PI3K Inhibitor GDC-0941 Bismesylate
Information
- Drug Name
- PI3K Inhibitor GDC-0941 Bismesylate
- Description
- Entry(CIViC)
- 2
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| breast cancer |
PIK3CA p.Glu545Lys (p.E545K) ( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Glu545Lys (p.E545K) ( ENST00000263967.4, ENST00000643187.1 ) |
D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 20453058 | Detail |
| colorectal cancer |
BRAF p.Val640Glu (p.V640E) ( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 23845441 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Breast cancer cell lines with oncogenic PIK3CA mut... | PIK3CA |
PIK3CA p.Glu545Lys (p.E545K) ( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Glu545Lys (p.E545K) ( ENST00000263967.4, ENST00000643187.1 ) |
Sensitivity | true | CIViC Evidence | detail |
| Combined PI3K inhibitor GDC0941 and BRAF inhibitor... | BRAF |
BRAF p.Val640Glu (p.V640E) ( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) |
Sensitivity | true | CIViC Evidence | detail |