chr7:140453135:> Detail (hg19) (BRAF)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr7:140,453,135-140,453,137 |
| hg38 | chr7:140,753,335-140,753,337 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| 17-AAG is a HSP90 inhibitor | MMMP | Detail |
| In human melanomas containing an activating BRAF mutation (BRAF-positive melanomas), IGFBP7 is epige... | MMMP | Detail |
| Inhibition of BRAF signaling using either a broad-spectrum Raf inhibitor (Sorafenib) or by selective... | MMMP | Detail |
| The growth rate of melanoma cells (but not colon carcinoma) harboring BRAF V600E is inhibited by BRA... | MMMP | Detail |
| C-Raf siRNA knockdown results in decreased viability of YULAC (B-Raf(V600K)) and YUROB (B-Raf(WT)) m... | MMMP | Detail |
| Treatment of metastatic melanoma with PLX4032 in patients with tumors that carry the V600E BRAF muta... | MMMP | Detail |
| Anti-melanoma efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAF(V600E) mutational st... | MMMP | Detail |
| U0126: MEK inhibitor | MMMP | Detail |
| AZ628: RAF selective inhibitor | MMMP | Detail |
| Oncogenic BRAF causes chemoresistance by promoting ERK-dependent inactivation of Bad and Bim, which ... | MMMP | Detail |
| Oncogenic BRAF causes chemoresistance by promoting ERK-dependent inactivation of Bad and Bim, which ... | MMMP | Detail |
| Oncogenic BRAF causes chemoresistance by promoting ERK-dependent inactivation of Bad and Bim, which ... | MMMP | Detail |
| Sorafenib: BRAF, CRAF, VEGFR and PDGFR inhibitor. Oncogenic mutationally activated BRAF acts through... | MMMP | Detail |
| CI-1040 is a MEK inhibitor. Mutation of BRAF is associated with enhanced and selective sensitivity t... | MMMP | Detail |
| PLX 4720 is a BRAF inhibitor with high selectivity for mutated BRAF V600E (compared to wild type) | MMMP | Detail |
| 17-AAG is a HSP90 inhibitor that works against melanoma cells independently of the BRAF mutational s... | MMMP | Detail |
| No objective responses were observed, either in BRAF mutant or wild type tumors | MMMP | Detail |
| When present, BRAF(V599E) appears to be essential for melanoma cell viability and transformation and... | MMMP | Detail |
| U0126 is a MEK inhibitor. When BRAF is mutated (V600E), targeting MEK is more effective than targeti... | MMMP | Detail |
| Sorafenib: BRAF, CRAF, VEGFR and PDGFR inhibitor. When BRAF is mutated (V600E), targeting MEK (with ... | MMMP | Detail |
| BRAF mutational status has no impact on the response to this treatment | MMMP | Detail |
| Tumor response was not associated with BRAF mutation. Sorafenib: BRAF, CRAF, VEGFR and PDGFR inhibit... | MMMP | Detail |
| Sorafenib: BRAF, CRAF, VEGFR and PDGFR inhibitor. Tumor response was minimal both in mutated and wil... | MMMP | Detail |
| RAF 265 is a BRAF inhibitor | MMMP | Detail |
| Sorafenib: BRAF, CRAF, VEGFR and PDGFR inhibitor | MMMP | Detail |
| AZ628 is a BRAF inhibitor | MMMP | Detail |
| PLX4032 is a BRAF inhibitor with high selectivity for mutated BRAF V600E | MMMP | Detail |
| Isolated limb infusion model. p16INK4a expression and absence of activated B-RAF are independent pre... | MMMP | Detail |
| Sorafenib: BRAF, CRAF, VEGFR and PDGFR inhibitor | MMMP | Detail |
| U0126: MEK inhibitor. ABT-737: BH3 mimetic. Treatment of B-RAF mutant human melanoma with a MEK inhi... | MMMP | Detail |
| PLX4032 is a BRAF inhibitor with high selectivity for mutated BRAF V600E. While PLX4032 has antitumo... | MMMP | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg19
- Position
- chr7:140,453,135-140,453,137
- Variant Type
- snv
- Reference Amino Acid
- V
- Alternative Amino Acid
- E
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