2018 | November 30, 2021 |
| NCT01876992 | Terminated | N/A | Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM) | January 2012 | June 2015 |
| NCT01051011 | Terminated | Phase 3 | A Study to Compare Taspoglutide and Insulin Glargine in Insulin-Naïve Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin and Sulfonylurea Combination Therapy | January 2010 | December 2010 |
| NCT05554679 | Terminated | Phase 4 | Maternal and Fetal Outcome With Metformin Therapy for Obese Pregnant Women . | February 1, 2021 | July 11, 2023 |
| NCT00881725 | Terminated | Phase 2 | A Study of Pre-operative Metformin in Prostate Cancer | June 2009 | June 2012 |
| NCT01717482 | Terminated | Phase 2 | Metformin as a Chemoprevention Agent in Non-small Cell Lung Cancer | October 2012 | May 22, 2019 |
| NCT01208740 | Terminated | Phase 4 | Metformin in Patients With PCOS and Predictors of Poor Ovarian Response Ongoing In-vitro Fertilization | January 2009 | March 2011 |
| NCT02409238 | Terminated | Phase 4 | Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study | March 11, 2015 | December 31, 2019 |
| NCT03380091 | Terminated | Phase 4 | Metformin, Vitamin D, and Depression in Polycystic Ovary Syndrome (PCOS) Trial | December 12, 2017 | September 1, 2019 |
| NCT01910441 | Terminated | Phase 4 | Comparison of Vildagliptin vs. Glimepiride on Glucose Variability in Metformin Uncontrolled Type 2 Diabetic Patients | July 2013 | September 2014 |
| NCT00366301 | Terminated | Phase 4 | The LANCET Trial: A Trial of Long-acting Insulin Injection to Reduce C-reactive Protein in Patients With Type 2 Diabetes | August 2006 | April 2009 |
| NCT03349775 | Terminated | Early Phase 1 | Cardiometabolic Disease and Pulmonary Hypertension | November 27, 2017 | December 22, 2020 |
| NCT01996696 | Terminated | Phase 2 | Prevention of Metabolic Syndrome and Increased Weight Using Metformin Concurrent to Androgen Deprivation Therapy and Radiotherapy for Locally Advanced Adenocarcinoma of the Prostate | September 2014 | November 2020 |
| NCT04504045 | Terminated | Phase 1 | Metformin's Effect on Drug Metabolism in Patients With Type 2 Diabetes | September 1, 2020 | May 10, 2022 |
| NCT01926769 | Terminated | Phase 2 | A Phase II Study to Determine the Safety and Efficacy of Second-line Treatment With Metformin and Chemotherapy (FOLFOX6 or FOFIRI) in the Second Line Threatment of Advanced Colorectal Cancer | February 2012 | December 2014 |
| NCT01929811 | Terminated | Phase 2 | NeoMET Study in Neoadjuvant Treatment of Breast Cancer | October 2013 | June 2020 |
| NCT00690456 | Terminated | Phase 3 | Effect of Rimonabant and Metformin Combination on Glycemic Control in Patients With Type 2 Diabetes | May 2008 | February 2009 |
| NCT01215032 | Terminated | Phase 2 | Metformin in Castration-Resistant Prostate Cancer | September 2010 | January 2015 |
| NCT02796144 | Terminated | Phase 4 | MEtformin and Lorcaserin for WeighT Loss in Schizophrenia | September 2016 | February 14, 2020 |
| NCT01440127 | Terminated | Phase 1 | Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related Pharmacodynamic Markers | August 2011 | October 2012 |
| NCT00263965 | Terminated | Phase 2 | ARAMIS: Actions of tesaglitazaR on fAt Metabolism and Insulin Sensitivity | August 2005 | July 2006 |
| NCT00479466 | Terminated | Phase 2 | Dose-Range Finding Study for MK0893 (0893-008) | July 2007 | May 2008 |
| NCT02945813 | Terminated | Phase 2 | SAKK 08/15 - PROMET - Salvage Radiotherapy +/- Metformin for Patients With Prostate Cancer After Prostatectomy | October 24, 2017 | February 28, 2022 |
| NCT02531308 | Terminated | Phase 2 | Metformin in Combination With Standard Induction Therapy for Large B-cell Lymphoma (DLBCL) | July 2015 | July 2016 |
| NCT02091336 | Unknown status | Phase 4 | Oral Antidiabetic Agents in Pregnancy | January 2014 | December 2016 |
| NCT00414245 | Unknown status | Phase 3 | Metformin for the Treatment of Diabetes in Pregnancy | January 2007 | |
| NCT03627039 | Unknown status | Metformin And Cardiovascular Effectiveness vs SGLT2 (MACES) | September 1, 2018 | August 1, 2020 | |
| NCT02129985 | Unknown status | Phase 4 | Effect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy | February 2014 | September 2015 |
| NCT02149459 | Unknown status | Phase 1 | Treatment of Recurrent Brain Tumors: Metabolic Manipulation Combined With Radiotherapy | June 2014 | July 2018 |
| NCT03629639 | Unknown status | Phase 4 | Metformin for Treatment of Psoriasis Combined With Disorders of Glucose and Lipid Metabolism | September 1, 2018 | December 1, 2020 |
| NCT03639545 | Unknown status | Phase 4 | The Effects of Empagliflozin on Arterial Wall Characteristics | March 1, 2018 | January 30, 2019 |
| NCT03681197 | Unknown status | Early Phase 1 | Metformin Use and Clinical Pregnancy Rate in Women With Unexplained Infertility | June 15, 2018 | May 2019 |
| NCT00832481 | Unknown status | N/A | Comparison of the Effects of Repaglinide and Metformin on Glucose Excursions | January 2009 | December 2009 |
| NCT03708549 | Unknown status | Phase 4 | Comparison of Berberine and Metformin for the Treatment for MS in Schizophrenia Patients | December 1, 2021 | December 1, 2023 |
| NCT00845936 | Unknown status | Phase 4 | Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics | May 2009 | May 2010 |
| NCT00396851 | Unknown status | N/A | Double Blind Randomized Trial to Compare Gurmar (Gymnema Sylvestre) With Metformin in Type 2 Diabetes | January 2007 | |
| NCT03717701 | Unknown status | N/A | Metformin and Esomeprazole in Treatment of Early Onset Preeclampsia | December 1, 2018 | January 1, 2021 |
| NCT03718715 | Unknown status | The Interaction Between Metformin and Microbiota - the MEMO Study. | February 20, 2019 | March 2022 | |
| NCT00883259 | Unknown status | Phase 4 | Metformin and Gestational Diabetes in High-risk Patients: a RCTs | September 2013 | |
| NCT03764605 | Unknown status | Phase 3 | Metformin vs Tolvaptan for Treatment of Autosomal Dominant Polycystic Kidney Disease | January 30, 2019 | January 30, 2022 |
| NCT02275845 | Unknown status | Phase 3 | Medico-GDM Trial - Metformine to Prevent Gestational Diabetes Mellitus | September 2014 | September 2017 |
| NCT00935805 | Unknown status | Glycemic And Blood Pressure Control In Type 2 Diabetes, In A Primary Care Unit: A Staged Management Strategy | July 2006 | July 2012 | |
| NCT02279758 | Unknown status | Phase 2 | A Pilot Study of Metformin Treatment in Patients With Well-differentiated Neuroendocrine Tumors | March 2014 | |
| NCT00941382 | Unknown status | Phase 3 | Sibutramine-metformin Combination Versus Sibutramine and Metformin Monotherapy in Obese Patients | November 2008 | September 2009 |
| NCT00396513 | Unknown status | N/A | Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial. | September 2005 | |
| NCT02325245 | Unknown status | Phase 3 | Effects of Metformin in Pre-frail Elderly | March 2015 | March 2017 |
| NCT03848533 | Unknown status | Phase 2 | Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes | August 22, 2019 | December 2021 |
| NCT00988078 | Unknown status | N/A | Effects of Metformin and Oral Hormonal Contraceptive in Adolescents With Polycystic Ovary Syndrome | July 2011 | December 2013 |
| NCT01001962 | Unknown status | Phase 4 | Double Blind Placebo Study of JARDIANCE® (Empagliflozin) in Prehypertensives Type II Diabetics | January 2016 | January 2020 |
| NCT02360618 | Unknown status | Phase 2 | Metformin and Simvastatin Use in Bladder Cancer | October 2015 | January 2018 |
| NCT00544518 | Unknown status | Phase 2 | Impact of Benfluorex Versus Metformin on Glucose Control and Insulin Secretion in Chinese Type 2 Diabetic Patients | October 2007 | October 2008 |
| NCT02366377 | Unknown status | Phase 1 | The PK/PD, Efficacy, Safety and Tolerability Study of SHR3824 in Combination With Metformin in Type 2 Diabetes Mellitus Patients | February 2015 | |
| NCT01025765 | Unknown status | Phase 4 | The Effects of Oral Hypoglycemic Agents on Chronic Hepatitis C Patients Receiving Peg-Intron Plus Ribavirin | November 2009 | December 2012 |
| NCT01035528 | Unknown status | Phase 4 | Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD) | April 2005 | August 2010 |
| NCT02394158 | Unknown status | Phase 4 | Preventing Recurrent Gestational Diabetes With Metformin | January 27, 2015 | September 30, 2019 |
| NCT03863405 | Unknown status | Phase 2 | Metformin Use in Rheumatoid Arthritis | January 9, 2019 | January 9, 2020 |
| NCT01046500 | Unknown status | Phase 2 | Myo-inositol Versus Metformin Administration in Post-menopausal Women With Metabolic Syndrome | January 2013 | December 2014 |
| NCT03968224 | Unknown status | Phase 2/Phase 3 | Effectiveness of Dapagliflozin for Weight Loss | July 7, 2018 | July 1, 2021 |
| NCT03980990 | Unknown status | Phase 4 | Metformin Continuation Versus Interruption Following Coronary Angiography: a Pilot Randomized Controlled Trial | June 17, 2019 | June 17, 2020 |
| NCT02437812 | Unknown status | Phase 2 | Study of Paclitaxel, Carboplatin and Oral Metformin in the Treatment of Advanced Stage Ovarian Carcinoma | January 2014 | April 2021 |
| NCT02438020 | Unknown status | Phase 4 | Study of Efficacy of Metformin in the Treatment of Acanthosis Nigricans in Children With Obesity | June 2015 | October 2016 |
| NCT02438397 | Unknown status | Phase 4 | the Efficacy of Acarbose and Metformin on Blood Glucose Fluctuation When Combined With Premix Insulin | December 2014 | October 2016 |
| NCT02443922 | Unknown status | N/A | Dynamic Responsiveness of Insulin Secretory Parameters To Sitagliptin and Glimeperide Administration in Type 2 DM | June 2015 | December 2015 |
| NCT00370617 | Unknown status | Phase 4 | Pegylated-Interferon and Ribavirin Plus Metformin in the Treatment of Chronic HCV Infection and Insulin Resistance | September 2006 | January 2009 |
| NCT03994744 | Unknown status | Phase 2 | Assessing Safety and Efficacy of Sintilimab and Metformin Combination Therapy in SCLC | August 20, 2019 | July 1, 2022 |
| NCT02470546 | Unknown status | Phase 4 | Metformin Experience on Minimal Hepatic Encephalopathy | March 2015 | December 2016 |
| NCT02477969 | Unknown status | Phase 3 | Efficacy and Safety Study of PEX168 in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin | February 27, 2014 | June 2017 |
| NCT04001725 | Unknown status | Phase 2 | Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases | October 15, 2019 | March 31, 2022 |
| NCT04029272 | Unknown status | Phase 4 | Metformin vs Metformin Combined With GLP-1RA (Glucagon-like Peptide 1 Receptor Agonist) on Overweight/Obese PCOS Patients | July 20, 2019 | December 31, 2020 |
| NCT02501616 | Unknown status | Phase 4 | Effect of Dapagliflozine on Systemic and Renal Endothelial Function | December 2014 | |
| NCT02501850 | Unknown status | Phase 4 | The Effect of the GLP-1 Receptor Agonists on Blood Levels of Lipoprotein (a) | October 2014 | October 2015 |
| NCT02502344 | Unknown status | Phase 4 | Effect of Medical Interventions in Insulin Resistance on Prevalence of Abnormal Glucose Tolerance | August 2015 | |
| NCT04053621 | Unknown status | N/A | Co-administration of Thiamine Pyrophosphate and Metformin in Type 2 Diabetes | January 2021 | March 2022 |
| NCT02506777 | Unknown status | Phase 2 | Neoadjuvant FDC With Melatonin or Metformin for Locally Advanced Breast Cancer. | July 2015 | August 2020 |
| NCT02506790 | Unknown status | Phase 2 | Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer | July 2015 | August 2022 |
| NCT02511665 | Unknown status | Phase 4 | Metformin And Longevity | July 2015 | July 2017 |
| NCT04089813 | Unknown status | Effect of Metformin on Chronic Pain After Thoracic Surgery in Diabetic Patients | September 10, 2019 | December 31, 2020 | |
| NCT02535299 | Unknown status | Phase 4 | Par-4 and Telomere-telomerase System in Type 2 Diabetes Patients Who Received GLP-1 or Metformin Treatment | June 2016 | December 2019 |
| NCT02535975 | Unknown status | N/A | The Effects of Metformin in Patients With Mild Graves' Ophthalmopathy | December 2014 | October 2019 |
| NCT04121468 | Unknown status | Phase 1/Phase 2 | A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children With Multiple Sclerosis | February 24, 2020 | December 2023 |
| NCT04131582 | Unknown status | Phase 3 | Effect of Empagliflozin + Linagliptin + Metformin + Lifestyle in Patients With Prediabetes | September 1, 2019 | December 30, 2020 |
| NCT04134650 | Unknown status | Phase 3 | Effect of Low Dose Combination of Linagliptin + Metformin to Prevent Diabetes | September 1, 2019 | July 1, 2020 |
| NCT04141163 | Unknown status | Phase 1/Phase 2 | Metformin in Patients With Fragile X | October 29, 2019 | March 2021 |
| NCT04145687 | Unknown status | Phase 4 | Metformin In Prevention of Lupus Nephritis | November 2019 | June 2022 |
| NCT04151459 | Unknown status | N/A | Effect of Metabolic Surgery on Live Birth Rate of Offspring in Obesity Polycystic Ovarian Syndrome Patients | January 16, 2019 | January 15, 2022 |
| NCT04155164 | Unknown status | N/A | Effect of Metformin on Visual Function in Patients With Glaucoma | December 10, 2019 | May 2024 |
| NCT01286233 | Unknown status | Study of Biomarkers Associated With Fatigue in Patients With Early-Stage Breast Cancer Treated With Metformin or Placebo on NCIC-CTG-MA.32 | July 2011 | September 2016 | |
| NCT04177303 | Unknown status | Phase 3 | Incretin Hormones in Type 1 Diabetes Mellitus;Effect of Metformin Treatment | November 29, 2019 | November 29, 2022 |
| NCT01300637 | Unknown status | N/A | Effects of Adjunctive Metformin on Metabolic Profiles in Clozapine-treated Schizophrenic Patients | November 2008 | July 2011 |
| NCT04194515 | Unknown status | Gut Microbiota and Bile Acids in Type 2 Diabetes Mellitus | January 1, 2020 | December 31, 2021 | |
| NCT04222348 | Unknown status | Phase 3 | MeDiGes Study: Metformine Use in Gestational Diabetes | October 26, 2016 | July 1, 2020 |
| NCT02605772 | Unknown status | Phase 4 | Safety and Efficacy of Acarbose+Saxagliptin Compared With Metformin+Saxagliptin in Patients With Type 2 Diabetes | December 2015 | March 2017 |
| NCT01329016 | Unknown status | Phase 1/Phase 2 | Glyburide and Metformin for Gestational Diabetes Mellitus (GDM) | July 2011 | June 2015 |
| NCT02614339 | Unknown status | Phase 3 | Effect of Adjunctive Metformin on Recurrence of Non-DM Colorectal Cancer Stage II High-risk/ III Colorectal Cancer | December 2015 | July 2021 |
| NCT01334684 | Unknown status | N/A | Gene Expression Profiles and Metformin Efficacy in Type 2 Diabetes | May 2011 | September 2013 |
| NCT04268563 | Unknown status | Phase 1/Phase 2 | Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients | January 10, 2020 | July 30, 2021 |
| NCT01342744 | Unknown status | Phase 4 | Metformin in Postmenopausal Women With Metabolic Syndrome | April 2011 | March 2012 |
| NCT02644954 | Unknown status | Phase 3 | Assessing the Efficacy and Safety of Metformin in Treatment of Moderate Psoriasis | January 2016 | |
| NCT02672488 | Unknown status | Phase 2 | Metformin Plus Sorafenib for Advanced HCC | December 2015 | December 2018 |
| NCT01366391 | Unknown status | Phase 4 | Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome | January 2011 | October 2011 |
| NCT01367054 | Unknown status | N/A | Adverse Events in Pharmaceutical Bioequivalence Study of Two Formulations of Metformine Hydrochloride 500 mg | June 2008 | December 2011 |
| NCT00319293 | Unknown status | N/A | Efficacy of Metformin in Lean Women With Polycystic Ovary Syndrome | ||
| NCT04387630 | Unknown status | Phase 2/Phase 3 | Neoadjuvant Chemotherapy With or Without Metformin in Early Breast Cancer. | June 5, 2020 | May 1, 2023 |
| NCT01389778 | Unknown status | N/A | Polycystic Ovary Syndrome Genetics and Treatment Response | June 2011 | October 2019 |
| NCT04390295 | Unknown status | Phase 3 | Efficacy and Safety of SHR3824 in Combination With Metformin in Subjects With Type 2 Diabetes | November 2, 2017 | May 2020 |
| NCT04407650 | Unknown status | Phase 4 | Ursodeoxycholic Acid vs Metformin in Gestational Diabetes Mellitus | July 1, 2021 | June 30, 2023 |
| NCT02719756 | Unknown status | Phase 4 | Effect of SGLT-2 Inhibitor Dapagliflozin on Glycemic Variability in Patients With Diabetes Mellitus Type 2 | April 2016 | December 2016 |
| NCT04500678 | Unknown status | Phase 2/Phase 3 | Impact of Metformin on Immuno-virologic Parameters in HIV | February 1, 2019 | December 31, 2022 |
| NCT04559308 | Unknown status | Phase 2 | The Effect of Metformin on Breast Cancer Patients | June 1, 2019 | October 2020 |
| NCT01471275 | Unknown status | N/A | Chinese Medicine Treatment of Obesity With Type 2 Diabetes, Dyslipidemia | November 2011 | December 2013 |
| NCT00501904 | Unknown status | Phase 4 | Metformin in Infertile PCOS Patients | April 2012 | December 2016 |
| NCT04615351 | Unknown status | Phase 3 | A Pragmatic Approach to Lowering the Risk of Diabetes Mellitus After A Diagnosis of Gestational Diabetes Mellitus | November 15, 2020 | June 30, 2022 |
| NCT02797340 | Unknown status | Phase 4 | Metformin Pharmacokinetics in Patients With Chronic and Acute Heart Failure | January 11, 2016 | April 30, 2018 |
| NCT02802215 | Unknown status | Phase 2/Phase 3 | Metformin for Prevention Gestational Diabetes in Pregnant Women With Polycystic Ovarian Syndrome | January 2016 | September 2016 |
| NCT02848950 | Unknown status | Phase 2 | The Effect of Metformin on Fecundability in an ART(Assisted Reproductive Technology) Setting - the Correlation to Uterine Flows | August 2016 | July 2017 |
| NCT04762966 | Unknown status | Study of Metformin Overdose | March 1, 2021 | September 1, 2021 | |
| NCT00699036 | Unknown status | Phase 2 | Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Avandia in the Treatment of Nonalcoholic Steatohepatitis (NASH) | April 2007 | August 2009 |
| NCT04766008 | Unknown status | Phase 4 | Metformin in Diabetic Patients Undergoing Coronary Angiography | January 15, 2020 | April 30, 2022 |
| NCT01544751 | Unknown status | N/A | Nonalcoholic Fatty Liver Disease (NAFLD) Pharmacological Treatment: Metformin Versus Atorvastatin | September 2011 | June 2015 |
| NCT04780854 | Unknown status | Phase 2 | Drug Repurposing for the Prevention of Chemotherapy-induced Peripheral Neuropathy (CIPN) | November 3, 2020 | July 2022 |
| NCT01565096 | Unknown status | Phase 4 | Effect of Adding Vildagliptin on Beta Cell Function and Cardiovascular Risk Markers in Patients With Moderate Metabolic Control During Metformin Monotherapy | November 2011 | |
| NCT01566799 | Unknown status | Phase 2 | Metformin Plus Neoadjuvant Chemotherapy in Breast Cancer | April 2012 | April 2014 |
| NCT04855513 | Unknown status | N/A | Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial | March 24, 2022 | December 30, 2023 |
| NCT02931591 | Unknown status | N/A | Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children | November 2016 | June 2020 |
| NCT00317928 | Unknown status | N/A | Efficacy of Metformin in PCOS: Metabolic and Hormonal Factors | August 2001 | September 2004 |
| NCT04930471 | Unknown status | Steroid and Behaviour Changes Under Metformin | June 2021 | December 2023 | |
| NCT02981121 | Unknown status | Phase 4 | Hospital-based Diabetes Prevention Study in Korea | November 2016 | November 2020 |
| NCT00303537 | Unknown status | Phase 2/Phase 3 | Metformin in Non-Alcoholic Fatty Liver Disease | November 2004 | June 2008 |
| NCT02984475 | Unknown status | Phase 4 | The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia Major | December 2016 | April 2019 |
| NCT02984722 | Unknown status | N/A | Extended-release vs Immediate-release Metformin in PCOS Women | December 2016 | |
| NCT02990728 | Unknown status | Phase 2 | Mirena® ± Metformin as Fertility-preserving Treatment for Young Asian Women With Early Endometrial Cancer | March 2016 | March 2020 |
| NCT03000218 | Unknown status | Phase 1 | Evaluation of PK and Biomarkers After UDCA Administrations to Subjects Who Are Overweight and Have Liver Problems | August 2016 | |
| NCT01664845 | Unknown status | Phase 2/Phase 3 | Effects of Metformin, Pegylated Interferon Alpha and Ribavirin for Chronic Hepatitis C With Insulin Resistance | August 2012 | August 2014 |
| NCT05013112 | Unknown status | N/A | Ameliorating Metabolic Profiling After Kidney Transplantation (AMPKT) | November 1, 2021 | May 1, 2023 |
| NCT05041673 | Unknown status | N/A | Anti-diabetic Drugs and Fatty Liver Management | February 23, 2021 | September 30, 2022 |
| NCT03018665 | Unknown status | Phase 4 | A Study of the Effect of Glucagon-like Peptide 1(GLP-1) Receptor Agonist in Combination With Metformin Therapy on Diabetes Remission in Subjects With Newly Diagnosed Type 2 Diabetes Who Are Overweight or Obese | February 2017 | |
| NCT03029390 | Unknown status | Phase 4 | Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes | March 2016 | December 2023 |
| NCT03056274 | Unknown status | Phase 2/Phase 3 | Metformin in Intrahepatic Cholestasis of Pregnancy | January 2019 | September 2019 |
| NCT01717911 | Unknown status | Phase 4 | ß-Cell Function and Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients With Moderate Hyperglycemia | September 2010 | December 2018 |
| NCT03071705 | Unknown status | N/A | Metformin Plus TKI Use in Patients With Non-Small Cell Lung Carcinoma | March 2016 | December 2017 |
| NCT05158374 | Unknown status | N/A | Molecular Effects of Aspirin & Metformin on Colonic Epithelium | August 2022 | June 2023 |
| NCT05262257 | Unknown status | Early Phase 1 | Evaluation and Intervention of Cognitive Function in Patients With Diabetes Mellitus. | April 1, 2022 | December 30, 2023 |
| NCT03137186 | Unknown status | Phase 2 | Repurposing Metformin as Anticancer Drug: in Advanced Prostate Cancer | January 2017 | January 2020 |
| NCT05326984 | Unknown status | N/A | Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia | February 9, 2021 | December 2023 |
| NCT03184493 | Unknown status | Phase 3 | Celebrex and Metformin for Postoperative Hepatocellular Carcinoma | June 2, 2017 | June 2021 |
| NCT03194009 | Unknown status | N/A | PRuDENTE; Diabetes Prevention Via Exercise, Nutrition and Treatment | August 10, 2017 | December 31, 2022 |
| NCT03204799 | Unknown status | Metagenomic Analysis of Human Gut Microbiota in Patients With Metabolic Diseases Including Diabetes | December 17, 2016 | December 16, 2019 | |
| NCT03238495 | Unknown status | Phase 2 | Randomized Trial of Neo-adjuvant Chemotherapy With or Without Metformin for HER2 Positive Operable Breast Cancer | August 15, 2017 | June 1, 2023 |
| NCT01855763 | Unknown status | Phase 2/Phase 3 | Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country | December 2008 | December 2013 |
| NCT00247117 | Unknown status | N/A | Metformin in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD) | January 2004 | August 2005 |
| NCT05416580 | Unknown status | Phase 3 | Efficacy of Ursodeoxycholic Acid (UDCA) in Patients With Type 2 Diabetes | September 12, 2022 | April 2024 |
| NCT05418452 | Unknown status | Phase 3 | Efficacy of 1% Metformin Gel Mixed With PRF in Augmenting Narrow Ridge | June 15, 2022 | June 15, 2023 |
| NCT01895569 | Unknown status | Phase 4 | Triple Therapy in Type 2 Diabetic Patients | June 2013 | June 2016 |
| NCT05463627 | Unknown status | Effects of Metformin on Metabolic and Reproductive Outcomes in Chinese PCOS Patients | January 1, 2016 | January 1, 2023 | |
| NCT01930864 | Unknown status | Phase 2 | Metformin Plus Irinotecan for Refractory Colorectal Cancer | September 1, 2015 | December 1, 2020 |
| NCT03375580 | Unknown status | N/A | Therapeutic Effects of Compound Zhenzhu Tiaozhi Capsules in NAFLD | December 31, 2017 | December 31, 2019 |
| NCT03377335 | Unknown status | Phase 4 | Dapagliflozin, Cardio-Metabolic Risk Factors and Type-2 Diabetes | December 22, 2017 | January 2019 |
| NCT03383068 | Unknown status | Phase 4 | Research of Intensive Metabolic Intervention Before Pregnancy in PCOS | January 1, 2018 | June 30, 2020 |
| NCT01960205 | Unknown status | Phase 4 | Effect of Saxagliptin on Pre-Diabetes Mellitus and Obesity | August 2013 | |
| NCT03421119 | Unknown status | Phase 3 | Comparing Efficacy and Safety of CinnaGen-liraglutide Versus Victoza® in Patients With Type II Diabetes | June 20, 2019 | December 1, 2019 |
| NCT03486626 | Unknown status | Phase 4 | Endometrial Thickness and Subendometrial Vascularity in Anovulatory Polycystic Ovarian Syndrome Patients Treated by Metformin | January 2, 2018 | October 2018 |
| NCT02026869 | Unknown status | Early Phase 1 | Vaginal Administration of Metformin in PCOS Patients. | January 2013 | February 2014 |
| NCT03489317 | Unknown status | Gut Microbiomes in Patients With Metabolic Syndrome | November 27, 2017 | December 2021 | |
| NCT03513874 | Unknown status | Phase 4 | Metformin Plus Insulin on Non-obese Autoimmune Diabetes | August 1, 2017 | April 1, 2021 |
| NCT03525028 | Unknown status | N/A | A Clinical Trial of Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis | November 1, 2018 | January 1, 2023 |
| NCT03538704 | Unknown status | N/A | Effect of Fertility-sparing Therapy of Early Endometrial Cancer | January 1, 2015 | December 31, 2020 |
| NCT03590262 | Unknown status | Phase 4 | Effect of Metformin as add-on Therapy on Glycemic Control and Other Outcomes in Type 1 Diabetes | January 1, 2018 | September 30, 2019 |
| NCT02063802 | Unknown status | Phase 2 | Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children | August 2012 | May 2014 |
| NCT03593668 | Unknown status | Phase 4 | Effect and Safety of Benaglutide or Metformin in Patients With Simple Obesity Who Have Inadequate Weight Control | December 30, 2017 | December 2019 |
| NCT02072382 | Unknown status | Phase 4 | The Hypotensive Effect of Metformin in Hypertensive Patients. | May 2013 | December 2015 |
| NCT03600363 | Unknown status | Phase 2 | A Clinical Trial of Metformin in the Maintenance of Non-Hodgkin's Lymphoma Patients | September 1, 2018 | December 2021 |
| NCT03452267 | Withdrawn | Phase 2/Phase 3 | Insulin Signaling in Skeletal Muscle | September 1, 2019 | June 2025 |
| NCT02848508 | Withdrawn | Phase 2 | Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up Study | March 16, 2016 | June 7, 2017 |
| NCT06083675 | Withdrawn | Phase 3 | Research Study to Compare Semaglutide Tablets With Empagliflozin or Metformin Tablets in People With Type 2 Diabetes | January 26, 2024 | May 28, 2027 |
| NCT03465345 | Withdrawn | Phase 1 | Study of Metformin Plus Oligomeric Procyanidin Complex for Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients | July 11, 2018 | July 11, 2018 |
| NCT04604678 | Withdrawn | Phase 2 | Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19 | February 2021 | October 2021 |
| NCT01423487 | Withdrawn | N/A | Efficacy and Safety of Metformin in Preventing Patients With Risperidone From Weight Gain and Amenorrhea | August 2011 | August 2013 |
| NCT05580250 | Withdrawn | Phase 1 | A Study of LY3526318 in Healthy Male Japanese Participants | November 22, 2022 | December 8, 2022 |
| NCT02719132 | Withdrawn | Phase 4 | Effect of DapagliFLOzin on Quality of Life in Patients With Type 2 Diabetes in a Real Clinical PrActice | July 2016 | November 2017 |
| NCT02694289 | Withdrawn | N/A | Effects of Metformin in Heart Failure Patients | November 2016 | September 10, 2018 |
| NCT03816488 | Withdrawn | Phase 1 | Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control | December 1, 2023 | December 1, 2024 |
| NCT00437970 | Withdrawn | Phase 4 | Medication in Early Diabetes (MED) Study | April 2008 | February 2009 |
| NCT00588172 | Withdrawn | Phase 4 | Genetic Variation in OCT1 and Response to Metformin | June 2010 | June 2011 |
| NCT03490019 | Withdrawn | Phase 2 | Treatment of Bardet-Biedl-Syndrome With Metformin for Evaluation of a Possible Visual Improvement | April 1, 2018 | August 2020 |
| NCT01352026 | Withdrawn | Phase 2 | Evaluation of Metformin Activity in Addition to Conventional Treatment of Grade II or III Pulmonary Arterial Hypertension (PAH) | May 2011 | |
| NCT02571608 | Withdrawn | Phase 4 | Continuation of Metformin to Improve And Keep Peri-operative Glycemic Control | January 1, 2022 | December 31, 2022 |
| NCT01171456 | Withdrawn | N/A | Early Intervention for Gestational Diabetes | April 2010 | July 2010 |
| NCT00536211 | Withdrawn | N/A | Physical Inactivity and Insulin Resistance in Skeletal Muscle. | June 2009 | December 2011 |
| NCT02306070 | Withdrawn | Phase 2 | Improving Fibrosis Outcomes With Metformin | January 2016 | April 3, 2018 |
| NCT00775164 | Withdrawn | Phase 4 | Pioglitazone Therapy in Obese Children With Insulin Resistance: A Randomized, Controlled Pilot Study | January 2009 | February 2011 |
| NCT02497638 | Withdrawn | Phase 2 | LIpitor and biGuanide to Androgen Delay Trial | December 2021 | December 2022 |
| NCT02042495 | Withdrawn | Phase 2 | Endometrial Cancer Biomarker Changes Following Exposure to Metformin | August 2016 | |
| NCT02143050 | Withdrawn | Phase 1/Phase 2 | Study of Dabrafenib, Trametinib and Metformin for Melanoma Patients | September 2014 | November 17, 2017 |
| NCT01910246 | Withdrawn | Phase 4 | Cardiovascular Effects of Metformin on Obesity | April 2015 | October 2016 |
| NCT02484209 | Withdrawn | Phase 3 | DiaFrail: A Short Duration Study in Older People ( DIAFRAIL Study) | February 2016 | November 2016 |
| NCT02457286 | Withdrawn | Phase 1 | Improving Insulin Resistance To Treat Non-Alcoholic Fatty Liver Disease: A Pilot Study | June 2015 | July 2017 |
| NCT01961388 | Withdrawn | Study to Assess the Dietary Carbohydrate Content of Indian Diabetics With Special Therapeutic View on Effectiveness of Acarbose and Metformin Monotherapy | August 2015 | June 2017 | |
| NCT00265746 | Withdrawn | Phase 4 | Prevention of Diabetes Mellitus Development in Women Who Had Already Experienced A Gestational Diabetes | November 2005 | |
| NCT00672464 | Withdrawn | Phase 4 | Cardio Risk of Acute Schizophrenia Olanzapine Duke | April 2008 | February 2010 |
| NCT00754689 | Withdrawn | Phase 3 | Study of Rimonabant/Metformin Combinations to Investigate Diabetes (Blood Sugar) Control in Patients With Type 2 Diabetes | September 2008 | November 2008 |
| NCT01733836 | Withdrawn | Phase 2 | Prostate Cancer Active Surveillance Metformin Trial | January 2013 | October 2014 |
| NCT03078725 | Withdrawn | Phase 4 | Failure Rate of GLyburide And Metformin Among Gestational Diabetics | June 20, 2017 | May 10, 2018 |
| NCT05102071 | Withdrawn | Clinical Outcomes and Healthcare Cost and Resource Utilization (HCRU) in Patients With Type 2 Diabetes and Cardiovascular Disease on 2nd Line Empagliflozin Versus 2nd Line Sulfonylureas | November 1, 2021 | June 15, 2022 | |
| NCT01718340 | Withdrawn | Phase 4 | Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia | June 2012 | June 2014 |
| NCT01638988 | Withdrawn | Phase 3 | Clomifene Citrate Versus Metformin in First-line Treatment of Infertility in Patients With Polycystic Ovary Syndrome and a Resistance to Insulin | September 2013 | December 2015 |
| NCT01561482 | Withdrawn | Phase 2 | Study of Metformin With Simvastatin for Men With Prostate Carcinoma | January 2012 | July 2014 |
| NCT00501787 | Withdrawn | Phase 4 | Metformin Administration in Infertile Anovulatory PCOS Patients | January 2008 |