Quarfloxin

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Information
Drug Name
Quarfloxin
Description
Entry(CIViC)
2
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
breast cancer BRCA1 LOSS-OF-FUNCTION BRCA1 LOSS-OF-FUNCTION D Predictive Supports Sensitivity/Response Unknown 4 28211448 Detail
breast cancer BRCA2 LOSS-OF-FUNCTION BRCA2 LOSS-OF-FUNCTION D Predictive Supports Sensitivity/Response Unknown 4 28211448 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
The authors show that in the CX-5461 and CX-3543, ... BRCA1 BRCA1 LOSS-OF-FUNCTION BRCA1 LOSS-OF-FUNCTION Sensitivity true CIViC Evidence detail
The authors show that in the CX-5461 and CX-3543, ... BRCA2 BRCA2 LOSS-OF-FUNCTION BRCA2 LOSS-OF-FUNCTION Sensitivity true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT00780663 Completed Phase 2 Quarfloxin in Patients With Low to Intermediate Grade Neuroendocrine Carcinoma October 2008 March 2010
NCT00955292 Terminated Phase 1 Dose-escalation Study of Quarfloxin in Patients With Advanced Solid Tumors or Lymphomas July 2007 December 2008