chr8:31497942:> Detail (hg19) (NRG1)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr8:31,497,942-32,622,294 |
| hg38 | chr8:31,640,426-32,764,776 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| head and neck squamous cell carcinoma | Lapatinib | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 21840482 | Detail |
| colorectal cancer | Cetuximab | D |
Predictive
|
Supports
|
Resistance |
N/A
|
4 | 21900593 | Detail |
| ovarian cancer | Seribantumab | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 20227043 | Detail |
| lung non-small cell carcinoma | Cisplatin,Gemcitabine,Carboplatin,Paclitaxel | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 23390248 | Detail |
| lung non-small cell carcinoma | Patritumab | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 26137564 | Detail |
| cancer | Anti-ErbB3 Monoclonal Antibody AV-203 | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 25542901 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| In non-HER2 amplified cell lines, sensitivity to HER2 kinase inhibitor lapatinib was found mainly in... | CIViC Evidence | Detail |
| NRG1 upregulation or ERBB2 amplification were the main causes of resistance to cetuximab in-vivo and... | CIViC Evidence | Detail |
| An NRG1-ERBB3 autocrine signal-transducing loop was identified in a subset of ovarian cancers and ce... | CIViC Evidence | Detail |
| In-vivo studies of residual NSCLC tumors (xenografts of 5 cell lines) after chemotherapy found incre... | CIViC Evidence | Detail |
| In this phase-2 study, 215 patients were randomized to either erlotinib and placebo or erlotinib and... | CIViC Evidence | Detail |
| This screening study in various tumor xenografts identified NRG1 expression to correlate with sensiv... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg19
- Position
- chr8:31,497,942-32,622,294
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- EXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000523534.1
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/314
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