Staurosporine
Information
- Drug Name
- Staurosporine
- Description
- Entry(CIViC)
- 1
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| lung non-small cell carcinoma |
EGFR p.Thr790Met (p.T790M) ( ENST00000275493.7, ENST00000450046.2, ENST00000455089.5 ) EGFR p.Thr790Met (p.T790M) ( ENST00000275493.7, ENST00000450046.2, ENST00000455089.5 ) |
E |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 1 | 24658966 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| In NSCLC containing a T790M mutation, staurosporin... | EGFR |
EGFR p.Thr790Met (p.T790M) ( ENST00000275493.7, ENST00000450046.2, ENST00000455089.5 ) EGFR p.Thr790Met (p.T790M) ( ENST00000275493.7, ENST00000450046.2, ENST00000455089.5 ) |
Sensitivity | true | CIViC Evidence | detail |
| IGF1 acts through upregulation of Bcl-2, Bcl-xL an... | IGF1 | IGF1 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| PRAS40 is an AKT3 target. Staurosporine is a pro-a... | AKT1S1 | AKT1S1 UNDEREXPRESSION | Sensitivity | true | MMMP | detail |
| Specific c-Myc inhibition increased melanoma susce... | MYC | MYC UNDEREXPRESSION | Sensitivity | true | MMMP | detail |