chr4:74445134:> Detail (hg38) (AREG)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr4:75,310,851-75,320,726 |
| hg38 | chr4:74,445,134-74,455,009 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| colorectal cancer | Panitumumab | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 26867820 | Detail |
| lung non-small cell carcinoma | Crizotinib | D |
Predictive
|
Supports
|
Resistance |
N/A
|
3 | 21791641 | Detail |
| lung non-small cell carcinoma | Crizotinib | B |
Predictive
|
Supports
|
Resistance |
N/A
|
2 | 23344087 | Detail |
| colorectal cancer | Cetuximab | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 23374602 | Detail |
| head and neck squamous cell carcinoma | Docetaxel,Cetuximab | B |
Predictive
|
Supports
|
Resistance |
N/A
|
2 | 21653686 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Prospectively planned retrospective biomarker study in archived tumor tissue from 323 patients from ... | CIViC Evidence | Detail |
| A cell line (DFCI076) with EML1-ALK fusion and resistance mutation L1152R showed no response to ALK ... | CIViC Evidence | Detail |
| Five patients with acquired resistance to crizotinib showed high concentration of amphiregulin in ma... | CIViC Evidence | Detail |
| 226 cetuximab-treated patients with colorectal cancer (CRC) were analyzed for mRNA expression (by qP... | CIViC Evidence | Detail |
| 47 HNSCC patients treated with cetuximab/docetaxel were retrospectively analyzed for EGFRvIII, EGFR ... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg38
- Position
- chr4:74,445,134-74,455,009
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- EXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000395748.3
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/315
Genome browser