chr7:55019101:> Detail (hg38) (EGFR)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr7:55,086,794-55,279,321 |
| hg38 | chr7:55,019,101-55,211,628 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| colorectal cancer | Cetuximab | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 18003960 | Detail |
| colorectal cancer | Panitumumab | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
2 | 17470858 | Detail |
| colorectal cancer | Cetuximab | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
1 | 14993230 | Detail |
| chordoma | Lapatinib | B |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
3 | 23559153 | Detail |
| lung non-small cell carcinoma | Gefitinib | B |
Predictive
|
Supports
|
Sensitivity/Response | 3 | 12748244 | Detail | |
| head and neck squamous cell carcinoma | Docetaxel,Cetuximab | B |
Predictive
|
Does Not Support
|
Sensitivity/Response | Somatic | 3 | 21653686 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Patients with refractory colorectal cancer expressing immunohistochemically detectable EGFR were ran... | CIViC Evidence | Detail |
| 463 patients with 1% or more EGFR tumor cell membrane staining, with metastatic CRC progressive afte... | CIViC Evidence | Detail |
| 57 patients with chemorefractory colorectal cancer expressing EGFR (IHC staining) were treated with ... | CIViC Evidence | Detail |
| 18 advanced progressing chordoma patients entered this study (median age: 61 years; disease extent: ... | CIViC Evidence | Detail |
| Double blind Phase II clinical trial found an objective response rate of 18.4% and 19% for two group... | CIViC Evidence | Detail |
| 47 HNSCC patients treated with cetuximab/docetaxel were retrospectively analyzed for EGFRvIII, EGFR ... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg38
- Position
- chr7:55,019,101-55,211,628
- Variant Type
- snv
- Variant (CIViC) (CIViC Variant)
- EXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000275493.2
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/354
Genome browser