TLR4 toll like receptor 4

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Information
Clinical Significance
Ranking
Frequency
Disease area statistics
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Information

Symbol: TLR4
Type: protein-coding
Description: toll like receptor 4
Entrez Gene ID: 7099
Genome: hg19
Position: chr9:120,466,681-120,487,013
Genome: hg38
Position: chr9:117,704,403-117,724,735
MIM: 603030 OMIM
HGNC: HGNC:11850 HGNC
Ensembl: ENSG00000136869 Ensembl
Links: NCBI Gene Cards OncoKB

Clinical Significance

	MGeND	ClinVar
Likely pathogenic	1	0
Benign	0	16
Likely benign	0	26
Conflicting classifications of pathogenicity	0	4
Conflicting classifications of pathogenicity; protective	0	2
not provided	0	4
Uncertain significance	0	74

Ranking

	ClinVar
	0
	0
	6
	100
	12

Frequency

EXAC_EAS

EXAC_EAS

HGVD

HGVD

TOMMO

TOMMO

Gene

Position

EXAC_EAS

EXAC_EAS

HGVD

HGVD

TOMMO

TOMMO

Gene

Position

Disease area statistics

Locus Zoom

Variants

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Target data	:	MGeND data only
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Variant name	Gene	AA change	CDS	Japanese frequency	TogoVar	MGeND				Genome	ClinVar			CIViC evidence	DisGeNET entry	COSMIC occurrence	Prediction
Variant name	Gene	AA change	CDS	Japanese frequency	TogoVar	Entry	Origin	Type	Annotation	Genome	Entry	Origin	Annotation	CIViC evidence	DisGeNET entry	COSMIC occurrence	Prediction

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Name	MGeND				Type	Genome	Size	Chromosome	Start	Stop	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry
Name	Entry	Origin	Type	Annotation	Type	Genome	Size	Chromosome	Start	Stop	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry

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Target data	:	MGeND data only
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Name	MGeND				Type	Genome	Gene symbol	Chromosome	Genomic start	Genomic stop	Strand	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry
Name	Entry	Origin	Type	Annotation	Type	Genome	Gene symbol	Chromosome	Genomic start	Genomic stop	Strand	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry

Type	ID
SYNONYM	ARMD10
SYNONYM	CD284
SYNONYM	TLR-4
SYNONYM	TOLL
MIM	603030 OMIM
HGNC	HGNC:11850 HGNC
Ensembl	ENSG00000136869 Ensembl
AllianceGenome	HGNC:11850

Descrption	Source	Links

ID	Genome	Chromosome	Start	End	Length
ENST00000472304.2	hg38	chr9	117,704,175	117,714,952	10,778
ENST00000355622.8	hg38	chr9	117,704,403	117,724,735	20,333
ENST00000394487.5	hg38	chr9	117,704,192	117,715,775	11,584
ENST00000472304.2	hg19	chr9	120,466,453	120,477,230	10,778
ENST00000394487.5	hg19	chr9	120,466,470	120,478,053	11,584
ENST00000355622.8	hg19	chr9	120,466,681	120,487,013	20,333

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